CN111789781A - Compound peptide emulsion with effects of resisting oxidation, maintaining beauty and keeping young - Google Patents
Compound peptide emulsion with effects of resisting oxidation, maintaining beauty and keeping young Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention belongs to the field of cosmetics, and particularly relates to a compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects and a preparation method thereof, wherein the compound peptide emulsion comprises the following components in parts by weight: 12-18 parts of peony peptide, 24-28 parts of fish skin collagen polypeptide, 13-17 parts of carnosine, 8-11 parts of glutathione, 3-6 parts of allantoin, 2-7 parts of hyaluronic acid, 1.3-2.8 parts of vitamin complex, 1-3 parts of liquorice, 1-3 parts of cetyl alcohol and 18-27 parts of emulsifier, wherein the used solvent is deionized water; the fish skin collagen polypeptide can improve SOD activity, reduce MDA content, remove free radicals and slow aging; glutathione and carnosine can remove free radicals, resist oxidation and delay aging; the synergistic effect of the saponin and unsaturated fatty acid in the peony peptide, the carnosine and the glutathione can improve the oxidation resistance and the anti-wrinkle capacity of the skin; the allantoin, the liquorice and the hyaluronic acid are mainly used as moisturizers, the compound vitamin can provide nutrition for the skin, and the substances are combined together to have strong antioxidation and moisturizing effects, so that the skin can be delayed to have elasticity and moist and glossy.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a preparation method of a compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects.
Background
"peptides can make people young and healthy, and peptides make cosmetics world change greatly", peptides are basic materials constituting all cells of human body, and peptides are the existing forms of life.
Peptides are constituent fragments in the structure of proteins, which are linked by amino acids with a certain sequence through amide bonds; a peptide consisting of two amino acids is called a dipeptide, a peptide consisting of 3 amino acids is called a tripeptide, and so on; the peptides that can be used in cosmetics are mostly small molecule peptides ranging from dipeptides to decapeptides; compared with other substances in organisms, the peptide has the greatest characteristics of extremely strong activity and diversity; the peptide plays an important role in the growth, development and metabolism of organisms and also plays a key regulation and control role in the natural aging and nursing processes of skin; the aging, wrinkles and dullness of human skin are caused by various factors inside and outside, excessive ultraviolet irradiation is only one of important external factors, and the aging of the skin can be caused by the reduction of functions of epidermis renewal, dermis in various aspects such as the removal of foreign chemicals, dermis thickness, immune response temperature regulation and the like, but the most important reason of the skin aging is that in vivo free radicals destroy normal cell behaviors and accelerate cell aging.
The small molecular peptide is non-toxic, high in activity, easy to absorb and has a special physiological activity effect, a series of problems of the skin can be essentially improved, and the application effect in the aspect of cosmetics is remarkable.
Disclosure of Invention
The invention aims to overcome the problems in the prior art and provide the compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young.
The invention also aims to provide a preparation method of the compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young.
The purpose of the invention is realized by the following technical scheme:
the compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young comprises the following components in parts by weight: 12-18 parts of peony peptide, 24-28 parts of fish skin collagen polypeptide, 13-17 parts of carnosine, 8-11 parts of glutathione, 3-6 parts of allantoin, 2-7 parts of hyaluronic acid, 1.3-2.8 parts of vitamin complex, 1-3 parts of liquorice, 1-3 parts of cetyl alcohol and 18-27 parts of emulsifier, and after being uniformly stirred, a proper amount of deionized water is added for dissolution.
The fish skin collagen polypeptide has proteins required by the skin, can improve the activity of skin superoxide dismutase (SOD), eliminate oxygen free radicals, reduce the content of Malondialdehyde (MDA), and improve the activity of Glutathione (GSH), wherein the MDA is a final product which is usually subjected to membrane lipid peroxidation during aging;
GSH has cell membrane protecting effect, polyunsaturated fatty acid in cell membrane is protected by GSH-Px to prevent lipid peroxidation, GSH has direct scavenging effect on free radicals, and H is removed under GSH-Px action2O2The GSH can also directly reduce some lipid free radicals and lipid peroxy free radicals to block the chain reaction of lipid peroxidation;
carnosine is a natural dipeptide, exists in tissues such as skeletal muscle, brain and the like of vertebrates, has strong oxidation resistance, can inhibit the pro-oxidation effect of metal ions and free radicals, and can reduce the concentration of lipid oxidation products; carnosine and GSH can regulate the growth of human fibroblast and repair aged human cells, and are natural anti-aging and anti-oxidation active peptides.
