CN113128631A - Biological sample management system for scientific research - Google Patents
Biological sample management system for scientific research Download PDFInfo
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- CN113128631A CN113128631A CN202011623761.4A CN202011623761A CN113128631A CN 113128631 A CN113128631 A CN 113128631A CN 202011623761 A CN202011623761 A CN 202011623761A CN 113128631 A CN113128631 A CN 113128631A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
- G06K17/0022—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisions for transferring data to distant stations, e.g. from a sensing device
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
- G06K17/0022—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisions for transferring data to distant stations, e.g. from a sensing device
- G06K17/0029—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisions for transferring data to distant stations, e.g. from a sensing device the arrangement being specially adapted for wireless interrogation of grouped or bundled articles tagged with wireless record carriers
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- G—PHYSICS
- G07—CHECKING-DEVICES
- G07C—TIME OR ATTENDANCE REGISTERS; REGISTERING OR INDICATING THE WORKING OF MACHINES; GENERATING RANDOM NUMBERS; VOTING OR LOTTERY APPARATUS; ARRANGEMENTS, SYSTEMS OR APPARATUS FOR CHECKING NOT PROVIDED FOR ELSEWHERE
- G07C9/00—Individual registration on entry or exit
- G07C9/00174—Electronically operated locks; Circuits therefor; Nonmechanical keys therefor, e.g. passive or active electrical keys or other data carriers without mechanical keys
- G07C9/00571—Electronically operated locks; Circuits therefor; Nonmechanical keys therefor, e.g. passive or active electrical keys or other data carriers without mechanical keys operated by interacting with a central unit
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- Physics & Mathematics (AREA)
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- General Engineering & Computer Science (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention provides a biological sample management system for scientific research, which is used for managing a biological sample with a sample label and comprises the following components: a sample cabinet; a scientific research personnel terminal; and a management server, wherein the sample cabinet comprises a cabinet body, a cabinet door, a judging part, a locking part and an identifying part, the management server comprises a biological sample related information storage part, a retrieval acquiring part and an access judgment updating part, once the identifying part identifies the identifying information, the sample cabinet control part controls the sample cabinet communication part to send the identifying information to the management server, controls the locking part to unlock when receiving a door opening permission signal, controls the judging part to judge the biological label to obtain corresponding biological sample judging information, and the access judgment updating part judges the access condition of the biological sample according to the received cabinet number, layer number and biological sample judging information and updates the corresponding sample position information in the biological sample related information storage part.
Description
Technical Field
The invention relates to a biological sample management system for scientific research.
Background
The biological sample refers to organs, tissues, cells, biological macromolecules and the like derived from human bodies, other animals or plants, and is used as a sample in scientific research work. Among them, important resource facilities in the scientific research of biological sample libraries composed of one or more types of biological samples, for example, in molecular genetics, some research projects require a large number of genetic resource samples, and thus need to utilize the human genome library for completion; pathological studies typically require a large number of pathological tissue samples and therefore rely on a library of pathological samples.
In order to ensure the rich diversity of biological samples, a large amount of biological samples need to be stored and managed in the process of establishing and subsequent maintenance of the biological sample library. Meanwhile, the storage conditions of these biological samples are harsh, and generally require environments such as a low-temperature freezer (-30 below) or an ultra-low-temperature freezer (-80 ℃) and even liquid nitrogen. Due to the large number and harsh conditions, the management of biological samples is often confused, for example, when it is necessary to take a biological sample, it is not clear where to store it, and when it is returned, it is not clear where to return it. Further, such circumstances make scientific research personnel take or need spend the long time to open the cabinet door and look over when returning, and in case the time of opening the door overlength, the temperature in low temperature or the ultra-low temperature freezer just rises by the external influence easily, even close the cabinet door also need the certain time cooling to resume, other biological samples in the cabinet still will receive the influence or even probably become invalid.
In order to solve the above problem, some sample libraries may use a method of dividing a specific storage area, which can solve the problem of disordered storage of samples to some extent. However, after the biological sample library is built, new samples are usually collected continuously, and there is a possibility that existing biological samples may be taken away for use, so that some storage cabinets are fully stacked but another part of storage cabinets are empty; if the storage location is replaced to balance the storage situation, the problem of storage confusion is newly generated.
Disclosure of Invention
In order to solve the above problems, the present invention provides a biological sample management system for scientific research, which can effectively manage biological samples, and the biological sample management system for scientific research is characterized by comprising: at least one sample holder for holding a biological sample; at least one researcher terminal held by a researcher using a biological sample; and a management server which is respectively in communication connection with the sample cabinet and the scientific research personnel terminal, wherein the sample cabinet comprises a cabinet body with at least one placing layer for placing biological samples, at least one cabinet door arranged corresponding to the placing layer, at least one judging part arranged corresponding to the placing layer, at least one locking part arranged corresponding to the cabinet door and used for locking the cabinet door, an identification part for identifying the identification information of the scientific research personnel, a sample cabinet communication part and a sample cabinet control part, the scientific research personnel terminal comprises a picture storage part, an input display part and a terminal side communication part, the management server comprises a biological sample related information storage part, a retrieval acquisition part, an access judgment updating part, a management side communication part and a management side control part, and the biological sample name of each biological sample is at least stored in the biological sample related information storage part, The corresponding sample discrimination information and the corresponding sample position information at least comprising the cabinet number of the sample cabinet where the biological sample is located and the layer number of the placed layer are stored in the picture storage part, a biological sample request picture and an extraction information display picture are stored in the picture storage part, the input display part displays the biological sample request picture to allow a scientific researcher to input the name of the biological sample to be extracted as the name of the required biological sample, once the scientific researcher confirms the input name of the required biological sample, the terminal side communication part sends the name of the required biological sample to the management server, the management side control part controls the retrieval acquisition part to retrieve the biological sample related information storage part according to the name of the required biological sample and acquire the corresponding sample position information, and controls the management side communication part to send the name of the required biological sample and the retrieved sample position information to the scientific researcher terminal as extraction information, the input display part displays an extracted information display picture and displays the received extracted information in the picture, thereby leading scientific research personnel to go to a corresponding sample cabinet according to the extracted information and operate the identification part to identify the identification part, once the identification part identifies the identification information, the sample cabinet control part controls the sample cabinet communication part to send the identification information to the management server for judgment, and controls the corresponding locking part to unlock when receiving a door opening permission signal fed back from the management server, thereby leading the scientific research personnel to open the cabinet door and extract a biological sample in a placing layer corresponding to the extracted information, simultaneously controls the judgment part to judge a biological label on the biological sample to obtain corresponding sample judgment information, further controls the sample cabinet communication part to send the obtained sample judgment information, the cabinet number of the sample cabinet and the corresponding layer number to the management server, the management-side control unit controls the access judgment update unit to determine the access condition of the biological sample based on the received cabinet number, layer number, and sample discrimination information, and updates the sample position information corresponding to the biological sample-related information storage unit.
Action and Effect of the invention
According to the biological sample management system for scientific research provided by the invention, each biological sample in the sample cabinet is provided with the sample label containing the sample distinguishing information, and each sample cabinet is provided with the distinguishing part for distinguishing the sample label, so that the biological label on the biological sample can be distinguished after the cabinet door is unlocked, and the corresponding sample distinguishing information can be obtained, the access judgment updating part can judge the access condition of the biological sample according to the sample distinguishing information and update the sample position information, and the position of each biological sample can be effectively obtained and timely updated and stored in the sample related information storage part.
