CN113181080A - Transparent oil solution of phosphorylcholine polymer and its preparation method and use - Google Patents
Transparent oil solution of phosphorylcholine polymer and its preparation method and use Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention provides a phosphorylcholine polymer transparent oil solution and a preparation method thereof, and particularly provides a phosphorylcholine polymer transparent oil solution containing a phosphorylcholine polymer, an emulsifier and grease and a preparation method thereof. The phosphorylcholine polymer is dissolved in a specific emulsifier and dispersed in an oil solution to form a transparent solution by utilizing the action of a hydrophobic monomer and a hydrophilic monomer in the structure of the phosphorylcholine polymer, so that the application of the phosphorylcholine polymer in cosmetics with oil-based, water-in-oil and oil-in-water formulas is increased, the irritation is reduced by utilizing the film forming property of the phosphorylcholine polymer on skin, and the stability and the moisturizing effect are improved.
Description
Technical Field
The invention relates to the field of cosmetic raw materials, in particular to a transparent oil solution of an oil-insoluble phosphorylcholine polymer, a preparation method and application thereof.
Background
In recent years, with the deterioration of the environment, the influence of atmospheric particle pollution, ultraviolet rays and water quality causes damage to the skin of a human body. Meanwhile, a series of factors cause the sub-health state of the skin along with the poor life style of anxiety, stress, night stay and the like in work in life and the unhealthy eating style. The cosmetics become necessary consumables in the life of men, women, old and young, and have higher requirements on the performance of the cosmetics along with the improvement of the cognition of people, and the performance of the cosmetics is improved and the raw materials in the cosmetics are not separated.
In recent years, phosphorylcholine polymer is taken as a bionic biomaterial with good biocompatibility, namely the heteroperian protuberance, and the high-end medical bionic material has high biocompatibility, is mainly applied to the fields of biological medicines and medical instruments, and is already used as a moisturizing raw material in high-grade cosmetics. At the end of the twentieth century, the japan grease corporation developed a series of biomimetic phosphorylcholine products that were praised as artificial cell membranes due to their extremely high moisture retention and air permeability and their extremely similar components and characteristics to human cell membranes. Wherein, the phosphorylcholine polymer (artificial cell membrane) represented by polyquaternium-51 gradually enters the visual field of people, and the change of the product performance is realized by polymerizing 2-Methacryloyloxyethyl Phosphorylcholine (MPC) with different hydrophobic alkyl chains and adjusting different polymerization ratios, and the application is applied to different fields. It has excellent histocompatibility and blood compatibility, and is commonly used in biomedical fields such as medical organ transplantation, ophthalmologic care, wound repair, etc.
The product is applied to cosmetics, a breathable biological membrane can be formed on the surface of skin to form a breathable water-retaining film, the intelligent water-retaining and moisture-retaining film has super-strong moisture-retaining performance which is twice that of hyaluronic acid, and meanwhile, the irritation of irritants in a finished product to the skin is inhibited, dust in the environment is shielded, a charge layer is adsorbed and stabilized, and static electricity is eliminated.
In addition, polyquaternium-51 forms an excellent water-washing resistant film, has a molecular nail effect, namely, the polyquaternium-51 can still be kept on the surface of the skin after multiple water washing, keeps moisture for a long time and reduces irritation. At present, due to the characteristics of phosphorylcholine, the phosphorylcholine is mostly used for water-based products, so that the application of the phosphorylcholine is limited.
Therefore, there is an urgent need in the art to develop a phosphorylcholine polymer oil solution with high transparency, high stability and high biocompatibility, which is suitable for various dosage forms such as oil-based, oil-in-water, water-in-oil and the like.
Disclosure of Invention
The invention aims to provide a phosphorylcholine polymer oil solution (stock solution) which is suitable for cosmetics and has high transparency, high stability and high biocompatibility, and a preparation method and application thereof.
In a first aspect of the present invention, there is provided a phosphorylcholine polymer oily stock solution, comprising, based on the total weight of the oily stock solution: 0.1-10% of phosphorylcholine polymer, 5-50% of emulsifier and 5-50% of grease.
In another preferred embodiment, the oily stock solution further contains 0.1-5% of antioxidant.
