CN113128633A - Intelligent management method for non-immobilized biological reagent - Google Patents

Abstract

The invention provides an intelligent management method of non-immobilized biological reagents, which is characterized in that a system comprising a reagent cabinet, a laboratory technician terminal and a management server is adopted to realize the management of the biological reagents with reagent labels, and comprises the following steps: judging whether the laboratory technician extracts the reagent judgment information of the front and back missing of the reagent; updating reagent related information containing reagent discrimination information according to the missing reagent discrimination information; storing the current time as extraction time, the missing reagent discrimination information and the identification information identified by the experimenter when opening the cabinet door as acquisition time information; and judging the time difference between the extraction time and the current time, if the time difference exceeds the first holding time, sending deadline reminding information to an experimenter, and if the time difference exceeds the second holding time, sending the deadline reminding information and corresponding identification information to an administrator for processing.

Description

Intelligent management method for non-immobilized biological reagent

Technical Field

The invention relates to an intelligent management method for non-immobilized biological reagents.

Background

The biological agent refers to a biological material or an organic compound for life science research, and a reagent for clinical diagnosis and medical research. As the common reagent types needed in the laboratory, different biological reagents have different properties, so that reagent cabinets with different temperatures are needed to store different biological reagents in the laboratory in a targeted manner, thereby avoiding the biological reagents from deteriorating before being used. Meanwhile, the preservation conditions of the biological reagents are harsh, and environments such as a low-temperature refrigerator (-below 30 ℃) or an ultra-low-temperature refrigerator (-80 ℃) and even liquid nitrogen are generally needed.

However, different biological reagents need different reagent cabinets to be stored, which aggravates the situation of reagent management confusion in a laboratory, and easily causes the problems of misplacing and mistaken taking of the biological reagents, so that a laboratory worker who takes the biological reagents later needs to spend a long time to find the reagent cabinet. Meanwhile, the administrator is difficult to effectively monitor the biological reagents in the reagent cabinets and cannot accurately know the specific biological reagents and the quantity and other state information in each reagent cabinet, so that effective statistics and management cannot be carried out, and daily operations of the administrator on scrapping, purchasing and the like of the biological reagents are influenced.

In order to solve the above problems, some laboratories store different biological reagents by dividing a specific storage area. This approach then requires a large number of management personnel to maintain, while still being prone to the wrong reagent cabinet.

Disclosure of Invention

In order to solve the above problems, the present invention provides an intelligent management method for an unfixed biological reagent, which can effectively manage biological reagents, and performs information management for biological reagents based on reagent tags, and further provides an intelligent management method for an unfixed biological reagent, wherein a system including a reagent cabinet, a laboratory technician terminal, and a management server is used to manage biological reagents having reagent tags, the method including the steps of: storing reagent discrimination information and reagent names of all biological reagents and reagent position information comprising a cabinet number of a reagent cabinet where the biological reagents are located and a layer number of a placing layer where the biological reagents are located as reagent related information; identifying the identification information of the experimenter by adopting an identification part of the reagent cabinet, and then sending the identification information to a management server; judging whether the experimenter has the opening authority or not at least based on the identification information by adopting a management server, and sending an opening permission signal to the reagent cabinet once the experimenter is judged to have the opening authority; the control module of the reagent cabinet releases the locking of the cabinet door according to the door opening permission so as to enable a laboratory technician to open the cabinet door for extraction or storage operation; the method comprises the steps that a judging part is adopted to continuously read and an induction part is adopted to induce whether a cabinet door is closed or not, and once the door of the laboratory technician is induced to be closed, at least read reagent judging information and a cabinet number of a reagent cabinet are sent to a management server; the management server judges the access condition of the biological reagent according to the sent information reagent judgment information and the cabinet number, and updates the reagent position information in the reagent related information; taking the current time as extraction time and storing the current time and the missing reagent discrimination information and the identification information as acquisition time information; a time judgment module is adopted to regularly judge whether the time difference between each extraction time and the current time in the acquired time information exceeds the first holding time or the second holding time according to the preset first holding time and the second holding time; if the time difference exceeds the first holding time, sending a time limit reminding message containing reagent judging information and extraction time to an experimenter for processing; and if the time difference exceeds the second holding time, sending the deadline reminding information and the corresponding identification information to an administrator for processing.

Action and Effect of the invention

According to the intelligent management method of the non-immobilized biological reagent, provided by the invention, the reagent labels are arranged for all biological reagents in a laboratory, and the reagents are judged by the judgment part arranged in the reagent cabinet, so that once a laboratory worker extracts the biological reagents from the reagent cabinet, the related information updating part can update the information of the corresponding biological reagents according to the reagent judgment information judged by the judgment part, and the management server can accurately manage the positions and the quantity of all biological reagents in the laboratory. Meanwhile, after the laboratory staff scrap the reagent and the related information updating part finishes updating, the reagent stock determining part can also determine whether the stock of the biological reagent is lower than the preset reagent stock number, so as to remind the administrator to purchase the biological reagent in time when a certain type of biological reagent needs to be supplemented in the laboratory, furthermore, after the administrator purchases the reagent, the administrator can also obtain the cabinet number of the reagent cabinet which can properly store the biological reagent according to the storage temperature information of the biological reagent through the cabinet number retrieval and acquisition part, thereby being convenient for the administrator to put the purchased biological reagent into the corresponding reagent cabinet, and when the biological reagent is put into the reagent cabinet, the administrator can also randomly put the purchased biological reagent into any position on any placement layer without worrying that the management of the biological reagent becomes disordered, thereby greatly saving the energy consumed for reagent scrap and management when purchasing in the laboratory, it also allows biological agents in the laboratory to be effectively managed. The quality guarantee period judging part judges the quality guarantee periods of all biological reagents in a laboratory, so that reagent scrap information is automatically generated according to the related information of the biological reagents when the quality guarantee periods exceed the quality guarantee periods, managers can scrap the discarded biological reagents, and accidents caused by the fact that deteriorated biological reagents are taken by the laboratory workers are avoided. Further, the reagent storage amount determination unit may determine the biological reagent storage amount after the administrator performs the disposal process, thereby intelligently notifying the administrator whether or not purchase of a new biological reagent is necessary.

