CN113274456A

CN113274456A - Chinese medicinal ointment for treating burn, scald, chemical burn, and electric injury, and its preparation method

Info

Publication number: CN113274456A
Application number: CN202110562581.8A
Authority: CN
Inventors: 刘锋; 赵金玲
Original assignee: Pingdingshan Zeus Biotechnology Co ltd
Current assignee: Pingdingshan Zeus Biotechnology Co ltd
Priority date: 2021-05-24
Filing date: 2021-05-24
Publication date: 2021-08-20

Abstract

The invention relates to a Chinese medicinal ointment for treating burns, scalds, chemical burns and electric injuries and a preparation method thereof, wherein the Chinese medicinal ointment is prepared from the following raw material medicaments in part by weight: 30-36 parts of saffron, 28-36 parts of dragon's blood, 27-33 parts of centella, 10-20 parts of caulis piperis, 12-18 parts of giant knotweed, 13-17 parts of bletilla, 13-17 parts of eupolyphaga, 12-18 parts of goldthread, 13-17 parts of sanguisorba, 7-13 parts of rheum officinale, 8-12 parts of musk and 2-4 parts of pearl powder. In addition, the invention also provides a preparation method of the traditional Chinese medicine ointment for treating burns, scalds, chemical burns and electric shock wounds. The invention is prepared by adopting targeted Chinese herbal medicines with unique effect of treating burn, and the effects of promoting blood circulation by removing blood stasis, diminishing inflammation, relieving pain, preventing corrosion, promoting granulation and the like can be achieved by blending and compounding the raw materials of the Chinese herbal medicines, thereby realizing the effect of treating both symptoms and root causes.

Description

Chinese medicinal ointment for treating burn, scald, chemical burn, and electric injury, and its preparation method

Technical Field

The invention relates to the technical field of ointment, in particular to a traditional Chinese medicine ointment for treating burns and scalds, chemical burns and electric shock wounds and a preparation method thereof.

Background

Burn is a common body injury in daily life, and is an extremely complex traumatic disease caused by the action of various factors on the body, such as physics, chemistry, paying-off and the like. In recent years, the research work of treating the burns in China has been greatly developed, but the death rate of the burns patients in China is still maintained to be 2.25-5.41%.

Since the modern medicine proposes the concept of wound sepsis, the western medicine also attaches importance to and develops the application of local external drugs for treating burn patients, mainly uses antibacterial drugs and various growth factors, but easily causes scar hyperplasia and has the problems of high cost, short storage life and the like. Traditional Chinese medicine and traditional Chinese medicine have a long history and rich experience in the aspect of treating burns and scalds, and have received wide attention. Although there are many burn external preparations on the market, all have advantages and disadvantages. Some have no antibacterial effect, and some are not good for wound healing. Among a plurality of Chinese herbal medicines, the development of an external medicament which can promote blood circulation to remove blood stasis, promote blood circulation to relieve pain, resist infection, promote healing, remove necrotic tissue and promote granulation, is economical and cheap becomes the key point for treating the burns and scalds.

In view of the background, the inventor finds a traditional Chinese medicine ointment for treating burns, scalds, chemical burns and electric shock injuries and a preparation method thereof through repeated research and repeated verification of in vitro and clinical tests, screens and obtains pure natural famous and precious Chinese herbal medicine materials which are superior and superior in the ministry of China according to the pathogenesis of the diseases, is specially prepared by combining the traditional method with modern medicine, and can achieve the effects of promoting blood circulation to remove blood stasis, diminishing inflammation, relieving pain, preventing corrosion, promoting granulation and the like, thereby achieving the effect of treating both principal and secondary aspects of diseases.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine ointment for treating burns, scalds, chemical burns and electric injuries and a preparation method thereof.

In order to achieve the purpose of the invention, the invention provides the following technical scheme:

a traditional Chinese medicine ointment for treating burns and scalds, chemical burns and electric shock wounds is prepared from the following raw material medicines in parts by weight:

30-36 parts of saffron, 28-36 parts of dragon's blood, 27-33 parts of centella, 10-20 parts of caulis piperis, 12-18 parts of giant knotweed, 13-17 parts of bletilla, 13-17 parts of eupolyphaga, 12-18 parts of goldthread, 13-17 parts of sanguisorba, 7-13 parts of rheum officinale, 8-12 parts of musk and 2-4 parts of pearl powder.

