CN113191463A

CN113191463A - Experiment-based intelligent management method for non-immobilized biological reagent

Info

Publication number: CN113191463A
Application number: CN202011623655.6A
Authority: CN
Inventors: 黄景锟; 张鹏; 何杨星; 况凤超; 仓超; 李斌
Original assignee: Hangzhou Shared Experimental Technology Development Co ltd
Current assignee: Hangzhou Shared Experimental Technology Development Co ltd
Priority date: 2020-01-10
Filing date: 2020-12-31
Publication date: 2021-07-30

Abstract

The invention provides an experiment-based non-fixed biological reagent intelligent management system, which is characterized in that biological reagents needing to be stored in a frozen mode are managed based on different types of experiments, and the system comprises: storing reagent related information; storing the experiment type information; the method comprises the steps that an experimenter terminal is adopted to enable an experimenter to input a name to be tested and send the name to be tested and position information of the experimenter to a management server; searching the experiment type information and the reagent related information by using a management server according to the sent name to be tested and acquiring corresponding reagent position information; the management server sorts each obtained reagent position information according to the position information of the experimenter to form an extraction position sequence, further generates an extraction list and sends the extraction list to the experimenter terminal; and the laboratory technician terminal displays the received extraction list, so that the laboratory technician goes to the corresponding low-temperature reagent cabinet according to the extraction list, searches for and takes out the required biological reagent at the rough position in the corresponding placing layer.

Description

Experiment-based intelligent management method for non-immobilized biological reagent

Technical Field

The invention relates to an experiment-based intelligent management method for non-immobilized biological reagents.

Background

The biological reagents are common biological samples or organic compounds in laboratories, the properties of different biological reagents are different, some organisms need to be stored at normal temperature, and some biological reagents need to be frozen and even stored in an environment of-30 ℃ to-100 ℃.

In order to keep biological reagents in a laboratory reasonably refrigerated, the laboratory is usually provided with a plurality of refrigerated cabinets for storing the biological reagents. The laboratory staff can look for required reagent in each freezer when needing the experiment, and this kind of mode makes the laboratory staff to spend more time and energy on looking for biological reagent undoubtedly, reduces efficiency, also can lead to the cabinet door to be opened for a long time or many times because looking for many times simultaneously to make the freezer because too much open leads to the air conditioning to lose, biological reagent in the freezer is very likely can consequently receive the influence even inefficacy.

Even if the laboratory ensures that the storage location of the biological reagent is clear by setting strict reagent management or reagent classification, there is still a possibility that many searches are generated due to the wrong memory of the laboratory operator for the biological reagent required for the experiment. In addition, in this way, when returning the used biological reagent, the laboratory technician needs to spend much time and effort on returning the biological reagent due to strict management, and the cold air loss of the refrigerator due to too much opening of the refrigerator is caused no matter whether searching for a storage location or arranging the refrigerator.

Disclosure of Invention

The present invention has been made to solve the above problems, and an object of the present invention is to provide an intelligent management method for a non-immobilized bio-reagent, which provides a laboratory technician with position information of a desired bio-reagent according to an experiment, so that the laboratory technician can quickly find the desired bio-reagent, and the laboratory technician can conveniently return the bio-reagent.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides an experiment-based non-fixed biological reagent intelligent management system, which is characterized in that a system comprising a low-temperature reagent cabinet, a laboratory terminal and a management server for storing biological reagents needing low-temperature environment freezing storage is adopted to manage the biological reagents with reagent labels in a laboratory based on different types of experiments, and comprises: correspondingly storing the reagent name of each biological reagent, corresponding reagent identification information and corresponding reagent position information comprising the cabinet number of the low-temperature reagent cabinet where the reagent bottle is located, the layer number of the placed layer and the rough position information of the rough position as reagent related information in a management server; correspondingly storing the experiment name of each experiment and the reagent name of the reagent required by the corresponding experiment as experiment type information; the method comprises the steps that an experimenter terminal is adopted to enable an experimenter to input the name of an experiment to be carried out as a name to be tested, and the name to be tested and experimenter position information representing the position of the experimenter are sent to a management server; searching the experiment type information by using a management server according to the sent name to be tested and acquiring all corresponding reagent names, searching the relevant information of the reagent according to the acquired reagent name and acquiring corresponding reagent position information; the management server sorts each obtained reagent position information according to the position information of the experimenter to form an extraction position sequence, further generates an extraction list according to the extraction position sequence and the corresponding reagent name and sends the extraction list to the experimenter terminal; and the laboratory technician terminal displays the received extraction list, so that the laboratory technician goes to the corresponding low-temperature reagent cabinet according to the extraction list, searches for and takes out the required biological reagent at the rough position in the corresponding placing layer.

Action and Effect of the invention

According to the experiment-based intelligent management method for the non-fixed biological reagents, reagent related information of all biological reagents in a laboratory is managed according to the types of experiments, so that when a laboratory technician needs to extract the biological reagents, the laboratory technician can directly input the name of the experiment and can use the management server to sort the required biological reagents according to the distance, the laboratory technician can conveniently go to the nearest and most convenient reagent cabinet to extract the biological reagents, meanwhile, when the biological reagents are extracted from the reagent cabinet, the laboratory technician can quickly find the required reagents at the corresponding rough positions of the corresponding placement layers according to the rough position information, time and energy spent by the laboratory technician in reagent extraction are further saved, and cold air in the low-temperature reagent cabinet is prevented from being dissipated due to reagent searching. In addition, the laboratory technician can conveniently return the biological reagent in the placing layer after selecting the reagent cabinet, thereby saving the time and the energy of the laboratory technician when returning the reagent.

Drawings

FIG. 1 is a system configuration diagram of a method for intelligent management of an unfixed biological reagent according to one embodiment of the present invention;

FIG. 2 is a schematic structural diagram of a reagent cabinet according to a first embodiment of the present invention;

FIG. 3 is a schematic view showing the placement of a reagent bottle according to a first embodiment of the present invention;

FIG. 4 is a functional block diagram of a medium and low temperature reagent cabinet according to an embodiment of the present invention;

FIG. 5 is a diagram illustrating the contents stored in the bin number layer number storage unit according to an embodiment of the present invention;

FIG. 6 is a flow chart of a method for intelligent management of non-immobilized biological agents in accordance with one embodiment of the present invention;

FIG. 7 shows the contents of reagent-related information in an embodiment of the present invention;

FIG. 8 is a diagram illustrating the contents of the experimental category information according to the first embodiment of the present invention;

FIG. 9 is a diagram illustrating the contents of an abstraction list according to an embodiment of the present invention;

FIG. 10 illustrates a request for recorded content according to an embodiment of the present invention;

FIG. 11 is a diagram illustrating the content of an extraction record according to an embodiment of the present invention;

FIG. 12 is a chart showing the contents of the reagent dosage record in accordance with one embodiment of the present invention;

FIG. 13 is a schematic structural diagram of a reagent cabinet according to a second embodiment of the present invention; and

FIG. 14 is a system configuration diagram of a method for intelligently managing an unfixed biological reagent in a third embodiment of the present invention.