Drawings

FIG. 1 is a diagram showing a system for realizing an intelligent management method of an unfixed biological reagent in an embodiment of the present invention;

FIG. 2 is a schematic view of a type I reagent cabinet according to an embodiment of the present invention;

FIG. 3 is a schematic view showing the placement of a reagent bottle according to a first embodiment of the present invention;

FIG. 3 is a functional block diagram of a type I reagent cabinet according to an embodiment of the present invention;

FIG. 4 is a schematic diagram of the structure of a placement layer in an embodiment of the invention;

FIG. 5 is a diagram illustrating the contents stored in the bin number layer number storage unit according to an embodiment of the present invention;

FIG. 6 is a schematic structural diagram of a type II reagent cabinet according to an embodiment of the present invention;

FIG. 7 is a flow chart of an extract return process in an embodiment of the present invention;

FIG. 8 is the contents of information relating to the reagent in an embodiment of the present invention;

FIG. 9 is the content of the extracted information in an embodiment of the present invention;

FIG. 10 is a flow chart of reagent discard in an embodiment of the present invention; and

FIG. 11 is a flow diagram of stale slice processing in an embodiment of the present invention.

Detailed Description

Hereinafter, the intelligent management method of the non-immobilized bioreagent according to the present invention will be described in detail with reference to the accompanying drawings.

As an embodiment, the invention provides an intelligent management method of non-fixed biological reagents, which is characterized in that a system comprising a reagent cabinet, a laboratory technician terminal and a management server is adopted to realize the management of the biological reagents with reagent labels, and the method comprises the following steps: storing reagent discrimination information and reagent names of all biological reagents and reagent position information comprising a cabinet number of a reagent cabinet where the biological reagents are located and a layer number of a placing layer where the biological reagents are located as reagent related information; identifying the identification information of the experimenter by adopting an identification part of the reagent cabinet, and then sending the identification information to a management server; judging whether the experimenter has the opening authority or not at least based on the identification information by adopting a management server, and sending an opening permission signal to the reagent cabinet once the experimenter is judged to have the opening authority; the control module of the reagent cabinet releases the locking of the cabinet door according to the door opening permission so as to enable a laboratory technician to open the cabinet door for extraction or storage operation; the method comprises the steps that a judging part is adopted to continuously read and an induction part is adopted to induce whether a cabinet door is closed or not, and once the door of the laboratory technician is induced to be closed, at least read reagent judging information and a cabinet number of a reagent cabinet are sent to a management server; the management server judges the access condition of the biological reagent according to the sent information reagent judgment information and the cabinet number, and updates the reagent position information in the reagent related information; taking the current time as extraction time and storing the current time and the missing reagent discrimination information and the identification information as acquisition time information; a time judgment module is adopted to regularly judge whether the time difference between each extraction time and the current time in the acquired time information exceeds the first holding time or the second holding time according to the preset first holding time and the second holding time; if the time difference exceeds the first holding time, sending a time limit reminding message containing reagent judging information and extraction time to an experimenter for processing; and if the time difference exceeds the second holding time, sending the deadline reminding information and the corresponding identification information to an administrator for processing.

Further, the intelligent management method for the non-immobilized biological reagent may further have a technical feature that an experimenter inputs a name of a biological reagent to be extracted through a scientific research terminal as a required reagent name and sends the required reagent name to a management server through an experimenter terminal, and the management server retrieves consistent reagent discrimination information from reagent related information according to the received required reagent name, thereby further acquiring reagent position information, and sends the retrieved reagent position information and the received required reagent name to the experimenter terminal as extraction information.

Further, the non-fixed biological reagent intelligent management method can also have the technical characteristics that a laboratory technician inputs the name of the biological reagent needing to be returned through the scientific research terminal as the name of the returned reagent, sends the name of the returned reagent to the management server through the laboratory technician terminal, and retrieves and obtains the number of the reagent cabinet with the environment temperature meeting the storage temperature of the corresponding biological reagent according to the name of the returned reagent by the management server as the number of the storage cabinet and sends the number of the reagent cabinet to the laboratory technician terminal.

Furthermore, the intelligent management method for the non-immobilized biological reagent can also have the technical characteristics that the method comprises the following delayed transaction steps: and after receiving the expiration reminding information, the experimenter terminal displays a delay handling picture to allow the experimenter to input reagent judgment information of the biological reagent to be delayed as delay reagent judgment information, and delay marking is carried out on corresponding extraction time in the acquired time information according to the delay reagent judgment information.

Further, the intelligent management method for the non-immobilized biological reagent can also have the technical characteristics that a laboratory technician inputs reagent judgment information of a reagent to be scrapped on a scrapping handling picture as scrapped reagent judgment information, a related information updating module is adopted to delete corresponding reagent judgment information, reagent name and reagent position information in the reagent related information according to the scrapped reagent judgment information, and then a management server is adopted to carry out scrapping management.

Further, the intelligent management method for the non-immobilized biological reagent can also have the technical characteristics that the management server carries out scrap management according to the following steps: after the laboratory technician is scrapped and transacted, the reagent stock judging part is adopted to judge whether the quantity of the corresponding biological reagent is lower than the preset reagent holding quantity according to the reagent receiving judging information, and once the quantity of the corresponding biological reagent is judged to be lower than the reagent holding quantity, the management server sends a purchase prompting message containing a reagent name corresponding to the judged biological reagent lower than the reagent holding quantity to the manager, so that the manager is reminded to purchase a new biological reagent.

Further, the above-mentioned non-fixed biological reagent intelligent management method may further have a technical feature that an administrator inputs reagent discrimination information of purchased biological reagents, corresponding reagent names, and corresponding storage temperatures as reagent update information on a reagent information input screen, updates reagent related information according to the reagent update information using a related information update module, retrieves and obtains a reagent cabinet number whose environmental temperature meets the storage temperature according to the storage temperature using a management server, and sends the reagent cabinet number as a storage cabinet number to the administrator, so that the administrator goes to the corresponding reagent cabinet to store the reagent.

Further, the intelligent management method for the non-immobilized biological reagent may further include storing reagent identification information of all reagents, a generation date of the biological reagent, and a corresponding quality guarantee period as quality guarantee period information, periodically determining whether a time difference between a current time and the generation date of the biological reagent exceeds the corresponding quality guarantee period according to the stored quality guarantee period information, and sending the reagent identification information of the biological reagent and reagent position information retrieved according to the reagent identification information as expiration reminding information to an administrator for disposal once the time difference is determined to exceed the quality guarantee period.

