CN108524773A - A kind of burn-treating liquid - Google Patents

A kind of burn-treating liquid Download PDF

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Publication number
CN108524773A
CN108524773A CN201810704045.5A CN201810704045A CN108524773A CN 108524773 A CN108524773 A CN 108524773A CN 201810704045 A CN201810704045 A CN 201810704045A CN 108524773 A CN108524773 A CN 108524773A
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mouse
burn
radix
treating liquid
situation
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黄绍恒
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739—Sanguisorba (burnet)
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

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Abstract

The invention discloses a kind of burn-treating liquids, include the following steps：Step 1, material selection；It is prepared by step 2；Step 3, mouse experiment select mouse 10,6 week old, female fifty-fifty, the weight 22g of hero, mouse adaptable fed one week under the conditions of 24 DEG C constant of room temperature and humidity 60wt%；Step 4, observation and index, observe area change, inflammation infection situation, incrustation and scab piece dropping situations at mouse scald, the variation of color, area, hardness after cicatrization；Step 5 compares.The present invention by smear burn-treating liquid, using burn-treating liquid to being smeared at mouse scald after, inflammatory reaction is slight, with slight oedema, 7d, surface of a wound cleaning at skin lesion, it is seen that moderate granulation tissue, without exudation, 28d, totally without crust at skin lesion, all healed, and have hair growth, quickly mouse can be treated.