Detailed Description

Hereinafter, the experimental-based intelligent management method for non-immobilized bioreagent according to the present invention will be described in detail with reference to the accompanying drawings.

In one aspect, the present invention provides an experiment-based intelligent management system for unfixed biological reagents, which is used for managing biological reagents having reagent labels in laboratories based on different types of experiments by using a system including a low-temperature reagent cabinet for storing biological reagents requiring low-temperature environmental freezing storage, a laboratory technician terminal, and a management server, the system including: correspondingly storing the reagent name of each biological reagent, corresponding reagent identification information and corresponding reagent position information comprising the cabinet number of the low-temperature reagent cabinet where the reagent bottle is located, the layer number of the placed layer and the rough position information of the rough position as reagent related information in a management server; correspondingly storing the experiment name of each experiment and the reagent name of the reagent required by the corresponding experiment as experiment type information; the method comprises the steps that an experimenter terminal is adopted to enable an experimenter to input the name of an experiment to be carried out as a name to be tested, and the name to be tested and experimenter position information representing the position of the experimenter are sent to a management server; searching the experiment type information by using a management server according to the sent name to be tested and acquiring all corresponding reagent names, searching the relevant information of the reagent according to the acquired reagent name and acquiring corresponding reagent position information; the management server sorts each obtained reagent position information according to the position information of the experimenter to form an extraction position sequence, further generates an extraction list according to the extraction position sequence and the corresponding reagent name and sends the extraction list to the experimenter terminal; and the laboratory technician terminal displays the received extraction list, so that the laboratory technician goes to the corresponding low-temperature reagent cabinet according to the extraction list, searches for and takes out the required biological reagent at the rough position in the corresponding placing layer.

In the above embodiment, there may be a technical feature that the process of taking out the biological reagent or returning the used biological reagent when the laboratory technician goes to the low temperature reagent cabinet is as follows: identifying the identification information of the experimenter by adopting an identification part of the low-temperature reagent cabinet, and sending the identification information to a management server for judgment; judging whether the laboratory worker has the authority of opening the cabinet door or not at least based on the identification information by adopting a management server, and sending a door opening permission signal to the low-temperature reagent cabinet once the laboratory worker is judged to have the door opening authority; the control module of the low-temperature reagent cabinet unlocks the cabinet door according to the door opening permission signal, so that a laboratory technician opens the cabinet door to perform extraction or storage operation; the method comprises the steps that a judging part is adopted to continuously judge reagent judging information contained in all reagent labels in a reagent cabinet, a sensing part is adopted to sense whether a cabinet door is closed or not, and once a laboratory technician is sensed to close the cabinet door, at least the read reagent judging information, the current cabinet number of the low-temperature reagent cabinet and the layer number of a corresponding placing layer are sent to a management server; the management server judges the access condition of the biological reagent and updates the reagent related information at least according to the transmitted reagent judgment information, the cabinet number and the layer number.

In the above embodiment, the technical feature may be that the determination unit continuously determines the reagent determination information included in all the reagent labels in the reagent cabinet based on at least two determination units having different part numbers provided for each of the placement layers, and the specific process is as follows: sending the read reagent discrimination information, the current cabinet number of the low-temperature reagent cabinet, the layer number of the corresponding placement layer and the part number corresponding to the discrimination part to a management server; the management server also judges the rough position information corresponding to the reagent discrimination information according to the received reagent discrimination information and the layer number; the management server updates the reagent-related information based on the rough location information when updating the reagent location information in the reagent-related information.

In the above embodiment, the method may further include the step of, when the management server determines that the biological reagent is being accessed, specifically: comparing the received reagent discrimination information with the reagent discrimination information in the reagent-related information to discriminate a missing reagent discrimination information corresponding to the taken-out biological reagent or an added reagent discrimination information corresponding to the returned biological reagent; and updating the reagent related information according to the missing reagent discrimination information or the added reagent discrimination information.

In the above-described embodiment, the management server may further determine whether or not the corresponding biological reagent is placed in the wrong reagent tank based on the additional reagent discrimination information and the corresponding tank number when the additional reagent discrimination information is determined.

In the above embodiment, there may be a technical feature that each low-temperature reagent cabinet is provided with a different low-temperature environment ranging from-10 ℃ to-100 ℃, the reagent related information further stores a storage temperature range corresponding to a required storage temperature of the biological reagent, and the management server determines whether the biological reagent is placed in the wrong reagent cabinet based on the storage temperature range and current temperature information corresponding to the low-temperature environment of the reagent cabinet, and specifically includes: judging whether the current temperature information corresponding to the cabinet number is in the storage temperature range corresponding to the added reagent judgment information; if the current temperature information is judged to be in the storage temperature range, judging that the biological reagent is not placed in the wrong reagent cabinet; and if the current temperature information is judged not to be in the storage temperature range, the biological reagent is judged to be placed in the wrong reagent cabinet, and the management server sends a warning signal to the corresponding low-temperature reagent cabinet.

In the above-described embodiment, the technical feature may be that the management server updates the reagent-related information and stores reagent discrimination information corresponding to the biological reagent determined to be extracted and the identification information received from the low-temperature reagent cabinet as one extraction record, and the management server determines whether or not the biological reagent is contained in the wrong reagent cabinet based on the extraction record, and specifically includes: judging whether the biological reagent is put into a wrong reagent cabinet or not according to the fact that whether the received cabinet number is consistent with the reagent position information of the corresponding reagent judgment information in the extraction record or not, and judging that the biological reagent is not put into the wrong reagent cabinet if the cabinet number is consistent with the reagent position information; and if the cabinet number is not consistent with the reagent position information, the biological reagent is judged to be put into the wrong reagent cabinet, and the management server sends a warning signal to the corresponding low-temperature reagent cabinet.

< example one >

FIG. 1 is a system configuration diagram of an intelligent management method for an unfixed biological reagent in the embodiment of the present invention.

As shown in fig. 1, the intelligent management method of the non-immobilized biological reagent is implemented based on a system 100, and the system 100 includes j reagent cabinets 1, a management server 2, a plurality of laboratory staff terminals 3, a manager terminal 4, and communication networks 5a, 5b, and 5 c. The system 100 is provided in a laboratory facility having a plurality of buildings, with laboratories and reagent storage chambers disposed on different floors of each building.

The management server 2 is connected to each reagent cabinet 1 through a communication network 5a, to each laboratory technician terminal 3 through a communication network 5b, and to the administrator terminal 4 through a communication network 5 c. In this embodiment, the communication networks 5a, 5b, and 5c are all local area networks in a laboratory.

The reagent cabinet 1 is used for storing biological reagents which need to be stored in a low-temperature environment in a laboratory, wherein the biological reagents are various biological materials and organic compounds or reagents for clinical and medical research. The reagent cabinet 1 is provided in each of the reagent storage chambers.

In this embodiment, different reagent cabinets 1 are configured with different low temperature environments for storing biological reagents that require different temperatures for storage.

FIG. 2 is a schematic structural diagram of a reagent cabinet according to an embodiment of the present invention.