Further, the intelligent management method for the non-immobilized biological reagent can also have the technical characteristics that the process of the scrap disposal by the administrator is as follows: identifying the identification information of an administrator by adopting an identification part of the reagent cabinet, and then sending the identification information to a management server; judging whether the administrator has the opening authority or not at least based on the identification information by adopting a management server, and sending a door opening permission signal to the reagent cabinet once the administrator is judged to have the door opening authority; the control module of the reagent cabinet releases the locking of the cabinet door according to the door opening permission so as to enable an administrator to open the cabinet door for extraction operation; the method comprises the steps that a judging part is adopted to continuously read and an induction part is adopted to induce whether a cabinet door is closed or not, and once an administrator is induced to close the cabinet door, at least read reagent judging information and a cabinet number of a reagent cabinet are sent to a management server; the management server judges the access condition of the biological reagent according to the sent information reagent judgment information and the cabinet number, and updates the reagent position information in the reagent related information.

< example >

FIG. 1 is a block diagram showing a system for realizing an intelligent management method of an unfixed biological reagent in the embodiment of the present invention.

As shown in fig. 1, the intelligent management method of the non-immobilized biological reagent is implemented based on a system 100, the system 100 includes j reagent cabinets 1, a management server 2, a plurality of laboratory terminals 3, a manager terminal 4, and communication networks 5a, 5b, and 5c, and the system 100 is installed in a laboratory.

The management server 2 is connected to each reagent cabinet 1 through a communication network 5a, to each laboratory technician terminal 3 through a communication network 5b, and to the administrator terminal 4 through a communication network 5 c. In this embodiment, the communication networks 5a, 5b, and 5c are all local area networks in a laboratory.

In this embodiment, the reagent cabinet 1 has an I-type reagent cabinet and an II-type reagent cabinet, and some of the I-type reagent cabinets are configured as scrapped reagent cabinets for the laboratory technician to place scrapped reagents.

FIG. 2 is a schematic view of a type I reagent cabinet according to an embodiment of the present invention.

As shown in fig. 2, the i-type reagent tank 1 includes a tank body 101, a temperature adjustment unit 102, five placement levels 103 located in the tank body, ten determination units 104 provided corresponding to the placement levels 103, a tank door 105 provided on the tank body 101, a locking unit 106, a sensing unit 107, an identification unit 108, a warning unit 109, and a main control chip 110.

The temperature control unit 102 is used to adjust the temperature inside the type i reagent tank to form a low temperature environment suitable for storing biological reagents.

In this embodiment, the low temperature environment manufactured by the temperature adjusting portion is between-10 ℃ and-30 ℃, the temperature adjusting portion includes a cooling mechanism such as a compressor, a temperature setting mechanism for setting a temperature, a temperature detecting mechanism for detecting a temperature in the placing layer 103, and a control mechanism for controlling the operation of the cooling mechanism according to a temperature detection result and the set temperature so as to realize temperature control, and specific configurations and operating principles of these mechanisms are the same as those in the ultra-low temperature refrigerator in the prior art, and are not described herein again.

The placing layer 103 is provided with five layers for placing various reagent bottles. In the low-temperature reagent tank 1, a first layer accommodating layer 103a, a second layer accommodating layer 103b, a third layer accommodating layer 103c, a fourth layer accommodating layer 103d, and a fifth layer accommodating layer 103e are arranged in this order from top to bottom. Wherein, each layer of the placing layer 103 has a placing plate on which the reagent bottles are placed (the placing plate of the fifth layer of the placing layer 103e is the bottom plate of the reagent cabinet 1).

FIG. 3 is a schematic view of a reagent bottle according to a first embodiment of the present invention.

Taking the first-layer placing layer 103a as an example, as shown in fig. 3, the reagent bottles 150 can be freely placed on the placing plate 151. A reagent label 151 is attached to the cap and body of the reagent bottle 150.

In this embodiment, the reagent label 151 is a low temperature resistant RFID label that contains reagent identification information corresponding to the reagent bottle 150, and can be installed at any position of the reagent bottle 150, such as a bottle cap, a bottle body, or a bottle bottom, and can normally operate at least in a low temperature environment of-30 ℃.

The determination unit 104 is an RFID reader operable at least in a low temperature environment of-30 ℃ and is configured to determine the reagent labels 151 of all the reagent bottles 150 on the respective placement layers 103 in the reagent tank 1

In this embodiment, each placement layer 103 is provided with two determination portions 104, and the two determination portions 104 are symmetrically provided on the left and right sides of the placement layer 103.

The cabinet door 105 corresponds to the type i reagent cabinet 1, and the laboratory technician needs to open the cabinet door 105 first to extract or return the biological reagents on each placing layer 103 of the reagent cabinet 1.

The locking part 106 is used for locking the cabinet door 105 of the I-type reagent cabinet. In this embodiment, the locking portion 106 is an electronic lock disposed on the cabinet door, and can be locked or unlocked according to a control signal of the main control chip 110.

The sensing part 107 is used for sensing the opening and closing state of the cabinet door. In this embodiment, the response portion is a sensor that sets up on cabinet door or door frame, can respond to whether the cabinet door is in the closed condition.

The identification unit 108 is a door card reader for identifying a door opening card held by an experimenter.

In this embodiment, the door opening card includes identification information of an experimenter, and the identity recognition portion 108 enables the experimenter to recognize the identification information corresponding to the experimenter in the door opening card in a card swiping manner. Each experimenter has respective identification information, and the identity recognition part 108 can correspondingly judge the identity of the experimenter through the identification information.

In this embodiment, the identification information corresponds to the identity of each experimenter, that is, each experimenter has its own unique identification information, and the identity of the experimenter can be directly determined correspondingly through the identification information.

The warning section 109 is used to generate warning information. In this embodiment, the warning portion 109 is a warning light disposed on the front surface of the cabinet door 105, and is configured to generate light flashing when receiving the warning information, so as to prompt the staff to take the wrong biological reagent.