Drawings
FIG. 1 is a schematic diagram showing a biological sample management system for scientific research according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a sample cabinet according to an embodiment of the present invention;
FIG. 3 is a schematic view of an installation location of an RFID reader of an embodiment of the present invention;
FIG. 4 is a range diagram of an RFID reader of an embodiment of the present invention;
FIG. 5 is a functional block diagram of a sample cabinet in an embodiment of the invention;
FIG. 6 is a schematic diagram of the storage contents of the cabinet number layer number storage unit in the embodiment of the present invention;
fig. 7 is a block diagram of the structure of a management server in the embodiment of the present invention;
FIG. 8 is a diagram showing the contents stored in the sample correlation information storage unit according to the embodiment of the present invention;
FIG. 9 is a schematic diagram of the storage contents of the request record storage unit in the embodiment of the present invention;
FIG. 10 is a schematic diagram of the storage contents of the extraction record storage unit in the embodiment of the present invention;
FIG. 11 is a block diagram showing a structure of a terminal of a researcher in the embodiment of the present invention;
FIG. 12 is a sample request screen diagram according to an embodiment of the invention;
FIG. 13 is a schematic view of an extracted information display screen according to an embodiment of the present invention;
FIG. 14 is a diagram illustrating a return request screen in an embodiment of the invention;
FIG. 15 is a flow chart of a sample request process in an embodiment of the present invention;
fig. 16 is a flow chart of a sample extraction or return process in an embodiment of the invention.
Detailed Description
The present invention will be described in detail with reference to the drawings.
In one aspect, the present invention provides a biological sample management system for scientific research for managing a biological sample having a sample label, including: at least one sample holder for holding a biological sample; at least one researcher terminal held by a researcher using a biological sample; and a management server which is respectively in communication connection with the sample cabinet and the scientific research personnel terminal, wherein the sample cabinet comprises a cabinet body with at least one placing layer for placing biological samples, at least one cabinet door arranged corresponding to the placing layer, at least one judging part arranged corresponding to the placing layer, at least one locking part arranged corresponding to the cabinet door and used for locking the cabinet door, an identification part for identifying the identification information of the scientific research personnel, a sample cabinet communication part and a sample cabinet control part, the scientific research personnel terminal comprises a picture storage part, an input display part and a terminal side communication part, the management server comprises a biological sample related information storage part, a retrieval acquisition part, an access judgment updating part, a management side communication part and a management side control part, and the biological sample name of each biological sample is at least stored in the biological sample related information storage part, The corresponding sample discrimination information and the corresponding sample position information at least comprising the cabinet number of the sample cabinet where the biological sample is located and the layer number of the placed layer are stored in the picture storage part, a biological sample request picture and an extraction information display picture are stored in the picture storage part, the input display part displays the biological sample request picture to allow a scientific researcher to input the name of the biological sample to be extracted as the name of the required biological sample, once the scientific researcher confirms the input name of the required biological sample, the terminal side communication part sends the name of the required biological sample to the management server, the management side control part controls the retrieval acquisition part to retrieve the biological sample related information storage part according to the name of the required biological sample and acquire the corresponding sample position information, and controls the management side communication part to send the name of the required biological sample and the retrieved sample position information to the scientific researcher terminal as extraction information, the input display part displays an extracted information display picture and displays the received extracted information in the picture, thereby leading scientific research personnel to go to a corresponding sample cabinet according to the extracted information and operate the identification part to identify the identification part, once the identification part identifies the identification information, the sample cabinet control part controls the sample cabinet communication part to send the identification information to the management server for judgment, and controls the corresponding locking part to unlock when receiving a door opening permission signal fed back from the management server, thereby leading the scientific research personnel to open the cabinet door and extract a biological sample in a placing layer corresponding to the extracted information, simultaneously controls the judgment part to judge a biological label on the biological sample to obtain corresponding sample judgment information, further controls the sample cabinet communication part to send the obtained sample judgment information, the cabinet number of the sample cabinet and the corresponding layer number to the management server, the management-side control unit controls the access judgment update unit to determine the access condition of the biological sample based on the received cabinet number, layer number, and sample discrimination information, and updates the sample position information corresponding to the biological sample-related information storage unit.
Above-mentioned embodiment can also have such technical characteristic among the biological sample management system for scientific research, wherein, the sample label is the RFID label, and the sample cabinet is low temperature type or the freezing storing compartment of ultra-low temperature type biological sample, and the cabinet door is the heat preservation cabinet door, and every layer interlayer board of placing the upside on layer has the layer eaves portion that extends to the outside, and the judgement portion is the RFID and reads the ware, installs the position department that is close to the outside surface of heat preservation cabinet door on the layer eaves portion.
Further, the biological sample management system for scientific research can also have the technical characteristics that two ends of the length direction of each layer of cornice part are respectively provided with an RFID reader, the reading range of the RFID readers is larger than one half of the width of the interlayer plate and smaller than the width of the interlayer plate, and the sample cabinet control part judges the placement position of a scientific research worker on a placement layer when returning or newly adding a biological sample according to the reading conditions of the two RFID readers when the RFID readers read the sample tags, so that the sample position information in the sample related information storage part also comprises the placement position.
Further, above-mentioned biological sample management system for scientific research can also have such technical characteristics, wherein, the sample cabinet still includes and corresponds the setting with the cabinet door and be used for carrying out the at least one response portion that responds to cabinet door open-close state, and sample cabinet control portion controls the portion of distinguishing and differentiates the biological label of placing the layer when response portion senses that the cabinet door is under the open mode and obtains corresponding sample discrimination information to control sample cabinet communication portion and send sample discrimination information and cabinet number and layer number for management server when response portion senses that the cabinet door is closed.
Further, the biological sample management system for scientific research can also have the technical characteristics that the reading direction of the RFID reader faces towards the inner side of the placing layer, and a slope portion inclining towards the placing layer is further arranged on the eaves portion of the placing layer.
In addition, above-mentioned biological sample management system for scientific research can also have such technical characteristics, and wherein, sample cabinet control part controls locking part and locks the cabinet door when receiving the signal of closing the door that response portion sensed the cabinet door and was closed by scientific research personnel.
The biological sample management system for scientific research according to the above-described embodiment may further include a management server that controls the sample locker communication unit to transmit the sample discrimination information, the locker number, and the layer number to the management server, and also to transmit the identification information identified by the identification unit to the management server, wherein the management-side control unit controls the extraction record storage unit to store the sample discrimination information and the identification information of the biological sample determined to be taken out as the extraction record when the access determination updating unit determines that the biological sample is to be taken out.
The scientific biological sample management system according to the above-described embodiment may further include such technical features, wherein the biological sample-related information storage unit further stores storage request information for each biological sample, the storage requirement information comprises a cabinet number and a layer number of a sample cabinet meeting the storage requirement of the biological sample, the image storage part also stores a return request image, the input display part also displays the return request image and displays an extraction record corresponding to the scientific research personnel received from the management server according to the identification information in the return request image so that the scientific research personnel can select the biological sample needing to be returned, and further displays the storage requirement information corresponding to the biological sample received from the management server according to the biological sample selected by the scientific research personnel in the return request image, thereby let scientific research personnel go to corresponding sample cabinet according to depositing requirement information and carry out the operation of returning.
The biological sample management system for scientific research of the above embodiment may further include a request record storage unit and an identity search determination unit, wherein the management server further includes a request record storage unit and an identity search determination unit, the terminal-side communication unit controls the management-side communication unit to send the input name of the required biological sample to the management server and send the identification information of the scientific research staff to the management server, the management-side control unit controls the management-side communication unit to send the extracted information to the terminal of the scientific research staff and controls the request record storage unit to store the extracted information and the identification information of the corresponding scientific research staff, and when the management-side communication unit receives the identification information sent from the sample cabinet, the identity search determination unit determines whether the corresponding extracted information exists in the request record storage unit according to the identification information and further determines whether the cabinet number of the sample cabinet sending the identification information exists in the extracted information, when the door is judged to exist, the management side communication part sends a door opening permission signal to the sample cabinet.