As shown in fig. 2, the reagent kit 1 includes a kit body 101, a temperature adjustment unit 102, five placement levels 103 located in the kit body, ten determination units 104 provided corresponding to the placement levels 103, a kit door 105 provided on the kit body 101, a locking unit 106, a sensing unit 107, an identification unit 108, a warning unit 109, and a main control chip 110.

The temperature adjustment unit 102 adjusts the temperature inside the reagent tank 1 to form a low-temperature environment suitable for storing biological reagents. In this embodiment, the low temperature environment manufactured by the temperature adjusting portion 102 is between-10 ℃ and-30 ℃, the temperature adjusting portion 102 includes a cooling mechanism such as a compressor, a temperature setting mechanism for setting a temperature, a temperature detecting mechanism for detecting a temperature in the placing layer 103, and a control mechanism for controlling the operation of the cooling mechanism according to a temperature detection result and the set temperature so as to realize temperature control, and specific configurations and operating principles of these mechanisms are the same as those in the ultra-low temperature refrigerator in the prior art, and are not described herein again.

The placing layer 103 is provided with five layers for placing various reagent bottles. In the low-temperature reagent tank 1, a first layer accommodating layer 103a, a second layer accommodating layer 103b, a third layer accommodating layer 103c, a fourth layer accommodating layer 103d, and a fifth layer accommodating layer 103e are arranged in this order from top to bottom. Wherein, each layer of the placing layer 103 has a placing plate on which the reagent bottles are placed (the placing plate of the fifth layer of the placing layer 103e is the bottom plate of the reagent cabinet 1).

FIG. 3 is a schematic view of a reagent bottle according to a first embodiment of the present invention.

Taking the first-layer placing layer 103a as an example, as shown in fig. 3, the reagent bottles 150 can be freely placed on the placing plate 151. A reagent label 151 is attached to the cap and body of the reagent bottle 150.

In this embodiment, the reagent label 151 is a low temperature resistant RFID label that contains reagent identification information corresponding to the reagent bottle 150, and can be installed at any position of the reagent bottle 150, such as a bottle cap, a bottle body, or a bottle bottom, and can normally operate at least in a low temperature environment of-30 ℃.

The determination unit 104 is an RFID reader operable at least in a low temperature environment of-30 ℃ and is configured to determine the reagent labels 151 of all the reagent bottles 150 on the respective placement layers 103 in the reagent tank 1

In this embodiment, two determination portions 104 are provided for each placement layer 103, and as in the first placement layer 103a, the determination portions 104a-1 and 104a-2 are provided symmetrically on the left and right sides of the placement layer 103 a.

The cabinet door 105 corresponds to the reagent cabinet 1, and the laboratory technician needs to open the cabinet door 105 first to extract or return the biological reagents on each placing layer 103 of the reagent cabinet 1.

The locking portion 106 includes an electronic lock 161 provided at an edge of the cabinet door and a locker 162 provided at the door frame. The electronic lock 131 can lock and unlock the cabinet door 12 according to the control signal of the main control chip 19 under the cooperation of the lock catch 162.

The sensing part 107 is a sensor provided on the cabinet door, and can sense whether the cabinet door 105 is in a closed state.

The identification unit 108 is a door card reader for identifying a door opening card held by an experimenter.

In this embodiment, the door opening card includes identification information of an experimenter, and the identity recognition portion 108 enables the experimenter to recognize the identification information corresponding to the experimenter in the door opening card in a card swiping manner. Each experimenter has respective identification information, and the identity recognition part 108 can correspondingly judge the identity of the experimenter through the identification information.

In this embodiment, the identification information corresponds to the identity of each experimenter, that is, each experimenter has its own unique identification information, and the identity of the experimenter can be directly determined correspondingly through the identification information.

The warning part 109 is a warning lamp arranged on the front surface of the cabinet door 105, and is used for generating light flicker when receiving warning information so as to prompt staff to take or return wrong biological reagents.

Fig. 4 is a functional block diagram of a medium and low temperature reagent cabinet according to an embodiment of the present invention.

As shown in fig. 4, the main control chip 110 is electrically connected to the temperature adjustment unit 103, the determination unit 104, the locking unit 106, the sensing unit 107, the identification unit 108, and the warning unit 109, respectively, and controls operations of these components. The main control chip 110 includes a reagent tank communication unit 1101 and the main control chip 110.

The reagent tank communication unit 1101 is a communication module of the main control chip 110, and is used for performing data communication between the main control chip 110 and the management server 2.

When the identification information of the laboratory technician is identified by the identification identifying unit 108, the reagent cabinet communication unit 1101 transmits the identification information and information such as the current cabinet number of the reagent cabinet 1 to the management server 2 for processing, and when the reagent cabinet communication unit 1101 receives the door opening permission signal fed back from the management server 2, the main control chip 110 controls the locking unit 106 to unlock, so that the laboratory technician opens the cabinet door 105 to extract or return the biological reagent. In addition, when the sensing part 107 senses that the cabinet door 105 is changed from the open state to the closed state, the main control chip 110 controls the locking part 106 to lock the cabinet door.

Fig. 5 shows the contents stored in the cabinet number layer number storage unit according to the first embodiment of the present invention.

In this embodiment, in order to distinguish the reagent cabinets 1, each reagent cabinet 1 in the laboratory is provided with a cabinet number for identification. Meanwhile, in each reagent cabinet 1, the respective placing layers 103 are also provided with corresponding layer numbers in sequence, for example, the layer number of the first placing layer 103a is 1. As shown in fig. 5, the cabinet number/layer number storage unit 1102 stores the cabinet number 1103 of the current reagent kit 1, the layer number 1104 of each of the set layers 103, and the determination unit number 1105 of the determination unit 104 (i.e., the part number of the determination unit 104) corresponding to each of the layer numbers 1104, and two determination unit numbers 1105 are associated with each of the layer numbers 1104 because two determination units 104 are provided for each of the set layers 103. In practical applications, the cabinet number is the chip identification code of the main control chip 110, and the identification part number is the machine code of each identification part 104.

When the laboratory technician opens or closes the cabinet door 105 when taking out or returning the reagent, the sensing unit 107 senses the open or closed state of the cabinet door, and at this time, the main control chip 110 controls the discriminating unit 104 to discriminate the reagent discriminating information corresponding to all the reagent bottles 150 on each of the placing layers 103, and further controls the management-side communication unit 191 to transmit the discriminated reagent discriminating information, the corresponding layer number, the cabinet number, and the part number of each discriminating unit to the management server 2 after the cabinet door is locked by the control locking unit 106.

In this embodiment, since the determination unit 104 is disposed in the placement layer 103, the main control chip 110 controls the determination unit 104 to perform the determination when the sensing unit 107 senses that the cabinet door is opened and then closed again.

The management server 2 is used for storing and managing biological reagents, i.e., information related thereto.

The experimenter terminal 3, the administrator terminal 4 and the management server 2 are in communication connection through a communication network 4, and are used for enabling an experimenter and an administrator to perform corresponding human-computer interaction including information input, information viewing and the like.

FIG. 6 is a flow chart of a method for intelligent management of non-immobilized bioreagent in an embodiment of the present invention.