Fig. 4 is a functional block diagram of a type I reagent cabinet according to a first embodiment of the present invention.

As shown in fig. 4, the main control chip 110 is electrically connected to the temperature adjustment unit 103, the determination unit 104, the locking unit 106, the sensing unit 107, the identification unit 108, and the warning unit 109, respectively, and controls operations of these components. The main control chip 110 includes a reagent tank communication unit 1101 and the main control chip 110.

The reagent tank communication unit 1101 is a communication module of the main control chip 110, and is used for performing data communication between the main control chip 110 and the management server 2.

When the identification information of the laboratory technician is identified by the identification identifying unit 108, the reagent cabinet communication unit 1101 transmits the identification information and information such as the current cabinet number of the I-type reagent cabinet 1 to the management server 2 for processing, and when the reagent cabinet communication unit 1101 receives the door opening permission signal fed back from the management server 2, the main control chip 110 controls the locking unit 106 to unlock, so that the laboratory technician opens the cabinet door 105 to extract or return the biological reagent. In addition, when the sensing part 107 senses that the cabinet door 105 is changed from the open state to the closed state, the main control chip 110 controls the locking part 106 to lock the cabinet door.

Fig. 5 shows the contents stored in the cabinet number layer number storage unit according to the first embodiment of the present invention.

In this embodiment, in order to distinguish the respective I-type reagent cabinets 1, each I-type reagent cabinet 1 in the laboratory is provided with a cabinet number for identification. Meanwhile, in each type I reagent cabinet 1, the respective placing layers 103 are also provided with corresponding layer numbers in sequence, for example, the layer number of the first placing layer 103a is 1. As shown in fig. 5, the cabinet number-layer number storage unit 1102 stores the cabinet number 1103 of the current type I reagent cabinet 1, the layer number 1104 of each of the rack layers 103, and the discrimination section number 1105 of the discrimination section 104 (i.e., the section number of the discrimination section 104) corresponding to each of the layer numbers 1104, and two discrimination sections 1105 are associated with each of the layer numbers 1104 because two discrimination sections 104 are provided for each of the rack layers 103. In practical applications, the cabinet number is the chip identification code of the main control chip 110, and the identification part number is the machine code of each identification part 104.

When the laboratory technician opens or closes the cabinet door 105 when taking out or returning the reagent, the sensing unit 107 senses the open or closed state of the cabinet door, and at this time, the main control chip 110 controls the discriminating unit 104 to discriminate the reagent discriminating information corresponding to all the reagent bottles 150 on each of the placing layers 103, and further controls the management-side communication unit 191 to transmit the discriminated reagent discriminating information, the corresponding layer number, the cabinet number, and the part number of each discriminating unit to the management server 2 after the cabinet door is locked by the control locking unit 106.

In this embodiment, since the determination unit 104 is disposed in the placement layer 103, the main control chip 110 controls the determination unit 104 to perform the determination when the sensing unit 107 senses that the cabinet door is opened and then closed again.

FIG. 6 is a schematic structural diagram of a type II reagent cabinet according to an embodiment of the present invention.

As shown in fig. 6, the reagent cabinet 6 is provided with a cabinet body 101, a temperature adjusting portion 102, a placing layer 113, an identification portion 108, a warning portion 109 and a main control chip 115, and is different from the first embodiment in that the reagent cabinet 5 is provided with a thermal insulation cabinet door 111 and a layer eaves 112 protruding outward to the outside of the reagent cabinet 1 at the top portion (i.e., a placing plate of a placing layer on each placing layer 113, and a first placing layer 113a is a top plate of the whole reagent cabinet 1) corresponding to each placing layer 113, each thermal insulation cabinet door 111 is provided with a locking portion 106 and a sensing portion 107 corresponding to each placing layer 113, and the placing layers 113 are only three layers.

In addition, two discrimination parts 114 corresponding to each layer of the placing layer 113 are arranged on the layer eaves 112 corresponding to the placing layer 113 and close to the outer side surface of the insulation cabinet door 111, and are used for discriminating reagent labels of all the reagent bottles 150 in the placing layer when an experimenter opens the insulation cabinet door 111 to take out or put in biological reagents, and the reagent labels used in the second embodiment are ultra-low temperature resistant RFID labels, and can normally operate in a low-temperature environment of-100 ℃.

In this embodiment, the discrimination range of the discrimination section 114 can discriminate the entire rack layer 113 to recognize the reagent discrimination positions of all the reagent bottles in each rack layer 113. Meanwhile, in the present embodiment, the discrimination range of each discrimination section 114 is larger than one-half of the width of the placement layer 113 and smaller than the width of the placement layer 113.

Because the determination portion 114 is disposed on the layer eaves 111 (i.e. the area of the outside of the reagent cabinet 5 exposed in the normal temperature), in the second embodiment, the main control chip 115 senses that the insulation cabinet door 111 is opened in the sensing portion 107 and then controls the determination portion 114 to perform determination continuously until the sensing portion 107 senses that the insulation cabinet door 111 is closed by the experimenter, at this time, the main control chip 115 controls the reagent cabinet communication portion 1101 to send all the reagent determination information sensed by each determination portion 104 in the opening and closing process of the insulation cabinet door 111 and the corresponding determination portion number, layer number, cabinet number and identification information of the experimenter to the management server 2.

Fig. 7 is a flowchart of an extraction return process in an embodiment of the present invention.

As shown in fig. 7, when the experimenter extracts or returns the slices, the following steps are performed:

step S1 stores the reagent discrimination information, the reagent name, and the reagent position information including the cabinet number of the reagent cabinet 1 in which the biological reagent is present and the layer number of the placing layer 103 in which the biological reagent is present as the reagent-related information, and then proceeds to step S2.

In step S1 of the present embodiment, the reagent-related information is stored in a management server 2 in a setup laboratory, and the management server 2 has a reagent-related information storage module for storing the reagent-related information.

FIG. 8 shows the contents of information relating to the reagent in the example of the present invention.

As shown in fig. 8, the reagent-related information 201 includes reagent identification information 301, a corresponding reagent name 302, storage temperature information 303, a reagent volume 304, expiration date information 305, and reagent position information 306.

The reagent discrimination information 301 is the number information of the reagent bottle 150, and the reagent label 151 on each reagent bottle 150 contains the reagent discrimination information indicating the different number.