Further, the biological sample management system for scientific research may further include a technical feature in which the management server further includes an extraction and verification unit, the sample cabinet further includes a warning unit for issuing a warning prompt, the request record storage unit stores the extraction information and the identification information in association with each other, and the biological sample name is stored, and when the access judgment update unit judges the access condition of the biological sample, the extraction and verification unit acquires the biological sample name corresponding to the identification information from the request record storage unit as an extraction subject name based on the identification information of the extracted biological sample, and acquires the corresponding biological sample name from the biological sample-related information storage unit as an actual extraction name based on the received sample discrimination information, and further determines whether the extraction subject name is identical to the actual extraction name, and when it is determined that the extraction subject name is not identical to the actual extraction subject name, the management side control part controls the management side communication part to send a warning signal to the corresponding sample cabinet, and the sample cabinet control part controls the warning part to start warning when the sample cabinet communication part receives the warning signal so as to remind scientific research personnel of extracting wrong biological samples.
< example >
FIG. 1 is a schematic diagram showing a biological sample management system for scientific research according to an embodiment of the present invention.
As shown in fig. 1, the biological sample management system 100 for scientific research of the present embodiment is used for managing biological samples 200, and includes a plurality of sample cabinets 1, a management server 2, a plurality of scientific research personnel terminals 3, and communication networks 4a and 4 b.
The management server 2 is respectively in communication connection with each sample cabinet 1 through a communication network 4a and is respectively in communication connection with each scientific research personnel terminal through a communication network 4 b. In this embodiment, the communication networks 4a and 4b are both local area networks.
The scientific research personnel terminals 3 are personal computers, are respectively held by different scientific research personnel and carry out related operations, and identification information corresponding to the respective scientific research personnel is stored in each scientific research personnel terminal 3. The scientific researchers involved in the present invention may be sample library management personnel who manage the biological sample 200, or may be scientific research experimenters who have access rights to the biological sample 200. In addition, the biological samples 200 are physiological or pathological samples of human body, other animals or plants obtained by sampling, including but not limited to organs, tissues, cells and biological macromolecules, and the forms of the biological samples 200 and the containers thereof may be the same or different according to the preservation requirement; either as containers containing a single sample (e.g., tubes, bags or bottles) or as containers containing multiple aliquots of the same sample (e.g., cartridges containing multiple tubes or tubes). A corresponding sample tag 201 is fixed to each container of the biological sample 200, and the sample tag 201 is a low-temperature RFID tag containing sample discrimination information and can normally operate in low-temperature and ultra-low-temperature environments.
Fig. 2 is a schematic structural diagram of a sample cabinet in an embodiment of the invention. In fig. 2, the storage rack and the storage cassette for storing the biological samples 200 are omitted to show the structure more clearly.
As shown in fig. 2, the sample chamber 1 includes a chamber body 10, a placement layer 11, a chamber door 12, a locking portion 13, a sensing portion 14, a determination portion 15, an identification portion 16, a warning portion 17, and a main control chip 18. In this embodiment, sample cabinet 1 still is equipped with cooling mechanism such as compressor, is used for carrying out the temperature setting mechanism that the temperature set for, is used for detecting the temperature detection mechanism who places layer 11 internal temperature and controls the control mechanism who realizes the control by temperature change according to temperature detection result and the work of setting for the temperature to cooling mechanism, thereby the specific constitution and the theory of operation of these mechanisms are the same with among the ultra-low temperature refrigerator among the prior art, and it is no longer repeated here.
Three placing layers 11 for placing the biological samples 200 are arranged in the cabinet 10, and the adjacent placing layers 11 are separated by a layer plate.
In this embodiment, the interlayer plate is a heat-insulating plate having a certain thickness. The interlayer sheet does not have any restriction structure for the sample, and thus the biological sample 200 can be freely placed on the placement layer 11.
The number of the cabinet door 12, the locking portion 13, the sensing portion 14, and the determination portion 15 is three, and each corresponds to each placement layer 11.
Wherein, the cabinet door 12 is hinged on the cabinet body 10 at the side position of the placing layer 11. Cabinet door 12 is the heat preservation cabinet door, by the metal level that is located the outside and be located the heat preservation of inboard and constitute, and the layer 11 is placed to the heat preservation orientation inside to realize the heat preservation function.
The locking portion 13 is an electronic lock, is disposed on the cabinet door 12 or on the cabinet body 10 at a position corresponding to the edge of the cabinet door 12, and can lock and unlock the cabinet door 12 according to the control electrical signal of the main control chip.
The sensing part 14 is a proximity switch, is disposed on each cabinet door 12 or on the cabinet body 10 at a position corresponding to the edge of each cabinet door 12, and can sense whether the corresponding cabinet door 12 is in a closed state and generate a corresponding electrical signal.
The discrimination unit 15 discriminates the specimen label 201 on the biological specimen 200 when the biological specimen 200 is taken out or placed.
Fig. 3 is a schematic view of an installation position of an RFID reader according to an embodiment of the present invention, and fig. 3 shows a partial sectional structure of a sample cabinet.
As shown in fig. 2 and 3, in the present embodiment, each determination unit 15 is constituted by two RFID readers 151. The upper interlayer board of each placement layer 11 extends outward to form a layer eaves portion 111, and the two RFID readers 151 are embedded in the layer eaves portions 111 of the upper interlayer boards of the placement layers 11 corresponding to the determination unit 15, and are located at both ends (corresponding to the left and right sides) in the width direction of the interlayer boards. Meanwhile, each RFID reader 151 is located at the outer edge position of the interlayer plate, and the position corresponds to the outer surface position of the cabinet door 12, that is, a space with a heat preservation effect is enclosed between the heat preservation layer of the cabinet door 12 and each interlayer plate of the placement layer 11, and the RFID reader is located outside the heat preservation space, so that the RFID reader is not affected by low temperature in the space and can work normally.
FIG. 4 is a range diagram of an RFID reader of an embodiment of the present invention. Wherein, fig. 4(B) is a schematic range diagram in the width direction, fig. 4(a) is a schematic range diagram in the depth direction, and the broken lines in the diagram each indicate the read range of the RFID reader; in addition, in fig. 4(B), the cabinet door 12 is omitted.
As shown in fig. 4(a), in the present embodiment, the read range D of the RFID reader 151 in width is greater than one-half of the width L of the interlayer board and smaller than the width L. Since the RFID readers 151 are respectively located at both ends of the interlayer sheet, when the biological sample 200 is stored from a position near one end of the interlayer sheet (for example, placed in the placement layer 11 from a position near the left or right), only one RFID reader 151 near the biological sample 200 can read the sample label 201 thereon, and when the biological sample 200 is picked up or placed from a position near the middle of the interlayer sheet, both RFID readers 151 can read the sample label 201 thereon. For example, in fig. 4(a), a biological sample 200a is put in from the right area, and its biological tag 201a is read only by the RFID reader 151 on the right side during the putting in; the biological sample 200b is put in from the middle area, so that the biological tag 201a thereof can be read by two RFID readers 151 at the same time during the putting in process; the biological specimen 200a is put in from the left area, and the biological tag 201a thereof is read only by the RFID reader 151 on the left side during the putting in. Thus, the specimen rack control unit can determine the approximate location (left area, right area, or middle area) where the biological specimen 200 is stored, based on the fact that the two RFID readers 151 read the biological tag 201.
In addition, as shown in fig. 4(B), the reading direction of the RFID reader 151 in the present embodiment is not directed inward (i.e., is not directed toward the inside of the setting layer 11) when viewed from the depth direction, so that the RFID reader 151 cannot read the sample label 201 on the biological sample 200 in the setting layer 11 regardless of the opened or closed state of the cabinet door 12.
