CN113288931A - Skin injury repairing preparation and preparation method and application thereof - Google Patents
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- CN113288931A CN113288931A CN202110568559.4A CN202110568559A CN113288931A CN 113288931 A CN113288931 A CN 113288931A CN 202110568559 A CN202110568559 A CN 202110568559A CN 113288931 A CN113288931 A CN 113288931A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention discloses a skin injury repairing preparation and a preparation method and application thereof. The skin injury repair preparation comprises the following raw materials in parts by weight: 1-10 parts of angelica dahurica, 1-10 parts of liquorice, 1-10 parts of angelica and 200-800 parts of eggs. The skin injury repairing preparation is prepared by a specific boiling process, contains various bioactive substances, can remarkably enhance the anti-injury capability of the skin, remarkably enhance the repairing capability of the skin, regulate the metabolism of the skin and is beneficial to maintaining the normal function of skin cell tissues; can be used for repairing laser burn, thermal burn (such as scald and burn), cold burn, and physical and chemical injury of skin, and can also be used for rapidly relieving and repairing skin allergy, red swelling, desquamation, and pruritus.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a skin injury repair preparation as well as a preparation method and application thereof.
Background
Burns are common injuries in industrial production, warfare and daily life, and include burns of body tissues caused by high temperature (flame, boiling water, steam, hot oil, hot metal), chemical substances (strong acid, strong alkali), electric current (high voltage electricity) and radioactive rays (X-ray, gamma ray), etc. Such skin injuries are generally treated by western medicine means such as treating wounds, preventing local infection and skin grafting, but not only pain is hard to endure but also scars are left after healing in the treatment process.
The traditional Chinese medicine has a long history of treating skin injury, a plurality of stored prescriptions are provided, many of the stored prescriptions are Chinese herbal medicine preparations, the main ingredients comprise sesame oil, garden burnet, rehmannia root, coptis root, borneol and the like, the traditional Chinese medicine can diminish inflammation and relieve pain, and has a certain curative effect on treating skin injury, but the treatment time is long, the effect is slow, and the skin injury is repaired slowly.
Disclosure of Invention
The invention aims to provide a skin injury repair preparation, a preparation method and application thereof, and aims to solve the technical problems.
In order to achieve the purpose, the technical scheme of the invention is as follows:
in a first aspect, the skin injury repair preparation provided by the invention comprises the following raw materials in parts by weight: 1-10 parts of angelica dahurica, 1-10 parts of liquorice, 1-10 parts of angelica and 200-800 parts of eggs.
Preferably, the skin injury repair preparation comprises the following raw materials in parts by weight: 3-7 parts of angelica dahurica, 3-7 parts of liquorice, 3-7 parts of angelica sinensis and 400-600 parts of eggs.
Further preferably, the skin injury repair preparation comprises the following raw materials in parts by weight: 5 parts of angelica dahurica, 5 parts of liquorice, 5 parts of angelica and 500 parts of eggs.
In a second aspect, the present invention provides a method for preparing a skin injury repair preparation according to the first aspect, comprising the steps of:
boiling egg, removing egg shell and egg white, leaving yolk, mashing the yolk, heating and decocting the yolk for the first time to obtain oil, adding radix Angelicae Dahuricae, Glycyrrhrizae radix and radix Angelicae sinensis, heating and decocting for the second time to obtain brown transparent oily substance, cooling, filtering to remove residue, and packaging to obtain skin injury repairing preparation.
Preferably, the conditions of the first heating and boiling are as follows: the time is 2-4 hours, and the temperature is 200-240 ℃.
Preferably, the second heating and boiling conditions are as follows: the time is 0.5-2 hours, and the temperature is 140-160 ℃.
Preferably, the radix angelicae, the liquorice and the angelica are respectively powder obtained by crushing and sieving dry radix angelicae raw materials, liquorice raw materials and angelica raw materials.
In a third aspect, the present invention provides a skin injury repairing preparation as described in the first aspect, for use in preparing a medicament for repairing skin injury.