The peony peptide is small peptide obtained by hydrolyzing peony seed protein, has obvious antioxidation, can reduce the degree of oxidation and hemolysis of red blood cells of a human body and inhibit the damage of a liposome membrane caused by lipid oxidation, and also has the capability of removing hydroxyl free radicals; the saponin and unsaturated fatty acid in the peony peptide can improve the antioxidant capacity and the anti-wrinkle capacity of the skin by cooperating with carnosine and GSH.
Allantoin is a humectant, and can stimulate the growth of healthy skin tissue and promote the exfoliation of dark skin layers; the licorice contains glycyrrhiza polysaccharide, licoflavone and glycyrrhetinic acid, has the function of a humectant, and also has the functions of resisting inflammation, eliminating free radicals, resisting allergy and the like; hyaluronic Acid (HA), also known as hyaluronic acid, HAs the main effects of moisturizing, is also an efficient free radical scavenger in cosmetics, can remove active oxygen free radicals generated by ultraviolet irradiation in epidermal cells, and prevents skin from being damaged; HA is used in the present invention primarily as a humectant, along with allantoin and licorice.
Preferably, the composition comprises the following components in parts by weight: 14-16 parts of peony peptide, 25-27 parts of fish skin collagen polypeptide, 15-16 parts of carnosine, 9-10 parts of glutathione, 3.5-5 parts of allantoin, 4-6 parts of hyaluronic acid, 2-2.5 parts of vitamin complex, 2-2.8 parts of liquorice, 1.5-2.5 parts of cetyl alcohol and 20-24 parts of emulsifier, and after being uniformly stirred, a proper amount of deionized water is added for dissolution.
Preferably, the composition comprises the following components in parts by weight: 15.3 parts of peony peptide, 25.8 parts of fish skin collagen polypeptide, 15.4 parts of carnosine, 9.7 parts of glutathione, 3.8 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of hexadecanol and 22.4 parts of emulsifier, and after being uniformly stirred, a proper amount of deionized water is added for dissolution.
Preferably, the vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
The compound vitamin can provide nutrient substances for the compound peptide.
Preferably, the emulsifier is one or more of sodium glyceryl stearate, stearic acid, cetyl alcohol, vinyl pyrrolidone and polydimethylsiloxane.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.0-7.0, and the material-liquid ratio is 1: 2-3, stirring for 60-80 min at 50-60 ℃ at 50-60 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and an emulsifier into an auxiliary tank heated by steam, and heating for 30-40 min at 50-60 ℃; s3, transferring the oil phase obtained in the step S2 into the water phase of the step S1, emulsifying at 50-60 ℃, stirring at 80-100 r/min for 10-15 min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 35-45 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, sterilizing the finished product obtained in the step S4 by electron beam irradiation, and subpackaging.
In the step S1, the main raw materials can generate synergistic effect through heating and dissolving reaction, and have strong antioxidant activity; the oil phase raw material and the water phase raw material are uniformly mixed to form an oil-in-water emulsion structure; the multivitamins are added at 35-45 ℃ to avoid damaging nutrient substances of the multivitamins at high temperature, and are naturally stirred and cooled.
Preferably, in the step S1, the pH value is 6.75, the material-liquid ratio is 1:2.5, and the stirring is carried out for 65min at the temperature of 55 ℃ at 55 r/min.
Preferably, the step S2 is carried out at 55 ℃ for 35 min.
Preferably, the cooling to 40 ℃ in step S4 is performed to add the vitamin complex.
Compared with the prior art, the invention has the following technical effects:
a compound peptide emulsion with antioxidant, skin caring and skin caring effects is prepared from fish skin collagen polypeptide, and has effects in improving SOD activity, reducing MDA content, scavenging free radicals, and delaying aging; glutathione and carnosine can remove free radicals, resist oxidation and delay aging; the peony peptide can remove free radicals, and the synergistic effect of the saponin, unsaturated fatty acid, carnosine and glutathione in the peony peptide can improve the antioxidant capacity and the anti-wrinkle capacity of the skin; the allantoin, the liquorice and the hyaluronic acid are mainly used as moisturizers, the compound vitamin can provide nutrition for the skin, and the substances are combined together to have strong antioxidation and moisturizing effects, so that the skin can be delayed to have elasticity and moist and glossy.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail with reference to specific embodiments. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Unless otherwise specified, the equipment used in this example, comparative example and experimental example was conventional experimental equipment, and the reagents used were commercially available.
