CN113316470A - 用于治疗偏头痛突破的cgrp拮抗剂 - Google Patents

用于治疗偏头痛突破的cgrp拮抗剂 Download PDF

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Publication number
CN113316470A
CN113316470A CN202080009963.1A CN202080009963A CN113316470A CN 113316470 A CN113316470 A CN 113316470A CN 202080009963 A CN202080009963 A CN 202080009963A CN 113316470 A CN113316470 A CN 113316470A
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weight
breakthrough
cgrp antagonist
migraine
antibody
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CN202080009963.1A
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Chinese (zh)
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V·科里克
R·克鲁普
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Biohaven Pharmaceutical Holding Co Ltd
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Biohaven Pharmaceutical Holding Co Ltd
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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  • Pain & Pain Management (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN202080009963.1A 2019-01-20 2020-01-19 用于治疗偏头痛突破的cgrp拮抗剂 Pending CN113316470A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962794665P 2019-01-20 2019-01-20
US62/794,665 2019-01-20
US201962844169P 2019-05-07 2019-05-07
US62/844,169 2019-05-07
US201962893206P 2019-08-29 2019-08-29
US62/893,206 2019-08-29
US201962910284P 2019-10-03 2019-10-03
US62/910,284 2019-10-03
US202062959088P 2020-01-09 2020-01-09
US62/959,088 2020-01-09
PCT/US2020/014239 WO2020150703A1 (en) 2019-01-20 2020-01-19 Cgrp antagonists for treating migraine breakthrough

Publications (1)

Publication Number Publication Date
CN113316470A true CN113316470A (zh) 2021-08-27

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ID=71613964

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CN202080009963.1A Pending CN113316470A (zh) 2019-01-20 2020-01-19 用于治疗偏头痛突破的cgrp拮抗剂

Country Status (13)

Country Link
US (2) US20210338654A1 (https=)
EP (1) EP3911409A4 (https=)
JP (1) JP2022517433A (https=)
KR (1) KR20210116560A (https=)
CN (1) CN113316470A (https=)
AU (1) AU2020210024A1 (https=)
BR (1) BR112021011546A2 (https=)
CA (1) CA3127328A1 (https=)
IL (1) IL284947A (https=)
MX (1) MX2021008191A (https=)
PH (1) PH12021551689A1 (https=)
SG (1) SG11202106721VA (https=)
WO (1) WO2020150703A1 (https=)

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TW202535450A (zh) * 2018-07-05 2025-09-16 愛爾蘭商歐樂根製藥國際有限公司 Cgrp拮抗劑及梭菌衍生物之組合療法
US20210121541A1 (en) * 2019-07-05 2021-04-29 Allergan Pharmaceuticals International Limited CGRP Antagonists and Clostridial Derivatives for the Treatment of Neuropsychiatric and Neurological Disorders
WO2021055769A1 (en) 2019-09-18 2021-03-25 Massachusetts Institute Of Technology Systems, compositions, and methods for producing sharp edges
WO2021062282A1 (en) * 2019-09-25 2021-04-01 Allergan Pharmaceuticals International Limited Combination therapy with cgrp antagonists
CN116390712A (zh) 2020-07-29 2023-07-04 阿勒根制药国际有限公司 治疗偏头痛
CN116456981A (zh) * 2020-11-19 2023-07-18 辉瑞爱尔兰制药公司 用于改善的grp抑制剂递送的组合物
WO2022109077A1 (en) * 2020-11-19 2022-05-27 Biohaven Pharmaceutical Holding Company Ltd. Compositions for improved delivery of cgrp inhibitors
IT202000029459A1 (it) * 2020-12-03 2022-06-03 Alberto Chiarugi Terapia dei disturbi emotivi
CA3206184A1 (en) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Treatment of migraine
US20240408080A1 (en) * 2021-02-01 2024-12-12 Pfizer Ireland Pharmaceuticals Pharmaceutical compositions of cgrp inhibitors and methods of their use
WO2023034466A1 (en) * 2021-09-02 2023-03-09 Pfizer Ireland Pharmaceuticals Cgrp antagonists for treating psoriasis
EP4408418A1 (en) 2021-09-27 2024-08-07 Allergan Pharmaceuticals International Limited Combination comprising atogepant for treating migraine
WO2023064195A1 (en) * 2021-10-11 2023-04-20 Pfizer Ireland Pharmaceuticals Cgrp antagonists for treating trigeminal neuralgia
CN114053232A (zh) * 2021-11-23 2022-02-18 莱默(北京)药业科技有限公司 一种乌布吉泮冻干口崩片及制备方法
WO2023177823A1 (en) * 2022-03-17 2023-09-21 Vasoceuticals, Inc. Combined use of individual compounds for treatment of chronic pain disorders

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