As a preferred scheme of the invention, the traditional Chinese medicine ointment is prepared from the following raw materials in parts by weight:

30 parts of saffron, 30 parts of dragon's blood, 30 parts of centella, 15 parts of caulis piperis futokadsurae, 15 parts of giant knotweed, 15 parts of bletilla, 15 parts of eupolyphaga, 15 parts of goldthread, 15 parts of sanguisorba, 10 parts of rheum officinale, 10 parts of musk and 3 parts of pearl powder.

The Chinese herbal medicine for treating the burn is selected, so that the components can play respective pharmacological action and play a mutual synergistic effect, the pharmacological action is enhanced, the formula is reasonable, the medicine flavor is refined, the heat clearing and dampness eliminating, the blood circulation promoting and pain relieving, the necrotic tissue removing and granulation promoting effects can be realized, and the Chinese herbal medicine has a good treatment effect on the burn.

The Chinese herbal medicine for treating burn of the invention comprises the following raw medicinal materials in part by weight:

the saffron, the dragon's blood and the asiatic centella are monarch drugs: has effects in cooling blood, removing toxic materials, promoting blood circulation, relieving pain, removing necrotic tissue, promoting granulation, and promoting tissue repair;

caulis piperis futokadsurae, giant knotweed rhizome, bletilla striata and eupolyphaga are ministerial drugs: anti-inflammatory, anti-infection, can protect the wound surface and promote the wound surface to heal;

the goldthread root, the garden burnet root and the rhubarb are used as adjuvant drugs: promoting blood circulation to stop bleeding, and assisting monarch and ministerial drugs to achieve the effects of promoting blood circulation and promoting tissue regeneration;

musk is used as a guiding drug: the medicine has the treatment capacity of maximum efficacy by being combined with the other medicines of the other drugs.

The burn treatment principle provided by the inventor is based on the scientific treatment principle of the traditional Chinese medicine, ministerial drugs such as caulis piperis futokadsurae, polygonum cuspidatum, bletilla striata and eupolyphaga are selected to be matched with adjuvant drugs such as coptis chinensis, garden burnet, rheum officinale, the adjuvant drugs are commonly supplemented with monarch drugs such as saffron, dragon's blood and centella asiatica, and the conductant drugs such as musk are selected to regulate and regulate the drugs, so that the effects of clearing heat and eliminating dampness, activating blood and relieving pain, removing necrotic tissue and promoting granulation are achieved.

By the compatibility principle of the composition, the final relief and treatment of the burn symptom can be realized, the effect of treating both symptoms and root causes is achieved, the rapid cure and the overall recovery are achieved, both the symptoms and root causes are treated, and the treatment is simple, convenient and rapid.

In addition, the invention also provides a preparation method of the traditional Chinese medicine ointment for treating burns, scalds, chemical burns and electric shock wounds, which comprises the following steps:

(1) weighing saffron, dragon's blood, centella asiatica, caulis piperis futokadsurae, polygonum cuspidatum, bletilla striata, eupolyphaga, goldthread root, garden burnet root, rheum officinale and musk according to specified weight parts, shearing, removing dust and drying to obtain medicinal materials;

(2) soaking the above materials in peanut oil, heating to boil, decocting with medium fire for 7-11min, then with slow fire for 25-30min, and finally with slow fire for 75-85min to obtain Chinese medicinal paste;

(3) filtering to remove residue when the temperature of the decocted paste is reduced to 56.3 deg.C, extracting and purifying, placing the obtained paste into a special sterile container with a loading of 3/4, heating to 66.8 deg.C, adding Borneolum Syntheticum and Margarita powder, and stirring to obtain Chinese medicinal paste;

(4) when the temperature of the Chinese medicinal ointment is reduced to 40-45 ℃, subpackaging into a plurality of sterile porcelain containers with the filling amount of 4/5, and sealing for 14-18 days;

(5) sterilizing the sealed Chinese medicinal ointment at high temperature and high pressure to obtain Chinese medicinal ointment for treating burn, scald, chemical burn, and electric injury.

As a preferable scheme of the invention, the Chinese medicinal materials in the step (2) are put into peanut oil and soaked for 65-75 hours.

As a preferable scheme of the invention, the medium fire is used for 9min, the small fire is used for 27min, and finally the slow fire is used for 81min in the step (2).

As a preferred scheme of the invention, the adding amount of the borneol in the step (3) is 5-8% of the traditional Chinese medicine ointment.

In a preferred embodiment of the present invention, the stirring manner in the step (3) is: stirring the mixture for 36 circles clockwise at intervals of 3 minutes, and stirring the mixture for one time anticlockwise until the mixture is uniformly stirred into a paste.

