CN113318001A - 含有Trehangelin的皮肤清洁剂及片层形成促进剂 - Google Patents
含有Trehangelin的皮肤清洁剂及片层形成促进剂 Download PDFInfo
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- CN113318001A CN113318001A CN202110061686.5A CN202110061686A CN113318001A CN 113318001 A CN113318001 A CN 113318001A CN 202110061686 A CN202110061686 A CN 202110061686A CN 113318001 A CN113318001 A CN 113318001A
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- extract
- trehangelin
- skin cleanser
- skin
- acid
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Abstract
本发明的课题在于，提供含有Trehangelin的皮肤清洁剂和片层形成促进剂。作为解决方法，本发明提供1.含有Trehangelin的皮肤清洁剂和片层形成促进剂。2.根据1.所述的皮肤清洁剂，其特征在于，Trehangelin相对于皮肤清洁剂总量的含量为0.001质量％以上10质量％以下。3.根据1.或2.所述的皮肤清洁剂，其特征在于，含有阴离子性表面活性剂。4.根据1.～3.中任一项所述的皮肤清洁剂，其特征在于，Trehangelin A相对于Trehangelin总量的含有率为40％以上80％以下。
Description
技术领域
本发明涉及含有Trehangelin的皮肤清洁剂和片层形成促进剂。
背景技术
Trehangelin为海藻糖的3，3’位的当归酸二酯。本申请人发现，关于Trehangelin向化妆品的应用，有皮肤老化抑制作用、美白作用、MMP-2及MMP-9的产生抑制作用(专利文献1：日本专利第6406636号公报)，进一步发现有光线过敏症抑制作用(专利文献2：日本专利第6249415号公报)。然而，关于Trehangelin对角质层细胞间脂质的片层结构的影响及向皮肤清洁剂的适用尚未研究。
角质层内中存在用于保持肌肤的湿润而重要的细胞间脂质规则正确排列的片层结构。存在因皮肤清洁剂中调配的表面活性剂或清洁中所用的水，细胞间脂质破坏，从而引起洗后干燥的课题。因此，追求可抑制细胞间脂质的溶出并可除去皮脂污垢的皮肤清洁剂，至今为止种种技术被开发。专利文献3(日本专利第6567808号公报)中记载有一种具有高选择性清洁性的清洁剂的技术，其特征在于，以特定的比例调配阴离子性表面活性剂、非离子表面活性剂及两性表面活性剂，可因角质的屏障功能抑制必要的细胞间脂质的溶出同时去除皮脂污垢。
已知糖类促进片层形成并保护片层结构，提高肌肤的屏障功能，保持湿润，通过向皮肤外用剂中调配糖类而保持皮肤的湿润的技术得到公开。专利文献4(日本特开2011-136957号公报)中记载有一种技术，其特征在于，通过在清洁剂中使用低聚糖、特定的非离子性表面活性剂及二元醇，冲洗时滑腻感少，清洁后的保湿优异，且作为低聚糖，可列举海藻糖、棉子糖等。
专利文献5(日本特开2001-247448号公报)中记载有一种皮肤清洁剂组合物，其特征在于，通过向清洁剂中调配相对于水的饱和溶解度以上的海藻糖作为擦洗材料，角质去除效果及按摩效果优异，且对皮肤的安全性、保湿性高，使用感优异。
专利文献6(日本专利第5707062号公报)中记载有一种技术，其特征在于，含有由甘露糖赤藓糖醇酯和蔗糖脂肪酸酯构成的脂质体的皮肤外用组合物可恢复角质层下层，尤其是至下层10层为止的细胞间脂质的片层结构。
专利文献7(日本特开2006-45186号公报)中记载有一种含有葡萄糖及/或棉子糖的皮肤的角质层细胞中的片层结构再生剂，及一种以含有葡萄糖和少糖类为特征，且作为少糖类，含有选自棉子糖、蜜二糖、海藻糖、蔗糖、麦芽糖、纤维二糖、龙胆三糖、水苏糖及环糊精中的1种以上的片层结构再生剂。
然而，尚不知晓通过在皮肤清洁剂中调配Trehangelin，来抑制片层的溶出并促进片层结构恢复的技术，且不知Trehangelin具有片层形成促进能力。
专利文献
专利文献1：日本专利第6406636号公报
专利文献2：日本专利第6249415号公报
专利文献3：日本专利第6567808号公报
专利文献4：日本特开2011-136957号公报