Example 1
15.3 parts of peony peptide, 25.8 parts of fish skin collagen polypeptide, 15.4 parts of carnosine, 9.7 parts of glutathione, 3.8 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of sodium glycerostearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E. A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at 55 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3 transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, and stirring at 90r/minStirring for 13min, and homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
Example 2
14.7 parts of peony peptide, 26.1 parts of fish skin collagen polypeptide, 15.7 parts of carnosine, 9.7 parts of glutathione, 4.2 parts of allantoin, 5.1 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of sodium glycerostearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at 55 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
Example 3
The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young comprises, by weight, 15.7 parts of peony peptide, 26.2 parts of fish skin collagen polypeptide, 15.3 parts of carnosine, 9.2 parts of glutathione, 4.4 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of sodium glycerostearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at 55 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
Comparative example 1
A compound peptide emulsion with effects of resisting oxidation, maintaining beauty and keeping young comprises, by weight, 10.3 parts of peony peptide, 22.3 parts of fish skin collagen polypeptide, 12.1 parts of carnosine, 6.3 parts of glutathione, 3.8 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of glycerol sodium stearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at 55 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
Compared with the embodiment 1, the content of the peony peptide, the fish skin collagen polypeptide, the carnosine and the glutathione in the comparative example is lower than that in the invention.
Comparative example 2
A compound peptide emulsion with effects of resisting oxidation, maintaining beauty and keeping young comprises, by weight, 20.3 parts of peony peptide, 29.4 parts of fish skin collagen polypeptide, 19.4 parts of carnosine, 13.2 parts of glutathione, 3.8 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of glycerol sodium stearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at 55 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
Compared with the embodiment 1, the content of the peony peptide, the fish skin collagen polypeptide, the carnosine and the glutathione in the comparative example is higher than that in the invention.
Comparative example 3
15.3 parts of peony peptide, 25.8 parts of fish skin collagen polypeptide, 15.4 parts of carnosine, 9.7 parts of glutathione, 1.9 parts of allantoin, 1.1 parts of hyaluronic acid, 2.3 parts of vitamin complex, 0.3 part of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of glycerol sodium stearate by weight, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at 55 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
In this comparative example, the allantoin, hyaluronic acid and licorice contents were lower than those of the present invention, compared to example 1.
Comparative example 4
The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young comprises, by weight, 15.3 parts of peony peptide, 25.8 parts of fish skin collagen polypeptide, 15.4 parts of carnosine, 9.7 parts of glutathione, 7.3 parts of allantoin, 8.2 parts of hyaluronic acid, 2.3 parts of vitamin complex, 3.9 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of sodium glycerostearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 0.1 part of vitamin A, 1.17 parts of vitamin C and vitamin D30.0015 part and 0.011 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at 55 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
In this comparative example, the allantoin, hyaluronic acid and licorice were contained in higher amounts than those of the present invention, compared to example 1.
Comparative example 5
15.3 parts of peony peptide, 25.8 parts of fish skin collagen polypeptide, 15.4 parts of carnosine, 9.7 parts of glutathione, 3.8 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of sodium glycerostearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.59, and the material-liquid ratio is 1:2.5, stirring at the temperature of 75 ℃ for 60min at a speed of 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
In this comparative example, the reaction temperature of step S1 was higher than the experimental temperature compared to example 1.
Comparative example 6
15.3 parts of peony peptide, 25.8 parts of fish skin collagen polypeptide, 15.4 parts of carnosine, 9.7 parts of glutathione, 3.8 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of sodium glycerostearate, and after being uniformly stirred, a proper amount of deionized water is added for dissolving.
The vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
A preparation method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects comprises the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and Glycyrrhrizae radix into a main tank, adding deionized water into the main tank, adjusting pH to 6.59, and stirring at 35 deg.C for 60min at a ratio of material to liquid of 1:2.5 at 55 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and sodium glycerostearate into steam-heated auxiliary tank, and heating at 55 deg.C for 35 min; s3, transferring the oil phase obtained in the step S2 into the water phase of S1, emulsifying at 55 ℃, stirring at 90r/min for 13min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 40 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
In this comparative example, the reaction temperature of step S1 was lower than the experimental temperature compared to example 1.