Specifically, the RFID reader 151 of the present embodiment is a directional RFID reader, and the directional RFID reader is installed slightly obliquely outward, that is, the reading direction of the directional RFID reader faces outward, so that the sample tag 201 is read only in the picking and placing process. For example, in fig. 4(B), once the cabinet door 12 is opened, the RFID reader 151 can read the bio-tag 201d on the biological sample 200d being put in, but cannot read the bio-tag 201e on the biological sample 200e already positioned in the setting layer 11. That is, since the reading directions of the RFID readers 151 are all facing outward, the sample tags 201 on the biological samples 200 in the placement layer 11 are not read, and the biological samples 200 can only pass through the reading area of the RFID readers 151 in the taking and placing processes, so that the sample tags 201 thereon are read.
In addition, in this embodiment, the interlayer plate further has a metal interlayer 112, and the metal interlayer 112 forms a shielding effect, so the RFID reader 151 does not read the sample tag 201 on the biological sample 200 in the adjacent placement layer 11.
The recognition unit 16 is provided on the cabinet 10 and recognizes recognition information of a researcher.
In this embodiment, the identification information is door opening information, a password, two-dimensional code information corresponding to the identity of a researcher, fingerprint information of the researcher, or face information in a door opening card held by the researcher, and the identification unit 16 is a door card reading device, a password input device, a two-dimensional code scanning device, a fingerprint identification device, or a face identification device corresponding to the identification information. The scientific researchers can operate the identification part 16 in a corresponding mode (namely, the operations of swiping a card, inputting a password, scanning a two-dimensional code, verifying a fingerprint, shooting a human face and the like) so that the identification part 16 can identify the identification information of the scientific researchers.
In this embodiment, the identification information corresponds to the identity of each scientific research personnel, that is, each scientific research personnel has unique identification information, and the identity of each scientific research personnel can be directly and correspondingly determined through the identification information.
The warning section 17 is used to generate warning information. In this embodiment, the warning portion 17 is a warning light disposed on the front surface of the cabinet 10, and is configured to generate a light flash when receiving the warning message.
Fig. 5 is a functional block diagram of a sample cabinet in an embodiment of the invention.
As shown in fig. 5, the main control chip 18 is electrically connected to the locking portion 13, the sensing portion 14, the determination portion 15, the identification portion 16, and the warning portion 17, respectively, and controls operations of these components. The main control chip 18 includes a sample cabinet communication section 181 and a cabinet number layer number storage section 182.
The sample chamber communication unit 181 is a communication module connected to the main control chip 18, and is used to perform data communication between the sample chamber 1 and the management server 2.
In this embodiment, the cabinet number layer number storage unit 182 records the respective cabinet number, and the scientific research personnel can find the corresponding sample cabinet 1 through the cabinet number. Meanwhile, in each sample cabinet 1, the respective placement layers 11 also have respective unique layer numbers. Since the determination unit 15 corresponds to each placement layer 11, actually, the determination unit 15 also corresponds to each layer number, so that when the determination unit 15 reads the sample label 201, the main control chip 18 can determine which determination unit 15 of which placement layer 11 has read the sample label according to the correspondence. For convenience of description, hereinafter, the three set layers 11 are referred to as a set layer 11a, a set layer 11b, and a set layer 11c, and the determination units 15 corresponding to the set layer 11a, the set layer 11b, and the set layer 11c are referred to as a determination unit 15a, a determination unit 15b, and a determination unit 15c, respectively.
Fig. 6 is a schematic diagram of the storage contents of the cabinet number layer number storage unit in the embodiment of the present invention.
As shown in fig. 6, the sample tank 1 having the tank number "GH 1" shown in fig. 6 is exemplified by having three storage layers 11, the layer numbers of which are "CHa", "CHb" and "CHc", respectively, and the numbers of the three discrimination sections are "PBa", "PBb" and "PBc", respectively.
In addition, similarly, since the locking part 13 and the sensing part 14 also correspond to the placing layer 11, the main control chip 18 can also perform corresponding control of locking or unlocking according to the corresponding relationship, or obtain the sensing result of the opening/closing state of the corresponding cabinet door 12.
Fig. 7 is a block diagram of the management server in the embodiment of the present invention.
As shown in fig. 7, the management server 2 includes a sample-related information storage unit 21, a search acquisition unit 22, a request record storage unit 23, an access determination update unit 24, an extraction record storage unit 25, an identity search determination unit 26, an extraction check unit 27, a management-side communication unit 28, and a management-side control unit 29.
The sample-related information storage unit 21 stores sample identification information, a corresponding sample name, sample position information, and storage request information.
Fig. 8 is a content stored in the sample related information storage unit in the embodiment of the present invention.
As shown in fig. 8, the sample-related information storage unit 21 stores the following information: sample discrimination information 211, sample name 212, sample position information 213, and storage request information 214. Specifically, the method comprises the following steps:
the specimen discrimination information 211 is unique number information of the biological specimen 200, which is also stored in the chip of the specimen tag 201, and thus can be obtained by an RFID reader once the specimen tag 201 is read.
The specimen name 212 is the name of the specimen contained in the specimen bottle.
The sample position information 213 includes the cabinet number of the sample cabinet 1, the layer number of the placement layer 11, and the position in the placement layer 11. Each sample position information 213 takes the form of a bin number and a layer number. Taking 1 having a bin number GH1 and including three placement levels 11 as an example, as shown in fig. 8, the first few bits of each sample position information 213 are the corresponding bin number, the last few bits are the level number, and the last few bits are the positions (left, middle, or right) in the placement level 11, thereby avoiding the situation where the same sample position information 213 occurs in the same number of placement levels 11 of different sample bins 1.
The storage request information 214 includes the bin number and the layer number of the sample bin 1 in which the biological sample 200 can be stored. Due to different storage requirements of different biological samples 200, the samples may be stored in the sample cabinets 1 with different set temperatures due to temperature requirements, and the samples with the same storage temperature may be stored separately due to sample storage safety requirements (for example, a physiological sample and a pathological sample should be stored separately, and a sample containing an infectious pathogen should be completely isolated from other samples). In addition, since the storage layers 12 are separated by the layer plates, they can be regarded as an independent storage environment, and the storage requirement information includes the number of the sample cabinet 1 in which a certain biological sample 200 can be stored and the layer number (i.e., the number of the sample cabinet 1 and the layer number that satisfy the storage requirements in various aspects such as the temperature requirement and the isolation requirement of the biological sample 200). The storage requirement information 214 of each biological sample 200 may have a plurality of bin number layer numbers (i.e., the biological sample 200 may be placed in any one of the corresponding plurality of placement layers 11), or may have only one (i.e., the biological sample 200 may be placed in only one of the corresponding placement layers 11), according to the storage requirement.
In this embodiment, the sample discrimination information 211 may have the same sample name (for example, if the biological samples 200 are formed by sub-packaging the same type of sample from the same source, the biological samples 200 all have the same sample name). Meanwhile, the plurality of sample discrimination information 211 may correspond to the same sample position information 213 (for example, a plurality of biological samples 200 are carried on a placement layer of the same sample cabinet). The sample name 212 may also include some information in the form of numbers, such as a sampling number, according to the naming requirement, but the number information in the sample name 212 and the number of the sample identification information 211 may be independent of each other and have no corresponding relationship. In addition, the storage request information 214 corresponding to each sample discrimination information 211 may include a plurality of the cabinet numbers and the layer numbers, for example, if a certain biological sample 200 may be stored in a plurality of the storage layers 12 of different sample cabinets 1, the storage request information 214 includes all the cabinet numbers and the layer numbers thereof that satisfy the storage request.
The search acquisition unit 22 is configured to, upon receiving the name of the required sample and the identification information transmitted from the researcher terminal 3, search the sample-related information storage unit 21 based on the received name of the required sample and acquire corresponding sample position information.
In the present embodiment, after the search acquisition unit 22 acquires the sample position information under the control of the management-side control unit 29, the management-side control unit 29 also controls the management-side communication unit 28 to transmit the searched sample position information and the received desired sample name to the researcher terminal 3 as the extraction information. In the extracted information, the sample position information corresponding to one demand sample name may be plural.
Fig. 9 is a schematic diagram of the storage content of the request record storage unit in the embodiment of the present invention.