专利文献5：日本特开2001-247448号公报
专利文献6：日本专利第5707062号公报
专利文献7：日本特开2006-45186号公报
发明内容
本发明的课题在于，提供含有Trehangelin的皮肤清洁剂和片层形成促进剂。
本发明的主要构成如下所示。
1.一种皮肤清洁剂，其特征在于，含有Trehangelin。
2.根据1.所述的皮肤清洁剂，其特征在于，Trehangelin相对于皮肤清洁剂总量的含量为0.001质量％以上10质量％以下。
3.根据1.或2.所述的皮肤清洁剂，其特征在于，含有阴离子性表面活性剂。
4.根据1.～3.中任一项所述的皮肤清洁剂，其特征在于，Trehangelin A相对于Trehangelin总量的含有率为40％以上80％以下。
5.一种片层形成促进剂，其特征在于，含有Trehangelin。
6.根据5.所述的片层形成促进剂，其特征在于，Trehangelin A相对于Trehangelin总量的含有率为40％以上80％以下。
通过本发明的含有Trehangelin的皮肤清洁剂，可期待皮肤清洁后的角质层细胞间脂质的溶出得到抑制，提高肌肤的屏障功能，保持湿润。
本发明中所用的Trehangelin具有促进角质层细胞间脂质的片层结构的形成、提高肌肤的屏障功能且保持湿润的效果，可提供含有Trehangelin的片层形成促进剂。
附图说明
图1为片层形成促进能力的评价结果。
图2为比较例1(添加水时的偏光十字图像)。
图3为比较例11(添加海藻糖0.1％水溶液时的偏光十字图像)。
图4为实施例1(添加Trehangelin 0.01％水溶液时的偏光十字图像)。
图5为实施例2(添加Trehangelin 0.1％水溶液时的偏光十字图像)。
图6为实施例3(添加Trehangelin 1.0％水溶液时的偏光十字图像)。
图7为实施例4(添加Trehangelin 10％水溶液时的偏光十字图像)。
图8为通过胶带剥离法采集的角质层中的片层率。
图9为通过胶带剥离法采集的角质层的图像。
具体实施方式
本发明涉及含有Trehangelin的皮肤清洁剂和片层形成促进剂。
本发明所使用的Trehangelin为海藻糖的3，3’位的当归酸二酯的系统名称，为日本北里大学生命化学研究所微生物功能研究室的研究团队发现的新型物质。在本说明书中，“Trehangelin”是指下述通式所表示的化合物及其类似物。
[化学式1]
(式中，R1～R3的任一个为2-甲基-2-丁烯酰基(2-methylbut-2-enoyl)，其余的两个表示氢原子，且R4表示氢原子，R5及R6的任一个为2-甲基-2-丁烯酰基，其余的一个表示氢原子。)
作为本说明书中的Trehangelin，例如可列举Trehangelin A、Trehangelin B及Trehangelin C。Trehangelin A为下述式(1)所表示的化合物。
[化学式2]
本说明书中，Trehangelin B为下述式(2)所表示的化合物。
[化学式3]
本说明书中，Trehangelin C为下述式(3)所表示的化合物。
[化学式4]
本说明书中，Trehangelin A为具有以下物性的化合物：
(1)性状：透明或白色粉末
(2)分子量：506
(3)分子式：C22H34O13
(4)基于高分辨率质量分析的[M+H]+理论值(m/z)507.2078，实测值(m/z)507.2087
(5)比旋度：[α]D 25.3＝+167.12°(c＝0.1，甲醇)
(6)紫外吸收极大值λmax(甲醇中)：216nm
(7)红外吸收极大值在νmax(KBr压片)：＝2919cm-1，，1033cm-1处具有极大吸收。
(8)1H NMR(重甲醇中)δppm：6.11(1H，m)，5.48(1H，dd)，5.21(1H，d)，3.92(1H，m)，3.80(1H，dd)，3.73(1H，m)，3.71(1H，dd)，3.56(1H，dd)，2.01(3H，m)，1.95(3H，m)
(9)13C NMR(重甲醇中)δppm：169.6，138.2，129.6，95.1，76.5，73.9，71.6，70.0，62.2，20.8，16.0
(10)相对于溶剂的溶解性：易溶于乙醇、甲醇及水。难溶于氯仿。
或者Trehangelin A为下述式(1)所表示的化合物。
[化学式5]
在本说明书中，Trehangelin B为具有以下物性的化合物：
(1)性状：透明或白色粉末
(2)分子量：506
(3)分子式：C22H34O13
(4)基于高分辨率质量分析的[M+H]+理论值(m/z)507.2078，实测值(m/z)507.2074