In a fourth aspect, the present invention provides the use of a skin damage repair formulation according to the first aspect in the manufacture of a cosmetic for repairing skin damage.
Preferably, the cosmetic formulation includes any one of a liquid cosmetic, an emulsion cosmetic, a cream cosmetic, and an oily cosmetic.
Preferably, the skin injury comprises laser burn, heat burn, cold burn, traumatic skin physicochemical injury.
Compared with the prior art, the invention has the beneficial effects that:
the skin injury repair preparation is prepared by taking eggs, angelica dahurica, liquorice and angelica as raw materials through a specific boiling process, contains various bioactive substances, can obviously enhance the anti-injury capability of skin, obviously enhance the repair capability of skin, regulate skin metabolism and help to maintain the normal function of skin cell tissues; can be used for repairing laser burn, thermal burn (such as scald and burn), cold burn, and physical and chemical injury of skin, and can also be used for rapidly relieving and repairing skin allergy, red swelling, desquamation, and pruritus.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a diagram showing the skin condition of the face before use according to example 1 of the present invention;
FIG. 2 is a graph of facial skin condition 5 days after use as provided in example 1 of the present invention;
figure 3 is a graph of facial skin condition after 3 months of use as provided in example 1 of the present invention.
Detailed Description
The following further describes embodiments of the present invention with reference to the drawings. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
The preparation method of the skin injury repair preparation provided by the embodiment comprises the following steps:
crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 5 parts of angelica dahurica powder, 5 parts of licorice powder, 5 parts of angelica powder and 500 parts of eggs. Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, heating and decocting with strong fire (200-240 ℃) for 2.5 hours to obtain yolk oil, adding angelica dahurica powder, licorice powder and angelica sinensis powder, heating and decocting with medium fire (120-140 ℃) for 1 hour to obtain a yellow brown transparent oily substance, cooling, filtering, removing residues, and subpackaging to obtain the skin injury repairing preparation.
Example 2
The preparation method of the skin injury repair preparation provided by the embodiment comprises the following steps:
crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 3 parts of angelica dahurica powder, 7 parts of licorice powder, 3 parts of angelica powder and 400 parts of eggs. Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, heating and decocting for 2 hours at a high fire (200-240 ℃) to obtain yolk oil, adding angelica dahurica powder, licorice powder and angelica sinensis powder, heating and decocting for 1 hour at a medium fire (120-140 ℃) to obtain a yellow brown transparent oily substance, cooling, filtering to remove residues, and subpackaging to obtain the skin injury repairing preparation.
Example 3
The preparation method of the skin injury repair preparation provided by the embodiment comprises the following steps:
crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 7 parts of angelica dahurica powder, 3 parts of licorice powder, 7 parts of angelica powder and 600 parts of eggs. Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, heating and decocting with strong fire (200-240 ℃) for 3 hours to obtain yolk oil, adding angelica dahurica powder, licorice powder and angelica sinensis powder, heating and decocting with medium fire (120-140 ℃) for 1 hour to obtain a yellow brown transparent oily substance, cooling, filtering, removing residues, and subpackaging to obtain the skin injury repairing preparation.
Example 4
The preparation method of the skin injury repair preparation provided by the embodiment comprises the following steps:
crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 1 part of angelica dahurica powder, 1 part of licorice powder, 1 part of angelica powder and 500 parts of eggs. Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, heating and decocting for 2.5 hours at a high fire (200-240 ℃) to obtain yolk oil, adding angelica dahurica powder, licorice powder and angelica powder, heating and decocting for 0.5 hour at a medium fire (120-140 ℃) to obtain a yellow brown transparent oily substance, cooling, filtering to remove residues, and subpackaging to obtain the skin injury repairing preparation.
Example 5
The preparation method of the skin injury repair preparation provided by the embodiment comprises the following steps:
crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 10 parts of angelica dahurica powder, 10 parts of licorice powder, 10 parts of angelica powder and 500 parts of eggs. Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, heating and decocting with strong fire (200-240 ℃) for 2.5 hours to obtain yolk oil, adding angelica dahurica powder, licorice powder and angelica sinensis powder, heating and decocting with medium fire (120-140 ℃) for 2 hours to obtain a yellow brown transparent oily substance, cooling, filtering, removing residues, and subpackaging to obtain the skin injury repairing preparation.