As shown in fig. 9, the request record storage unit 23 is configured to store the extracted information and the identification information received from the terminal 3 of the scientific researcher as one request record 231 while the management-side communication unit 28 transmits the extracted information. In this embodiment, when the scientific researcher selects a plurality of demand samples at the same time, the request record storage unit 23 also stores each corresponding piece of extracted information and identification information as a different request record 231.
The access judgment update unit 24 is used to update the specimen judgment information and the specimen position information in the specimen-related information storage unit 21 when the researcher takes the biological specimen 200 or returns the biological specimen 200.
In this embodiment, the main control chip 18 controls the determining part 15 to continuously perform the reading action after the sensing part 14 senses that the cabinet door 12 is opened, so that the sample label 201 can be determined by the determining part 15 when the biological sample 200 is taken and placed; meanwhile, the main control chip 18 also temporarily stores all the sample discrimination information read during the continuous reading operation and the number of times of reading. Then, when the sensing unit 14 senses that the cabinet door 12 is closed again, the main control chip 18 controls the sample cabinet communication unit 181 to transmit the identification number, the cabinet number, the layer number corresponding to the determination unit 15, and all the sample determination information and the number of readings read by the layer number to the management server 2 while controlling the locking unit 13 to lock the cabinet door 12.
The access judgment updating section 24 judges the access of the biological sample 200 based on the transmitted information, and updates the sample position information in the biological sample related information storage section 21. That is, when the same sample discrimination information is read for an odd number of times, it is first determined whether the cabinet number and the layer number already exist in the sample position information corresponding to the sample discrimination information, and if so, it is determined that the biological sample 200 is taken out, and the sample position information corresponding thereto is rewritten to "taken out" or similar contents indicating that it has been taken out; if there is no cabinet number and layer number (i.e., it has been marked as "taken out"), it is determined that the biological sample 200 is placed, and at this time, the corresponding sample position information is rewritten into the cabinet number and layer number corresponding to the determination section 15 (which can be obtained from the information sent from the sample cabinet 1), and further added to the sample position information based on the position information (for example, the left, right, or middle area) read by the determination section 15. When the same sample discrimination information is read even times, the access judgment update unit 24 does not rewrite the corresponding sample position information at the time when the corresponding biological sample 200 is considered to be taken out and put back or taken out after putting in.
Fig. 10 is a schematic diagram of the storage content of the extraction record storage unit in the embodiment of the present invention.
As shown in fig. 10, when the access judgment update unit 24 judges that a certain biological sample 200 has been taken out, the extraction record storage unit 25 stores the corresponding sample discrimination information and the identification information received from the sample rack 1 as one extraction record 251. In this embodiment, the extraction record storage unit 25 also deletes the corresponding extraction record 251 when the access judgment update unit 24 judges that a certain biological sample 200 is returned. When the access judgment update unit 24 judges that a certain biological sample 200 has been taken out, the request record storage unit 23 also deletes the corresponding request record 231 based on the received identification information.
The identity retrieval determination unit 26 is configured to perform a search of the request record storage unit 23 and the extracted record storage unit 25 to determine whether or not the scientific researcher has the authority to open the sample cabinet based on the information received from the sample cabinet 1.
In this embodiment, when the scientific researcher operates the recognition unit 16 to recognize the identification information by the recognition unit 16, and the sample cabinet communication unit 181 transmits the identification information and the cabinet number of the sample cabinet to the management server 2, the identity search determination unit 26 searches the request record storage unit 23 and the extraction record storage unit 25 under the control of the management-side control unit 29, respectively, and thereby completes the determination.
Specifically, when the request record storage unit 23 is searched, the identity search determination unit 26 searches the request record storage unit 23 based on the received identification information and the bin number, determines whether or not a matching request record 231 exists, and further determines whether or not the bin number exists in the sample position information of the matching request record 231 when the matching request record exists; when the extraction record storage unit 25 is searched, the identity search determination unit 26 searches the extraction record storage unit 25 based on the received identification information and determines whether or not there is a matching extraction record 251, and when there is a matching extraction record 251, acquires the corresponding storage request information from the sample basic information storage unit 21 based on the sample identification information in the extraction record 251 and determines whether or not the cabinet number is present in the acquired storage request information.
When the final result of any one of the two determinations is present (that is, the transmitted cabinet number is present in the sample position information of the request record 231 or the cabinet number is present in the storage request information), the management-side control unit 29 controls the management-side communication unit 28 to transmit a door opening permission signal to the sample cabinet 1, thereby allowing the scientific researcher to open the cabinet door. The door open permission signal includes a layer number, which is the layer number in the request record in the case where the request records 231 match; in the case where the extraction records 251 match, the layer number is one or more layer numbers corresponding to the cabinet number in the storage requirement information.
If neither of the above determinations is determined to exist, no response is made (alternatively, the management-side communication unit 28 may transmit a warning signal to the corresponding sample rack 1, and the warning unit 17 may issue a warning to warn the scientific researchers).
The extraction checking section 27 checks whether or not the extracted biological sample 200 is correct based on the determination result of the access determination updating section 24 and the storage contents in the extraction record storage section 25.
In the present embodiment, once the access judgment updating unit 24 has completed the judgment of the access situation of the biological sample 200, the extraction checking unit 27 acquires the name of the corresponding biological sample 200 from the request record storage unit 23 as the name to be extracted based on the identification information, and acquires the name of the corresponding biological sample 200 from the biological sample-related information storage unit 21 as the actual extraction name based on the received sample judgment information 211, and further judges whether the name to be extracted and the actual extraction name are identical, and if not, judges that the scientific researcher has extracted an erroneous sample. At this time, the management-side control unit 29 controls the management-side communication unit 28 to transmit a warning signal to the corresponding sample rack 1, and causes the warning unit 17 to activate a warning to notify the scientific research staff that an erroneous sample has been taken out.
The management-side communication unit 28 is used for performing data communication between the management server 2 and the reagent cabinets 1 and the scientific research staff terminals 3.
The management-side control unit 29 includes a computer program for controlling the operations of the respective units of the management server 2.
Fig. 11 is a block diagram of a terminal of a researcher in the embodiment of the present invention.
As shown in fig. 11, the terminal 3 of the scientific researcher includes a screen storage unit 31, an input display unit 32, a terminal-side communication unit 33, and a terminal-side control unit 34.
The screen storage unit 31 stores a sample request screen 311, an extracted information display screen 312, and a return request screen 313.
FIG. 12 is a sample request screen diagram according to an embodiment of the invention.
As shown in fig. 12, the sample request screen 311 is used for displaying when the scientific research personnel applies for the sample and displaying an input box in the screen to let the scientific research personnel input the name of the required sample. Specifically, the sample request screen 311 includes a text box 3111 for allowing a researcher to input characters and a confirmation button 3112 for confirming the input contents, and when the researcher confirms by inputting a character in the text box 3111 and clicking the confirmation button 3112, the terminal-side communication unit 33 transmits the character as a required sample name to the management server 2, and the search acquisition unit 22 searches the required sample name received for the matching sample discrimination information from the sample-related information storage unit 21, thereby further acquiring the sample position information. In actual use, the sample request screen may display the sample name of the existing biological sample 200 received from the management server 2 in a pull-down menu or list display manner, so that the researcher may input the sample name for retrieval and selection.
Fig. 13 is a schematic diagram of an extracted information display screen according to an embodiment of the present invention.
As shown in fig. 13, the extracted information display screen 312 is used to display the received extracted information when the extracted information sent by the management server 2 is received, so that the scientific research personnel can go to the corresponding sample cabinet 1 and obtain the biological sample 200 in the corresponding placement layer 11.