The reagent name 302 is a reagent name of the biological reagent contained in the reagent bottle 150.

The storage temperature information 303 is the appropriate storage temperature of the biological reagent in the reagent bottle 150.

The reagent volume 304 is the volume of biological reagent in the reagent bottle 150.

The expiration date information 305 indicates the expiration date time of the bio-reagent in the reagent bottle 150 at the corresponding location.

The reagent position information 306 includes the cabinet number of the reagent cabinet 1, the layer number of the placing layer 103, and rough position information of the reagent bottle 150 at the rough position of the placing layer 103.

In this embodiment, since the determination units 104 are symmetrically disposed on the left and right sides of each of the placement layers 103 to detect the left and right sides of the placement layer 103, respectively, and the reagent bottles 150 located in the middle of the placement layers 103 can be determined by the two determination units 104 at the same time, the rough position information corresponds to the left, middle, and right sides of the placement layers 103, and the laboratory technician can directly search for the desired biological reagents at the corresponding positions of the placement layers 103 according to the information.

As can be seen from the above figure, as the reagent position information corresponding to the reagent discrimination information P1 and P2, the case number and the layer number are the same, indicating that two reagent bottles 150 containing different reagents are stored in the same reagent storage layer 15 of the same reagent case 1, but one of the two reagent bottles 150 is on the left side of the reagent storage layer and the other is on the right side.

The reagent identification information P2, P3, and P4 correspond to the same information such as the reagent name and the reagent volume, but correspond to different reagent position information, indicating that three reagent bottles containing the same reagent are placed at different positions (the reagent bottles corresponding to P2 and P3 are placed on different placement levels 15 of the same reagent kit 1, and the reagent bottles corresponding to P4 are placed in different reagent kits 1).

The reagent position information corresponding to the reagent discrimination information P5 and P7 is null, and indicates that the reagent bottle corresponding to the reagent discrimination information is in a state of being extracted by the laboratory technician and is not in the reagent tank 1.

In this embodiment, the reagent identification information is the number of each reagent bottle 150, and each reagent bottle 150 has unique reagent identification information.

In this embodiment, when the experimenter applies for the reagent, the experimenter terminal 3 needs to log in the management server 2 by using the identification information, and the name of the required reagent is input through the human-computer interaction picture of the experimenter terminal 3. Subsequently, the laboratory technician terminal 3 transmits the input required reagent name to the management server 2, and then the management server 2 retrieves consistent reagent information from the reagent-related information according to the received required reagent name, thereby further acquiring the reagent position information and transmitting the reagent position information and the received required reagent name as extraction information to the laboratory technician terminal 3.

Fig. 9 is the content of the extracted information in the embodiment of the present invention.

Taking the input required reagent name SJ2 as an example, as shown in fig. 9, the extraction information 221 includes the reagent name 2211 and the corresponding reagent position information 2212. It can be seen that the reagent position information in the extraction information 221 may be multiple, and reagents representing the needs of the laboratory technician are stored at multiple positions.

In this embodiment, the reagent cabinet 1 in which the reagent bottles 150 are located has a cabinet body 101, a cabinet door 105 disposed on the cabinet body 101, and a plurality of placing layers 103 located in the cabinet body 101, the placing layers 103 are flat plates fixed in the cabinet body 101, and do not have any limiting structure for reagents, and each reagent bottle 150 is placed on the placing layers 103 at will. Each reagent cabinet 1 has a respective cabinet number according to which the laboratory technician can find the corresponding reagent cabinet 1 in the laboratory. Meanwhile, each placing layer 103 also has a unique layer number, and the laboratory technician can find the corresponding placing layer 103 in the reagent cabinet 1 according to the layer number.

The reagent position information includes the number of the cabinet where the corresponding reagent bottle 150 is located and the number of the layer.

In step S2, the identification information of the laboratory technician is identified by the identification unit 108 of the reagent kit 11, the identification information is transmitted to the management server 2, and the process proceeds to step S3.

In step S3, the management server 2 determines whether or not the laboratory technician has the opening authority based on the identification information, and transmits a door opening permission signal to the reagent kit 1 when the laboratory technician has the door opening authority, and the process proceeds to step S4.

In step S3 of this embodiment, the identity determination module is a computer program provided in the management server 2, and when determining the identification information, the identity determination module can retrieve the identification information of all the laboratory workers stored in the management server 2 according to the identification information, and if the identification information matches the identification information, the identity determination module sends a door opening permission signal to the reagent cabinet 1, and the locking module releases the locking of the cabinet door 105 to allow the laboratory workers to open the cabinet door 105. After the laboratory technician opens the cabinet door 105, the corresponding placing layer 103 is found according to the reagent position information in the extraction information, and the required reagent is taken out.

In step S4, the main control chip of the reagent cabinets (I-type reagent cabinet and II-type reagent cabinet) unlocks the cabinet door 105 according to the door-opening permission, so that the laboratory technician opens the cabinet door 105 to perform the picking or storing operation, and then the process proceeds to step S5.

In step S5, the determination unit 104 continues the reading operation, the sensing unit senses whether the cabinet door 105 is closed, and when it is sensed that the laboratory technician closes the cabinet door 105, at least the read reagent determination information and the cabinet number of the reagent cabinet 1 are transmitted to the management server 2, and the process proceeds to step S6.

In this embodiment, the control module of the reagent cabinet 1 controls the determination unit 104 to continuously perform the reading action after the sensing unit senses that the cabinet door 105 is opened, so that the reagent label 151 can be read by the determination unit 104 when the biological reagent is taken and placed; meanwhile, the control module of the reagent cabinet 1 also temporarily stores all the reagent discrimination information read in the continuous process of the reading action and the reading times thereof. Then, after the sensing portion senses that the cabinet door 105 is closed again, the reagent cabinet 1 control module controls the reagent cabinet 1 communication module to send the identification number, the cabinet number, the layer number corresponding to the determination portion 104, all the read reagent determination information and the read times to the management server 2 while controlling the locking portion 106 to lock the cabinet door 105.

In step S6, the management server 2 determines the access status of the biological reagent based on the transmitted reagent identification information and the cabinet number, updates the reagent position information in the reagent-related information, and proceeds to step S7.