As a preferable embodiment of the present invention, the step (4) is performed by sealing for 16 days.

The invention is prepared by adopting Chinese herbal medicines which are targeted and have unique functions for treating burn, and the components can play respective pharmacological action and play mutual synergistic action, so that the pharmacological action is enhanced, the formula is reasonable, the medicine taste is refined, the effects of promoting blood circulation to remove blood stasis, diminishing inflammation, relieving pain, preventing corrosion, promoting granulation and the like can be achieved, and the effect of treating both principal and secondary aspects of diseases is realized;

the traditional Chinese medicine composition disclosed by the invention is prepared and combined according to the traditional Chinese medicine theory and the scientific Chinese medicine theory, and the achievements of scientific research of modern traditional Chinese medicines are referred, so that the components can play respective pharmacological effects and also play mutual synergistic effects, the pharmacological effects are enhanced, the formula is reasonable, and the effects of promoting blood circulation to remove blood stasis, diminishing inflammation, relieving pain, preventing corrosion, promoting granulation and the like can be achieved, so that the effect of treating both symptoms and root causes is realized;

according to the preparation method provided by the invention, the active chemical components in the raw materials are extracted as far as possible through the extraction, concentration and extraction processes according to the physicochemical characteristics of the raw materials. Compared with the conventional direct medicinal powder application, the patch can remove part of the toxicity of raw materials, and can improve the content of active ingredients of the medicine and ensure safer administration.

Detailed Description

The foregoing aspects of the present invention are described in further detail below by way of examples, but it should not be construed that the scope of the subject matter of the present invention is limited to the following examples, and that all the technologies that can be realized based on the above aspects of the present invention are within the scope of the present invention.

Example 1:

the traditional Chinese medicine ointment for treating burns, scalds, chemical burns and electric shock wounds is prepared from the following raw material medicines in parts by weight:

33g of saffron, 32g of dragon's blood, 30g of centella asiatica, 15g of caulis piperis, 15g of giant knotweed, 15g of bletilla striata, 15g of eupolyphaga, 15g of goldthread root, 15g of sanguisorba, 10g of rheum officinale, 10g of musk and 3g of pearl powder.

The preparation method of the traditional Chinese medicine ointment for treating burns, scalds, chemical burns and electric shock wounds comprises the following steps:

(1) weighing saffron, dragon's blood, centella asiatica, caulis piperis futokadsurae, polygonum cuspidatum, bletilla striata, eupolyphaga, goldthread root, garden burnet root, rheum officinale and musk according to specified weight parts, shearing, removing dust, drying and crushing to obtain medicinal materials;

(2) soaking the above materials in peanut oil, heating to boil, decocting with medium fire for 9min, then with slow fire for 27min, and finally with slow fire for 80min to obtain Chinese medicinal paste;

(4) when the temperature of the Chinese medicinal ointment is reduced to 43 ℃, subpackaging into a plurality of sterile porcelain containers with the filling amount of 4/5, and sealing for 16 days;

Example 2:

30g of saffron, 28g of dragon's blood, 27g of centella asiatica, 10g of caulis piperis, 12g of giant knotweed, 13g of bletilla striata, 13g of eupolyphaga, 12g of goldthread root, 13g of sanguisorba, 7g of rheum officinale, 8g of musk and 2g of pearl powder.

(2) soaking the above materials in peanut oil, heating to boil, decocting with medium fire for 7min, then with slow fire for 25min, and finally with slow fire for 75min to obtain Chinese medicinal paste;

(4) when the temperature of the Chinese medicinal ointment is reduced to 40 ℃, subpackaging the Chinese medicinal ointment into a plurality of sterile porcelain containers with the filling amount of 4/5, and sealing for 14 days;

Example 3:

36g of saffron, 36g of dragon's blood, 33g of centella asiatica, 20g of caulis piperis, 18g of giant knotweed, 17g of bletilla striata, 17g of eupolyphaga, 18g of coptis chinensis, 17g of sanguisorba officinalis, 13g of rheum officinale, 12g of musk and 4g of pearl powder.

(2) soaking the above materials in peanut oil, heating to boil, decocting with medium fire for 11min, then with slow fire for 30min, and finally with slow fire for 85min to obtain Chinese medicinal paste;

(4) when the temperature of the Chinese medicinal ointment is reduced to 45 ℃, subpackaging into a plurality of sterile porcelain containers with the filling amount of 4/5, and sealing for 14-18 days;

Example 4:

32g of saffron, 30g of dragon's blood, 30g of centella asiatica, 13g of caulis piperis, 14g of giant knotweed, 14g of bletilla striata, 14g of eupolyphaga, 14g of goldthread root, 14g of sanguisorba, 9g of rheum officinale, 8-12g of musk and 2.5g of pearl powder.