In addition, when the retrieval acquiring unit 22 does not retrieve the corresponding sample position information according to the desired sample name, the management-side control unit 29 controls the management-side communication unit 28 to transmit an extraction message not containing the desired sample name and the sample position information to the scientific researcher terminal 3, and the extraction message display screen 312 displays a corresponding prompt character (for example, "no corresponding result is retrieved") to notify the scientific researcher that the corresponding biological sample 200 is not retrieved.
Fig. 14 is a diagram illustrating a return request screen in an embodiment of the present invention.
As shown in fig. 14, the return request screen 313 is used for displaying when the researcher performs a return operation, the return request screen 313 includes an extraction information display portion 3121 and a storage request display portion 3122, the extraction information display portion 3121 is used for displaying the corresponding extraction record 251 received from the management server 2 according to the identification information of the researcher, and displaying the sample name corresponding to the extraction record 251, so that the researcher can select the biological sample 200 to be returned; the storage requirement display portion 3122 is configured to display storage requirement information corresponding to the biological sample 200 received from the management server 2 according to the biological sample 200 selected by the scientific researcher, so that the scientific researcher can go to the corresponding sample cabinet 1 to return the biological sample according to the storage requirement information.
The input display part 32 is used for displaying the pictures, so that scientific research personnel can complete corresponding human-computer interaction through the pictures.
In this embodiment, the scientific research personnel terminal 3 needs to log in the scientific research personnel through the respective identification information in advance to record the identification information, and when communicating with the management server 2, the terminal side communication unit 33 can transmit the identification information of the scientific research personnel to the management server 2.
The terminal-side communication unit 33 is used to perform data interaction between the terminal 3 of the scientific researcher and the management server 2.
The terminal-side control unit 34 includes a computer program for controlling the operation of each unit of the terminal 3 of the researcher.
Fig. 15 is a flowchart of a sample request process in an embodiment of the invention.
As shown in fig. 15, the sample extraction process of the scientific biological sample 200 management system 100 includes the following steps:
step 1-1, the input display part 32 displays a sample request picture to allow a scientific researcher to input a required sample name, and then the step 1-2 is carried out;
step 1-2, the terminal side communication part 33 sends the name of the demand sample and the identification information input in step 1-1 to the management server 2, and then the procedure goes to step 1-3;
step 1-3, the management-side control section 29 controls the retrieval-acquisition section 22 to retrieve the sample-related information storage section 21 based on the required sample name received in step 1-2 to acquire corresponding sample position information 213, and then proceeds to step 1-4;
step 1-4, the management-side control part 29 controls the management-side communication part 28 to send the name of the required sample received in step 1-2 and the sample position information 213 retrieved and acquired in step 1-3 as extraction information to the researcher terminal 3, and controls the request record storage part 23 to store the name of the required sample received in step 1-2, the extraction information sent in step 1-4 and the identification information received in step 1-2 as a request record 231, and then to proceed to step 1-5;
in step 1-5, the input display unit 38 displays an extracted information display screen, displays the extracted information received in step 1-4 on the screen for the scientific research worker to view, and enters an end state.
Fig. 16 is a flow chart of a sample extraction or return process in an embodiment of the invention.
As shown in fig. 16, when the scientific research personnel arrives at the corresponding sample cabinet 1 according to the prompt information and performs the identification operation on the identification part 16, the following steps are started:
step 2-1, the identification part 16 identifies and obtains identification information of scientific researchers, and then the step 2-2 is carried out;
step 2-2, the sample cabinet communication part 181 sends the identification information identified in step 2-1 and the cabinet number of the sample cabinet 1 to the management server 2, and then the process goes to step 2-3;
step 2-3, the management side control part 29 controls the identity retrieval and determination part 26 to respectively retrieve the request record storage part 23 and the extraction record storage part 25 according to the identification information and the cabinet number received in the step 2-2 and determine whether the scientific research personnel has the authority to open the sample cabinet 1, if so, the step 2-4 is carried out, and if not, the step 2-10 is carried out;
step 2-4, the management side control part 29 controls the management side communication part 28 to send a door opening permission signal containing a layer number to the sample cabinet 1, and then the step 2-5 is carried out;
step 2-5, the sample cabinet control part 181 controls the corresponding locking part 13 to unlock the cabinet door 12 according to the layer number in the door opening permission signal, so that a scientific researcher can open the cabinet door 12 to perform extraction or storage operation, and once the scientific researcher opens the cabinet door 12 so that the induction part 14 induces the cabinet door 12 to be opened, the step 2-6 is performed;
step 2-6, the main control chip 18 controls the judging part 15 to continuously read and temporarily store the judging information and times of the read samples, and once the scientific research personnel finish extracting or storing and close the cabinet door 12 to enable the induction part 14 to induce the cabinet door 12 to be closed, the step 2-7 is carried out;
step 2-7, the main control chip 18 controls the locking part 13 to lock the cabinet door 12, controls the sample cabinet communication part 181 to send the identification number, the cabinet number, the layer number corresponding to the judgment part 15, and all the read sample judgment information and the read times thereof to the management server 2, and then the step 2-8 is carried out;
step 2-8, the access judgment updating part 24 judges the access condition of the biological sample 200 according to the identification number, the cabinet number, the layer number sample judgment information and the reading frequency sent by the sample cabinet 1, the management side control part 29 controls the biological sample related information storage part 21 to update the sample position information according to the access condition, controls the request record storage part 23 to delete the corresponding request record 231 when judging to be taken out, controls the extraction record storage part 25 to add one extraction record 251 when judging to be taken out, deletes the corresponding extraction record 251 when judging to be put back, and then enters step 2-9;
step 2-9, the extraction and review part 27 reviews and confirms whether the extracted biological sample 200 is correct, and enters step 2-10 when the scientific research personnel is judged to have an extraction error, and enters an ending state when the scientific research personnel is judged to have no extraction error;
in step 2-10, the management-side control unit 29 controls the management-side communication unit 28 to send an alarm signal to the corresponding sample cabinet 1, so that the alarm unit 17 starts an alarm to perform corresponding reminding (including reminding that the door has no door-opening authority or the wrong sample is taken out), and then enters an end state.
Examples effects and effects
According to the biological sample management system for scientific research provided by the embodiment, each biological sample in the sample cabinet is provided with the sample label containing the sample identification information, and each sample cabinet is provided with the identification part for identifying the sample label, so that the biological label on the biological sample can be identified after the cabinet door is unlocked to obtain the corresponding sample identification information, the access judgment updating part can judge the access condition of the biological sample according to the sample identification information and update the sample position information, and the position of each biological sample can be effectively obtained and timely updated and stored in the sample related information storage part.
In addition, because the opening and closing of the induction part induction cabinet door is adopted, the judgment part is allowed to judge when the cabinet door is opened, so that the sample labels can be continuously read under the states that the cabinet door is closed and the sample cabinet is not used, the working time of the judgment part is shortened, the service life of the judgment part is prolonged, and the problem that the reading work of the cabinet door on the judgment part is influenced due to the fact that the cabinet door is read under the condition that the cabinet door is closed is also avoided. For example, if the reading is performed when the cabinet door is closed, the sample label is not easily read by the determination part due to the blockage of the cabinet door; however, if the cabinet door is arranged on the inner side of the cabinet door, the temperature in the placing layer is too low to work normally.
In the embodiment, the biological sample related information storage part also stores the storage requirement information of each biological sample, so that the storage requirement of the biological sample to be returned can be displayed through the return request picture when the scientific research personnel need to return, and the storage of the biological sample to a sample cabinet or a placing layer which does not meet the storage requirement during returning is avoided.