(5)比旋度：[α]D 25.3＝+13.5°(c＝0.1，甲醇)
(6)紫外吸收极大值λmax(甲醇中)：218nm
(7)红外吸收极大值在νmax(KBr压片)：＝2942cm-1，，1147cm-1处具有极大吸收。
(8)1H NMR(重甲醇中)δppm：6.22(1H，m)，6.12(1H，m)，5.37(1H，d)，5.30(1H，dd)，5.16(1H，d)，4.76(1H，dd)，4.13(1H，dd)，3.93(1H，ddd)，3.82(1H，dd)，3.72(1H，dd)，3.68(1H，dd)，3.67(1H，dd)，3.64(1H，dd)，3.60(1H，m)，3.59(1H，m)，3.44(1H，dd)，2.08(3H，qd)，2.00(3H，qd)，1.96(3H，dd)，1.94(3H，dq)
(9)13C NMR(重甲醇中)δppm：169.6，168.8，141.2，138.5，129.6，128.5，95.6，92.8，76.4，74.3，74.0，73.9，72.1，72.0，71.5，69.0，62.5，61.6，20.9，20.8，16.5，16.0
(10)相对于溶剂的溶解性：易溶于乙醇、甲醇及水。难溶于氯仿。
或者Trehangelin B为下述式(2)所表示的化合物。
[化学式6]
在本说明书中，Trehangelin C为具有以下物性的化合物：
(1)性状：透明或白色粉末
(2)分子量：506
(3)分子式：C22H34O13
(4)基于高分辨率质量分析的[M+H]+理论值(m/z)507.2078，实测值(m/z)507.2074
(5)比旋度：[α]D 25.3＝+11.4°(c＝0.1，甲醇)
(6)紫外吸收极大值λmax(甲醇中)：218nm
(7)红外吸收极大值在νmax(KBr压片)：＝2927cm-1，，1149cm-1处具有极大吸收。
(8)1H NMR(重甲醇中)δppm：6.15(1H，m)，5.20(1H，d)，4.91(1H，dd)，4.07(1H，ddd)，4.02(1H，dd)，3.61(1H，dd)，3.59(1H，dd)，3.51(1H，dd)，1.99(3H，m)，1.91(3H，m)
(9)13C NMR(重甲醇中)δppm：168.8，139.5，129.0，95.1，73.4，72.4，72.3，72.0，62.3，20.7，16.1
(10)相对于溶剂的溶解性：易溶于乙醇、甲醇及水。难溶于氯仿。
或者Trehangelin C为下述式(3)所表示的化合物。
[化学式7]
(Trehangelin类似物)
由于Trehangelin具有羟基，因此可利用本领域的技术人员通常所知的酰基化反应获得作为酯化合物的前体药物。本发明的Trehangelin包含这样的Trehangelin的酯化合物。具体而言，包含Trehangelin的羟基与饱和或不饱和的低级脂肪酸或高级脂肪酸酯键合而得酯化合物。作为赋予本发明的Trehangelin的酯化合物的酸可列举丁烯酸、乙酸、戊酸等脂肪族羧酸；安息香酸等芳基羧酸；单或二烷基氨基甲酸；丙磺酸等脂肪族磺酸；苯磺酸等芳基磺酸；吗啉基羧酸、恶唑烷基羧酸、氮杂环丁烷羧酸等杂环羧酸等。
(Trehangelin的生产)
本发明的化妆料等中所用的Trehangelin可通过各种有机溶剂对分类为放线菌的Polymorphospora rubra K07-0510菌株(委托编号NITE BP-01411)的脱脂小麦胚芽培养基中培养的培养液进行萃取而得。
此外，本发明的Trehangelin可为这样从放线菌培养物中萃取而得的物质，也可为从其他植物、微生物等自然界存在的物质中萃取而得的物质，还可以为化学合成的物质。另外，从自然界中存在的物质中萃取时，其精制程度只要为可表现作为本发明的化妆料的效果的程度即可，也可为在此限度中含有杂质的粗精制的提取物。
(Trehangelin产生菌)
本发明的Trehangelin可通过以下方法制造：在培养基中培养属于具有Trehangelin生产能力的放线菌的微生物，使Trehangelin在培养物中累积，并从该培养物中采集Trehangelin(分离、萃取、精制)。
“属于具有Trehangelin生产能力的放线菌的微生物”为属于放线菌的菌，只要是具有Trehangelin生产能力的微生物则无特别限定。
在可用于本发明的Trehangelin的制造方法的菌株中，除上述菌株以外，包含以其变异菌株为首的属于放线菌的具有Trehangelin生产能力的所有菌。微生物为“属于具有Trehangelin生产能力的放线菌的微生物”，例如可通过下述筛选方法来获得。
(筛选方法)