In this embodiment, when updating the reagent position information based on the missing or added reagent discrimination information, the updating method is to delete the reagent position information corresponding to the missing reagent discrimination information to form a null value, thereby indicating that the reagent bottle 150 corresponding to the reagent discrimination information is not present in the reagent cabinet 1; and storing the reagent position information corresponding to the added reagent discrimination information in association with the reagent discrimination information.

In step S7, the current time is stored as the extraction time together with the missing reagent discrimination information and the identification information as the acquisition time information, and the process proceeds to step S8.

In this embodiment, the acquisition time information specifically includes identification information, reagent discrimination information corresponding to the extracted reagent, extraction time when the reagent is extracted, and whether or not delay information is included. Wherein, the default value of whether the delay information is not delayed is the delay.

Step S8, the time determination module is used to periodically determine whether the time difference between each extraction time in the acquired time information and the current time exceeds the first holding time or the second holding time according to the preset first holding time and the second holding time, if so, the step S9 is performed, and if so, the step S12 is performed.

In this embodiment, the first holding time and the second holding time may be set to a duration of one week, fifteen days, or one month, etc. according to the actual situation, wherein the second holding time should be greater than the first holding time. Step S9 may be performed on a periodic basis daily, hourly, or weekly.

In step S9, a time limit reminding message containing the reagent discrimination information and the extraction time is sent to the experimenter for processing, and then the process proceeds to step S9.

In step S10 of the present embodiment, the term reminding information is displayed on the term reminding screen displayed on the display device (for example, a display) of the laboratory technician terminal 3 owned by the laboratory technician.

Step S10 is a display delay transaction screen for the laboratory technician to input reagent discrimination information of the biological reagent to be delayed as delay reagent discrimination information, and the process proceeds to step S11.

And step S11, according to the delay reagent identification information, carrying out delay marking on the corresponding extraction time in the acquisition time information, and then entering an ending state.

In this embodiment, a text box for allowing the experimenter to input characters is displayed on the delay transaction screen, after the experimenter inputs and confirms the characters in the text box through an input device (for example, a keyboard or the like) of the experimenter terminal 3, the experimenter terminal 3 sends the characters to the management server 2 as delay reagent determination information and identification information of the experimenter, and the management server 2 modifies whether the delay information corresponding to the delay reagent determination information is delayed into delayed when receiving the delay reagent determination information.

And step S12, if the time difference exceeds the second holding time, sending the deadline reminding information and the corresponding identification information to the administrator for processing, and then entering an ending state.

When the experimenter needs to extract a specific biological reagent, the following steps are carried out:

in step N1, the laboratory technician inputs the name of the biological reagent to be extracted as the required reagent name via the research terminal and sends the required reagent name to the management server 2 via the laboratory technician terminal 3, and then proceeds to step N1.

In step N2, the management server 2 retrieves the matching reagent discrimination information from the reagent-related information based on the received required reagent name, thereby further acquiring the reagent position information, and sends the retrieved reagent position information and the received required reagent name as extraction information to the laboratory technician terminal 3, and then proceeds to step S2.

When the experimenter needs to return a specific biological reagent, the following steps are carried out:

in step R1, the laboratory technician inputs the name of the biological reagent to be returned as the returned reagent name through the research terminal and sends the returned reagent name to the management server 2 through the laboratory technician terminal 3, and then proceeds to step R2.

In step R2, the management server 2 is used to retrieve and obtain the reagent cabinet number 1 whose ambient temperature matches the storage temperature of the corresponding biological reagent from the returned reagent name, and send the retrieved reagent cabinet number as the storage cabinet number to the laboratory technician terminal 3, and then the process proceeds to step S2.

FIG. 10 is a flow chart of reagent discard in an embodiment of the present invention.

Step A1, the laboratory technician inputs the reagent discrimination information of the reagent to be discarded as the discarding reagent discrimination information on the discarding transaction screen, and then the process proceeds to step A2.

And step A2, deleting the corresponding reagent identification information, the reagent name and the reagent position information in the relevant reagent information according to the scrapped reagent identification information by using a relevant information updating module, and then entering step A3.

In step A3, the reagent remaining amount determination unit determines whether the amount of the corresponding biological reagent is less than a predetermined reagent remaining amount based on the reagent receiving determination information, and the process proceeds to step A4.

In step a4, upon determining that the quantity of the biological reagent is lower than the reagent holding quantity, the management server 2 sends a purchase prompting message containing a reagent name corresponding to the biological reagent determined to be lower than the reagent holding quantity to the administrator, thereby prompting the administrator to purchase a new biological reagent, and then proceeds to step a 5.

In step a5, the administrator inputs reagent discrimination information of the purchased biological reagent, a corresponding reagent name, and a corresponding storage temperature as reagent update information on the reagent information input screen, and then proceeds to step a 6.

Step A6, updating the reagent related information according to the reagent update information by using the related information update module, and then proceeding to step A7.

And step A7, retrieving and acquiring the number of the reagent cabinet 1 with the environment temperature according to the storage temperature by the management server 2, sending the number as the storage cabinet number to the administrator, enabling the administrator to go to the corresponding reagent cabinet 1 to store the reagent, and then entering the ending state.

FIG. 11 is a flow diagram of stale slice processing in an embodiment of the present invention.

And step T1, correspondingly storing the reagent identification information of all the reagents, the production date of the biological reagent and the corresponding quality guarantee period as quality guarantee time information, and then entering step T2.

And step T2, periodically judging whether the time difference between the current time and the production date of the biological reagent exceeds the corresponding quality guarantee period according to the stored quality guarantee time information, and entering step T3 if the time difference exceeds the quality guarantee period.

And step T3, sending the reagent discrimination information of the biological reagent and the reagent position information retrieved according to the reagent discrimination information as expiration reminding information to an administrator for disposal, and then entering step T4.

In step T4, the identification information of the administrator is identified by the identification unit 108 of the reagent kit 1, the identification information is transmitted to the management server 2, and the process proceeds to step T5.

At step T5, the management server 2 determines whether or not the administrator has the opening authority based on at least the identification information, and if it is determined that the administrator has the opening authority, transmits a door opening permission signal to the reagent kit 1, and the routine proceeds to step T6.