In the embodiment, the sample tag is an RFID tag, and the determination unit is an RFID reader and is mounted on the layer eaves portion formed by the outward extension of the interlayer plate, so that the biological sample with the sample tag can be read in and out of the placement layer, and the access determination update unit can effectively determine the access condition of the biological sample. Furthermore, the reading direction of the RFID reader faces outwards, the corresponding sample tags in the placed layers cannot be read, meanwhile, the interlayer plate is provided with the metal interlayer, the RFID reader can be prevented from reading the adjacent sample tags in the placed layers, therefore, misreading can be prevented, and the accuracy of the access judgment updating part is improved. In addition, because the length direction both ends of every layer eaves portion respectively are equipped with an RFID and read the ware, and the reading range that each RFID read the ware is greater than the half of the width of layer board between, is less than the width of layer board between, consequently can also judge biological sample and place the approximate position on the layer through the reading condition of two RFID readers, let scientific research personnel can take biological sample according to this approximate position more fast to reduce the time that the cabinet door was opened, let and place intralamellar low temperature environment and maintain stably more easily.
In the embodiment, the request recording part can store the extraction request of the scientific research personnel, and the extraction record storage part can store the extraction record of the scientific research personnel, so that the extraction request condition of the scientific research personnel and the condition of the extracted biological sample can be effectively recorded; furthermore, the sample cabinet communication part sends the identification information and the cabinet number to the management server after the identification part identifies the sample cabinet, the identity retrieval determination part can retrieve the request record storage part and the extraction record storage part according to the sent identification information and the cabinet number so as to determine whether the sample cabinet has the authority to open, and the management side control part controls the management side communication part to send the door opening permission signal when the authority to open exists, so that the cabinet door can be unlocked when the scientific research personnel really needs to access, and the influence of mistaken opening on the low-temperature environment in the placing layer is avoided. Moreover, in the embodiment, the door opening permission signal further includes a layer number in the request record or a layer number corresponding to the cabinet number in the storage requirement information, so that the sample cabinet control part can control the locking part of the corresponding placing layer to unlock according to the layer number, and further the scientific research personnel is prevented from opening the wrong placing layer when taking and placing the sample cabinet.
In addition, in the embodiment, after the access judgment updating unit has completed the judgment of the access situation, the extraction review unit can acquire the name to be extracted from the identification information, acquire the actual extraction name from the sample judgment information, and judge whether the two names are identical, so that it can be judged whether the researcher has extracted the wrong biological sample. Further, because the sample cabinet still has warning portion, management side control division can send warning signal to corresponding sample cabinet when extracting audit portion judgement scientific research personnel and draw the error for warning portion starts the warning and reminds scientific research personnel, consequently can form warning prompt effect, lets scientific research personnel return the biological sample of mistake taking out. The access judgment updating part updates the position information after judging the access condition, and the extraction record storage part stores corresponding extraction records, so that the identity retrieval judgment part can judge the opening authority according to the extraction records in the extraction record storage part so as to open the corresponding cabinet door when a scientific research worker reads the identification information by using the identification part under the condition of mistaken extraction, and therefore, the scientific research worker can smoothly return the cabinet door even under the condition of mistaken extraction.
The above-described embodiments are merely illustrative of specific embodiments of the present invention, and the present invention is not limited to the description of the above-described embodiments.
For example, in the above embodiment, the RFID reader is mounted on the layer eaves portion and the reading direction thereof faces outward, so that the sample tag can be read when leaving or entering the placement layer, and the access determination and update portion can perform corresponding access determination and update. However, in other embodiments of the present invention, the reading direction of the RFID reader may be directed to the inside, for example, the directional RFID reader is installed slightly inclined inward, so that the reading direction of the directional RFID reader is directed to the inside immediately, and at the same time, an inward inclined slope portion may be provided at the eaves of the layer where the RFID reader is located, so that the electromagnetic wave of the RFID reader enters the placement layer to read the sample tag on the biological sample therein. In the embodiment, the sample cabinet control part controls the judging part to continuously read and temporarily store the sample judging information contained in the read sample labels according to the opening condition of the cabinet door sensed by the sensing part when the cabinet door is opened, and sends the finally read sample judging information, the layer number and the cabinet number of all the sample labels to the management server after the cabinet door is closed, so that the sample judging information corresponds to the biological sample actually existing in the layer currently placed after the scientific research personnel finishes taking and placing actions. Then, the access judgment updating part acquires all corresponding sample judgment information (equivalent to the biological samples stored in the placing layer before the taking and the placing) from the sample related information storage part according to the cabinet number and the layer number, and compares the sample judgment information with the sample judgment information of the biological samples actually existing in the current placing layer sent by the sample cabinet, so that the taken or placed biological samples can be judged, and the sample related information storage part is updated.
In addition, the RFID reader of the embodiment is a directional reader, so that the RFID reader can be installed towards the outer side, and the purpose of reading in the placing layer is not achieved. However, the RFID reader of the present invention may also be a common non-directional RFID reader, and when the RFID reader is mounted, the non-directional RFID reader is embedded in the interlayer board, and a certain shielding layer is disposed at an inner side of the non-directional RFID reader (for example, a metal plate is attached to the inner side of the non-directional RFID reader as a shielding layer), so that electromagnetic waves can be prevented from entering the placing layer during reading, and the reading direction faces outward.
In addition, the interlayer plate of the embodiment is provided with a shielding layer so as to prevent an RFID reader from reading the labels on the biological samples of other layers. As a further embodiment, in the present invention, a shielding layer may be further disposed at an outer side position of each directional RFID reader, so as to prevent the reading range of the RFID reader from extending outward too much, in this case, the reading range of each RFID reader is only equivalent to a region vertically below the reading range, so that repeated reading (for example, the biological sample is taken by a scientific researcher during taking and placing or is temporarily placed on the taking and placing tray and thus is located at the position) when the biological sample is located at an outer side position close to the placement layer can be avoided, and thus the moving condition of the sample label in and out of the placement layer can be more accurately read.
In an embodiment, the extraction checking section can check whether or not the extraction is correct based on the determination result of the access determination updating section and the storage content in the extraction record storage section, and a similar checking mechanism does not exist when the storage is performed. However, in another embodiment of the present invention, in order to prevent the biological sample from being affected by the storage error (for example, stored in a storage layer having an inappropriate temperature), the management server may include a storage checking unit that retrieves and acquires the corresponding storage request information from the biological sample-related information storage unit based on the sample discrimination information of the biological sample stored in the determination result of the access determination updating unit, further determines whether or not the bin number and the layer number storing the biological sample are present in the acquired storage request information, and if it is determined that the biological sample is not present, indicates that the biological sample is stored in the storage layer having an inappropriate temperature, the management-side control unit may control the management-side communication unit to transmit an alarm signal to the corresponding sample bin, thereby causing the alarm unit to activate an alarm to prompt the scientific researcher to place the biological sample at the incorrect storage layer. Further, in other embodiments of the present invention, in order to ensure that the erroneously stored biological sample can be returned smoothly, a misplaced record storage unit may be further provided in the management server, and configured to store, as a misplaced record, the erroneously stored sample discrimination information, the stored position information, and the erroneously stored identification information of the researcher when the storage auditing unit determines that the storage position is incorrect, so that the identity retrieval determination unit may determine the opening permission according to the request record and the extraction record, and may determine the opening permission according to the erroneously stored record, so that the erroneously stored researcher himself or herself may take out the erroneously stored biological sample and store the erroneously stored biological sample to a suitable position.
For example, in the above embodiment, the warning portion is a warning light disposed on the front surface of the cabinet door. In another aspect of the present invention, the warning unit may be an audible and visual alarm or other device having a prompt effect, and may be disposed at a position where the reagent tank is easily viewed or where sound is easily emitted, as required.
For example, in the above-described embodiment, the sample-related information storage section is used to store the sample discrimination information, the corresponding sample name, and the sample position information and the storage request information. In another aspect of the present invention, the sample-related information storage unit may store other sample-related information, for example, other related information such as a sampling source and a sampling time of the biological sample.