In another preferred embodiment, the antioxidant is selected from: tocopherol, tocopherol acetate, tocopherol succinate, a tocopherol mixture, or a mixture thereof.
In another preferred embodiment, the phosphorylcholine polymer contains (a) hydrophilic groups; (b) a hydrophobic group.
In another preferred embodiment, the hydrophilic group has a branched structure represented by formula I:
in the formula, R1，R2And R3Each independently selected from: H. c1-C4Alkyl radical, C3-C4A cycloalkyl group of (a).
In another preferred embodiment, the backbone unit of the phosphorylcholine polymer is selected from the group consisting of:
A5) A1-A4 combination.
In another preferred example, in A1-A5, the phosphorylcholine group represented by formula I is represented by-CO-O-CH2-CH2-、-CO-O-CH2-CH2-O-, and/or-CO-O- (CH)2)m-CH2-linked to the main chain, wherein m is a positive integer from 2 to 17.
In another preferred embodiment, the backbone is selected from the group consisting of:
in another preferred embodiment, the phosphorylcholine polymer is selected from: 2-methacryloyloxyethyl phosphorylcholine homopolymers, copolymers of 2-methacryloyloxyethyl phosphorylcholine and other hydrophilic and/or hydrophobic monomers or combinations thereof, polyphosphocholine ethylene glycol acrylate, polyphosphocholine n-butyl methacrylate, or combinations thereof.
In another preferred embodiment, the grease is selected from: isopropyl palmitate, isooctyl palmitate, isononyl isononanoate, white oil, glyceryl caprylate/caprate triester, octyldodecanol, coconut oil acid, lauryl alcohol, isopropyl myristate, shea butter, isooctyl 12-hydroxystearate, diisostearyl malate, squalane, jojoba oil, soybean oil, olive oil, sweet almond oil, avocado oil, wheat germ oil, or combinations thereof.
In another preferred embodiment, the emulsifier is selected from the group consisting of: polyglycerol esters, sorbitan fatty acid ester series, sorbitol cocoate, sucrose fatty acid ester, alkyl glycosides, hydrogenated lecithin, fatty alcohol polyoxyethylene ether, alkylphenol ethoxylates, fatty acid polyoxyethylene esters, polyethers, glyceryl caprylic/capric acid esters, or combinations thereof.
In a second aspect of the present invention, there is provided a method for preparing the phosphorylcholine polymer oily stock solution of the first aspect, comprising the steps of:
(1) providing a phosphorylcholine polymer and an emulsifier, and mixing the phosphorylcholine polymer and the emulsifier into an oil phase mixture according to a certain proportion;
(2) heating the oil phase mixture in the step (1) to 45-120 ℃, preferably 60-120 ℃;
(3) adding other grease into the mixture obtained in the step (2), and then cooling to 10-60 ℃ to obtain the phosphorylcholine polymer oily stock solution.
In a third aspect of the present invention, there is provided a use of the phosphorylcholine polymer oily stock solution of the first aspect for the manufacture of oil-based, water-in-oil, oil-in-water formulations.
In a fourth aspect of the present invention, there is provided a cosmetic comprising the phosphorylcholine polymer oily stock solution according to the first aspect.
In another preferred example, the cosmetic is an oil-based formula cosmetic or contains an oily auxiliary material.
In another preferred example, the oil-based cosmetic comprises: a facial mask, spray, wet wipe, lotion, cream, lotion, gel, shampoo, conditioner, hair and scalp care essence, make-up or other cosmetic for skin and hair, or a combination thereof.
It is to be understood that within the scope of the present invention, the above-described features of the present invention and those specifically described below (e.g., in the examples) may be combined with each other to form new or preferred embodiments. Not to be reiterated herein, but to the extent of space.
Drawings
Figure 1 shows a clear phosphorylcholine polymer oily stock solution prepared in one embodiment of the present invention.
Figure 2 shows a prior art phosphorylcholine polymer mixed liquid (turbid liquid) with oil.
Detailed Description
The present inventors have made extensive and intensive studies and, through a large number of screenings, have for the first time unexpectedly developed an oily stock solution (emulsion stock solution) of a phosphorylcholine polymer having high stability, high compatibility and transparency. Specifically, the inventor adds specific components (phosphorylcholine polymer emulsifier and grease) to obtain an oily stock solution with high transparency, high stability and high biocompatibility. The high-transparency oily stock solution can be widely applied to cosmetics, so that the quality and the effect of the cosmetics are improved. The present invention has been completed based on this finding.