Experimental example 1
Moisture retention performance determination method of compound peptide emulsion with antioxidant, beauty maintaining and young keeping effects
Carrying out a control experiment on the experimental examples 1-3 and the comparative examples 1-6 under the conditions that the air humidity is 70% and the temperature is 23 ℃; taking 10 groups of 10 culture dishes with the diameter of 12.5cm in each group, injecting 100g of water into each culture dish to cover a gelatin layer of gel with the diameter of 2-3 cm, coating the emulsions prepared in the experimental examples 1-3 and the comparative examples 1-6 on the outer surface of the gel, and arranging another group of blank groups without any substance, wherein the coating thickness is about 0.1 mm; in this experiment, water moved through the gel, similar to the sweating of the skin, after standing for 8h, the amount of water remaining under the gel layer was weighed, and the experimental data are expressed in standard deviation;
TABLE 1 simulated skin Water loss
| Sample (I) | Water loss per gram | Sample (I) | Water cut off amount/g |
| Example 1 | 2.8+/-0.11 | Comparative example 3 | 4.8+/-0.32 |
| Example 2 | 3.2+/-0.24 | Comparative example 4 | 5.2+/-0.56 |
| Example 3 | 3.1+/-0.41 | Comparative example 5 | 6.2+/-0.54 |
| Comparative example 1 | 4.9+/-0.56 | Comparative example 6 | 5.1+/-0.36 |
| Comparative example 2 | 5.1+/-0.48 | Blank group | 14.5+/-0.29 |
The emulsion obtained in experimental examples 1-3 has good moisturizing performance, when the content of the compound peptide is higher or lower than that in the experiment and the content of the allantoin, hyaluronic acid and liquorice which are used as the moisturizing agents is higher or lower than that in the experiment, the moisturizing effect is reduced to some extent, and when the reaction temperature is higher than that in the experiment, the influence of the moisturizing effect is greatest, and partial polypeptide is possibly inactivated.
Experimental example 2
The method comprises the steps that testers verify efficacy, 9 groups of volunteers and females are selected, the female is aged 20-30 years old, 10 volunteers in each group are tried on the embodiment 1-3, the comparative example 1-6 and the Fenuna moisturizing emulsion for one week, after face cleaning is carried out in the morning and evening each day, the experimental example and the Fenuna moisturizing emulsion are respectively and uniformly coated on the left face and the right face, after the face cleaning is finished, the absorption condition, the moisturizing condition, the fragrance preference and the purchasing preference of the facial mask liquid are evaluated by filling the surface, and before the filling is finished, the testers are not informed of which is the experimental example and which is the Fenuna moisturizing emulsion.
Table 2 comparison of the experimental examples with the osmunona moisturizing emulsion
| Group of | Has good absorption | Good water replenishing effect | Good moisturizing effect | Liking of fragrance | Willing to purchase |
| Example 1 | 8 persons | 8 persons | 8 persons | 7 persons | 9 persons |
| Example 2 | 9 persons | 7 persons | 7 persons | 6 persons | 8 persons |
| Example 3 | 7 persons | 8 persons | 8 persons | 6 persons | 7 persons |
| Comparative example 1 | 4 persons | 5 persons | 5 persons | 6 persons | 4 persons |
| Comparative example 2 | 3 persons | 2 persons | 4 persons | 5 persons | 3 persons |
| Comparative example 3 | 2 persons | 3 persons | 3 persons | 6 persons | 2 persons |
| Comparative example 4 | 1 person | 2 persons | 2 persons | 6 persons | 2 persons |
| Comparative example 5 | 3 persons | 1 person | 1 person | 8 persons | 2 persons |
| Comparative example 6 | 5 persons | 2 persons | 3 persons | 6 persons | 3 persons |
Verification experiments show that the comparison results of the moisturizing emulsions of the examples 1 to 3 and the osmunona are good, most of the volunteers are willing to buy the moisturizing emulsions, and the moisturizing and moisturizing effects of the comparative examples 1 to 6 are insufficient, so that most of the volunteers are unwilling to buy the moisturizing emulsions.
The devices, apparatus, devices, systems and so on referred to in this disclosure are intended to be illustrative examples only. These devices, apparatuses, devices, systems may be connected, arranged, configured in any manner, as will be appreciated by those skilled in the art. Words such as "including," "comprising," "having," and the like are open-ended words that mean "including, but not limited to," and are used interchangeably therewith. The words "or" and "as used herein mean, and are used interchangeably with, the word" and/or, "unless the context clearly dictates otherwise. The word "such as" is used herein to mean, and is used interchangeably with, the phrase "such as but not limited to".
Also, as used herein, the use of "or" in a list of items beginning with "at least one" indicates a separate list, e.g., "A, B or at least one of C" means A or B or C, or AB or AC or BC, or ABC (i.e., A and B and C). Furthermore, the word "exemplary" does not mean that the described example is preferred or better than other examples.
The previous description of the disclosed aspects is provided to enable any person skilled in the art to make or use the present disclosure. Various modifications to these aspects will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other aspects without departing from the scope of the disclosure.
The foregoing description has been presented for purposes of illustration and description. Furthermore, the description is not intended to limit the disclosed embodiments to the form disclosed herein. While a number of example aspects and embodiments have been discussed above, those of skill in the art will recognize certain variations, modifications, alterations, additions and sub-combinations thereof.
