CN112336823A - External pharmaceutical composition, preparation method, preparation and application thereof - Google Patents
External pharmaceutical composition, preparation method, preparation and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The invention discloses an external pharmaceutical composition, a preparation method, a preparation and application thereof. The external pharmaceutical composition is prepared from bletilla striata, lily, radix stemonae, Chinese yam, isatis root, radix angelicae, semen ginkgo and coruscula. The method is that the raw materials in the formula ratio are respectively crushed, sieved and mixed uniformly to obtain the product. The application is the application of the external pharmaceutical composition in preparing the medicine for treating burn. The Chinese medicinal composition is a multi-component compound medicament, has the characteristics of multiple targets and multiple action channels, and has unique advantages in the aspect of skin burn. The traditional Chinese medicine composition has the advantages of reasonable formula, definite medicinal material source and medicine application position, scientific preparation method, definite and controllable quality index, high safety, obvious curative effect and wide application prospect.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an external pharmaceutical composition, and a preparation method, a preparation and application thereof.
Background
Burn is a local or systemic acute injury caused by the action of heat (flame, hot gas, liquid or solid), electric energy, chemical substances, radiation and the like on the human body. The strong heat attacks the human body, causing the skin and meat to rot. The intense heat mainly includes flame, hot water (oil), steam, current, laser, radioactive rays, chemical substances, and a war fire. Only skin and flesh are damaged in mild cases; in severe cases, both qi and yin are damaged due to excessive fire-toxin, fluid consumption, and yang-qi damage, except skin and flesh damage. Or fire toxin invades nutrient-blood to attack viscera, resulting in viscera disharmony and imbalance of yin and yang, leading to death of serious patients.
In ancient times, the patients who had burned with fire and scalded with soup were also called as scald caused by water or fire, burn due to boiling water or fire, burn and scald due to fire, boil due to boiling water or fire, and fire and sore due to fire. Due to the development of modern science and technology, chemical burns, radioactive burns, electric shock wounds and the like appear.
The history of traditional Chinese medicine on treating burn is long, and records of 'long-term calking for burn due to fire scalding or oil adding' and 'frying willow bark into paste by lard and forming into paste' are recorded in the Shangdai (back of the elbow) of jin Dynasty. Doctors of all generations accumulate abundant treatment experiences in clinical practice, and some doctors are still clinically applied up to now. In recent times, China has achieved favorable results in the aspect of preventing and treating burns by combining Chinese and western medicine.
Western medicine believes that high temperature can directly cause local tissue cell damage, so that degeneration, necrosis and even charring of the tissue cell occur. Extensive severe burns can cause systemic changes and early shock can be caused by massive fluid loss and severe pain. Bacterial infections during the fluid recovery phase and eschar abscission phase can cause sepsis. The wound surface can be repaired and healed to form a large number of scars or form intractable ulcers. Therefore, it is necessary to develop a drug that can address the therapeutic needs of the patients.
Disclosure of Invention
The first object of the present invention is to provide a pharmaceutical composition for external use; the second purpose is to provide a preparation method of the external pharmaceutical composition; the third purpose is to provide the application of the external pharmaceutical composition.
The first purpose of the invention is realized by that the external pharmaceutical composition is composed of 10-35 parts of bletilla striata, 7-25 parts of lily, 5-15 parts of radix stemonae, 13-27 parts of Chinese yam, 2-18 parts of isatis root, 5-25 parts of radix angelicae, 6-19 parts of semen ginkgo and 2-15 parts of coruscula.
The second purpose of the invention is realized by respectively crushing, sieving and uniformly mixing the raw materials in the formula ratio.
The third purpose of the invention is realized by the application of the external pharmaceutical composition in preparing the medicine for treating burn.