Specifically, the phosphorylcholine polymer oil solution (also called as "oily stock solution") provided by the invention utilizes hydrophobic side chain groups (or monomers) and hydrophilic side chain groups (or monomers) in the phosphorylcholine polymer structure to dissolve in a specific emulsifier, so that the solubility of the phosphorylcholine polymer in cosmetics in oil-based, water-in-oil and oil-in-water formulations is obviously improved, and the oily stock solution with high transparency, high stability and high biocompatibility is obtained.
The transparent phosphorylcholine polymer oil solution disclosed by the invention is beneficial to applying the phosphorylcholine polymer to oil-based, water-in-oil and oil-in-water formula cosmetics, reduces stimulation and improves moisturizing repair effects through the film-forming property of the phosphorylcholine polymer on skin, and solves the problems that the phosphorylcholine polymer is insoluble in oil, poor in stability, low in bioavailability and the like in the prior art.
Term(s) for
As used herein, "active ingredient," "active ingredient of the present invention," "phosphorylcholine polymer oil solution of the present invention," which are used interchangeably, all refer to a polymer containing the active ingredient phosphorylcholine.
As used herein, the terms "oily raw liquid of the present invention", "transparent oil solution of the present invention", "phosphorylcholine polymer transparent oil solution of the present invention", and the like, which are used interchangeably, refer to an oily raw liquid having high transparency, high stability, high biocompatibility, which is formed by mixing an oil-insoluble phosphorylcholine polymer with specific ingredients such as an emulsifier and an oil or fat.
Phosphorylcholine polymer compound
In the oily stock solution of the present invention, one core component is a phosphorylcholine polymer.
In the present invention, the phosphorylcholine polymer refers to a polymer containing a phosphorylcholine group, particularly a polymer having a phosphorylcholine group in a side chain. The phosphorylcholine polymers of the present invention may be homopolymers or copolymers, including random copolymers, block copolymers, or combinations thereof. The copolymers of the invention may be binary, ternary or higher order copolymers.
In the present invention, the phosphorylcholine group may be directly linked (e.g., terminated) to a polymer backbone (backbone) or indirectly linked to the backbone via a linking group (e.g., a divalent linking group, or a divalent linking group).
In addition, in the present invention, the preferred phosphorylcholine polymer further contains a hydrophobic group, for example, a hydrophobic group at a side chain, or a hydrophobic group at a terminal.
Preferably, the phosphorylcholine polymers of the invention are copolymers formed, for example, by copolymerization of monomers containing phosphorylcholine groups with monomers containing no phosphorylcholine groups.
In another preferred embodiment, the phosphorylcholine polymer of the present invention is a polymer formed by polymerization of a hydrophobic monomer (monomer not containing a phosphorylcholine group) and a hydrophilic monomer (monomer containing a phosphorylcholine group).
The phosphorylcholine polymer of the present invention can be prepared by a known method, or can be obtained commercially. In addition, the phosphorylcholine polymer of the present invention also includes a phosphorylcholine polymer prepared by modifying a polymer.
Preferably, the phosphorylcholine polymer of the invention contains phosphorylcholine groups (preferably as groups on a branch) of formula I:
in the formula, R1、R2And R3Each independently selected from: H. c1-C4Alkyl of (A), C3-C4Cycloalkyl groups of (a);
n is 1,2, 3, or 4.
Preferably, R1、R2And R3Each independently selected from: H. methyl or ethyl.
Preferably, n is 2 or 3.
In another preferred example, the molecular weight of the phosphorylcholine polymer is not particularly limited, and a preferred weight-average molecular weight or number-average molecular weight is 1 to 300 ten thousand, more preferably 5 to 200 ten thousand.
In another preferred embodiment, examples of the phosphorylcholine polymer include (but are not limited to): 2-methacryloyloxyethyl phosphorylcholine homopolymer, copolymer of 2-methacryloyloxyethyl phosphorylcholine and other hydrophilic and/or hydrophobic monomers or combination thereof, polyphosphoric acid choline ethylene glycol acrylate, polyphosphoric acid choline n-butyl methacrylate.