In step T6, the control module of the reagent cabinet 1 unlocks the cabinet door 105 according to the door-opening permission to allow the administrator to open the cabinet door 105 for the extraction operation, and then the process proceeds to step T7.

Step T7, the determination unit 104 continues the reading operation and the sensing unit senses whether the cabinet door 105 is closed, and upon sensing that the administrator closes the cabinet door 105, the management server 2 transmits at least the read reagent determination information and the cabinet number of the reagent cabinet 1 to the management server, and then the process proceeds to step T8.

In step T8, the management server 2 determines the access condition of the biological reagent based on the transmitted information reagent identification information and the cabinet number, updates the reagent position information in the reagent-related information, and enters the end state.

Examples effects and effects

According to the intelligent management method for the non-immobilized biological reagents provided by the embodiment, the reagent labels are set for all biological reagents in the laboratory, the reagents are distinguished by the distinguishing parts arranged in the reagent cabinets, once a laboratory worker extracts the biological reagents from the reagent cabinets, the related information updating parts can update the information of the corresponding biological reagents according to the reagent distinguishing information distinguished by the distinguishing parts, and therefore the management server can accurately manage the positions and the number of all biological reagents in the laboratory. Meanwhile, after the laboratory staff scrap the reagent and the related information updating part finishes updating, the reagent stock determining part can also determine whether the stock of the biological reagent is lower than the preset reagent stock number, so as to remind the administrator to purchase the biological reagent in time when a certain type of biological reagent needs to be supplemented in the laboratory, furthermore, after the administrator purchases the reagent, the administrator can also obtain the cabinet number of the reagent cabinet which can properly store the biological reagent according to the storage temperature information of the biological reagent through the cabinet number retrieval and acquisition part, thereby being convenient for the administrator to put the purchased biological reagent into the corresponding reagent cabinet, and when the biological reagent is put into the reagent cabinet, the administrator can also randomly put the purchased biological reagent into any position on any placement layer without worrying that the management of the biological reagent becomes disordered, thereby greatly saving the energy consumed for reagent scrap and management when purchasing in the laboratory, it also allows biological agents in the laboratory to be effectively managed.

In addition, in the embodiment, the quality guarantee period determination part can determine the quality guarantee periods of all biological reagents in the laboratory, so that reagent abandonment information is automatically generated according to the related information of the biological reagents when the quality guarantee period is exceeded, an administrator can abandon the abandoned biological reagents, and the phenomenon that the deteriorated biological reagents are taken by the laboratory staff to cause accidents is avoided. Further, the reagent storage amount determination unit may determine the biological reagent storage amount after the administrator performs the disposal process, thereby intelligently notifying the administrator whether or not purchase of a new biological reagent is necessary.

In addition, because the II-type reagent cabinet is at-30 ℃ to-100 ℃ in a low-temperature environment, the outward protruding layer eaves are arranged corresponding to each placing layer, and the judging part is arranged below each layer eaves, the judging part which is difficult to work at an excessively low temperature can be arranged at a normal temperature, and the identification of the reagent judging information of each biological reagent in the placing layer is realized in a short time when the cabinet door is opened by a laboratory technician. By the method, the non-fixed biological reagent intelligent management system realizes effective and accurate management effect on all reagent bottles in the reagent cabinet at extremely low temperature.

In addition, because the opening and closing of the cabinet door are sensed by the sensing part, the determination part is allowed to determine when the cabinet door is opened, so that the reagent labels can be continuously read in the states that the cabinet door is closed and the reagent cabinet is not used, the working time of the determination part is shortened, the service life of the determination part is prolonged, and the problem that the reading operation of the cabinet door on the determination part is influenced due to the fact that the reading operation is performed under the condition that the cabinet door is closed is also avoided. For example, if reading is performed when the cabinet door is closed, the discrimination unit is not easy to read the reagent label due to the blockage of the cabinet door; however, if the cabinet door is arranged on the inner side of the cabinet door, the temperature in the placing layer is too low to work normally.

In addition, in the embodiment, the delay handling picture is provided to allow the laboratory technician to carry out the delay handling procedure on the reagent, so that the holding time of the reagent is prolonged by the procedure when the laboratory technician still needs to use the reagent.

In addition, in the embodiment, the scrapping handling picture enables the medical staff to scrap and handle the used up reagent, so that the medical staff can scrap the reagent through the procedure when the reagent needs to be discarded.

Further, since the reagent information updating unit updates the reagent information based on the entry information input by the administrator, the reagent-related information storage unit can be updated when the administrator obtains a new collected human tissue reagent of the patient, and maintenance work of the reagent information can be performed more favorably.

The above-described embodiments are merely illustrative of specific embodiments of the present invention, and the present invention is not limited to the description of the above-described embodiments.

For example, in the above embodiment, the type i reagent cabinet is provided with two symmetrically arranged determination portions on each of the placement layers, and the rough position information is the left side and the right side corresponding to the positions of the determination portions, respectively. In other aspects of the invention, each placing layer can be correspondingly provided with more RFID readers and is uniformly arranged in the placing layer, and the number of corresponding rough positions is further increased, so that the rough position information is more accurate, and the position of the reagent bottle on the placing layer can be more accurately judged.

In addition, in the above embodiment, the type ii reagent cabinet is provided with two determination portions on the layer eaves corresponding to each layer of the placing layer, and the range of the determination portions can cover the whole placing layer. In other schemes of the invention, in order to facilitate the discrimination part to discriminate the whole placement layer, a form of a directional RFID reader can be adopted, the directional RFID reader is installed slightly obliquely outward, i.e. the reading direction of the directional RFID reader faces inward, and meanwhile, an inward inclined slope part can be arranged on the layer brim at the position of the RFID reader, so that electromagnetic waves of the RFID reader enter the placement layer to read the sample label on the biological sample in the placement layer.

Further, when in actual use, more discrimination parts can be correspondingly arranged under each layer of eave according to actual requirements, so that the accuracy of discrimination of rough position information is improved.

For example, in the above embodiment, the warning portion is a warning lamp provided on the front surface of the cabinet door. In another aspect of the present invention, the warning unit may be a sound-light alarm, a display, or another device having a presentation effect, and may be provided at a position on the reagent tank where the warning unit is easily viewed.