In the external medicine composition, the bletilla striata is bitter, sweet, astringent and cold in nature and enters lung, stomach and liver meridians. The bletilla striata has the efficacies of astringing to stop bleeding, healing sore and promoting granulation, and is mainly used for treating various skin slight cracks and dry cracks, and erosion and ulcer of visceral mucosa in clinic. The Bulbus Lilii is dried fleshy scaly leaf of Liliaceae plant herba Centellae. The lily has the effects of detoxifying, regulating spleen and invigorating stomach, promoting diuresis and removing food retention, calming heart and tranquilizing mind, contains certain skin moistening components, promotes blood circulation and the like, is collected and dug in autumn, and is prepared from lily with the weight of more than 150 g, large, fresh, non-discoloring, non-moth-eaten, non-tetanus and excellent quality. And washing away silt and impurities on the surface of the bulb by using clear water. Removing the withered scales and the base plate of the stem at the periphery of the lily, peeling the scales, slightly scalding in boiling water, immediately putting the scalded scales into flowing cold water for rinsing till the scales are cold, fishing out the scales, draining water, and drying. Radix Angelicae Dahuricae is a perennial herb, and is prepared by collecting root, removing fibrous root and silt, and drying in the sun or at low temperature. Pungent in property and flavor and warm in nature, enter lung, spleen and stomach meridians. Has effects in eliminating pathogenic factors, removing dampness, promoting pus discharge, promoting granulation, promoting blood circulation, relieving swelling, relieving pain, and lubricating skin. Dried root tuber of Stemona tuberosa (radix Stemonae) and Stemona tuberosa (radix Stemonae) belonging to perennial herbaceous plants of Stemona. Harvesting in autumn, cutting root tuber, removing beard, washing away silt, scalding in boiling water for 10 min, and sun drying. The medicine has the following properties and tastes: sweet and bitter, slightly warm, antibacterial. It has inhibitory effect on Escherichia coli, Pseudomonas aeruginosa, Diplococcus pneumoniae, and Bacillus dysenteriae. The radix Isatidis is dried root of Isatis indigotica of Cruciferae of Papaveraceae, collected in autumn, removed silt, cleaned, and sun-dried. The radix isatidis is used as a medicine by root, has the effects of clearing away heat and toxic materials, cooling blood, removing ecchymoses and relieving pain, and has the effect of resisting pathogenic microorganisms. The heat-clearing and detoxifying effects are mainly reflected in the treatment of acute infectious diseases. The medicine has analgesic effect on skin burn, and has good effect in recovering and eliminating scar. "Chuanguo" (another name) is the pseudobulb of Fritillaria hybrida (Wenshan Chinese herbal medicine) "belonging to the family Orchidaceae, and the whole herb can be used as medicine. Collected all the year round. This herb is pungent and numb in nature and flavor, cool in nature, and has the actions of cooling blood, stopping bleeding, alleviating pain and relaxing tendons. It is indicated for bleeding due to trauma. The Huanfeng tree is a characteristic medicine of Yunan Yi nationality, collected in autumn, cleaned and dried. The product has slightly bitter and warm taste, and has the functions of preventing and treating infection of the skin burn of the children and promoting wound healing, etc.
The Chinese medicinal composition is a multi-component compound medicament, has the characteristics of multiple targets and multiple action channels, and has unique advantages in the aspect of skin burn. The traditional Chinese medicine composition has the advantages of reasonable formula, definite medicinal material source and medicine application position, scientific preparation method, definite and controllable quality index, high safety, obvious curative effect and wide application prospect. Experimental research shows that the traditional Chinese medicine composition is clinically used by tens of burn patients, and the total rate of the traditional Chinese medicine composition reaches 98%.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to be limiting in any way, and any modifications or alterations based on the teachings of the present invention are intended to fall within the scope of the present invention.
The external pharmaceutical composition is prepared from 10-35 parts of bletilla striata, 7-25 parts of lily, 5-15 parts of radix stemonae, 13-27 parts of Chinese yam, 2-18 parts of isatis root, 5-25 parts of radix angelicae, 6-19 parts of semen ginkgo and 2-15 parts of coruscula.
The external pharmaceutical composition is composed of, by weight, 10-15 parts of bletilla striata, 7-12 parts of lily, 5-9 parts of radix stemonae, 13-17 parts of Chinese yam, 2-8 parts of isatis root, 5-15 parts of radix angelicae, 6-12 parts of semen ginkgo stopping and 2-15 parts of coruscula.
The external medicine composition is composed of 23 parts of bletilla striata, 18 parts of lily, 10 parts of radix stemonae, 22 parts of Chinese yam, 12 parts of isatis root, 18 parts of radix angelicae, 12 parts of semen ginkgo and 9 parts of coruscula.
The external medicine composition is composed of raw materials of 10 parts of bletilla striata, 7 parts of lily, 5 parts of radix stemonae, 13 parts of Chinese yam, 2 parts of isatis root, 5 parts of angelica dahurica, 6 parts of semen ginkgo and 2 parts of coruscula.
The preparation method of the external pharmaceutical composition is to respectively crush, sieve and uniformly mix the raw materials in the formula ratio.
The crushing and sieving is to crush and sieve through a 100-mesh sieve.
The application of the external pharmaceutical composition is the application of the external pharmaceutical composition in preparing a medicament for treating burn.