The inventors of the present invention have unexpectedly found that when a specific emulsifier is used, the solubility of an oil-insoluble phosphorylcholine polymer can be significantly improved, and the oil-insoluble phosphorylcholine polymer can be well dissolved and dispersed in an oil or an oily solvent, so that the oil solution of a phosphorylcholine polymer (an oily stock solution containing a high-concentration phosphorylcholine polymer compound) of the present invention has high transparency, and has excellent characteristics of higher stability, higher biocompatibility, and the like, thereby significantly increasing the content of the phosphorylcholine polymer in cosmetics made from the oil solution of a phosphorylcholine polymer, increasing the permeability of the phosphorylcholine polymer, and enhancing the effects or efficacies of moisturizing repair, and the like of the phosphorylcholine polymer.
Other ingredients
In the oily stock solution of the present invention, one or more additional ingredients may be further added as long as the additional ingredients do not substantially affect the oily stock solution of the present invention (e.g., cause a significant decrease in the solubility of the phosphorylcholine polymer, cause opacity, etc.).
These additional ingredients are optional, and representative additional ingredients include (but are not limited to): preservatives, perfumes, antioxidants, pigments (e.g. natural pigments), fragrances, or other cosmetically acceptable active ingredients (e.g. ceramides) or adjuvants.
For example, a fragrance may be added to the oily stock solution of the present invention to obtain a predetermined fragrance.
Preservatives may be added to the oily stock solutions of the present invention to further achieve long-term shelf life performance. Representative preservatives are selected from: phenoxyethanol, methyl benzoate, sorbic acids, 1, 3-butanediol, 1, 2-pentanediol, 1, 2-hexanediol, or combinations thereof.
The antioxidant is selected from: tocopherol, tocopherol acetate, tocopherol succinate, a tocopherol mixture, or a mixture thereof.
Preparation method
The invention also provides a method for preparing the transparent phosphorylcholine polymer oily stock solution.
In a preferred embodiment, the method comprises the steps of:
(1) providing a phosphorylcholine polymer and an emulsifier, and mixing the phosphorylcholine polymer and the emulsifier into an oil phase mixture according to a certain proportion;
(2) heating the oil phase mixture in the step (1) to 45-120 ℃, preferably 60-120 ℃;
(3) adding other grease into the mixture obtained in the step (2), and then cooling to 10-60 ℃ to obtain the phosphorylcholine polymer oily stock solution.
The main advantages of the invention include:
(a) the method improves the solubility of phosphorylcholine polymer in the oily stock solution, so that the content of the phosphorylcholine polymer in oil-based, water-in-oil and oil-in-water cosmetics prepared from the oily stock solution is increased, and the moisturizing and repairing effects of the cosmetics are enhanced.
(b) The method improves the stability of the phosphorylcholine polymer in the oily stock solution, so that the phosphorylcholine polymer can be used as an active ingredient more widely and is continuously applied to oil-based, water-in-oil and oil-in-water cosmetics.
(c) In the oily stock solution, the phosphorylcholine polymer is fully dispersed, and turbidity cannot be caused by insolubility, so that the biocompatibility of oil-based, water-in-oil and oil-in-water formula cosmetics prepared from the oily stock solution is enhanced.
(d) The phosphorylcholine polymer oily stock solution has good transmittance.
(e) In the oily stock solution, the phosphorylcholine ester polymer and the emulsifier are fully mixed to form a compound, so that the phosphorylcholine ester polymer of the oil-based, water-in-oil and oil-in-water formula cosmetics prepared from the oily stock solution has good film-forming property and good moisturizing and irritation reducing performances.
(f) The oil solution of the invention can be directly used for preparing oil-based, water-in-oil and oil-in-water formula cosmetics.
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. The experimental procedures, in which specific conditions are not noted in the following examples, are generally carried out under conventional conditions or conditions recommended by the manufacturers. Unless otherwise indicated, percentages and parts are percentages and parts by weight.