As shown in fig. 6, the intelligent unfixed biological reagent management method of the present embodiment is implemented based on the system 100 of the reagent cabinet 1, the management server 2, the laboratory technician terminal 3 and the communication network 4, and is used for managing information of the reagent bottle 150 storing a biological reagent based on the reagent tag 151 formed by an RFID tag, and specifically includes the following steps:

in step S1, the stored reagent discrimination information, the corresponding reagent name, the reagent specification, the reagent capacity, and the reagent position information are stored as the reagent-related information, and the process proceeds to step S2.

FIG. 7 shows the information related to the reagent in accordance with one embodiment of the present invention.

As shown in fig. 7, the reagent-related information 201 is stored in the management server 2 and includes reagent discrimination information 301, a corresponding reagent name 302, a reagent specification 302, a reagent capacity 303, and reagent position information 303.

The reagent discrimination information 301 is the number information of each reagent bottle 150, and the reagent label on each reagent bottle 150 contains the reagent discrimination information indicating the different number.

The reagent name 302 is a reagent name of the reagent contained in the reagent bottle 150.

The reagent specification 303 is specification information such as purity (amount of impurities) and use of the biological reagent.

The volume of reagent 304 is the volume of biological reagent in the reagent bottle 150

The reagent position information 305 includes the cabinet number of the reagent cabinet 1, the layer number of the placing layer 103, and rough position information of the reagent bottle 150 at the rough position of the placing layer 103.

In this embodiment, since the determination units 104 are symmetrically disposed on the left and right sides of each of the placement layers 103 to detect the left and right sides of the placement layer 103, respectively, and the reagent bottles 150 located in the middle of the placement layers 103 can be determined by the two determination units 104 at the same time, the rough position information corresponds to the left, middle, and right sides of the placement layers 103, and the laboratory technician can directly search for the desired biological reagents at the corresponding positions of the placement layers 103 according to the information.

As can be seen from fig. 7, the reagent position information corresponding to the reagent discrimination information P1 and P2 has the same cabinet number and layer number, and indicates that two reagent bottles 150 containing different reagents are stored in the same reagent storage layer 15 of the same reagent storage 1, but the two reagent bottles 150 are arranged one on the left side and the other on the right side of the reagent storage layer.

The reagent identification information P2, P3, and P4 correspond to the same reagent name, the same reagent specification, and the same reagent capacity, but correspond to different reagent position information, indicating that three reagent bottles containing the same reagent are placed at different positions (the reagent bottles corresponding to P2 and P3 are placed in different placement levels 15 of the same reagent cabinet 1, and the reagent bottles corresponding to P4 are placed in other reagent cabinets 1).

Although the reagent name and the reagent capacity corresponding to the reagent discrimination information P4 and P5 are the same as the reagent position information, the reagent specification differs, indicating that the reagents corresponding to these two records are the same name but have different specifications, for example, one has a purity of 99.8% and the other has a purity of 99.5%.

The reagent position information corresponding to the reagent discrimination information P7 is a null value, indicating that the reagent bottle corresponding to the reagent discrimination information is in a state of being extracted by the laboratory technician and is not in the reagent tank 1.

In this embodiment, the cabinet number of the reagent cabinet corresponds to a unique room number, floor number, and is used to indicate the location of the reagent cabinet.

In this embodiment, the information may be entered and stored by a manager who logs in the management server 2 while purchasing a new biological reagent using the management terminal, or the information may be stored by introducing existing information into the management server 2. In addition to the above-mentioned information association storage, other necessary related information such as the reagent specification and the use necessity of the biological reagent may be associated with the reagent discrimination information and stored.

In step S2, the experiment name and the reagent names of the respective reagents required for the corresponding experiment are stored as the experiment type information, and the process proceeds to step S3.

Fig. 8 shows the contents of the experimental category information in the first embodiment of the present invention.

As shown in fig. 8, the experiment type information 202 is stored in the management server 2, and the experiment type information 202 includes the following information for M experiments (M ═ 1,2, …, M) in the laboratory: the name 221 of each experiment and the reagent names 222 of the various biological reagents required for that experiment. The experiment name SY1 corresponds to reagent names SJ2 and SJ3, the experiment name SY2 corresponds to L-1 reagent names (L is 1,2, …, L), the experiment name SY2 corresponds to 3 reagent names SJ4, SJ7 and SJ13, and each experiment can correspond to different numbers of experiment reagents with different names according to actual conditions.

In this embodiment, the information may be entered and stored by the administrator logging in the management server 2 while the administrator uses the administrator terminal 4 to establish a new experiment (for example, when the administrator agrees to perform the experiment after applying for the new experiment and planning the biological reagents required for the experiment), or the existing information may be imported into the management server 2 to be stored.

In step S3, the laboratory technician inputs the name of the experiment to be performed as the name of the experiment to be performed through the laboratory technician terminal 3 and sends the name to the management server 2, and then the process proceeds to step S4.

In this embodiment, when the experimenter applies for the reagent, the experimenter terminal 3 needs to log in the management server 2 by using the identification information, and inputs the name to be tested through the man-machine interaction picture of the experimenter terminal 3, and at this time, the experimenter terminal 3 sends the name to be tested and the identification information of the experimenter to the management server 3. Meanwhile, in this embodiment, the experimenter terminal 3 further stores experimenter position information of an experimenter (for example, input by the experimenter in advance or acquired by a position acquisition system), and the experimenter terminal 3 sends the experimenter position information of the experimenter to the management server 2 when sending the name to be tested and the identification information.

In step S4, the management server 2 retrieves the information of the test type according to the sent name of the test to obtain the corresponding reagent name, further retrieves the corresponding reagent location information (i.e. all the reagent location information corresponding to all the reagent names obtained under the test type) and the reagent specification from the reagent-related information according to the obtained reagent name, and then proceeds to step S5.

In step S5, the management server 2 sorts the reagent position information acquired in step S4 based on the received position information of the laboratory technician to form an extraction position sequence, and further generates an extraction list based on the extraction position sequence, the reagent name and the reagent specification acquired in step S4, and transmits the extraction list to the laboratory technician terminal 3.

In this embodiment, the laboratory position information is the position of the laboratory where the laboratory is located, and includes the building number, the floor number, and the room number. When the management server 2 sorts the reagent position information, the proximity degree between the laboratory staff position information and the reagent position information is determined in order according to the floor number, and the room number, and the reagent position information is sorted according to the proximity degree. Specifically, the ranking process of the management server 2 includes the steps of:

and step S5-1, storing preset weight values respectively corresponding to the floor number, the floor number and the room number. The weight values are decreased gradually in sequence, and the weight value corresponding to the building number is the maximum value.

In this embodiment, the weight value corresponding to the floor number is 100, the weight value corresponding to the floor number is 10, and the weight value corresponding to the room number is 1.

And step S5-2, respectively calculating the similarity between the position information of the experimenter and the position information of each reagent according to the weight value.

In this embodiment, when calculating the similarity between the laboratory position information and the reagent position information, the matching floor number, or room number is denoted as 1, the non-matching floor number is denoted as 0, and the sum of the results multiplied by the weights corresponding to the floor numbers and the room number is the similarity between the floor numbers and the room numbers.