The burn is scald caused by water or fire, soup splashing fire, fire burn, soup fire sore, chemical burn, radioactive burn or electric shock.
The invention is further illustrated by the following specific examples:
example 1
Weighing bletilla striata 10g, lily 7g, stemona root 5g, Chinese yam 13g, isatis root 2g, angelica dahurica 5g, semen ginkgo 6g and corm-leaf holly bark 2g respectively, crushing respectively, sieving with a 100-mesh sieve, and uniformly mixing to obtain the target external pharmaceutical composition.
Example 2
Weighing bletilla striata 15g, lily 12g, stemona root 9g, Chinese yam 17g, isatis root 8g, dahurian angelica root 15g, semen ginkgo 12g and corm tree 15g respectively, crushing respectively, sieving with a 100-mesh sieve, and mixing uniformly to obtain the target external pharmaceutical composition.
Example 3
Weighing bletilla striata 35g, lily 25g, stemona root 15g, Chinese yam 27g, isatis root 18g, dahurian angelica root 25g, semen ginkgo 19g and corm tree 15g respectively, crushing respectively, sieving with a 100-mesh sieve, and mixing uniformly to obtain the target external pharmaceutical composition.
Example 4
Weighing bletilla striata 10g, lily 25g, stemona root 9g, Chinese yam 27g, isatis root 18g, dahurian angelica root 15g, semen ginkgo 19g and corm tree 12g respectively, crushing respectively, sieving with a 100-mesh sieve, and mixing uniformly to obtain the target external pharmaceutical composition.
Example 5
23g of bletilla striata, 18g of lily, 10g of radix stemonae, 22g of yam, 12g of isatis root, 18g of angelica dahurica, 12g of semen ginkgo and 9g of corm-vine are respectively weighed, respectively crushed, sieved by a 100-mesh sieve and uniformly mixed to obtain the target external pharmaceutical composition.
Example 6
Weighing bletilla striata 10g, lily 7g, stemona root 5g, Chinese yam 13g, isatis root 2g, angelica dahurica 5g, semen ginkgo 6g and corm-leaf holly bark 2g respectively, crushing respectively, sieving with a 100-mesh sieve, and uniformly mixing to obtain the target external pharmaceutical composition.
Example 7
Clinical tests are respectively carried out on the pharmaceutical compositions prepared in the embodiments 1 to 6, and the total effective rate of treatment is 98%.
The following is further explained by some practical cases:
case one
When a certain Zhao, a woman is 35 years old, the certain Zhao is played with a brother and is carelessly pushed into a pot by the brother to scald, the scald area reaches 72 percent, the scald is 34 percent above three degrees, a doctor can see before one week, small maggots grow in the leg bends, pain is hard to endure, and the woman cries all night all day;
taking the medicines before treatment: uniformly mixing vegetable oil and lime, smearing, charring, grinding, and spreading on affected part.
The treatment conditions were as follows: firstly, the wound surface is cleaned, the pain is relieved after the medicine composition prepared in the embodiment 2 is used for twenty minutes, the patient can fall asleep at night, the pain is obviously improved after three days, the patient can be cured for 70% in twelve days, and the patient can be cured for eighteen days, and scars are remained.
Case two
Wangzhi, male, 52 years old, car driver, when turning over the car in the course of transporting beer bottle, the fuel tank is burned, the burn area is 64%, and the burn area is above three degrees 37%.
Pre-visit treatment: after the burn is sent to a hospital for treatment, the burn still has no improvement after 6 days.
Treatment of the condition: after the patient is received, the gauze bound up is removed for two hours, the wound surface is cleaned in one hour, the pain is relieved after the medicine composition prepared in the example 4 is taken for 15 minutes, the patient can sit down and go to a toilet in the next morning, 90% of the medicine can be cured after 12 days, and the medicine can be cured after 16 days.
Case three
In Lu Yi, a man, 35 years old, a coach in a driving school carelessly falls into a cooling circulation water pool to scald when working in a smelting plant before the coach in the driving school, the scald area is that all scalds below the navel are caused, scalds of more than 81% are caused by more than three degrees, the patient enters a hospital, the family members of the patient negotiate with a hospital party, the medical scheme is that the pharmaceutical composition prepared in the external application medical embodiment 5 is applied according to the hospital scheme, the hospital party does not bear medical accident responsibility, and the scald depth is too deep, so that the scalded skin can be cured by slowly growing a new skin and furling the skin after three more than three months of treatment.