可通过以下方法来决定某微生物是否为属于具有Trehangelin生产能力的放线菌的微生物：在培养基中培养属于放线菌的微生物，并对该培养物进行分析，若Trehangelin存在，则该微生物为属于具有Trehangelin生产能力的放线菌的微生物。
作为培养方法，例如可列举以下方法：分别将1mL其他候选的放线菌植入装有100mL由淀粉2.4％、葡萄糖0.1％、蛋白胨0.3％、鲣鱼提取物0.3％、酵母提取物0.5％、碳酸氢钙0.4％构成的液体培养基(pH7.0)的500mL容量的三角烧瓶中，并于27℃下震荡培养3日后，分别将1mL得到的各种培养液植入装有100mL由淀粉2.0％、甘油0.5％、脱脂小麦胚芽1.0％、鲣鱼肉提取物0.3％、干酵母0.3％、碳酸氢钙0.4％构成的液体培养基(pH7.0)的500mL容量的三角烧瓶中，并于27℃下震荡培养9日。
且，通过上述培养方法而得的培养物的中，若Trehangelin存在，则可决定该微生物为属于具有Trehangelin生产能力的放线菌的微生物。
作为这样的属于具有Trehangelin生产能力的放线菌的微生物，优选列举Polymorphospora rubra K07-0510菌株。
(Polymorphospora rubra K07-0510菌株)
本菌株作为Polymorphospora rubra K07-0510由日本北里大学托管于日本独立行政法人制品评价技术基盘机构专利生物托管中心(委托日2012年8月28日，委托编号NITEBP-01411)。
用于培养属于具有Trehangelin生产能力的放线菌的微生物的培养基中，作为营养源，使用可作为放线菌的营养源使用的物质即可。此外，属于具有Trehangelin生产能力的放线菌的微生物的培养，可通过在生产菌可发育并生产Trehangelin的温度范围(例如10-40℃，优选为25-30℃)下震荡培养数日～2周来实施。培养条件可参考本说明书的记载，根据所使用的Trehangelin的生产菌的性质适当选择实施。
Trehangelin的采集可通过用乙酸乙酯等水不混合性的有机溶剂从培养液中萃取来实施。除本萃取法以外，还可适当组合脂溶性物质的采集中所用的公知的方法，例如通过吸附色谱法、分配色谱法、凝胶过滤色谱法、薄层色谱法的提取，离心逆流分配色谱法、高速液体色谱法等，或者可通过重复来精制直到纯粹。
从而，本申请发明的发明者等，获得了上述Trehangelin具有促进角质层细胞间脂质的片层结构的形成，提高肌肤的屏障功能，保持湿润的效果的见解，完成了含有Trehangelin的片层形成促进剂。进一步发现使用含有Trehangelin的皮肤清洁剂时，可抑制片层结构的溶出，促进片层结构的恢复，完成了含有Trehangelin的皮肤清洁剂。以下，针对本申请发明的皮肤清洁剂和片层形成促进剂进行说明。
[皮肤清洁剂]
本发明的皮肤清洁剂可依照通常使用的制剂化方法来制造，可含有植物油一类的油脂类、高级脂肪酸、高级醇、硅酮、阴离子性表面活性剂、阳离子性表面活性剂、两性表面活性剂、非离子表面活性剂、防腐剂、糖类、金属离子封锁剂、水溶性高分子一类的高分子、增粘剂、粉体成分、紫外线吸收剂、紫外线阻隔剂、透明质酸一类的保湿剂、香料、pH调节剂等。还可含有维生素类、皮肤激活剂、血液循环促进剂、常驻菌控制剂、活性氧消除剂、抗炎症剂、美白剂、杀菌剂等其他药效成分、生理活性成分。
在本发明中，Trehangelin总量为上述Trehangelin A、B、C及类似物的总量。
本发明的皮肤清洁剂中含有的Trehangelin的浓度并无特别限制，作为优选例可列举0.001质量％以上10质量％以下，作为进一步的优选例可列举0.01质量％以上10质量％以下。本发明的皮肤清洁剂中含有的Trehangelin A的浓度并无特别限制，作为优选例可列举0.0004质量％以上0.08质量％以下，作为进一步的优选例可列举0.004质量％以上0.08质量％以下。
就本发明的皮肤清洁剂中含有的Trehangelin而言，Trehangelin A、B、C或类似物可各自单独存在，也可为它们之中的任意2种以上共存的状态，并无特别限制，作为优选例可列举Trehangelin A相对于Trehangelin总量的含有率为40％以上80％以下，作为进一步的优选例可列举为50％以上70％以下。作为优选例可列举Trehangelin A以外的Trehangelin B、C及类似物相对于Trehangelin总量的含有率为20％以上60％以下，作为进一步的优选例可列举为30％以上50％以下。
本发明的皮肤清洁剂可制成粉末、固体、液体、膏状等剂型。此外，还可为压泡型泡状制剂、多层状制剂、喷雾制剂、含浸于无纺布等而得的片材或凝胶涂敷制剂，通常可依照皮肤清洁剂中使用的制剂化方法制造，可作为洗手液、洗面奶、沐浴液、洗发剂使用。