Claims (10)
1. The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young is characterized by comprising the following components in parts by weight: 12-18 parts of peony peptide, 24-28 parts of fish skin collagen polypeptide, 13-17 parts of carnosine, 8-11 parts of glutathione, 3-6 parts of allantoin, 2-7 parts of hyaluronic acid, 1.3-2.8 parts of vitamin complex, 1-3 parts of liquorice, 1-3 parts of cetyl alcohol and 18-27 parts of emulsifier.
2. The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 1, is characterized by comprising the following components in parts by weight: 14-16 parts of peony peptide, 25-27 parts of fish skin collagen polypeptide, 15-16 parts of carnosine, 9-10 parts of glutathione, 3.5-5 parts of allantoin, 4-6 parts of hyaluronic acid, 2-2.5 parts of vitamin complex, 2-2.8 parts of liquorice, 1.5-2.5 parts of cetyl alcohol and 20-24 parts of emulsifier.
3. The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 1, is characterized by comprising the following components in parts by weight: 15.3 parts of peony peptide, 25.8 parts of fish skin collagen polypeptide, 15.4 parts of carnosine, 9.7 parts of glutathione, 3.8 parts of allantoin, 4.7 parts of hyaluronic acid, 2.3 parts of vitamin complex, 2.7 parts of liquorice, 1.8 parts of cetyl alcohol and 22.4 parts of emulsifier.
4. The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 1, 2 or 3, wherein the solvent used is deionized water.
5. The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 1, wherein the compound vitamin comprises the following components in parts by weight: the vitamin complex comprises the following components in parts by weight: 1.1 parts of vitamin A, 1.17 parts of vitamin C and vitamin D30.015 parts and 0.015 part of vitamin E.
6. The compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 1, wherein the emulsifier is one or more of sodium glyceryl stearate, stearic acid, vinylpyrrolidone and polydimethylsiloxane.
7. The preparation method of the compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 1, which is characterized by comprising the following steps: s1, heating a water-phase raw material: adding peony peptide, fish skin collagen polypeptide, carnosine, glutathione, allantoin, hyaluronic acid and liquorice into a main tank, adding deionized water into the main tank, wherein the pH value is 6.0-7.0, and the material-liquid ratio is 1: 2-3, stirring for 60-80 min at 50-60 ℃ at 50-60 r/min; s2, heating oil phase raw materials: putting cetyl alcohol and an emulsifier into an auxiliary tank heated by steam, and heating for 30-40 min at 50-60 ℃; s3, transferring the oil phase obtained in the step S2 into the water phase of the step S1, emulsifying at 50-60 ℃, stirring at 80-100 r/min for 10-15 min, and starting homogenizing while stirring; s4, after emulsification is finished in the step S3, naturally stirring and cooling, cooling to 35-45 ℃, adding the multivitamin, and continuously stirring and cooling to room temperature to obtain a finished product; s5, performing irradiation sterilization on the finished product obtained in the step S4 by using an electronic book, and packaging.
8. The preparation method of the compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 6, wherein the pH value is 6.75 in the step S1, the material-liquid ratio is 1:2.5, and the compound peptide emulsion is stirred for 65min at 55 ℃ at 55 r/min.
9. The method for preparing the compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 6, wherein the heating at 55 ℃ in the step S2 is carried out for 35 min.
10. The method for preparing the compound peptide emulsion with the effects of resisting oxidation, maintaining beauty and keeping young as claimed in claim 6, wherein the temperature is cooled to 40 ℃ in step S4, and the compound vitamin is added.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115252500A (en) * | 2022-08-25 | 2022-11-01 | 山东贝世康生物科技有限公司 | Skin care composition containing peony extract and application thereof |
| WO2023171639A1 (en) * | 2022-03-07 | 2023-09-14 | 株式会社カネカ | Agricultural composition and method for cultivating plants using same |
| CN115252500B (en) * | 2022-08-25 | 2024-06-07 | 山东贝世康生物科技有限公司 | Skin care composition containing peony extract and application thereof |
-
2019
- 2019-04-09 CN CN201910281828.1A patent/CN111789781A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023171639A1 (en) * | 2022-03-07 | 2023-09-14 | 株式会社カネカ | Agricultural composition and method for cultivating plants using same |
| CN115252500A (en) * | 2022-08-25 | 2022-11-01 | 山东贝世康生物科技有限公司 | Skin care composition containing peony extract and application thereof |
| CN115252500B (en) * | 2022-08-25 | 2024-06-07 | 山东贝世康生物科技有限公司 | Skin care composition containing peony extract and application thereof |
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