For example, when the laboratory position information S is floor 2, floor 1, floor 3, the reagent position information of reagent a is floor 2, floor 8, floor 2, floor 1, reagent B is floor 2, and the reagent position information of reagent C is floor 3, floor 8, SA is 110, SB is 11, and SC is 100.

And step S5-3, sequencing the reagent position information according to the similarity from big to small to form an extraction position sequence.

FIG. 9 is a diagram of the contents of an abstraction list in an embodiment of the present invention.

Taking the name SY1 to be tested, which is input by the laboratory technician with identification information SYY1, as an example, as shown in fig. 9, the extraction list 251 includes a reagent name 2511, a reagent specification 2512, and reagent position information 2513. The extracted list 251 with the list name QD1 contains the reagent names SJ2 and SJ3 required for the experiment SY1 and the corresponding reagent specification and reagent position information.

As can be seen from fig. 9, in one extraction list 251, a plurality of records may be associated with one reagent name 2511, which indicates that a plurality of reagents are required by the laboratory technician, and the laboratory technician may extract the required reagents in the vicinity according to the reagent position information in the extraction list 251. In fig. 7, the reagent name corresponding to the record whose reagent discrimination information is P7 is also SJ3, but since the reagent position information corresponding to this record is null, the extraction list generation unit 25 does not place this record in the extraction list 251.

Meanwhile, the reagent names (and the corresponding reagent specifications) in the extraction list 251 are sequentially ordered according to the extraction position sequence, so that when an experimenter extracts the required reagents according to the extraction list, the experimenter can determine the reagents required to be extracted according to the reagent names and the reagent specifications, and go to the corresponding reagent cabinet 1 according to the reagent position information and obtain reagent bottles in the corresponding placement layer 103.

Fig. 10 shows the content requested to be recorded in the first embodiment of the present invention.

The management server 2 also stores the name to be tested, the extraction list, and the identification information received from the experimenter terminal 3 as one request record while transmitting the extraction list. As shown in fig. 10, the management server 2 stores a plurality of request records 209, each of which includes a list 281 of extracts and identification information 282 of the experimenter who requested the list 281 of extracts. With each request record, the identity search determination unit 211 can determine whether or not the laboratory technician has the authority to open the reagent kit 1 based on the reagent position information in the extraction list requested by the laboratory technician.

In step S6, when the laboratory technician selects one reagent kit 1 and takes in and out the biological reagent, the identification information of the laboratory technician is identified by the identification unit 108, and the identification information is transmitted to the management server 2 via the reagent kit communication unit 1101 of the reagent kit 1, and the process proceeds to step S7.

In step S7, the management server 2 determines whether the laboratory technician has the authority to open the reagent kit 1 based on the received identification information and the kit number, and transmits a door opening permission signal to the corresponding reagent kit 1 if it is determined that the laboratory technician has the authority to open the reagent kit 1, and then the process proceeds to step S8.

Fig. 11 is the content of the extraction record in the embodiment of the present invention.

When the laboratory technician takes out a certain biological reagent from the reagent tank 1, the management server 2 stores the corresponding reagent discrimination information and the identification information received from the reagent tank 1 as one extraction record. As shown in fig. 11, the management server 2 stores therein a plurality of extraction records 210, each including a piece of missing reagent discrimination information 291 and corresponding identification information 292, the missing reagent discrimination information 291 being extracted by an experimenter having the identification information 292.

In this embodiment, the management server 2 performs the determination in step S3 on the basis of the request record and the extracted record, and specifically, when retrieving the request record, the management server 2 retrieves the request record according to the received identification information and the cabinet number, and determines whether there is matching identification information and cabinet number (i.e., the cabinet number included in the reagent position information in the extracted list); when retrieving the extracted record, the management server 2 retrieves the extracted record based on the received identification information and determines whether there is matching identification information.

Once any one of the two determinations is determined to exist, the management server 2 sends a door opening permission signal to the reagent cabinet 1, and the main control chip 110 of the reagent cabinet 1 controls the locking part 106 to unlock the cabinet door 105, so that an experimenter can open the cabinet door 105 and perform extraction operation. If neither of the above determinations is determined to be present, no response is made (alternatively, the service-side communication unit 210 may transmit an alert signal to the corresponding reagent kit 1, and the warning unit 109 may issue an alert to alert the laboratory technician).

In step S8, the main control chip 110 controls the locking part 106 to unlock the cabinet door 105, so that the laboratory technician opens the cabinet door 105 and performs the retrieving or returning operation, that is, the operation of searching for and taking out the reagent bottle 150 at the rough position of the placing layer 103 corresponding to the retrieval list, or the operation of storing the reagent bottle 150 at any position of any placing layer 103. Once the experimenter opens the cabinet door 105 so that the sensing part 107 senses that the cabinet door 105 is opened, the process proceeds to step S9; if the sensing part 107 does not sense that the cabinet door 105 is opened within a predetermined time, the main control chip 110 controls the locking part 106 to lock the cabinet door 105 again.

In step S9, the main control chip 110 can control the determination unit 104 to continuously perform the reading operation, and when the sensing unit 107 senses that the cabinet door 105 is closed, the main control chip sends the reagent determination information read by the determination unit 104, the part number of the determination unit 104, the layer number of the corresponding placement layer 103, and the cabinet number of the current reagent cabinet 1 to the management server 2, and then the process proceeds to step S10.

In this embodiment, the reagent discrimination information sent by the reagent cabinet 1 to the management server 2 is the reagent discrimination information of all the reagent bottles 150 in the reagent cabinet 1 immediately before the cabinet door 105 is closed, and at this time, the reagent bottles 150 in the reagent cabinet 1 have been extracted or returned by the experimenter.

In step S9 of this embodiment, when the sensing part 107 senses that the cabinet door 105 is closed, the main control chip 110 controls the locking part 106 to lock the cabinet door 105.

In step S10, the management server 2 compares the reagent discriminating information received in step S9 with the reagent discriminating information stored in the reagent related information based on the cabinet number and the layer number received in step S9 to determine missing or newly added reagent discriminating information, updates the reagent related information based on these information, and updates the extraction record and the request record, and then proceeds to step S11.

In this embodiment, since two discrimination units 104 are provided for each placement layer 103, when receiving the reagent discrimination information, the management server 2 combines the reagent discrimination information corresponding to the same placement layer 103 and compares the combined information with the reagent discrimination information in the reagent-related information to determine missing or added reagent discrimination information.

Further, when the management server 2 determines the added reagent discrimination information, the corresponding discrimination unit 104 is determined based on the part number corresponding to the added reagent discrimination information, and the rough position information is determined based on the position information of the discrimination unit 104.

In this embodiment, two determination sections 104 are provided for each of the placement levels 103, namely, a left determination section corresponding to the left side of the placement level and a right determination section corresponding to the right side of the placement level, and when the rough position information is set by the rough position determination section, the rough position information is set to the left side (right side) when the rough position information is set by the left determination section (or right determination section), and the rough position information is set to the middle when both determination sections 104 determine that the reagent bottles 150 are present.