本发明的皮肤清洁剂中，在不损害本发明的效果的范围内可含有阴离子性表面活性剂、阳离子性表面活性剂、两性表面活性剂、非离子表面活性剂、防腐剂、糖类、水溶性高分子一类的高分子、增粘剂、擦洗剂、保湿剂、香料、pH调节剂、植物提取物、活性氧消除剂、抗炎症剂、皮脂抑制剂等药效成分。
作为阴离子表面活性剂，例如可列举月桂酸钠等脂肪酸盐、十二烷基硫酸钠等高级烷基硫酸酯盐、POE十二烷基硫酸三乙醇胺等烷基醚硫酸酯盐、N-酰基肌氨酸盐、N-酰基羟乙磺酸盐、磺基琥珀酸盐、N-酰基谷氨酸盐、脂肪酸盐等。
作为阳离子表面活性剂，例如可列举硬脂基三甲基氯化铵等烷基三甲基铵盐、苯扎氯铵、苄索氯铵等。
作为两性表面活性剂，例如可列举烷基甜菜碱、酰胺甜菜碱等甜菜碱类表面活性剂等。
作为非离子表面活性剂，例如可列举山梨糖醇酐单油酸酯等山梨糖醇酐脂肪酸酯类、硬化蓖麻油衍生物。
作为防腐剂，例如可列举羟苯甲酯、羟苯乙酯、苯氧乙醇等。
作为高分子增粘剂，可列举阿拉伯胶、黄蓍胶、半乳聚糖、瓜尔胶、卡拉胶、果胶、琼脂、榅桲子、糊精、右旋糖酐、普鲁兰多糖、黄原胶、膨润土、酪蛋白、明胶、甲基纤维素、羟丙基纤维素、羟乙基纤维素、羧甲基纤维素钠(CMC)、羧甲基右旋糖酐钠(SodiumCarboxymethyl Dextran)、海藻酸钠、聚羧乙烯(CARBOPOL等)等乙烯类高分子等。
作为保湿剂，例如可列举聚乙二醇、丙二醇、二丙二醇、1，3-丁二醇、1，2-戊二醇、甘油、二甘油、聚甘油、木糖醇、麦芽糖醇、甘露糖醇、麦芽糖、山梨糖醇、葡萄糖、果糖、软骨素硫酸钠、透明质酸钠、乳酸钠、吡咯烷酮羧酸、环糊精等。
作为植物提取物，具体而言可列举洋甘菊提取物、欧芹提取物、葡萄酒酵母提取物、葡萄柚提取物、忍冬提取物、稻提取物、葡萄提取物、啤酒花提取物、稻糠提取物、药蜀葵提取物、枇杷提取物、黄蘖提取物、黄连提取物、黄芩提取物、薏仁提取物、日本獐牙菜提取物、草木犀提取物、白桦提取物、甘草提取物、芍药提取物、肥皂草提取物、丝瓜提取物、辣椒提取物、柠檬提取物、黄龙胆提取物、紫苏提取物、柳兰提取物、芦荟提取物、迷迭香提取物、鼠尾草提取物、百里香提取物、粗齿绣球提取物、茶提取物、海藻提取物、黄瓜提取物、丁香提取物、胡萝卜提取物、霍霍巴叶提取物、欧洲七叶树提取物、金缕梅提取物、桑树提取物、牡丹提取物等各种提取物。
作为药效成分，只要为以往在医药品、医药部外品、化妆品、卫生材料等中使用并可溶解或分散于水中的物质就可无特别限定地使用。具体而言可列举滨海当归提取物、鳄梨果提取物、粗齿绣球提取物、药蜀葵提取物、山金车提取物、杏提取物、杏仁提取物、茴香提取物、姜黄提取物、乌龙茶提取物、狭叶松果菊叶提取物、黄芩提取物、黄蘖提取物、大麦提取物、西洋菜提取物、橙子提取物、海水干燥物、水解弹性蛋白、水解小麦末、水解蚕丝蛋白、洋甘菊提取物、胡萝卜提取物、茵陈蒿提取物、甘草提取物、Calcade提取物、猕猴桃提取物、鸡纳树提取物、黄瓜提取物、鸟苷、维氏熊竹提取物、胡桃提取物、葡萄柚提取物、葡萄叶铁线莲提取物、酵母提取物、牛蒡提取物、聚合草提取物、胶原蛋白、越桔提取物、柴胡提取物、脐带提取液、鼠尾草提取物、肥皂草提取物、小竹提取物、山楂提取物、香菇提取物、地黄提取物、紫草根提取物、椴树提取物、榆绣线菊提取物、菖蒲根提取物、白桦提取物、问荆提取物、忍冬提取物、洋常春藤提取物、洋山楂提取物、西洋接骨木提取物、欧蓍草提取物、辣薄荷提取物、欧锦葵提取物、日本獐牙菜提取物、大枣提取物、百里香提取物、丁香提取物、茅草提取物、陈皮提取物、酸橙提取物、鱼腥草提取物、番茄提取物、纳豆提取物、胡萝卜提取物、野蔷薇提取物、玫瑰茄提取物、麦冬提取物、欧芹提取物、蜂蜜、药用墙草提取物、香茶菜提取物、红没药醇、款冬提取物、蜂斗菜提取物、茯苓提取物、假叶树提取物、葡萄提取物、蜂胶、丝瓜提取物、薄荷提取物、阔叶椴提取物、啤酒花提取物、松树提取物、欧洲七叶树提取物、水芭蕉提取物、无患子提取物、桃提取物、矢车菊提取物、桉树提取物、柚子提取物、魁蒿提取物、薰衣草提取物、苹果提取物、莴苣提取物、柠檬提取物、紫云英提取物、玫瑰提取物、迷迭香提取物、罗马洋甘菊提取物、蜂王浆提取物等。
