CN113214422B - 细胞内递送媒介物 - Google Patents

细胞内递送媒介物 Download PDF

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Publication number
CN113214422B
CN113214422B CN202110469355.5A CN202110469355A CN113214422B CN 113214422 B CN113214422 B CN 113214422B CN 202110469355 A CN202110469355 A CN 202110469355A CN 113214422 B CN113214422 B CN 113214422B
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group
formula
alkyl
alkoxy
temperature
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Chinese (zh)
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CN113214422A (zh
Inventor
辻俊一
井门久美子
山田小百合
内山圣一
河本恭子
德山英利
冈野健太郎
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Tohoku University NUC
Kirin Holdings Co Ltd
University of Tokyo NUC
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Tohoku University NUC
Kirin Holdings Co Ltd
University of Tokyo NUC
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
    • C08F212/02—Monomers containing only one unsaturated aliphatic radical
    • C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
    • C08F212/06—Hydrocarbons
    • C08F212/08—Styrene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F122/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F122/36—Amides or imides
    • C08F122/38—Amides
    • C08F122/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
    • C08F212/02—Monomers containing only one unsaturated aliphatic radical
    • C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
    • C08F212/06—Hydrocarbons
    • C08F212/12—Monomers containing a branched unsaturated aliphatic radical or a ring substituted by an alkyl radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C—CHEMISTRY; METALLURGY
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    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/106—Esters of polycondensation macromers
    • C08F222/1063—Esters of polycondensation macromers of alcohol terminated polyethers
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    • C08F297/00—Macromolecular compounds obtained by successively polymerising different monomer systems using a catalyst of the ionic or coordination type without deactivating the intermediate polymer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
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    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
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    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/104—Esters of polyhydric alcohols or polyhydric phenols of tetraalcohols, e.g. pentaerythritol tetra(meth)acrylate
    • C08F222/1045—Esters of polyhydric alcohols or polyhydric phenols of tetraalcohols, e.g. pentaerythritol tetra(meth)acrylate of aromatic tetraalcohols
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    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
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    • C08F2438/00—Living radical polymerisation
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • General Physics & Mathematics (AREA)
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  • Inorganic Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202110469355.5A 2015-09-07 2016-09-06 细胞内递送媒介物 Active CN113214422B (zh)

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JP2015-176106 2015-09-07
JP2015176106A JP6666673B2 (ja) 2015-09-07 2015-09-07 細胞内送達ベヒクル
PCT/JP2016/076175 WO2017043484A1 (ja) 2015-09-07 2016-09-06 細胞内送達ベヒクル
CN202110469355.5A CN113214422B (zh) 2015-09-07 2016-09-06 细胞内递送媒介物
CN201680051805.6A CN108350479B (zh) 2015-09-07 2016-09-06 细胞内递送媒介物

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EP (2) EP3760193B9 (enExample)
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KR (2) KR102205918B1 (enExample)
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JP7154088B2 (ja) * 2017-09-29 2022-10-17 キリンホールディングス株式会社 毛髪用化粧料組成物
JP7341126B2 (ja) * 2018-04-26 2023-09-08 キリンホールディングス株式会社 抗微生物性樹脂および塗材
JP7154089B2 (ja) * 2018-09-27 2022-10-17 キリンホールディングス株式会社 皮膚用化粧料組成物
CN110455430B (zh) * 2019-08-16 2021-04-02 中国科学院理化技术研究所 一种靶向线粒体的荧光寿命温度传感器及其制备方法及应用
JP7356875B2 (ja) 2019-11-20 2023-10-05 キリンホールディングス株式会社 カチオン性重合開始剤
JP2021088554A (ja) * 2019-11-27 2021-06-10 キリンホールディングス株式会社 紫外線吸収性の皮膚用／毛髪用化粧料組成物
JP2021088555A (ja) * 2019-11-27 2021-06-10 キリンホールディングス株式会社 紫外線吸収性のカチオン性ポリマー粒子
JP7540890B2 (ja) * 2020-01-10 2024-08-27 キリンホールディングス株式会社 低毒性のポリマー粒子の製法
CN117836354A (zh) 2021-08-26 2024-04-05 麒麟控股株式会社 含有阳离子性聚合物的抗菌粒子
EP4442717A4 (en) 2021-12-03 2025-12-24 Kirin Holdings Kk HIGH VISCOSITY AND HIGH RESISTANCE POLYMER GEL
EP4538328A1 (en) 2022-06-13 2025-04-16 Kirin Holdings Kabushiki Kaisha Particles used for formation of pickering emulsion or like
CN116462796B (zh) * 2023-04-21 2025-04-29 广东广纳安疗科技有限公司 温敏凝胶聚合物及其制备方法、示踪剂和栓塞剂

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WO2008029770A1 (en) * 2006-09-05 2008-03-13 The University Of Tokyo Fluorescent molecular thermometer

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CN108350479A (zh) 2018-07-31
KR20210008174A (ko) 2021-01-20
EP3760193A1 (en) 2021-01-06
SG10202108915VA (en) 2021-09-29
EP3760193B9 (en) 2023-11-01
WO2017043484A1 (ja) 2017-03-16
JP6666673B2 (ja) 2020-03-18
KR102205918B1 (ko) 2021-01-20
EP3760193B1 (en) 2023-07-05
US10712346B2 (en) 2020-07-14
US11452697B2 (en) 2022-09-27
EP3348648A1 (en) 2018-07-18
CN113214422A (zh) 2021-08-06
US20190137503A1 (en) 2019-05-09
KR102403515B1 (ko) 2022-05-31
EP3348648B1 (en) 2020-08-19
JP2017051113A (ja) 2017-03-16
KR20180040714A (ko) 2018-04-20
SG11201801783VA (en) 2018-04-27
CN108350479B (zh) 2021-05-14
EP3348648A4 (en) 2019-03-20
US20200309782A1 (en) 2020-10-01

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