After the comparison determination is completed, if the management server 2 compares the missing reagent discrimination information (that is, if the plurality of pieces of reagent discrimination information stored in the reagent-related information storage unit 201 include reagent discrimination information that is not included in the received reagent discrimination information and indicate that a reagent bottle is taken out from the rack), the management server 2 deletes the corresponding reagent position information in the reagent-related information based on the missing reagent discrimination information; if the management server 2 compares the added reagent discrimination information (that is, the received plurality of pieces of reagent discrimination information include reagent discrimination information that is not included in the reagent discrimination information in the reagent related information and indicate that a new reagent bottle is placed in the placement layer), the management server 2 adds the corresponding cabinet number, layer number, and rough position information as the corresponding reagent position information in the reagent related information according to the added reagent discrimination information.

Further, when the management server 2 determines the missing reagent discrimination information, it updates the extracted record based on the missing reagent discrimination information and the identification information transmitted from the reagent tank 1, and deletes the corresponding request record.

In step S11, the management server 2 checks the extraction record and the request record to determine whether the laboratory technician has extracted or returned the wrong biological reagent, and if the laboratory technician has extracted or returned the wrong biological reagent, the process proceeds to step S12, and if the laboratory technician has not extracted or returned the wrong biological reagent, the process proceeds to the end state.

In this embodiment, after the extraction record is updated in step S10, the management server 2 checks whether the reagent discrimination information in the extraction list matches the reagent name corresponding to the reagent discrimination information newly stored in the extraction record based on the identification information, thereby determining whether the laboratory technician has extracted the wrong biological reagent. If the result of the examination is inconsistent, the laboratory staff extracts wrong biological reagents.

Meanwhile, the management server 2 checks the returned biological reagent according to the newly added reagent discrimination information discriminated in step S10 and the cabinet number of the corresponding reagent cabinet 1, thereby determining whether the laboratory technician returned the wrong biological reagent.

In the present embodiment, the reagent-related information stored in the management server 2 further includes a storage temperature range corresponding to the reagent identification information, and the temperature adjustment unit 102 of each reagent kit 1 stores current temperature information corresponding to the current temperature to be adjusted. When the reagent tank communication unit 1101 transmits the reagent discrimination information discriminated by the discrimination unit 104 to the management server 6, the current temperature information is also transmitted to the management server 6 at the same time.

Further, when the management server 2 checks the returned biological reagent, it may determine whether the biological reagent is placed in the wrong reagent cabinet according to whether the received current temperature information is within the storage temperature range corresponding to the missing reagent determination information. If the current temperature information exceeds the storage temperature range, it indicates that the biological reagent is erroneously placed in the reagent storage 1 having an inappropriate storage temperature by the laboratory technician.

In step S12, the management server 3 sends a corresponding warning alert to the reagent kit 1 according to the determination result in step S11, so that the warning unit 109 activates a warning alert to remind the scientific research staff of taking out the wrong reagent, and then enters an end state.

In addition, after the laboratory technician returns the reagent, the laboratory technician terminal 3 can input the name of the returned biological reagent and the usage amount consumed in the experiment, and the laboratory technician terminal 3 sends the name of the reagent, the usage amount and the corresponding identification information to the management server 2 and stores the information as the reagent usage amount record by the management server 2.

FIG. 12 shows the contents of the reagent dosage record in the example of the present invention.

As shown in fig. 12, the reagent use amount record 213 includes reagent discrimination information 321, a reagent name 322, an experiment name 323, a use amount 324 generated after each use, and identification information 325 of an experimenter as a user.

< example two >

In the second embodiment, the same reference numerals are given to the components having the same configurations as those in the first embodiment, and the description thereof will be omitted.

The second embodiment provides a low-temperature reagent cabinet capable of storing biological reagents requiring a low-temperature environment of-30 ℃ to-100 ℃, in which conventional electronic devices cannot work normally, and an RFID card reader and other devices cannot be arranged in the reagent cabinet, so that the design of the reagent cabinet in the second embodiment is different from that of the reagent cabinet in the first embodiment, and the specific differences are as follows:

fig. 13 is a schematic structural diagram of a reagent cabinet according to a second embodiment of the present invention.

As shown in fig. 13, the reagent cabinet 6 is provided with a cabinet body 101, a temperature adjusting portion 102, a placing layer 113, an identification portion 108, a warning portion 109 and a main control chip 115, and is different from the first embodiment in that the reagent cabinet 5 is provided with a thermal insulation cabinet door 111 and a layer eaves 112 protruding outward to the outside of the reagent cabinet 1 on the top portion (i.e., a placing plate of a placing layer on each placing layer 113, and a first placing layer 113a is a top plate of the whole reagent cabinet 1) corresponding to each placing layer 113, each thermal insulation cabinet door 111 is provided with a locking portion 106 and a sensing portion 107 corresponding to each placing layer 113, and the placing layers 113 are only three layers.

In addition, two discrimination parts 114 corresponding to each layer of the placing layer 113 are arranged on the layer eaves 112 corresponding to the placing layer 113 and close to the outer side surface of the insulation cabinet door 111, and are used for discriminating reagent labels of all the reagent bottles 150 in the placing layer when an experimenter opens the insulation cabinet door 111 to take out or put in biological reagents, and the reagent labels used in the second embodiment are ultra-low temperature resistant RFID labels, and can normally operate in a low-temperature environment of-100 ℃.

In this embodiment, the discrimination range of the discrimination section 114 can discriminate the entire rack layer 113 to recognize the reagent discrimination positions of all the reagent bottles in each rack layer 113. Meanwhile, in the present embodiment, the discrimination range of each discrimination section 114 is larger than one-half of the width of the placement layer 113 and smaller than the width of the placement layer 113.

Because the determination portion 114 is disposed on the layer eaves 111 (i.e. the area of the outside of the reagent cabinet 5 exposed in the normal temperature), in the second embodiment, the main control chip 115 senses that the insulation cabinet door 111 is opened in the sensing portion 107 and then controls the determination portion 114 to perform determination continuously until the sensing portion 107 senses that the insulation cabinet door 111 is closed by the experimenter, at this time, the main control chip 115 controls the reagent cabinet communication portion 1101 to send all the reagent determination information sensed by each determination portion 104 in the opening and closing process of the insulation cabinet door 111 and the corresponding determination portion number, layer number, cabinet number and identification information of the experimenter to the management server 2.

In the second embodiment, the principle of the intelligent management method for unfixed biological reagents based on the reagent cabinet 6 is the same as that of the first embodiment, and is not described herein again.

< example three >

In the third embodiment, the same reference numerals are given to the components having the same configurations as those in the first and second embodiments, and the description thereof will be omitted.

The third embodiment provides a biological reagent intelligent management system for uniformly managing a normal temperature reagent cabinet and low temperature reagent cabinets with different temperatures, wherein the normal temperature reagent cabinet and the low temperature reagent cabinet with the temperature of-30 ℃ adopt the same structure as the reagent cabinet 1 in the first embodiment (the temperature is adjusted by the temperature adjusting part 102), and the low temperature reagent cabinet with the temperature of-30 ℃ to-100 ℃ adopts the structure of the reagent cabinet 6 in the second embodiment. At this time, the structure of the system 200 is as shown in fig. 14.

In the third embodiment, the intelligent management method of the non-immobilized bioreagent based on the system 200 is the same as the first embodiment, and is not described herein again.