Description

A kind of burn-treating liquid
Technical field
The present invention relates to burn treating technical field, more particularly to a kind of burn-treating liquid.
Background technology
Refer generally to heating power, including hydrothermal solution (water, soup, oil etc.), steam, high-temperature gas, flame, red-hot metal liquid or solid Histologic lesion caused by (such as molten steel, steel ingot) etc..The preparation of burn-treating liquid needs to test drug, avoids the occurrence of drug pair There is counteractive situation in human body.
Therefore, it is necessary to solve the above problems to invent a kind of burn-treating liquid.
Invention content
The purpose of the present invention is to provide a kind of burn-treating liquids, using burn-treating liquid to being smeared at mouse scald after, inflammation Reaction is slight, with slight oedema, 7d, and surface of a wound cleaning at skin lesion, it is seen that moderate granulation tissue, no exudation, 28d, skin lesion Place is totally without crust, all healed, and has hair growth, can quickly be treated to mouse, to solve above-mentioned background The problem of being proposed in technology.
To achieve the above object, the present invention provides the following technical solutions：A kind of burn-treating liquid, includes the following steps：
Step 1, material selection：Choose Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, safflower 100g, Radix Notoginseng 100g, first pearl 50g, Moschus 15g, longan pericarp 100g, longan seed 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, giant knotweed 80g, Fructus Forsythiae 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g, Rhizoma Atractylodis Macrocephalae 100g, peppermint 100g and distilled water 1000g；
It is prepared by step 2：By Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, Safflower 100g, Radix Notoginseng 100g, first pearl 50g and Moschus 15g, which are put into after being mixed with water inside terrine, heats boiling, by longan pericarp 100g, longan seed 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, tiger Cane 80g, Fructus Forsythiae 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g and Rhizoma Atractylodis Macrocephalae 100g are ground into the size powder of 100-120 mesh, Powder after grinding is added to behind terrine inside after boiling, 30 DEG C is then cooled the temperature to, filters, removes slag while hot, then will Peppermint twirl is added after wearing into liquid inside filtered medicament, and envelope bottle is carried out after being cooled to room temperature and obtains the burn configured Liquid；
Step 3, mouse experiment：Mouse 10 is selected, 6 week old, male female fifty-fifty, weight 22g, mouse is in constant room temperature Adaptable fed one week under the conditions of 24 DEG C and humidity 60wt% is divided into each 5 of two groups of mouse, half male and half female, intraperitoneal injection 10wt% chloral hydrate anesthesias, 8wt% sodium sulfide solutions carry out the depilation 2cm*4cm at back, for 24 hours after, mouse local topical 70wt% ethanol disinfection hair removal sections, alcolhol burner is lighted, and mouse hair removal section is placed at the 2cm of flame envelope upper end after 10s and is removed, and is established Mouse deep second degree burn model, modeling pneumoretroperitoneum inject 0.9wt% sodium chloride injections 2mL with Hemorrhagic shock；
Step 4, observation and index：Area change, inflammation infection situation, incrustation and scab piece fall off at observation mouse scald Situation, the variation of color, area, hardness after cicatrization, the case where by 7d, 14d and 28d wounds, by 7d, 14d and 28d takes out part cicatricial tissue, and the healing situation of wound behind part is taken out in then observation；
Step 5 compares：The picture situation of wound in two groups of mouse is compared, in same time, is smeared One group of mouse of burn-treating liquid, the good ratio of burned part is very fast, do not smear one group of mouse wound of burn-treating liquid it is possible that Edema or the situation of inflammation.
Preferably, in the step 2, when digestion time 1h-3h, wherein boiling, is arrived temperature promotion with big fire 100℃。
Preferably, in the step 3, will be pressed after 5 mouse of one of which prepared burn-treating liquid of cotton swab It rubs, twice daily, is spaced 12h, successive administration 28d.
Preferably, in the step 4, ensure the one of mouse weather while observing mouse wound situation Cause property, avoids data influence caused by outside environmental elements.
The technique effect and advantage of the present invention：
1, the present invention by smear burn-treating liquid, using burn-treating liquid to being smeared at mouse scald after, inflammatory reaction is slight, With slight oedema, 7d, surface of a wound cleaning at skin lesion, it is seen that moderate granulation tissue, no exudation, 28d, totally without scab at skin lesion Skin, all healed, and have hair growth, quickly mouse can be treated；
2, the present invention facilitates area change, inflammation infection situation, knot at two groups of mouse scalds of observation by preparing burn-treating liquid Scab and scab piece dropping situations, the variation of color, area, hardness after cicatrization, by the feelings of 7d, 14d and 28d wounds 7d, 14d and 28d are taken out part cicatricial tissue by condition, and the healing situation of wound behind part is taken out in then observation.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.
With reference to embodiment, the present invention is further described.
Embodiment 1
A kind of burn-treating liquid, includes the following steps：
Step 1, material selection：Choose Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, safflower 100g, Radix Notoginseng 100g, first pearl 50g, Moschus 15g, longan pericarp 100g, longan seed 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, giant knotweed 80g, Fructus Forsythiae 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g, Rhizoma Atractylodis Macrocephalae 100g, peppermint 100g and distilled water 1000g；
It is prepared by step 2：By Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, Safflower 100g, Radix Notoginseng 100g, first pearl 50g and Moschus 15g, which are put into after being mixed with water inside terrine, heats boiling, by longan pericarp 100g, longan seed 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, tiger Cane 80g, Fructus Forsythiae 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g and Rhizoma Atractylodis Macrocephalae 100g are ground into the size powder of 100 mesh, will grind Powder after mill is added to behind terrine inside after boiling, is then cooled the temperature to 30 DEG C, is filtered, removes slag while hot, then by peppermint Twirl is added after wearing into liquid inside filtered medicament, and envelope bottle is carried out after being cooled to room temperature and obtains the burn-treating liquid configured, Temperature is promoted to 100 DEG C with big fire when digestion time is 1h, wherein boiling；
