CN113304069A - Retinol nanocrystalline wrap and preparation method thereof - Google Patents
Retinol nanocrystalline wrap and preparation method thereof Download PDFInfo
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- CN113304069A CN113304069A CN202110609943.4A CN202110609943A CN113304069A CN 113304069 A CN113304069 A CN 113304069A CN 202110609943 A CN202110609943 A CN 202110609943A CN 113304069 A CN113304069 A CN 113304069A
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- Prior art keywords
- retinol
- nanocrystalline
- wrap
- poloxamer
- stabilizer
- Prior art date
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 title claims abstract description 115
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 229960003471 retinol Drugs 0.000 title claims abstract description 57
- 235000020944 retinol Nutrition 0.000 title claims abstract description 57
- 239000011607 retinol Substances 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000006184 cosolvent Substances 0.000 claims abstract description 11
- 239000003381 stabilizer Substances 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 5
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 19
- 229960000502 poloxamer Drugs 0.000 claims description 19
- 229920001983 poloxamer Polymers 0.000 claims description 19
- 239000002159 nanocrystal Substances 0.000 claims description 14
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 10
- -1 polyoxyethylene Polymers 0.000 claims description 10
- 238000009210 therapy by ultrasound Methods 0.000 claims description 6
- 238000004108 freeze drying Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 9
- 230000000694 effects Effects 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 208000001140 Night Blindness Diseases 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000037306 mature skin Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000002088 nanocapsule Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a retinol nanocrystalline wrap, which belongs to the technical field of skin product raw material preparations and comprises the following components in percentage by mass, wherein retinol 1-25%, cosolvent 1-5%, stabilizer 1-20% and the balance of water, the sum of the mass percentages of the raw materials is 100%, and the cosolvent is any one of ethanol and dimethyl sulfoxide or a mixture of ethanol and dimethyl sulfoxide.
Description
Technical Field
The invention belongs to the technical field of skin care product raw material preparations, and particularly relates to a retinol nanocrystalline wrap and a preparation method thereof.
Background
Retinol has effects in treating nyctalopia, inhibiting tumor growth, and enhancing immunity. Retinol is vitamin A, also called A alcohol, not only can effectively treat nyctalopia, inhibit tumor growth and enhance immunity, but also has the functions of beautifying and protecting skin, such as preventing alopecia, resisting aging, removing wrinkles, fading spots, removing acnes and the like. The early use of retinol helps to increase the elasticity of skin and promote the production of collagen, and in the case of mature skin, retinol helps to increase collagen and stimulate cell renewal, thereby causing the exfoliation of dead skin layers to achieve skin thinning, and the repeated use of retinol also reduces black spots and improves skin texture, and retinol is also one of the 13 vitamins necessary for the human body. Research shows that the retinol can help the skin stratum corneum to restore normal metabolism, thicken the stratum corneum of the skin, enhance the water storage capacity of the skin and simultaneously promote the generation of collagen in the dermis layer of the skin. Therefore, retinol has effects of refining pores, resisting aging and wrinkle, removing acne, and whitening skin. . The existing retinol has the following defects: retinol is a fat-soluble antioxidant, and the existing retinol has fat solubility but no water solubility, and can maintain vision and promote bone growth in human body. Is fat-soluble vitamin which can be dissolved in fat, resists high temperature and is easy to oxidize in the air. There is a need for a process for improving the water dispersibility of retinol
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a retinol nanocrystal wrap and a preparation method thereof, which can improve the water dispersibility of retinol. The technical scheme is as follows:
a novel retinol nanocrystal wrap is composed of the following components:
the following fractions are all calculated by weight, wherein retinol: 1 to 25 percent; cosolvent: 1 to 5 percent; a stabilizer; 1 to 20 percent; the balance of water, and the sum of the mass percentages of the raw materials is 100%.
Wherein the cosolvent is any one or a mixture of ethanol and dimethyl sulfoxide, and when the cosolvent is the mixture of ethanol and dimethyl sulfoxide, the mass percent of ethanol to dimethyl sulfoxide is 2: the effect is better at 3 days.
