CN113248624B - Syntac多肽及其用途 - Google Patents
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
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- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201462013715P | 2014-06-18 | 2014-06-18 | |
| US62/013,715 | 2014-06-18 | ||
| PCT/US2015/035777 WO2015195531A2 (en) | 2014-06-18 | 2015-06-15 | Syntac polypeptides and uses thereof |
| CN201580027510.0A CN106456733B (zh) | 2014-06-18 | 2015-06-15 | Syntac多肽及其用途 |
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| CN201580027510.0A Division CN106456733B (zh) | 2014-06-18 | 2015-06-15 | Syntac多肽及其用途 |
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| JP2019516665A (ja) * | 2016-03-02 | 2019-06-20 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| US20190046648A1 (en) * | 2016-03-03 | 2019-02-14 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US11505591B2 (en) | 2016-05-18 | 2022-11-22 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR20190044029A (ko) * | 2016-05-18 | 2019-04-29 | 알버트 아인슈타인 컬리지 오브 메디슨, 인크. | 변이체 pd-l1 폴리펩타이드, t-세포 조절 다량체 폴리펩타이드 및 이들의 사용 방법 |
| WO2018027252A1 (en) * | 2016-08-11 | 2018-02-15 | The Council Of The Queensland Institute Of Medical Research | Immune-modulating compounds |
| DK3558339T5 (da) | 2016-12-22 | 2024-09-02 | Cue Biopharma Inc | T-celle-modulerende multimere polypeptider og fremgangsmåder til anvendelse deraf |
| EP3565829A4 (en) * | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | T-CELL-MODULATING MULTIMERIC POLYPEPTIDES AND METHOD OF USING THEREOF |
| US20200010528A1 (en) * | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| US11407806B2 (en) * | 2017-04-06 | 2022-08-09 | Albert Einstein College Of Medicine | Precision activation of HIV-specific CTLS to eliminate reactivated latent T cells |
| EP3638258A4 (en) * | 2017-06-12 | 2021-09-08 | Sinai Health System | ALLOGRAFT TOLERANCE WITHOUT REQUIRING SYSTEMIC IMMUNE SUPPRESSION |
| CN107266581B (zh) * | 2017-06-13 | 2021-07-09 | 四川大学 | 藏猪il-12重组质粒增强pcv2疫苗免疫佐剂的制备方法及应用 |
| WO2019030581A1 (en) * | 2017-08-10 | 2019-02-14 | Grifols Diagnostic Solutions Inc. | COMPOSITIONS, METHODS AND / OR KITS COMPRISING AN EXTRACELLULAR DOMAIN OF RECOMBINANT HUMAN CD38 |
| KR20200064083A (ko) * | 2017-09-07 | 2020-06-05 | 큐 바이오파마, 인크. | 항원-제시 폴리펩티드 및 이의 사용 방법 |
| IL272085B2 (en) * | 2017-09-07 | 2023-03-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| CN111315768A (zh) * | 2017-09-07 | 2020-06-19 | 库尔生物制药有限公司 | 具有缀合位点的t细胞调节性多聚体多肽及其使用方法 |
| TW201925235A (zh) * | 2017-09-07 | 2019-07-01 | 美商信號生物製藥公司 | 具有化學結合位點之抗原呈現多肽及其使用方法 |
| CN110167959A (zh) * | 2017-11-30 | 2019-08-23 | 盖立复诊断解决方案公司 | 用于监测对免疫检查点抑制剂pd1和pd-l1的抗体治疗的免疫测定和工程化蛋白 |
| CN111886241A (zh) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| HUE070158T2 (hu) | 2018-03-24 | 2025-05-28 | Regeneron Pharma | Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk |
| US20220047710A1 (en) * | 2018-09-12 | 2022-02-17 | Washington University | Single chain constructs |
| US20220016181A1 (en) * | 2018-12-13 | 2022-01-20 | Sinai Health System | Immunomodulatory cells and uses thereof |
| TWI856047B (zh) * | 2018-12-19 | 2024-09-21 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| AU2019401183A1 (en) * | 2018-12-19 | 2021-08-12 | Cue Biopharma, Inc. | Multimeric T-cell modulatory polypeptides and methods of use thereof |
| EP3897690A4 (en) * | 2018-12-19 | 2022-09-28 | Cue Biopharma, Inc. | T LYMPHOCYTE MODULATOR MULTIMERIC POLYPEPTIDES HAVING CONJUGATION SITES AND METHODS OF USE THEREOF |
| EP3935080A4 (en) * | 2019-03-06 | 2023-04-05 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2020180501A1 (en) * | 2019-03-06 | 2020-09-10 | Cue Biopharma, Inc. | T-cell modulatory antigen-presenting polypeptides and methods of use thereof |
| EP3976084A4 (en) * | 2019-05-29 | 2023-06-21 | Cue Biopharma, Inc. | MULTIMERIC T LYMPHOCYTE MODULATING POLYPEPTIDES AND METHODS OF USE THEREOF |
| EP3986448A4 (en) * | 2019-06-19 | 2023-07-12 | Cue Biopharma, Inc. | MULTIMERIC T-CELL-MODULATING POLYPEPTIDES AND METHODS OF USE THEREOF |
| CA3146591A1 (en) * | 2019-09-20 | 2021-03-25 | Ronald D. Seidel Iii | T-cell modulatory polypeptides and methods of use thereof |
| JP2023500574A (ja) * | 2019-10-23 | 2023-01-10 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節性キメラ分子及びその使用方法 |
| WO2021127495A1 (en) | 2019-12-20 | 2021-06-24 | Regeneron Pharmaceuticals, Inc. | Novel il2 agonists and methods of use thereof |
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