Example 6
The preparation method of the skin injury repair preparation provided by the embodiment comprises the following steps:
crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 1 part of angelica dahurica powder, 1 part of licorice powder, 1 part of angelica powder and 800 parts of eggs. Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, heating and decocting for 4 hours at a strong fire (200-240 ℃) to obtain yolk oil, adding angelica dahurica powder, licorice powder and angelica sinensis powder, heating and decocting for 0.5 hour at a medium fire (120-140 ℃) to obtain a yellow brown transparent oily substance, cooling, filtering to remove residues, and subpackaging to obtain the skin injury repairing preparation.
Example 7
The preparation method of the skin injury repair preparation provided by the embodiment comprises the following steps:
crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 10 parts of angelica dahurica powder, 10 parts of licorice powder, 10 parts of angelica powder and 200 parts of eggs. Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, heating and decocting for 2 hours at a strong fire (200-240 ℃) to obtain yolk oil, adding angelica dahurica powder, licorice powder and angelica sinensis powder, heating and decocting for 2 hours at a medium fire (120-140 ℃) to obtain a yellow brown transparent oily substance, cooling, filtering to remove residues, and subpackaging to obtain the skin injury repairing preparation.
Comparative example 1
Crushing the radix angelicae, the liquorice and the angelica raw materials respectively by using a crusher, sieving the crushed materials by a 100-mesh sieve to obtain radix angelicae powder, liquorice powder and angelica powder, and weighing the following raw materials in parts by weight: 5 parts of angelica dahurica powder, 5 parts of licorice powder, 5 parts of angelica powder and 500 parts of vaseline. Adding vaseline into a thick-bottom pot, heating and decocting for 2.5 hours with strong fire (200-240 ℃), adding angelica dahurica powder, licorice powder and angelica powder, heating and decocting for 1 hour with medium fire (120-140 ℃) to obtain a yellow brown transparent oily substance, cooling, filtering to remove residues, and subpackaging to obtain the skin injury repairing preparation.
Comparative example 2
Boiling eggs, removing eggshells and egg white, leaving yolk, adding the yolk into a thick-bottom pot, mashing, and heating and decocting with strong fire (200-240 ℃) for 2.5 hours to obtain the yolk oil.
To further illustrate the beneficial effects of the present invention, the present invention performed stability test tests on the formulations obtained in the above examples and comparative examples:
(1) the packaged preparation is placed in an environment of 48 ℃ for 24 hours and then placed in an environment of-5 ℃ for 24 hours, and the appearance of the preparation obtained in each example and each comparative example is observed to be unchanged, which shows that the heat-resistant and cold-resistant stability of each product is good;
(2) and taking out the packaged preparation, placing the preparation in a centrifuge tube, centrifuging the preparation for 30min at the rotating speeds of 2000r/min, 3000r/min and 4000r/min respectively, and observing to show that no layering phenomenon is found, thereby showing that the stability of each product is good.
To further illustrate the beneficial effects of the present invention, the following tests were also performed on the products obtained in the above examples and comparative examples:
randomly selecting 180 volunteers with burned faces, wherein the ages of the volunteers are 18-56 years, the male and female volunteers respectively account for 50%, randomly dividing the volunteers into 9 groups, and each group has 20 patients with the burn symptoms: redness and swelling of the skin, associated with pain or itching, with ulceration.
The using method comprises the following steps: the wound surface is cleaned by normal saline, distilled water and cold white water, a part of soaked skin is cut off, the wound surface cleaning liquid is sucked dry, the skin injury repair preparation is directly coated on the wound surface and is reapplied every 6 hours, and the skin injury repair preparation is continuously used for 3-10 days after the skin injury repair preparation is naturally dropped or is dropped in a hospital through laser and the skin injury repair preparation is completely dropped during the scabbing period of the wound surface and the scab is prevented from being manually stripped.