Example 1 preparation of clear phosphorylcholine polymer Compound oily stock solution No.1
Weighing the components according to the raw material proportion shown in the table 1, and then operating according to the following steps:
(1) providing a phosphorylcholine polymer and an emulsifier, and mixing the phosphorylcholine polymer and the emulsifier into an oil phase mixture according to a certain proportion;
(2) heating the oil phase mixture in the step (1) to 45-120 ℃, preferably 60-120 ℃;
(3) adding other grease into the mixture obtained in the step (2), and then cooling to 10-60 ℃ to obtain the phosphorylcholine polymer oily stock solution No.1 (total 100 g).
Table 1 raw material formulation (weight percent)
| Raw materials | Example 1 | Example 2 | Comparative example 1 |
| Phosphorylcholine polymer | 2 | 4 | 2 |
| Oil and fat | 50 | 46 | 98 |
| Emulsifier | 48 | 50 | 0 |
Example 2 preparation of clear Phosphorylcholine oily stock solution No.2
Example 1 was repeated except that the components were weighed in accordance with the raw material proportions of example 2 shown in Table 1 to obtain phosphorylcholine oily stock solution No. 2.
Comparative example 1 preparation of clear phosphorylcholine oily stock solution No. C1
Example 1 was repeated except that the components were weighed in accordance with the raw material proportions of comparative example 1 shown in Table 1 to obtain phosphorylcholine oily stock solution No. C1.
Example 3 Performance testing
In this example, the performance of the oil stock solutions of phosphorylcholine nos. 1 to 2 prepared in examples 1 to 2 and the mixed liquid of phosphorylcholine No. c1 prepared in comparative example 1 were measured.
1. Appearance:
the test method comprises the following steps: room temperature, photographs were taken, contrasting transparency with the naked eye.
As a result:
example 1: transparent in appearance (fig. 1);
example 2: the appearance is transparent;
comparative example 1: turbid appearance (fig. 2)
2. Stability:
the test method comprises the following steps: the sample was left at room temperature for 1 month; circulating at 45 deg.C (standing at 45 deg.C for 24h, returning to room temperature for 24h, and circulating for 1 month); the transparency was visually checked at 5 ℃ for 1 month and at-10 ℃ for 1 month.
As a result: as shown in table 2.
Table 2 stability test results
| Example 1 | Example 2 | Comparative example 1 | |
| Room temperature (25 ℃) for 1 month | The appearance remains transparent | The appearance remains transparent | Appearance of precipitation |
| 45 deg.C, 1 month | The appearance remains transparent | The appearance remains transparent | Appearance of precipitation |
| 5 deg.C, 1 month | The appearance remains transparent | The appearance remains transparent | Appearance of precipitation |
| At-10 deg.C for 1 month | The appearance remains transparent | The appearance remains transparent | Appearance of precipitation |
All documents referred to herein are incorporated by reference into this application as if each were individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention can be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the present invention as defined by the appended claims.
Claims (9)
1. The phosphorylcholine polymer oily stock solution is characterized by comprising the following components in percentage by weight based on the total weight of the oily stock solution: 0.1-10% of phosphorylcholine polymer, 5-50% of emulsifier and 5-50% of grease.
2. The phosphorylcholine-polymer oily stock solution of claim 1, wherein the phosphorylcholine-polymer contains (a) hydrophilic groups; (b) a hydrophobic group.
3. The phosphorylcholine-polymer oily stock solution of claim 2, wherein the hydrophilic group contains a branched structure represented by formula I:
in the formula, R1，R2And R3Each independently selected from: H. c1-C4Alkyl radical, C3-C4A cycloalkyl group of (a).
4. The phosphorylcholine polymer oily stock solution according to claim 1, wherein the oil or fat is selected from the group consisting of: isopropyl palmitate, isooctyl palmitate, isononyl isononanoate, white oil, glyceryl caprylate/caprate triester, octyldodecanol, coconut oil acid, lauryl alcohol, isopropyl myristate, shea butter, isooctyl 12-hydroxystearate, diisostearyl malate, squalane, jojoba oil, soybean oil, olive oil, sweet almond oil, avocado oil, wheat germ oil, or combinations thereof.