Examples effects and effects

According to the experiment-based intelligent management method for the non-fixed biological reagents, reagent related information of all biological reagents in a laboratory is managed according to the experiment types, so that when a laboratory technician needs to extract the biological reagents, the laboratory technician can directly input the experiment name to obtain an extraction list for sequencing the required biological reagents according to the distance through the management server, the laboratory technician can conveniently go to the nearest and most convenient reagent cabinet to extract the biological reagents, meanwhile, when the biological reagents are extracted from the reagent cabinet, the laboratory technician can quickly find the required reagents at corresponding rough positions of corresponding placing layers according to rough position information, time and energy spent by the laboratory technician in reagent extraction are further saved, and cold air loss in the low-temperature reagent cabinet caused by reagent searching is avoided. In addition, the laboratory technician can conveniently return the biological reagent in the placing layer after selecting the reagent cabinet, thereby saving the time and the energy of the laboratory technician when returning the reagent.

In addition, in the first embodiment, since the determination unit for identifying the reagent label is disposed between the respective placement layers in the low-temperature environment of-10 ℃ to-30 ℃, once the laboratory technician extracts or returns the biological reagent, the determination unit can identify the reagent determination information of each biological reagent in the reagent cabinet after the cabinet door is closed, and thus the position state of the biological reagent can be counted without the intervention of the laboratory technician, and whether the reagent bottle of the biological reagent is extracted or returned by the laboratory technician can be accurately determined.

In addition, in the second embodiment, since the outwardly protruding layer eaves are provided for each of the placement layers and the determination part is provided below each layer eaves in the low-temperature environment of-30 ℃ to-100 ℃, the determination part that is difficult to operate at an excessively low temperature can be provided at a normal temperature, and the identification of the reagent discrimination information of each biological reagent in the placement layer is realized in a short time when the laboratory technician opens the cabinet door. By the method, the intelligent management method for the non-fixed biological reagent realizes the effect of effectively and accurately managing all reagent bottles in the reagent cabinet at extremely low temperature.

Furthermore, in the embodiment, the determination part is arranged on the reagent cabinet, so that when a laboratory technician extracts or returns the biological reagent provided with the reagent label from the reagent cabinet, the reagent identification information of the corresponding biological reagent can be identified through the determination part, and the updating of the relevant information of the reagent is further completed according to the reagent identification information, so that each bottle of biological reagent in a laboratory can be monitored, the storage position of the bottle of biological reagent can be accurately confirmed, and the recovery of the laboratory technician is facilitated.

In addition, in the third embodiment, when the normal temperature reagent cabinet and the low temperature reagent cabinet are disposed in the laboratory in a mixed manner, when the laboratory staff returns the reagent, the return reagent audit determination part may determine whether the biological reagent returned by the laboratory staff is placed in the wrong reagent cabinet, and the warning part of the reagent cabinet warns and reminds, so that the biological reagent is prevented from being damaged and lost due to the fact that the storage temperature of the biological reagent is not consistent with the actual temperature in the reagent cabinet, and the laboratory staff is prevented from returning the wrong biological reagent in the reagent cabinet due to a mistake and the like (for example, the reagent with smaller difference due to similar color).

Further, because when judging that the wrong reagent is returned, because the discrimination portion of reagent cabinet sets up on the layer eaves in the second embodiment, consequently can discern the reagent discrimination information that the laboratory technician put into more rapidly, at this moment, thereby the management server also can accomplish more rapidly and judge and make warning portion remind the laboratory technician to put into wrong reagent more timely to avoid the laboratory technician to the influence that the biological reagent caused when taking place to return the mistake better. And to the reagent cabinet in the embodiment one, because the temperature is higher relatively, can not lead to the fact the effect of freezing more fast to biological reagent, consequently remind the laboratory technician relatively more slowly can not cause biological reagent's loss.

In addition, when the intelligent management method for the non-fixed biological reagent is arranged in a large-scale experiment place, the reagent cabinet can be arranged in the reagent storage chambers of different buildings. In this case, the management server sorts the reagent positions by the floor number, and room number, and thereby can determine the reagent position closest to the laboratory technician, and further allow the laboratory technician to go to the closest position to extract the required reagent at the time of extraction.

The above-described embodiments are merely illustrative of specific embodiments of the present invention, and the present invention is not limited to the description of the above-described embodiments.

For example, in the first embodiment, the reagent name and the reagent specification are stored separately in the reagent-related information storage unit. However, in another embodiment of the present invention, the reagent specification can be directly entered together with the name at the time of reagent naming to form a reagent name including name information and specification information.

Further, in the above-mentioned first embodiment, the names of the experiments are the names of the various types of experiments. In another embodiment of the present invention, the experiment name may be an experiment number, or may be a field formed by combining the experiment name and the experiment number, and the experiment type storage unit may store experiment related information such as experiment details and budget corresponding to the experiment name.

For example, in the first embodiment, the reagent site sorting unit performs sorting by calculating the weight of the floor number, and room number. In another embodiment of the present invention, the reagent position sorting unit can also complete sorting by comparing the floor number, and the room number, for example, the degree of similarity corresponding to the position information in which the floor numbers are inconsistent is the lowest, the degree of similarity between the position information in which the floor numbers are consistent but the floor numbers are inconsistent is lower than the degree of similarity between the position information in which the floor numbers are consistent and the floor numbers are consistent, and so on.

For example, in the first embodiment, two symmetrically arranged determination portions are provided for each placement layer, and the rough position information is the left side and the right side corresponding to the positions of the determination portions, respectively. In other aspects of the invention, each placing layer can be correspondingly provided with more RFID readers and is uniformly arranged in the placing layer, and the number of corresponding rough positions is further increased, so that the rough position information is more accurate, and the position of the reagent bottle on the placing layer can be more accurately judged.

In addition, in the second embodiment, two determination portions are provided on the layer eaves corresponding to each layer of the placement layer, and the range of the determination portions can cover the entire placement layer. In other schemes of the invention, in order to facilitate the discrimination part to discriminate the whole placement layer, a form of a directional RFID reader can be adopted, the directional RFID reader is installed slightly obliquely outward, i.e. the reading direction of the directional RFID reader faces inward, and meanwhile, an inward inclined slope part can be arranged on the layer brim at the position of the RFID reader, so that electromagnetic waves of the RFID reader enter the placement layer to read the sample label on the biological sample in the placement layer.

Further, when in actual use, more discrimination parts can be correspondingly arranged under each layer of eave according to actual requirements, so that the accuracy of discrimination of rough position information is improved.

For another example, in the reagent kit according to the second embodiment, the reagent discrimination information recognized by the judgment section is the reagent discrimination information of all the biological reagents in the entire rack, and the management server judges the missing or added reagent discrimination information by the comparison judgment section. However, in another embodiment of the present invention, the determination unit provided on the layer eaves may directly identify the reagent extracted or returned by the laboratory technician, that is, the laboratory technician may pass through the layer eaves when taking out (or returning) the reagent from the placement layer, and in this case, the determination unit may identify the corresponding reagent determination information, and may further transmit the reagent determination information to the management server, and the management server may determine whether the reagent is extracted or placed in the original reagent-related information based on whether the reagent determination information is present in the original reagent-related information.