(2) soaking the above materials in peanut oil, heating to boil, decocting with medium fire for 8min, then with slow fire for 29min, and finally with slow fire for 78min to obtain Chinese medicinal paste;

(4) when the temperature of the Chinese medicinal ointment is reduced to 42 ℃, subpackaging the Chinese medicinal ointment into a plurality of sterile porcelain containers with the filling amount of 4/5, and sealing for 15 days;

Example 5:

35g of saffron, 35g of dragon's blood, 31g of centella asiatica, 18g of caulis piperis, 16g of giant knotweed, 16g of bletilla striata, 16g of eupolyphaga, 16g of goldthread root, 16g of sanguisorba, 11g of rheum officinale, 11g of musk and 3.5g of pearl powder.

(2) soaking the above materials in peanut oil, heating to boil, decocting with medium fire for 10min, then with slow fire for 26min, and finally with slow fire for 83min to obtain Chinese medicinal paste;

(4) when the temperature of the Chinese medicinal ointment is reduced to 44 ℃, subpackaging the Chinese medicinal ointment into a plurality of sterile porcelain containers with the filling amount of 4/5, and sealing for 17 days;

Experimental example:

clinical experiment of Chinese medicinal ointment for treating burn

The invention adopts the pure natural traditional Chinese medicine materials as the raw material medicines, is formed by reasonable compatibility, can activate blood circulation to dissipate blood stasis, diminish inflammation and relieve pain, prevent corrosion and promote tissue regeneration and other effects, thereby realizing the effect of treating both symptoms and root causes, uniformly smearing the traditional Chinese medicine ointment on the wound surface, carrying out aseptic bandaging, and changing the medicine once a day. The medicine is changed every other day after 10 days, and the treatment course is 24 days.

1.1 clinical data

360 patients aged 30-60 years were selected for clinical trials.

Of the treatments for 360 patients with burns, 130 men, 120 women, and 110 children were aged between 1-70 years, with the average age being 35 years.

1.2 methods of treatment

The Chinese medicinal ointment is uniformly applied on the wound surface and aseptically bandaged, and the dressing is changed once a day. The medicine is changed every other day after 10 days, and the treatment course is 24 days.

1.3 results

The pain is relieved after the medicine is taken for 2 to 3 days, the pain is not obvious after 1 course of general patient taking, and the pain can be radically cured after 2 to 3 courses of treatment; patients with serious illness can be cured radically after taking the medicine for 4-5 courses, the cure rate reaches 98.6 percent, the effective rate is 100 percent, and the specific table shows that the medicine is used for treating the serious illness.

Table 1 clinical treatment statistical table:

type of disease	Number of cases	Cure of disease	Is effective	Invalidation	Cure rate (%)	Effective rate (%)
							Male sex	130	127	3	0	97.7	100
Female with a view to preventing the formation of wrinkles	120	118	2	0	98.3	100
							Children's toy	110	110	0	0	100	100
Total up to	360	355	5	0	98.6%	100

As can be seen from Table 1, the final treatment results show that 355 patients in 360 patients are cured, the cure rate is 98.6%, and the effective rate is 100%, which shows that the traditional Chinese medicine ointment can effectively treat burns.

Typical clinical cases are:

case 1: the patient, female, is 50 years old, and when the liquefied gas is ignited by cooking chicken in 2020, 5 months, the pipeline leaks and catches fire. Many parts of the whole body are burned. Sulai me burn department, physical examination: refreshing mind, regulating spirit and checking physical cooperation. There is no deformity in the skull, eyelid edema, conjunctival congestion, equal-large pupils on both sides, soft neck, central trachea, and no swelling in the thyroid gland. Bilateral thoracic symmetry and no deformity. Left untouched under the rib of the liver and spleen. Burn on face, right upper limb and right chest. The diagnosis is that the deep II burn, most skin blister, eyebrow burnt, skin avulsion, body red and white, peculiar smell, conjunctival congestion, sclera yellow stain free, and sensitive light response. The total area of the diagnosed burn was about 36%. Physical examination: T36.6R 24 times/minute BP 135/85mmg, pale complexion, accompanied with sweating, excited mood, and painful complexion. After conventional disinfection and debridement, the first burn is smeared on the wound surface and is aseptically bandaged. After 15 minutes, the state of the disease is stable, the emotion is recovered, and the hospitalization procedure is handled for comprehensive treatment. Hospitalization was immediately given oxygen, given by intravenous drip (anti-inflammatory, sperm, colloid, electrolyte correction and symptomatic treatment) and changed once a day. The disease condition is improved after one week, and the edema and exudation are obviously reduced. The dressing change is carried out once every other day in the second week, the patient is discharged after being cured 18 days after hospitalization, and no scar is left on the wound surface.