Wherein the stabilizer is any one of poloxamer with the molecular weight of 13000 and the polyoxyethylene content of 81 percent and poloxamer with the molecular weight of 6200 and the polyoxyethylene content of 78 percent or a mixture of the two, and when the stabilizer is the mixture of the two, the mass percent of the two is 1: the effect is better at 1.
The preparation method of the retinol nanocrystal wrap comprises the following steps:
(1) adding retinol with the formula amount into a cosolvent to be dissolved, so as to obtain a retinol cosolvent solution;
(2) uniformly dispersing the stabilizer with the formula amount in water;
(3) adding the solution obtained in the step (1) into the solution obtained in the step (2), performing ultrasonic treatment for 2-10min, standing for 60-90 min to obtain a retinol nanocrystalline wrapping solution, and further performing freeze drying to obtain water-soluble retinol nanocrystalline wrapping powder.
The invention has the following beneficial effects: compared with the traditional retinol preparation, the retinol nanocrystal wrap has better water dispersibility, so that the retinol nanocrystal wrap has wider application range and better heat preservation effect, and is suitable for comprehensive popularization and application.
Drawings
FIG. 1 is a graph of the hydrated particle size of a synthetic retinol nanocrystal wrap;
fig. 2 is a surface potential of the synthesized retinol nanocapsules.
Detailed Description
Example 1
Adding 1% of retinol into ethanol with twice equivalent to dissolve to obtain an ethanol solution of retinol; uniformly dispersing 1% of poloxamer in water; then, adding an ethanol solution of retinol into 1% poloxamer in water, wherein the poloxamer has the molecular weight of 13000 and the content of polyoxyethylene of 81%, performing ultrasonic treatment for 2min, standing for 30min to obtain a retinol nanocrystal wrap solution, and further performing freeze drying to obtain water-soluble retinol nanocrystal wrap powder.
Example 2
Adding 5% retinol into the mixed solution of ethanol and dimethyl sulfoxide with equivalent weight for dissolving to obtain retinol solution; uniformly dispersing 5% of poloxamer in water, wherein the poloxamer has a molecular weight of 13000 and a polyoxyethylene content of 81%; and then adding the retinol solution into 20% poloxamer in water, carrying out ultrasonic treatment for 10min, and standing for 90min to obtain the retinol nanocrystal wrap solution.
Example 3
Adding 10% of retinol into ethanol with twice equivalent to dissolve to obtain an ethanol solution of retinol; uniformly dispersing 1% of poloxamer in water, wherein the poloxamer is a mixture of poloxamer with the molecular weight of 13000 and the content of polyoxyethylene of 81% and poloxamer with the molecular weight of 13000 and the content of polyoxyethylene of 81%, and the mass percentages of the poloxamer and the poloxamer are 1: 1; then, adding the ethanol solution of retinol into 10% poloxamer in water, performing ultrasonic treatment for 5min, standing for 60min to obtain a retinol nanocrystal wrap solution, and further performing freeze drying to obtain water-soluble retinol nanocrystal wrap powder.
The foregoing is only a preferred embodiment of this invention and it should be noted that modifications can be made by those skilled in the art without departing from the principle of the invention and these modifications should also be considered as the protection scope of the invention.
Claims (7)
1. A retinol nanocrystal wrap, characterized in that: the composite material comprises, by mass, 1-25% of retinol, 1-5% of cosolvent, 1-20% of stabilizer and the balance of water, wherein the sum of the mass percentages of the raw materials is 100%.
2. The retinol nanocrystalline wrap according to claim 1, wherein: the cosolvent is any one of ethanol and dimethyl sulfoxide or a mixture of ethanol and dimethyl sulfoxide.
3. The retinol nanocrystalline wrap according to claim 1, wherein: the stabilizer is poloxamer with the molecular weight of 13000 and the content of polyoxyethylene of 81 percent.