此外，还可列举氨基酸、尿素、吡咯烷酮羧酸钠、甜菜碱、乳清、三甲基甘氨酸等保湿剂；鞘脂、神经酰胺、胆固醇、胆固醇衍生物、磷脂等油性成分；ε-氨基己酸、甘草酸、β-甘草次酸、氯化溶菌酶、愈创蓝油烃、皮质醇等抗炎症剂；维生素A、B2、B6、D、E、泛酸钙、生物素、烟酰胺等维生素类；生育酚、类胡萝卜素、类黄酮、丹宁、木脂体、皂苷等抗氧化剂；γ-谷维素、维生素E衍生物等血液循环促进剂；视黄醇、视黄醇衍生物等创伤治愈剂；脱氧核糖核酸、软骨素硫酸钠、胶原蛋白、弹性蛋白、壳多糖、壳聚糖、水解蛋壳膜等生体高分子；尿囊素、二氯乙酸二异丙胺、4-氨基甲基环己烷羧酸等活性成分；千金藤素、辣椒酊、日柏醇(Hinokitiol)、碘化大蒜提取物、盐酸吡哆醇、dl-α-生育酚、乙酸dl-α-生育酚、烟酸、烟酸衍生物、D-泛醇、泛醇基乙基醚乙酸酯、生物素、尿囊素、异丙基甲基酚、雌二醇、炔雌醇、卡普氯铵、苯扎氯铵、盐酸苯海拉明、Takanal、樟脑、水杨酸、壬酸香草胺、壬酸香草胺(Nonanoic Acid Vanillylamide)、吡啶酮乙醇胺盐、十五酸甘油酯、硝基愈创木酚、间苯二酚、γ-丁胺酸、苄索氯铵、盐酸美西律、生长素、女性荷尔蒙、斑蝥酊、环孢素、皮质醇、聚氧乙烯山梨醇酐单硬脂酸酯山梨糖醇酐等。
[片层形成促进剂]
本发明的片层形成促进剂可作为以片层形成促进为目的的添加材料提供，此外，本发明的片层形成促进剂也可作为以片层形成促进作用为目的的皮肤外用剂、化妆料、医药部外品、医药品提供，可依照通常使用的制剂化方法来制造，可含有植物油一类的油脂类、高级脂肪酸、高级醇、硅酮、阴离子性表面活性剂、阳离子性表面活性剂、两性表面活性剂、非离子表面活性剂、防腐剂、糖类、金属离子封锁剂、水溶性高分子一类的高分子、增粘剂、粉体成分、紫外线吸收剂、紫外线阻隔剂、透明质酸一类的保湿剂、香料、pH调节剂等。还可含有维生素类、皮肤激活剂、血液循环促进剂、常驻菌控制剂、活性氧消除剂、抗炎症剂、美白剂、杀菌剂等其他药效成分、生理活性成分。
在本发明中，Trehangelin总量为上述Trehangelin A、B、C及类似物的总量。
就本发明的片层形成促进剂中含有的Trehangelin而言，Trehangelin A、B、C或类似物可各自单独存在，也可为它们之中的任意2种以上共存的状态，并无特别限制，作为优选例可列举Trehangelin A相对于Trehangelin总量的含有率为40％以上80％以下，作为进一步的优选例可列举为50％以上70％以下。作为优选例可列举Trehangelin A以外的TrehangelinB、C及类似物相对于Trehangelin总量的含有率为20％以上60％以下，作为进一步的优选例可列举为30％以上50％以下。
本发明的片层形成促进剂包括化妆料、医药部外品、医药品，可制成化妆水、乳液、乳霜、凝胶等溶液状、乳化物状、高分子凝胶状制剂。此外，还可为泡状制剂、多层状制剂、喷雾制剂、含浸于无纺布等而得的片材或凝胶涂敷制剂。
本发明的片层形成促进剂中，作为根据目的的任意成分，可含有保湿剂、表面活性剂、增粘剂、抗炎症剂、维生素类、抗氧化剂、血液循环促进剂、创伤治愈剂、抗菌性物质、皮肤激活剂、常驻菌控制剂、活性氧消除剂、美白剂等药效成分。
作为药效成分，只要为以往在医药品、医药部外品、化妆品、卫生材料等中使用并可溶解或分散于水中的物质就可无特别限定地使用。具体而言可列举滨海当归提取物、鳄梨果提取物、粗齿绣球提取物、药蜀葵提取物、山金车提取物、杏提取物、杏仁提取物、茴香提取物、姜黄提取物、乌龙茶提取物、狭叶松果菊叶提取物、黄芩提取物、黄蘖提取物、大麦提取物、西洋菜提取物、橙子提取物、海水干燥物、水解弹性蛋白、水解小麦末、水解蚕丝蛋白、洋甘菊提取物、胡萝卜提取物、茵陈蒿提取物、甘草提取物、Calcade提取物、猕猴桃提取物、鸡纳树提取物、黄瓜提取物、鸟苷、维氏熊竹提取物、胡桃提取物、葡萄柚提取物、葡萄叶铁线莲提取物、酵母提取物、牛蒡提取物、聚合草提取物、胶原蛋白、越桔提取物、柴胡提取物、脐带萃取液、鼠尾草提取物、肥皂草提取物、小竹提取物、山楂提取物、香菇提取物、地黄提取物、紫草根提取物、椴树提取物、榆绣线菊提取物、菖蒲根提取物、白桦提取物、问荆提取物、忍冬提取物、洋常春藤提取物、洋山楂提取物、西洋接骨木提取物、欧蓍草提取物、辣薄荷提取物、欧锦葵提取物、日本獐牙菜提取物、大枣提取物、百里香提取物、丁香提取物、茅草提取物、陈皮提取物、酸橙提取物、鱼腥草提取物、番茄提取物、纳豆提取物、胡萝卜提取物、野蔷薇提取物、玫瑰茄提取物、麦冬提取物、欧芹提取物、蜂蜜、药用墙草提取物、香茶菜提取物、红没药醇、款冬提取物、蜂斗菜提取物、茯苓提取物、假叶树提取物、葡萄提取物、蜂胶、丝瓜提取物、薄荷提取物、阔叶椴提取物、啤酒花提取物、松树提取物、欧洲七叶树提取物、水芭蕉提取物、无患子提取物、桃提取物、矢车菊提取物、桉树提取物、柚子提取物、魁蒿提取物、薰衣草提取物、苹果提取物、莴苣提取物、柠檬提取物、紫云英提取物、玫瑰提取物、迷迭香提取物、罗马洋甘菊提取物、蜂王浆提取物等。