Case four
In a case where a left hand of a woman who is a littleman or a girl who is a third year old is burned in a coal fire for baking flue-cured tobacco, the burned area accounts for 70% of the left hand, and the burned area of the left hand is 90% of the burned area of the third year old or more, and the burn depth of the patient is too deep, it is recommended to perform a change-to-state hospital operation in a county hospital, and the pharmaceutical composition prepared in example 6 is used for treatment after the operation, and the left hand is cured after three months of treatment.
Claims (8)
1. The external pharmaceutical composition is characterized by comprising, by weight, 10-35 parts of bletilla striata, 7-25 parts of lily, 5-15 parts of radix stemonae, 13-27 parts of Chinese yam, 2-18 parts of radix isatidis, 5-25 parts of radix angelicae, 6-19 parts of semen ginkgo stopping and 2-15 parts of coruscula.
2. The external pharmaceutical composition as claimed in claim 1, wherein the external pharmaceutical composition comprises, by weight, 10-15 parts of bletilla striata, 7-12 parts of lily, 5-9 parts of stemona, 13-17 parts of yam, 2-8 parts of isatis root, 5-15 parts of angelica dahurica, 6-12 parts of semen ginkgo and 2-15 parts of coruscula.
3. The external pharmaceutical composition of claim 1, wherein the external pharmaceutical composition comprises 23 parts by weight of bletilla striata, 18 parts by weight of lily, 10 parts by weight of radix stemonae, 22 parts by weight of yam, 12 parts by weight of radix isatidis, 18 parts by weight of radix angelicae, 12 parts by weight of semen ginkgo biloba and 9 parts by weight of corm.
4. The external pharmaceutical composition of claim 1, wherein the external pharmaceutical composition comprises raw materials of, by weight, 10 parts of bletilla striata, 7 parts of lily, 5 parts of stemona, 13 parts of Chinese yam, 2 parts of isatis root, 5 parts of angelica dahurica, 6 parts of semen ginkgo and 2 parts of corm.
5. A preparation method of the external pharmaceutical composition as claimed in any one of claims 1 to 4, which is characterized in that the external pharmaceutical composition is prepared by respectively crushing, sieving and uniformly mixing the raw materials in the formula ratio.
6. The method of claim 5, wherein said pulverizing and sieving is pulverizing and sieving with 100 mesh sieve.
7. Use of the pharmaceutical composition for external use according to any one of claims 1 to 4, for the manufacture of a medicament for the treatment of burns.
8. The topical pharmaceutical composition for use according to claim 7, wherein the burn is a water and fire scald, a soup-on-fire burn, a soup-on-fire sore, a chemical burn, a radiation burn, or an electric shock.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011384996.2A CN112336823A (en) | 2020-12-02 | 2020-12-02 | External pharmaceutical composition, preparation method, preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202011384996.2A CN112336823A (en) | 2020-12-02 | 2020-12-02 | External pharmaceutical composition, preparation method, preparation and application thereof |
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| CN112336823A true CN112336823A (en) | 2021-02-09 |
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| CN202011384996.2A Pending CN112336823A (en) | 2020-12-02 | 2020-12-02 | External pharmaceutical composition, preparation method, preparation and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101219190A (en) * | 2007-01-09 | 2008-07-16 | 李保力 | Traditional Chinese medicine preparation and medical ointment for treating empyrosis |
| CN102327478A (en) * | 2011-09-28 | 2012-01-25 | 韩树华 | Pharmaceutical composition for treating burns and scalds and preparation method thereof |
| CN105709062A (en) * | 2015-04-17 | 2016-06-29 | 唐均停 | Medicine for treating scalds and burns |
| CN109771569A (en) * | 2019-03-20 | 2019-05-21 | 吴永春 | Medicine liquid for treating burns and scalds |
-
2020
- 2020-12-02 CN CN202011384996.2A patent/CN112336823A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101219190A (en) * | 2007-01-09 | 2008-07-16 | 李保力 | Traditional Chinese medicine preparation and medical ointment for treating empyrosis |
| CN102327478A (en) * | 2011-09-28 | 2012-01-25 | 韩树华 | Pharmaceutical composition for treating burns and scalds and preparation method thereof |
| CN105709062A (en) * | 2015-04-17 | 2016-06-29 | 唐均停 | Medicine for treating scalds and burns |
| CN109771569A (en) * | 2019-03-20 | 2019-05-21 | 吴永春 | Medicine liquid for treating burns and scalds |
Non-Patent Citations (1)
| Title |
|---|
| 家庭养生食谱大全: "《家庭养生食谱大全》", 31 January 2016, 黑龙江科学技术出版社 * |
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