Evaluation criteria: the curative effect is divided into recovery, partial relief and ineffectiveness according to the improvement condition of symptoms, the recovery refers to wound surface healing, no obvious convex or concave scar, no bleeding and weeping, and no pain and itching feeling; the evaluation of the healing time refers to the evaluation value of the total use time of wound healing of a healing volunteer from the date of use.
TABLE 1 statistics of wound healing
Serial number | Product source | Recovery rate (%) | Healing time (Tian) |
1 | Example 1 | 100 | 19 |
2 | Example 2 | 100 | 23 |
3 | Example 3 | 100 | 20 |
4 | Example 4 | 95 | 27 |
5 | Example 5 | 90 | 29 |
6 | Example 6 | 85 | 32 |
7 | Example 7 | 85 | 35 |
8 | Comparative example 1 | 35 | 41 |
9 | Comparison ofExample 2 | 30 | 46 |
Randomly selecting a subject with facial skin shown in fig. 1, and applying the skin injury repair preparation of the embodiment on the skin uniformly to enable the preparation to completely infiltrate into the skin; after continuously applying for 5 days, the facial skin is shown in figure 2, and the facial wound has scabbed; after continuous application for 3 months, the facial skin is shown in figure 3.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (9)
1. The skin injury repair preparation is characterized by comprising the following raw materials in parts by weight: 1-10 parts of angelica dahurica, 1-10 parts of liquorice, 1-10 parts of angelica and 200-800 parts of eggs.
2. The skin injury repair preparation according to claim 1, which comprises the following raw materials in parts by weight: 3-7 parts of angelica dahurica, 3-7 parts of liquorice, 3-7 parts of angelica sinensis and 400-600 parts of eggs.
3. The skin injury repair preparation according to claim 2, which comprises the following raw materials in parts by weight: 5 parts of angelica dahurica, 5 parts of liquorice, 5 parts of angelica and 500 parts of eggs.
4. A method of preparing a skin lesion repair formulation according to claim 1, comprising the steps of:
boiling egg, removing egg shell and egg white, leaving yolk, mashing the yolk, heating and decocting the yolk for the first time to obtain oil, adding radix Angelicae Dahuricae, Glycyrrhrizae radix and radix Angelicae sinensis, heating and decocting for the second time to obtain brown transparent oily substance, cooling, filtering to remove residue, and packaging to obtain skin injury repairing preparation.
5. The method for preparing a skin injury repair preparation according to claim 4, wherein the conditions of the first heating and boiling are as follows: the time is 2-4 hours, and the temperature is 200-240 ℃.
6. The method for preparing a skin injury repair preparation according to claim 4, wherein the second heating and boiling are performed under the following conditions: the time is 0.5-2 hours, and the temperature is 120-140 ℃.
7. The method for preparing a skin injury repair preparation according to claim 4, wherein the dahurian angelica root, the licorice root and the Chinese angelica are powders obtained by pulverizing and sieving dried dahurian angelica root raw material, licorice root raw material and Chinese angelica root raw material, respectively.
8. Use of the skin injury-repairing preparation according to claim 1 for the preparation of a medicament for repairing skin injury.
9. Use of the skin damage-repairing preparation according to claim 1 for the preparation of a cosmetic for repairing skin damage.
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CN202110568559.4A CN113288931A (en) | 2021-05-25 | 2021-05-25 | Skin injury repairing preparation and preparation method and application thereof |
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Citations (3)
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2021
- 2021-05-25 CN CN202110568559.4A patent/CN113288931A/en active Pending
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CN102000008A (en) * | 2010-11-03 | 2011-04-06 | 张家港市怡情农庄有限公司 | Skin-renewing and whitening facial mask |
CN103040706A (en) * | 2012-12-20 | 2013-04-17 | 青岛盛瀚色谱技术有限公司 | Moisture mask |
CN103357011A (en) * | 2013-07-10 | 2013-10-23 | 深圳市宝舜泰生物医药股份有限公司 | Pharmaceutical composition and composite burn cream for treating burns and scalds and preparation method thereof |
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