此外，还可列举氨基酸、尿素、吡咯烷酮羧酸钠、甜菜碱、乳清、三甲基甘氨酸等保湿剂；鞘脂、神经酰胺、胆固醇、胆固醇衍生物、磷脂等油性成分；ε-氨基己酸、甘草酸、β-甘草次酸、氯化溶菌酶、愈创蓝油烃、皮质醇等抗炎症剂；维生素A、B2、B6、D、E、泛酸钙、生物素、烟酰胺等维生素类；生育酚、类胡萝卜素、类黄酮、丹宁、木脂体、皂苷等抗氧化剂；γ-谷维素、维生素E衍生物等血液循环促进剂；视黄醇、视黄醇衍生物等创伤治愈剂；脱氧核糖核酸、软骨素硫酸钠、胶原蛋白、弹性蛋白、壳多糖、壳聚糖、水解蛋壳膜等生物高分子；尿囊素、二氯乙酸二异丙胺、4-氨基甲基环己烷羧酸等活性成分；千金藤素、辣椒酊、日柏醇(Hinokitiol)、碘化大蒜提取物、盐酸吡哆醇、dl-α-生育酚、乙酸dl-α-生育酚、烟酸、烟酸衍生物、D-泛醇、泛醇基乙基醚乙酸酯、生物素、尿囊素、异丙基甲基酚、雌二醇、炔雌醇、卡普氯铵、苯扎氯铵、盐酸苯海拉明、Takanal、樟脑、水杨酸、壬酸香草胺、壬酸香草胺(Nonanoic Acid Vanillylamide)、吡啶酮乙醇胺盐、十五酸甘油酯、硝基愈创木酚、间苯二酚、γ-丁胺酸、苄索氯铵、盐酸美西律、生长素、女性荷尔蒙、斑蝥酊、环孢素、皮质醇、聚氧乙烯山梨醇酐单硬脂酸酯山梨糖醇酐等。
以下，针对本申请发明者实施的试验，即获得Trehangelin具有优异的片层形成促进能力，此外含有Trehangelin的皮肤清洁剂与通常的皮肤清洁剂相比可显著抑制片层结构的溶出的见解的试验进行说明。
实施例
＜片层形成促进能力的评价＞
(人工细胞间脂质的制作)
将以下物质作为人工细胞间脂质：作为水相，将Ceramide TIC-001(高砂香料工业株式会社)0.04g、Ceramide 3(Evonik Degussa公司，德国)0.04g、Ceramide4(EvonikDegussa公司，德国)0.04g、硫酸胆固醇(Sigma-Aldrich日本)0.02g、纯化水2.5g，作为油相，将硬脂酸(富士胶片和光纯药株式会社)0.08g、胆固醇(富士胶片和光纯药株式会社)0.08g分别于80℃下熔解后，将水相添加至油相并混合。然后，于10℃下进行10分钟超声波处理，再次于80℃下熔解混合，于10℃下进行10分钟的超声波处理而得的物质。
(评价被检物的制备)
作为实施例，制备Trehangelin 0.01、0.1、1.0、10质量％水溶液。
使用相对于Trehangelin总量，Trehangelin A的含有率为63％，Trehangelin B、C及类似物的含有率为37％的Trehangelin生产品。
作为比较例，制备海藻糖的0.01、0.1、1.0质量％水溶液、葡萄糖、蔗糖、山梨糖醇、棉子糖的0.1、1.0质量％水溶液。另外，葡萄糖作为单糖，海藻糖和蔗糖作为二糖，山梨糖醇作为糖醇，棉子糖作为三糖的代表例来使用。向人工细胞间脂质40mg中分别添加10μL制备的各糖水溶液及不含糖的水(对照)。在80℃的水浴中加热10分钟，并充分混合。然后，于10℃下进行10分钟超声波处理，将通过在80℃的水浴中重复10分钟的加热2次所得的片层乳浊液作为评价被检物。
(观察和解析)
量取评价被检物2mg至载玻片，以用盖玻片均匀地展开的状态，用偏光显微镜(奧林巴斯株式会社BX50，γ＝530nm，倍率200倍，观察范围110μm×82μm)进行观察并摄影。用图像分析软件(三谷商事株式会社WinROOF)测定摄影的图像的观察范围中的偏光十字图像(与片层结构同义)的面积和个数。计算添加水时及各评价被检物的偏光十字图像的平均面积，求与将添加水时的平均面积作为1时进行比较而得的各评价被检物的平均面积的比，作为片层形成促进率。
(结果)
结果示于表1、图1。将表1的结果用图表表示为图1。此外，比较例1、11、实施例1～4的偏光十字图像示于图2～7。
与比较例所示的糖的片层形成促进率相比，Trehangelin的片层形成促进率即使在0.01质量％的低浓度下也为5.41倍，0.1质量％下为4.33倍，1.0质量％下为8.39倍、10质量％下为9.38倍。即，确认了Trehangelin具有显著的片层形成促进能力。
[表1]
＜抑制细胞间脂质的溶出及促进片层形成作用的确认＞
(皮肤清洁剂的制备)
[实施例5]
制备将Trehangelin以最终浓度达到0.1质量％的方式溶解的10％SDS水溶液，作为皮肤清洁剂。
[实施例6]
制备将Trehangelin以最终浓度达到1.0质量％的方式溶解的10％SDS水溶液，作为皮肤清洁剂。
使用Trehangelin A相对于Trehangelin总量的含有率为63％，Trehangelin B、C及类似物的含有率为37％的Trehangelin。
[比较例13]
制备不含糖的10％SDS水溶液，作为皮肤清洁剂。