Claims (9)

1. An intelligent management method for non-fixed biological reagents is characterized in that a system comprising a reagent cabinet, a laboratory technician terminal and a management server is adopted to realize the management of the biological reagents with reagent labels, and comprises the following steps:

storing reagent identification information and reagent names of all the biological reagents and reagent position information comprising the cabinet number of the reagent cabinet where the biological reagents are located and the layer number of the placing layer as reagent related information;

identifying the identification information of the experimenter by adopting an identification part of the reagent cabinet, and then sending the identification information to the management server;

judging whether the laboratory technician has the opening authority or not at least based on the identification information by adopting the management server, and sending an opening permission signal to the reagent cabinet once the laboratory technician is judged to have the opening authority;

the control module of the reagent cabinet releases the locking of the cabinet door according to the door opening permission so as to enable the experimenter to open the cabinet door for extraction or storage operation;

adopting a judging part to continuously read and adopting a sensing part to sense whether the cabinet door is closed or not, and sending the read reagent judging information and the cabinet number of the reagent cabinet to the management server once sensing that the laboratory technician closes the cabinet door;

the management server judges the access condition of the biological reagent according to the sent information, the reagent discrimination information and the cabinet number, and updates the reagent position information in the reagent related information;

taking the current time as extraction time and storing the current time, the missing reagent discrimination information and the identification information as acquisition time information;

a time judgment module is adopted to regularly judge whether the time difference between each extraction time and the current time in the acquired time information exceeds the first holding time or the second holding time according to a preset first holding time and a second holding time;

if the time difference exceeds the first holding time, sending a time limit reminding message containing the reagent distinguishing information and the extraction time to the experimenter for processing;

and if the time difference exceeds the second holding time, sending the deadline reminding information and corresponding identification information to an administrator for processing.

2. The intelligent management method of non-immobilized bioreagent according to claim 1, wherein:

wherein the experimenter inputs the name of the biological reagent to be extracted as a required reagent name through the scientific research terminal and sends the required reagent name to the management server through the experimenter terminal,

the management server retrieves the consistent reagent discrimination information from the reagent-related information according to the received required reagent name, thereby further acquiring the reagent position information, and sends the retrieved reagent position information and the received required reagent name as extraction information to the experimenter terminal.

3. The intelligent management method of non-immobilized bioreagent according to claim 1, wherein:

wherein the laboratory technician inputs the name of the biological reagent to be returned as the name of the returned reagent through the scientific research terminal and sends the name of the returned reagent to the management server through the laboratory technician terminal,

and retrieving and obtaining the reagent cabinet number of which the environmental temperature accords with the storage temperature of the corresponding biological reagent according to the returned reagent name by adopting a management server, and sending the reagent cabinet number serving as the storage cabinet number to the laboratory technician terminal.

4. The intelligent management method for non-immobilized biological agents according to claim 1, further comprising the following postponed transaction steps:

when the experimenter terminal receives the expiration reminding information, a delay handling picture is displayed to allow the experimenter to input the reagent judgment information of the biological reagent to be delayed as delay reagent judgment information,

and carrying out delay marking on corresponding extraction time in the acquisition time information according to the delay reagent judgment information.

5. The intelligent management method of non-immobilized bioreagent according to claim 1, wherein:

wherein the laboratory technician inputs the reagent discrimination information of the reagent to be discarded as the discarded reagent discrimination information on the discarded transaction screen,

and deleting the corresponding reagent discrimination information, the reagent name and the reagent position information in the reagent related information by using a related information updating module according to the scrapped reagent discrimination information, and then performing scrapping management by using the management server.

6. The intelligent management method of non-immobilized bioreagent according to claim 5, wherein:

the management server carries out scrap management according to the following steps:

after the laboratory technician has performed the discard transaction, the reagent stock determination part is adopted to determine whether the quantity of the corresponding biological reagent is lower than a preset reagent stock quantity according to the reagent determination information,

upon determining that the number of biological reagents is lower than the reagent holding number, the administration server transmits a purchase prompting message containing a reagent name corresponding to the biological reagent determined to be lower than the reagent holding number to the administrator, thereby prompting the administrator to purchase a new biological reagent.

7. The intelligent management method of non-immobilized bioreagent according to claim 1, wherein:

wherein the administrator inputs reagent discrimination information of purchased biological reagents, corresponding reagent names and corresponding storage temperatures as reagent update information on a reagent information input screen,

updating the reagent related information by adopting a related information updating module according to the reagent updating information,

and retrieving and acquiring the reagent cabinet number of which the environmental temperature accords with the storage temperature by adopting a management server according to the storage temperature, and sending the reagent cabinet number serving as the storage cabinet number to the administrator, so that the administrator goes to a corresponding reagent cabinet to store the reagent.

8. The intelligent management method of non-immobilized bioreagent according to claim 1, wherein:

wherein the reagent discrimination information, the production date of the biological reagent, and the corresponding quality guarantee period of all the reagents are stored as the quality guarantee time information,

periodically determining whether the time difference between the current time and the date of production of the biological agent exceeds the corresponding shelf life based on the stored shelf life information,

and once the time difference is judged to exceed the quality guarantee period, the reagent judgment information of the biological reagent and the reagent position information obtained by searching according to the reagent judgment information are sent to the administrator as expiration reminding information for scrapping treatment.

9. The intelligent management method of non-immobilized bioreagent according to claim 8, wherein:

wherein, the process of the scrap disposal by the administrator is as follows:

identifying the identification information of an administrator by using an identification part of the reagent cabinet, and then sending the identification information to the management server;

judging whether the administrator has the opening authority or not at least based on the identification information by adopting the management server, and sending a door opening permission signal to the reagent cabinet once the administrator is judged to have the door opening authority;

the control module of the reagent cabinet releases the locking of the cabinet door according to the door opening permission so as to enable the administrator to open the cabinet door for extraction operation;

adopting the judging part to continuously read and adopting the sensing part to sense whether the cabinet door is closed or not, and sending the read reagent judging information and the cabinet number of the reagent cabinet to the management server once sensing that the manager closes the cabinet door;

the management server judges the access condition of the biological reagent according to the transmitted information, the reagent discrimination information and the cabinet number, and updates the reagent position information in the reagent related information.

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