4. The retinol nanocrystalline wrap according to claim 1, wherein: the stabilizer is poloxamer with the molecular weight of 6200 and the content of polyoxyethylene of 78 percent.
5. The retinol nanocrystalline wrap according to claim 1, wherein: the stabilizer is a mixture of poloxamer with the molecular weight of 13000 and the content of polyoxyethylene of 81 percent and poloxamer with the molecular weight of 6200 and the content of polyoxyethylene of 78 percent.
6. A preparation method of a retinol nanocrystal wrap comprises the following steps:
(1) adding retinol with the formula amount into a cosolvent to be dissolved, so as to obtain a retinol cosolvent solution;
(2) uniformly dispersing the stabilizer with the formula amount in water;
(3) adding the solution obtained in the step (1) into the solution obtained in the step (2), performing ultrasonic treatment for 2-10min, standing for 30-90 min to obtain a retinol nanocrystalline wrapping solution, and further performing freeze drying to obtain water-soluble retinol nanocrystalline wrapping powder.
7. The method for preparing a retinol nanocrystal wrap according to claim 7, wherein: the ultrasonic treatment time in the step (3) is 5min, and the standing time is 90 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110609943.4A CN113304069A (en) | 2021-06-01 | 2021-06-01 | Retinol nanocrystalline wrap and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110609943.4A CN113304069A (en) | 2021-06-01 | 2021-06-01 | Retinol nanocrystalline wrap and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113304069A true CN113304069A (en) | 2021-08-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110609943.4A Pending CN113304069A (en) | 2021-06-01 | 2021-06-01 | Retinol nanocrystalline wrap and preparation method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919718A (en) * | 2013-01-11 | 2014-07-16 | 沈阳兴齐眼药股份有限公司 | Vitamin A palmitate eye drop, preparation method and use thereof |
| KR101547611B1 (en) * | 2015-02-13 | 2015-08-27 | (주)바이오제닉스 | Manufacturing method for stabilized retinol emulsion compositions using catechin |
| CN105147596A (en) * | 2015-09-28 | 2015-12-16 | 薇碧生物科技（上海）有限公司 | Water-soluble supramolecular salicylic acid gel technology |
| CN108451787A (en) * | 2018-05-23 | 2018-08-28 | 上海格兰化妆品有限公司 | A kind of nano-lipid carrier and preparation method thereof of embedding vitamin A alcohol |
| CN111214477A (en) * | 2020-02-12 | 2020-06-02 | 中国药科大学 | Rutin nanocrystal, rutin nanocrystal transdermal delivery gel and preparation method thereof |
| CN111920702A (en) * | 2020-08-21 | 2020-11-13 | 上海益好纳米科技有限公司 | Retinol nano liposome and preparation method thereof |
-
2021
- 2021-06-01 CN CN202110609943.4A patent/CN113304069A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919718A (en) * | 2013-01-11 | 2014-07-16 | 沈阳兴齐眼药股份有限公司 | Vitamin A palmitate eye drop, preparation method and use thereof |
| KR101547611B1 (en) * | 2015-02-13 | 2015-08-27 | (주)바이오제닉스 | Manufacturing method for stabilized retinol emulsion compositions using catechin |
| CN105147596A (en) * | 2015-09-28 | 2015-12-16 | 薇碧生物科技（上海）有限公司 | Water-soluble supramolecular salicylic acid gel technology |
| CN108451787A (en) * | 2018-05-23 | 2018-08-28 | 上海格兰化妆品有限公司 | A kind of nano-lipid carrier and preparation method thereof of embedding vitamin A alcohol |
| CN111214477A (en) * | 2020-02-12 | 2020-06-02 | 中国药科大学 | Rutin nanocrystal, rutin nanocrystal transdermal delivery gel and preparation method thereof |
| CN111920702A (en) * | 2020-08-21 | 2020-11-13 | 上海益好纳米科技有限公司 | Retinol nano liposome and preparation method thereof |
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| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Xue Fengfeng Inventor after: Bian Qianjin Inventor before: Bian Qianjin |
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Application publication date: 20210827 |
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