Claims (10)
1. A scientific biological sample management system for managing biological samples with sample labels, comprising:
at least one sample holder for holding the biological sample;
at least one researcher terminal held by a researcher using the biological sample; and
the management server is respectively in communication connection with the sample cabinet and the scientific research personnel terminal,
wherein the sample cabinet comprises a cabinet body with at least one placing layer for placing the biological sample, at least one cabinet door arranged corresponding to the placing layer, at least one judging part arranged corresponding to the placing layer, at least one locking part arranged corresponding to the cabinet door and used for locking the cabinet door, an identification part used for identifying the identification information of the scientific research personnel, a sample cabinet communication part and a sample cabinet control part,
the scientific research personnel terminal comprises a picture storage part, an input display part and a terminal side communication part,
the management server includes a biological sample-related information storage unit, a search acquisition unit, an access determination update unit, a management-side communication unit, and a management-side control unit,
the biological sample related information storage part at least stores the biological sample name of each biological sample, the corresponding biological sample distinguishing information and the corresponding sample position information at least comprising the cabinet number of the sample cabinet where the biological sample is located and the layer number of the placed layer,
the picture storage part stores a biological sample request picture and an extracted information display picture,
the input display part displays the biological sample request picture to allow the scientific research personnel to input the name of the biological sample needing to be extracted as the name of the required biological sample,
the terminal-side communication section transmits the required biological sample name to the management server upon confirmation of the input required biological sample name by the researcher,
the management side control part controls the retrieval acquisition part to retrieve the biological sample related information storage part according to the required biological sample name and acquire corresponding sample position information, and controls the management side communication part to send the required biological sample name and the retrieved sample position information to the scientific research personnel terminal as extraction information,
the input display part displays the extraction information display picture and displays the received extraction information in the picture, so that the scientific research personnel can go to the corresponding sample cabinet according to the extraction information and operate the identification part to enable the identification part to identify the identification information,
when the identification unit identifies the identification information, the specimen cabinet control unit controls the specimen cabinet communication unit to transmit the identification information to the management server for determination, controls the corresponding lock unit to unlock the door when receiving a door opening permission signal fed back from the management server, allows the scientific researcher to open the door and extract the biological specimen in the placement layer corresponding to the extracted information, controls the determination unit to determine the biological label on the biological specimen to obtain corresponding biological specimen determination information, and further controls the specimen cabinet communication unit to transmit the biological specimen determination information, the cabinet number of the specimen cabinet, and the corresponding layer number obtained by the determination to the management server,
the management-side control unit controls the access determination updating unit to determine the access condition of the biological sample based on the received cabinet number, the layer number, and the biological sample discrimination information, and updates the sample position information corresponding to the biological sample-related information storage unit.
2. The scientific biological specimen management system according to claim 1, wherein:
wherein the sample tag is an RFID tag,
the sample cabinet is a low-temperature or ultralow-temperature biological sample freezing storage cabinet, the cabinet door is a heat preservation cabinet door,
the interlayer plate at the upper side of each placing layer is provided with a layer brim part extending towards the outer side,
the distinguishing part is an RFID reader and is arranged at a position, close to the outer side surface of the heat preservation cabinet door, on the layer eaves part.
3. The scientific biological specimen management system according to claim 2, wherein:
wherein two ends of each layer of eave part in the length direction are respectively provided with one RFID reader,
the read range of the RFID reader is greater than one-half the width of the interlayer sheet and less than the width of the interlayer sheet,
and the sample cabinet control part judges the placing position of the scientific research personnel on the placing layer when returning or newly adding the biological sample according to the reading conditions of the two RFID readers when the RFID readers read the sample tags, so that the sample position information in the sample related information storage part also comprises the placing position.
4. The scientific biological specimen management system according to claim 2, wherein:
wherein the sample cabinet also comprises at least one induction part which is arranged corresponding to the cabinet door and is used for inducing the opening and closing state of the cabinet door,
the sample cabinet control part controls the distinguishing part to distinguish the biological label of the placing layer when the induction part induces that the cabinet door is in an opening state to obtain corresponding biological sample distinguishing information, and controls the sample cabinet communication part to send the sample distinguishing information, the cabinet number and the layer number to the management server when the induction part induces that the cabinet door is closed.
5. The scientific biological specimen management system according to claim 2, wherein:
wherein the reading direction of the RFID reader faces to the inner side of the placing layer,
the layer eaves portion is provided with a slope portion inclining towards the placing layer.
6. The scientific biological sample management system according to claim 4 or 5, wherein:
when the sample cabinet control part receives a door closing signal that the induction part induces that the cabinet door is closed by the scientific research personnel, the sample cabinet control part controls the locking part to lock the cabinet door.
7. The scientific biological specimen management system according to claim 1, wherein:
wherein the management server further has an extraction record storage unit,
the specimen rack control unit controls the specimen rack communication unit to transmit the biological specimen discrimination information, the rack number, and the layer number to the management server and also to transmit the identification information identified by the identification unit to the management server,
the extraction record storage unit stores, as an extraction record, the biological sample discrimination information and the identification information of the biological sample determined to be taken, when the access determination update unit determines the access condition of the biological sample.
8. The scientific biological specimen management system according to claim 7, wherein:
wherein the biological sample-related information storage unit further stores storage request information for each biological sample, the storage request information including a bin number and a layer number of the sample bin that satisfy the storage request for the biological sample,
the screen storage section further stores a return request screen,
the input display part also displays the returning request picture, displays the extraction record corresponding to the scientific research personnel received from the management server according to the identification information in the returning request picture to enable the scientific research personnel to select the biological sample needing to be returned, and further displays the storage requirement information corresponding to the biological sample received from the management server according to the biological sample selected by the scientific research personnel in the returning request picture, so that the scientific research personnel can go to the corresponding sample cabinet to carry out returning operation according to the storage requirement information.
9. The scientific biological specimen management system according to claim 1, wherein:
wherein the management server further comprises a request record storage unit and an identity search determination unit,
the terminal-side communication unit transmits the identification information of the scientific researcher to the management server while transmitting the input name of the required biological sample to the management server,
the management-side control unit controls the management-side communication unit to send the extracted information back to the scientific research personnel terminal, and controls the request record storage unit to store the extracted information and the identification information of the corresponding scientific research personnel,
when the management-side communication unit receives the identification information transmitted from the sample cabinet, the identity retrieval determination unit determines whether or not the extracted information is present in the request record storage unit based on the identification information, and further determines whether or not the cabinet number of the sample cabinet to which the identification information is transmitted is present in the extracted information,
when the door opening permission signal is judged to exist, the management side communication part sends the door opening permission signal to the sample cabinet.
10. The scientific biological specimen management system according to claim 9, wherein:
wherein the management server further has an extraction audit portion,
the sample cabinet is also provided with a warning part for giving out warning prompt,
the request record storage unit stores the biological sample name while storing the extraction information and the identification information in association with each other,
when the access determination updating section determines that the biological sample is accessed, the extraction review section acquires the name of the biological sample corresponding to the identification information from the request record storage section as an extraction target name based on the identification information of the biological sample determined to be extracted, and acquires the corresponding name of the biological sample from the biological sample-related information storage section as an actual extraction target based on the received biological sample discrimination information, and further determines whether or not the extraction target name and the actual extraction target name match each other,
when the judgment result shows that the sample cabinets are inconsistent, the management side control part controls the management side communication part to send a warning signal to the corresponding sample cabinet,
and the sample cabinet control part controls the warning part to start warning when the sample cabinet communication part receives the warning signal so as to remind the scientific research personnel of extracting wrong biological samples.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020100261026 | 2020-01-10 | ||
| CN202010026102 | 2020-01-10 |
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| Publication Number | Publication Date |
|---|---|
| CN113128631A true CN113128631A (en) | 2021-07-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011623761.4A Pending CN113128631A (en) | 2020-01-10 | 2020-12-31 | Biological sample management system for scientific research |
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| Country | Link |
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| CN (1) | CN113128631A (en) |
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2020
- 2020-12-31 CN CN202011623761.4A patent/CN113128631A/en active Pending
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