Step 3, mouse experiment：Mouse 10 is selected, 6 week old, male female fifty-fifty, weight 22g, mouse is in constant room temperature Adaptable fed one week under the conditions of 24 DEG C and humidity 60wt% is divided into each 5 of two groups of mouse, half male and half female, intraperitoneal injection 10wt% chloral hydrate anesthesias, 8wt% sodium sulfide solutions carry out the depilation 2cm*4cm at back, for 24 hours after, mouse local topical 70wt% ethanol disinfection hair removal sections, alcolhol burner is lighted, and mouse hair removal section is placed at the 2cm of flame envelope upper end after 10s and is removed, and is established Mouse deep second degree burn model, modeling pneumoretroperitoneum inject 0.9wt% sodium chloride injections 2mL with Hemorrhagic shock, by one of which 5 It is massaged after the mouse prepared burn-treating liquid of cotton swab, twice daily, is spaced 12h, successive administration 28d；
Step 4, observation and index：Area change, inflammation infection situation, incrustation and scab piece fall off at observation mouse scald Situation, the variation of color, area, hardness after cicatrization, the case where by 7d, 14d and 28d wounds, by 7d, 14d and 28d takes out part cicatricial tissue, and the healing situation of wound behind part is taken out in then observation, in observation mouse wound shape The consistency for ensureing mouse weather while condition, avoids data influence caused by outside environmental elements；
Step 5 compares：The picture situation of wound in two groups of mouse is compared, in same time, is smeared One group of mouse of burn-treating liquid, the good ratio of burned part is very fast, do not smear one group of mouse wound of burn-treating liquid it is possible that Edema or the situation of inflammation.
Embodiment 2
A kind of burn-treating liquid, includes the following steps：
Step 1, material selection：Choose Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, safflower 100g, Radix Notoginseng 100g, first pearl 50g, Moschus 15g, longan pericarp 100g, longan seed 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, giant knotweed 80g, Fructus Forsythiae 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g, Rhizoma Atractylodis Macrocephalae 100g, peppermint 100g and distilled water 1000g；
It is prepared by step 2：By Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, Safflower 100g, Radix Notoginseng 100g, first pearl 50g and Moschus 15g, which are put into after being mixed with water inside terrine, heats boiling, by longan pericarp 100g, longan seed 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, tiger Cane 80g, Fructus Forsythiae 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g and Rhizoma Atractylodis Macrocephalae 100g are ground into the size powder of 120 mesh, will grind Powder after mill is added to behind terrine inside after boiling, is then cooled the temperature to 30 DEG C, is filtered, removes slag while hot, then by peppermint Twirl is added after wearing into liquid inside filtered medicament, and envelope bottle is carried out after being cooled to room temperature and obtains the burn-treating liquid configured, Temperature is promoted to 100 DEG C with big fire when digestion time is 3h, wherein boiling；
Step 3, mouse experiment：Mouse 10 is selected, 6 week old, male female fifty-fifty, weight 22g, mouse is in constant room temperature Adaptable fed one week under the conditions of 24 DEG C and humidity 60wt% is divided into each 5 of two groups of mouse, half male and half female, intraperitoneal injection 10wt% chloral hydrate anesthesias, 8wt% sodium sulfide solutions carry out the depilation 2cm*4cm at back, for 24 hours after, mouse local topical 70wt% ethanol disinfection hair removal sections, alcolhol burner is lighted, and mouse hair removal section is placed at the 2cm of flame envelope upper end after 10s and is removed, and is established Mouse deep second degree burn model, modeling pneumoretroperitoneum inject 0.9wt% sodium chloride injections 2mL with Hemorrhagic shock, by one of which 5 It is massaged after the mouse prepared burn-treating liquid of cotton swab, twice daily, is spaced 12h, successive administration 28d；
Step 4, observation and index：Area change, inflammation infection situation, incrustation and scab piece fall off at observation mouse scald Situation, the variation of color, area, hardness after cicatrization, the case where by 7d, 14d and 28d wounds, by 7d, 14d and 28d takes out part cicatricial tissue, and the healing situation of wound behind part is taken out in then observation, in observation mouse wound shape The consistency for ensureing mouse weather while condition, avoids data influence caused by outside environmental elements；
Step 5 compares：The picture situation of wound in two groups of mouse is compared, in same time, is smeared One group of mouse of burn-treating liquid, the good ratio of burned part is very fast, do not smear one group of mouse wound of burn-treating liquid it is possible that Edema or the situation of inflammation.
Table is obtained according to embodiment 1-2 data：
According to table：Using burn-treating liquid to being smeared at mouse scald after, inflammatory reaction is slight, with slight water It is swollen, 7d, surface of a wound cleaning at skin lesion, it is seen that moderate granulation tissue, no exudation, 28d, totally without crust at skin lesion, entirely Portion heals, and has hair growth, does not smear one group of mouse of burn-treating liquid, and 7d will produce blister, and sense of touch is sensitive, compressing by Injury bleaches, 14d, and with swelling, the situation suppurated, skin healing is slow, 28d, and in burn site, there are sizable scars Trace, there is no hair growth, this is that dead mouse comparison be not in the presence of, not may require that and is generated when burn is excessively serious The overweight situation comparison of inflammation.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used With technical scheme described in the above embodiments is modified or equivalent replacement of some of the technical features, All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's Within protection domain.