[比较例14]
制备将葡萄糖以最终浓度达到1.0质量％的方式溶解的10％SDS水溶液，作为皮肤清洁剂。
(方法)
对象设为2名。
用水清洗前腕内侧，适应5分钟。用起泡后的各皮肤清洁剂清洁前腕内侧10秒，用自来水冲洗30秒，用擦拭纸(日本制纸Crecia株式会社)轻轻按压于前腕内侧去除水分。于清洁前、清洁后即刻、清洁1分钟后及清洁3分钟后，通过胶带剥离法从每次采集场所不同的前腕内侧部位采集角质层。用数字显微镜(株式会社基恩士VHX-5000)以500的倍率对采集的角质层每个被检者摄影3枚，取总计6枚的分析值的平均。通过用图像分析软件进行阈值处理，检测撮影的图像中的角质层、片层结构，计算角质层总面积(单位像素)及片层结构总面积(单位像素)，通过以下的式子求片层率。
片层率＝片层结构总面积÷角质层总面积
结果示于图8。图8纵轴表示将清洁前的片层率作为100％时的片层率，横轴表示清洁前、清洁后即刻、清洁1分钟后及清洁3分钟后的时间经过。撮影的角质层示于图9。
(结果)
清洁后即刻，角质层中的片层结构在比较例13(不含糖类10％SDS)中仅残存8％，在比较例14(1.0质量％葡萄糖)中仅残存15％。
在实施例5、6(含有0.1，1.0质量％的Trehangelin的10％SDS水溶液)中，清洁后，残存的片层结构分别为53％、60％。即，确认了基于皮肤清洁剂的片层的溶出因Trehangelin得到显著抑制。此外，确认了清洁后1、3分钟后，含有Trehangelin的清洁剂恢复片层结构。
Claims (6)
1.一种皮肤清洁剂，其特征在于，含有Trehangelin。
2.根据权利要求1所述的皮肤清洁剂，其特征在于，Trehangelin相对于皮肤清洁剂总量的含量为0.001质量％以上10质量％以下。
3.根据权利要求1或2所述的皮肤清洁剂，其特征在于，含有阴离子性表面活性剂。
4.根据权利要求1～3中任一项所述的皮肤清洁剂，其特征在于，TrehangelinA相对于Trehangelin总量的含有率为40％以上80％以下。
5.一种片层形成促进剂，其特征在于，含有Trehangelin。
6.根据权利要求5所述的片层形成促进剂，其特征在于，Trehangelin A相对于Trehangelin总量的含有率为40％以上80％以下。
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| JP2020021674A JP6835990B1 (ja) | 2020-02-12 | 2020-02-12 | トレハンジェリン含有皮膚洗浄剤 |
| JP2020021673A JP7459419B2 (ja) | 2020-02-12 | 2020-02-12 | ラメラ形成促進剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006045186A (ja) * | 2004-07-05 | 2006-02-16 | Fancl Corp | ラメラ構造再生剤及び皮膚外用剤 |
| WO2014034147A1 (ja) * | 2012-09-03 | 2014-03-06 | 学校法人北里研究所 | 新規光線過敏症抑制剤トレハンジェリン物質及びその製造法 |
| JP2015024985A (ja) * | 2013-06-19 | 2015-02-05 | 学校法人北里研究所 | 化粧料または皮膚外用剤 |
| JP2017158546A (ja) * | 2016-03-04 | 2017-09-14 | 学校法人北里研究所 | トレハンジェリンの製造法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006045186A (ja) * | 2004-07-05 | 2006-02-16 | Fancl Corp | ラメラ構造再生剤及び皮膚外用剤 |
| WO2014034147A1 (ja) * | 2012-09-03 | 2014-03-06 | 学校法人北里研究所 | 新規光線過敏症抑制剤トレハンジェリン物質及びその製造法 |
| JP2015024985A (ja) * | 2013-06-19 | 2015-02-05 | 学校法人北里研究所 | 化粧料または皮膚外用剤 |
| JP2017158546A (ja) * | 2016-03-04 | 2017-09-14 | 学校法人北里研究所 | トレハンジェリンの製造法 |
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