5. The phosphorylcholine-polymer oily stock solution according to claim 1, wherein the emulsifier is selected from the group consisting of: polyglycerol esters, sorbitan fatty acid ester series, sorbitol cocoate, sucrose fatty acid ester, alkyl glycosides, hydrogenated lecithin, fatty alcohol polyoxyethylene ether, alkylphenol ethoxylates, fatty acid polyoxyethylene esters, polyethers, glyceryl caprylic/capric acid esters, or combinations thereof.
6. A process for preparing the phosphorylcholine polymer oily stock solution of claim 1, characterized by comprising the steps of:
(1) providing a phosphorylcholine polymer and an emulsifier, and mixing the phosphorylcholine polymer and the emulsifier into an oil phase mixture according to a certain proportion;
(2) heating the oil phase mixture in the step (1) to 45-120 ℃, preferably 60-120 ℃;
(3) adding other grease into the mixture obtained in the step (2), and then cooling to 10-60 ℃ to obtain the phosphorylcholine polymer oily stock solution.
7. Use of the phosphorylcholine polymer oily stock solution according to claim 1, for the manufacture of oil-based, water-in-oil, oil-in-water formulations.
8. A cosmetic comprising the phosphorylcholine polymer oily raw liquid according to claim 1.
9. The cosmetic according to claim 8, wherein the cosmetic is an oil-based formulation or contains an oily vehicle.
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| CN202110179830.5A CN113181080A (en) | 2021-02-07 | 2021-02-07 | Transparent oil solution of phosphorylcholine polymer and its preparation method and use |
| PCT/CN2022/075196 WO2022166926A1 (en) | 2021-02-02 | 2022-01-30 | Clear oily solution of phosphorylcholine polymer, cosmetic raw material stock solution, and preparation method therefor and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114259421A (en) * | 2022-01-29 | 2022-04-01 | 江苏奥洁生物科技有限公司 | Daily chemical raw material based on phosphorylcholine polymer and preparation method thereof |
| CN114869803A (en) * | 2022-06-06 | 2022-08-09 | 郑州迈健医药科技有限公司 | Cosmetic emulsion |
| WO2022166926A1 (en) * | 2021-02-02 | 2022-08-11 | 上海奥利实业有限公司 | Clear oily solution of phosphorylcholine polymer, cosmetic raw material stock solution, and preparation method therefor and application thereof |
| CN114939079A (en) * | 2022-05-19 | 2022-08-26 | 上海奥利实业有限公司 | Preparation method and application of retinol and derivative inclusion thereof |
| CN115581637A (en) * | 2022-10-26 | 2023-01-10 | 上海奥麟材料科技有限公司 | Organic surface treatment method of phosphorylcholine polymer for titanium dioxide |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103442684A (en) * | 2012-02-10 | 2013-12-11 | 株式会社资生堂 | Oil-in-water-type emulsion skin cosmetic |
| CN105670022A (en) * | 2016-02-25 | 2016-06-15 | 西安科技大学 | Preparation method of phosphorylcholine bionic coating |
| CN111529444A (en) * | 2020-05-25 | 2020-08-14 | 湖北省麦诗特生物科技有限公司 | Composition with skin barrier repair function and preparation method and application thereof |
| CN111743807A (en) * | 2020-08-03 | 2020-10-09 | 上海奥利实业有限公司 | Water-oil insoluble transparent ceramide aqueous solution and preparation method thereof |
| CN111803393A (en) * | 2020-08-03 | 2020-10-23 | 上海奥利实业有限公司 | Transparent aqueous solution of water-oil insoluble licoflavone, and preparation method and application thereof |
-
2021
- 2021-02-07 CN CN202110179830.5A patent/CN113181080A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103442684A (en) * | 2012-02-10 | 2013-12-11 | 株式会社资生堂 | Oil-in-water-type emulsion skin cosmetic |
| CN105670022A (en) * | 2016-02-25 | 2016-06-15 | 西安科技大学 | Preparation method of phosphorylcholine bionic coating |
| CN111529444A (en) * | 2020-05-25 | 2020-08-14 | 湖北省麦诗特生物科技有限公司 | Composition with skin barrier repair function and preparation method and application thereof |
| CN111743807A (en) * | 2020-08-03 | 2020-10-09 | 上海奥利实业有限公司 | Water-oil insoluble transparent ceramide aqueous solution and preparation method thereof |
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