In another embodiment of the present invention, the normal temperature reagent cabinet and the low temperature reagent cabinet mixed in the third embodiment may both have the reagent cabinet structure of the second embodiment. At this moment, all reagent cabinets can realize going on more fast that biological reagent puts into wrong warning to avoid the experimenter to the influence that biological reagent caused when taking place to return the mistake better.

For example, in the above-described embodiment, the management server determines that the basis of the return error of the biological reagent is the temperature of the reagent tank and the storage temperature range of the biological reagent. However, in another embodiment of the present invention, the management server stores the reagent kit number of the reagent kit and the reagent kit information of the corresponding classification information, and when the management server determines whether or not the biological reagent is loaded in the wrong reagent kit, the biological reagent can be verified based on the reagent name (or other attribute information) and the classification information corresponding to the biological reagent.

For example, in the above embodiment, the warning portion is a warning lamp provided on the front surface of the cabinet door. In another aspect of the present invention, the warning unit may be a sound-light alarm, a display, or another device having a presentation effect, and may be provided at a position on the reagent tank where the warning unit is easily viewed.

Claims

1. The utility model provides a biological reagent intelligent management system of non-fixed type based on experiment which characterized in that, based on different kinds of experiments and adopt the system that contains low temperature reagent cabinet, laboratory technician terminal and the management server that is used for depositing the biological reagent that needs low temperature environment freezing storage to realize managing the biological reagent that has the reagent label in the laboratory, include:

correspondingly storing the reagent name of each biological reagent, the corresponding reagent identification information and the corresponding reagent position information comprising the cabinet number of the low-temperature reagent cabinet in which the reagent bottle is positioned, the layer number of the positioned layer and the rough position information of the rough position as reagent related information in the management server;

correspondingly storing the experiment name of each experiment and the reagent name of the reagent required by the corresponding experiment as experiment type information;

the experimenter terminal is adopted to enable the experimenter to input the name of an experiment to be carried out as the name of the experiment to be carried out, and the name of the experiment to be carried out and the position information of the experimenter, which represents the position of the experimenter, are sent to the management server;

searching the experiment type information and acquiring all corresponding reagent names by using the management server according to the sent name to be tested, and searching the relevant information of the reagent and acquiring the corresponding reagent position information according to the acquired reagent name;

the management server sorts each obtained reagent position information according to the experimenter position information to form an extraction position sequence according to the degree of distance, further generates an extraction list according to the extraction position sequence and the corresponding reagent name, and sends the extraction list to the experimenter terminal;

and the experimenter terminal displays and receives the extraction list so that the experimenter can go to the corresponding low-temperature reagent cabinet according to the extraction list and search and take out the required biological reagent at the rough position in the corresponding placing layer.

2. The intelligent non-immobilized bioreagent management system of claim 1 wherein:

wherein, the process of taking out the biological reagent or returning the used biological reagent when the experimenter goes to the low-temperature reagent cabinet is as follows:

adopting an identity recognition part of the low-temperature reagent cabinet to recognize the identification information of the experimenter and sending the identification information to the management server for judgment;

judging whether the laboratory technician has the authority to open the cabinet door or not at least based on the identification information by adopting the management server, and sending a door opening permission signal to the low-temperature reagent cabinet once the laboratory technician has the authority to open the door;

the control module of the low-temperature reagent cabinet unlocks a cabinet door according to the door opening permission signal so as to enable the experimenter to open the cabinet door for extraction or storage operation;

adopting a judging part to continuously judge reagent judging information contained in all reagent labels in the reagent cabinet and adopting a sensing part to sense whether the cabinet door is closed, and sending the read reagent judging information, the current cabinet number of the low-temperature reagent cabinet and the layer number of the corresponding placing layer to the management server once sensing that the laboratory technician closes the cabinet door;

the management server judges the access condition of the biological reagent and updates the reagent-related information at least according to the transmitted reagent judgment information, the cabinet number and the layer number.

3. The intelligent non-immobilized bioreagent management system of claim 2 wherein:

the determination part continuously determines the reagent determination information contained in all the reagent labels in the reagent cabinet based on that at least two determination parts with different part numbers are correspondingly arranged on each placing layer, and the specific process is as follows:

sending the read reagent identification information, the current cabinet number of the low-temperature reagent cabinet, the layer number of the corresponding placement layer and the part number corresponding to the identification part to the management server;

the management server also judges rough position information corresponding to the reagent discrimination information according to the received reagent discrimination information and the layer number;

and when updating the reagent position information in the reagent related information, the management server also updates the reagent related information according to the rough position information.

4. The intelligent non-immobilized bioreagent management system of claim 2 wherein:

wherein, when the management server judges the access condition of the biological reagent, the method specifically comprises the following steps:

comparing the received reagent discrimination information with the reagent discrimination information in the reagent-related information to discriminate a missing reagent discrimination information corresponding to the taken-out biological reagent or an added reagent discrimination information corresponding to the returned biological reagent;

and updating the reagent-related information according to the missing reagent discrimination information or the added reagent discrimination information.

5. The intelligent non-immobilized bioreagent management method according to claim 4, wherein:

when the management server judges the added reagent judgment information, whether the corresponding biological reagent is placed in the wrong reagent cabinet is judged according to the added reagent judgment information and the corresponding cabinet number.

6. The intelligent management method of non-immobilized bioreagent according to claim 5, wherein:

wherein each low-temperature reagent cabinet is provided with different low-temperature environments which are from-10 ℃ to-100 ℃,

the reagent-related information further stores a storage temperature range corresponding to a required storage temperature of the biological reagent,

the management server determining whether the biological reagent is placed in a wrong reagent cabinet is performed based on the storage temperature range and current temperature information corresponding to the low-temperature environment of the reagent cabinet, specifically comprising the following steps:

judging whether the current temperature information corresponding to the cabinet number is in the storage temperature range corresponding to the added reagent judgment information;

if the current temperature information is judged to be in the storage temperature range, judging that the biological reagent is not placed in a wrong reagent cabinet;

and if the current temperature information is not within the storage temperature range, the biological reagent is placed in the wrong reagent cabinet, and the management server sends a warning signal to the corresponding low-temperature reagent cabinet.

7. The intelligent management method of non-immobilized bioreagent according to claim 5, wherein:

wherein the management server updates the reagent-related information and stores reagent discrimination information corresponding to the biological reagent determined to be extracted and identification information received from the low-temperature reagent tank as one extraction record,

the management server judges whether the biological reagent is put into the wrong reagent cabinet or not based on the extraction record, and the method specifically comprises the following steps:

determining whether the biological reagent is loaded into a wrong reagent tank based on whether the received tank number matches the reagent position information corresponding to the reagent discrimination information in the extraction record,

if the cabinet number is judged to be consistent with the reagent position information, judging that the biological reagent is not put into a wrong reagent cabinet;

and if the cabinet number is judged to be inconsistent with the reagent position information, judging that the biological reagent is placed in the wrong reagent cabinet, and sending a warning signal to the corresponding low-temperature reagent cabinet by the management server.