Up to now, the follow-up patients have no uncomfortable symptoms, have clear mind and good spirit and can normally live and work. The patients are satisfied with the treatment effect.

Case 2: the patient, male, 29 years old, when the patient is connected in a large-scale meter box by 7-12 days in 2014, carelessly causes the fire of the circuit connecting line in the meter box (a plurality of big fireballs directly burn the whole body to cause large-area burns of the whole body, the patient comes to the burn department, T36.5R 25 times/BP 130/80mmg, Shenshiqing, spiritual, cooperation of the body, no deformity of the skull, eyelid edema, conjunctival congestion, large isocircles such as pupils on both sides, soft neck, trachea in the middle, thyroid gland in middle, chest contour symmetry on both sides, no deformity, no touching under the ribs of liver and spleen, face, neck, anterior chest and upper limbs are all burned to deep | burn, partial skin scorching, peculiar smell, emotional excitement, extremely painful face, particularly the right upper limb is deep III burn, diagnosis, the burn total area is about 48% of the whole body, the burn number is uniformly smeared on the wound surface, and is subjected to sterile debridement, bandaged, and subjected to anti-inflammatory therapy is immediately given to intravenous infusion (intravenous infusion) Sperm, colloid, correct electrolytes and symptomatic treatment) and changed once a day. The dressing change is carried out every other day after 10 days of continuous dressing change, the patient is discharged after 24 days of hospitalization, and no scar is left on the affected part of the burn.

Follow-up patients one week after discharge from hospital: shenqing, good state, less itching and pain, and normal life and work after the shubaoning ointment is applied for two months.

In conclusion, the traditional Chinese medicine ointment for treating burns, scalds, chemical burns and electric injuries and the preparation method thereof provided by the invention are prepared by adopting targeted Chinese herbal medicines with unique burn treatment effects, and the effects of promoting blood circulation to remove blood stasis, diminishing inflammation, relieving pain, preventing corrosion, promoting granulation and the like can be achieved by blending and compounding the raw materials of the Chinese herbal medicines, so that the effect of treating both symptoms and root causes is realized.

The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. The equivalent substitution or change made by the technical personnel in the technical field on the basis of the invention is all within the protection scope of the invention. The protection scope of the invention is subject to the claims.

Claims

1. A traditional Chinese medicine ointment for treating burns and scalds, chemical burns and electric shock is characterized by being prepared from the following raw material medicines in parts by weight:

2. The traditional Chinese medicine ointment for treating burns and scalds, chemical burns and electric shock wounds according to claim 1, which is prepared from the following raw material medicines in parts by weight:

3. The method for preparing a Chinese medicinal ointment for treating burn and scald, chemical burn and electric burn according to any one of claims 1-2, comprising the following steps:

4. The method for preparing a Chinese medicinal ointment for treating burn and scald, chemical burn and electric burn according to claim 3, wherein the Chinese medicinal herbs in the step (2) are soaked in peanut oil for 65-75 hours.

5. The method for preparing a Chinese medicinal ointment for treating burn and scald, chemical burn and electric injury according to claim 3, wherein the step (2) is carried out by using middle fire for 9min, then carrying out the step by using small fire for 27min, and finally carrying out the step by using slow fire for 81 min.

6. The method for preparing Chinese medicinal ointment for treating burns and scalds, chemical burns and electric shock wounds according to claim 3, wherein the borneol is added in the step (3) in an amount of 5-8% of the Chinese medicinal ointment.

7. The method for preparing a Chinese medicinal ointment for treating burn and scald, chemical burn and electric burn according to claim 3, wherein the stirring manner in the step (3) is as follows: stirring the mixture for 36 circles clockwise at intervals of 3 minutes, and stirring the mixture for one time anticlockwise until the mixture is uniformly stirred into a paste.

8. The method for preparing a Chinese medicinal ointment for treating burn, scald, chemical burn and electric burn according to claim 3, wherein the step (4) is carried out for 16 days.