Claims (4)

1. a kind of burn-treating liquid, which is characterized in that include the following steps：
Step 1, material selection：Choose Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, safflower 100g, Radix Notoginseng 100g, first pearl 50g, Moschus 15g, longan pericarp 100g, longan seed 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, giant knotweed 80g, Fructus Forsythiae 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g, Rhizoma Atractylodis Macrocephalae 100g, peppermint 100g and distilled water 1000g；
It is prepared by step 2：By Radix Astragali 100g, root of Dahurain angelica 100g, bletilla striata 100g, coptis 100g, rheum officinale 100g, honeysuckle 100g, safflower 100g, Radix Notoginseng 100g, first pearl 50g and Moschus 15g, which are put into after being mixed with water inside terrine, heats boiling, by longan pericarp 100g, dragon Eye core 100g, Radix Glycyrrhizae 50g, borneol 100g, charred RADIX SANGUISORBAE 100g, charred CACUMEN PLATYCLADI 100g, Asian puccoon 100g, streptomysin 60g, giant knotweed 80g, connect The size powder that 100g, Radix Codonopsis 80g, Radix Angelicae Sinensis 100g, radix rehmanniae preparata 100g and Rhizoma Atractylodis Macrocephalae 100g are ground into 100-120 mesh is stuck up, after grinding Powder be added to behind terrine inside after boiling, then cool the temperature to 30 DEG C, filter, remove slag while hot, then peppermint is twisted and is ground At being added after liquid inside filtered medicament, envelope bottle is carried out after being cooled to room temperature and obtains the burn-treating liquid configured；
Step 3, mouse experiment：Mouse 10 is selected, 6 week old, female fifty-fifty, the weight 22g of hero, mouse is in 24 DEG C constant of room temperature With adaptable fed one week under the conditions of humidity 60wt%, it is divided into each 5 of two groups of mouse, 10wt% water is injected intraperitoneally in half male and half female Close chloralization, 8wt% sodium sulfide solutions carry out the depilation 2cm*4cm at back, for 24 hours after, mouse local topical 70wt% second Alcohol sterilizes hair removal section, and alcolhol burner is lighted, mouse hair removal section is placed at the 2cm of flame envelope upper end after 10s and is removed, and establishes mouse deep two Bum model is spent, modeling pneumoretroperitoneum injects 0.9wt% sodium chloride injections 2mL with Hemorrhagic shock；
Step 4, observation and index：Area change, inflammation infection situation, incrustation and scab piece dropping situations at mouse scald are observed, The variation of color, area, hardness after cicatrization, the case where by 7d, 14d and 28d wounds, by 7d, 14d and 28d takes out part cicatricial tissue, and the healing situation of wound behind part is taken out in then observation；
Step 5 compares：The picture situation of wound in two groups of mouse is compared, in same time, smears burn One group of mouse of liquid, the good ratio of burned part is very fast, does not smear one group of mouse wound of burn-treating liquid it is possible that edema Or the situation of inflammation.
2. a kind of burn-treating liquid according to claim 1, it is characterised in that：In the step 2, digestion time 1h-3h, Wherein boiling when with big fire by temperature promoted to 100 DEG C.
3. a kind of burn-treating liquid according to claim 1, it is characterised in that：In the step 3, by 5 mouse of one of which With being massaged after the prepared burn-treating liquid of cotton swab, twice daily, it is spaced 12h, successive administration 28d.
4. a kind of burn-treating liquid according to claim 1, it is characterised in that：In the step 4, in observation mouse wound shape The consistency for ensureing mouse weather while condition, avoids data influence caused by outside environmental elements.
CN201810704045.5A 2018-06-29 2018-06-29 A kind of burn-treating liquid Pending CN108524773A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114306512A (en) * 2022-01-12 2022-04-12 黄绍良 Ointment for promoting wound healing and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114306512A (en) * 2022-01-12 2022-04-12 黄绍良 Ointment for promoting wound healing and preparation method thereof

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