CN113111982A

CN113111982A - Biological sample management method for scientific research

Info

Publication number: CN113111982A
Application number: CN202011630098.0A
Authority: CN
Inventors: 黄景锟; 张鹏; 何杨星; 况凤超; 仓超; 李斌
Original assignee: Hangzhou Shared Experimental Technology Development Co ltd
Current assignee: Hangzhou Shared Experimental Technology Development Co ltd
Priority date: 2020-01-10
Filing date: 2020-12-31
Publication date: 2021-07-13

Abstract

The invention aims to solve the problem that the biological samples exceeding the taking times are still put back, and provides a biological sample management method for scientific research, which adopts a system comprising a sample cabinet, a scientific research personnel terminal and a management server to realize the management of the biological samples with sample labels, and comprises the following steps: storing sample related information; storing sampling related information; the method comprises the steps that a management server is adopted to judge the access condition of biological samples according to sample judging information sent by a sample cabinet and a cabinet number, at least sample position information in sample related information is updated, the number of times of extraction of the biological samples judged to be taken out is added with 1, whether the current number of times of extraction of each extracted biological sample is greater than or equal to the corresponding effective number of times is judged in sequence, when the number of times of extraction is greater than or equal to the corresponding effective number of times, the biological samples are judged to be abandoned, an abandonment prompt is formed by the management server, and the formed abandonment prompt is sent to a scientific research personnel terminal.

Description

Biological sample management method for scientific research

Technical Field

The invention relates to a biological sample management method for scientific research.

Background

The biological sample refers to organs, tissues, cells, biological macromolecules and the like derived from human bodies, other animals or plants, and is used as a sample in scientific research work. Among them, important resource facilities in the scientific research of biological sample libraries composed of one or more types of biological samples, for example, in molecular genetics, some research projects require a large number of genetic resource samples, and thus need to utilize the human genome library for completion; pathological studies typically require a large number of pathological tissue samples and therefore rely on a library of pathological samples.

In general, repeated freezing and thawing of a biological sample after collection is not suitable, so that the sample obtained by each collection needs to be divided into a plurality of biological samples with the division specifications, and only one part of the biological sample is taken for each use. However, a lot of collection work needs to be continuously performed in the operation process of the biological sample library, and meanwhile, some biological samples are taken away by scientific researchers from time to time according to scientific research requirements, so that the samples collected at different periods often exist in the same sampling source at the same time, and the scientific researchers are not convenient to search and use. In addition, in general, the entire sample obtained from each sampling is not suitable for use, and the sample should be appropriately retained. In order to confirm the quantity, all biological samples sampled at the same time need to be put together, so that the problem of space shortage is caused when the quantity is large, and the problem of space waste is easily caused when the quantity is small. If the biological samples of each subpackage specification are stored separately, the storage condition is disordered, and when the biological samples need to be taken, the storage position is not clear. Because the preservation conditions of biological samples are harsh, environments such as a low-temperature freezer (-30 below) or an ultra-low-temperature freezer (-80 ℃) and even liquid nitrogen deep low temperature are usually needed, if the storage condition is disordered, scientific researchers need to spend a long time to open a cabinet door to find the biological samples when taking the biological samples, so that the temperature in the freezer is influenced by the outside to rise, the temperature is reduced for recovery within a certain time even if the cabinet door is closed, and other biological samples in the cabinet are influenced to be repeatedly frozen and thawed and even possibly fail. Moreover, repeated freezing and thawing has a great influence on the effectiveness of the biological samples, the biological samples cannot be reused after being used for several times, and some biological samples with volatile effect can be even used for one time only by freezing and thawing. Due to the large quantity and the difficulty in sorting, scientific research personnel can not know which biological samples exceed the proper taking times and can not be reused or can not be put back after the biological samples are used, and the biological samples which are invalid can be used, so that the experimental progress of scientific research projects is influenced, and even incorrect experimental results can be obtained.

Moreover, in some cases, the scientific researchers may replace the failed biological sample again because it is unclear whether the number of times of taking the biological sample exceeds the number of times of taking the biological sample, in which case, the failure condition of the biological sample can be confirmed only after the biological sample is taken out and verified, and if no verification or no detection is carried out, the failed sample occupies a storage space and wastes freezing resources; if the personnel are arranged to check the failure samples, the consumed manpower and material resources are huge, and the failure samples are difficult to be effectively checked in time.

Disclosure of Invention

In order to solve the problems that the biological samples exceeding the taking times are still put back and the invalid samples are difficult to check, the invention provides a biological sample management method for scientific research, which is characterized in that a system comprising a sample cabinet, a scientific research personnel terminal and a management server is adopted to manage the biological samples with sample labels, and the method comprises the following steps: correspondingly storing the sample discrimination information, the sampling information, the sample position information and the storage requirement information as sample related information in a management server; storing the sampling information and the corresponding effective times as sampling related information in a management server; the method comprises the steps that a management server is adopted to form extraction information containing sample distinguishing information, sample position information and received sampling-required information according to the sampling-required information, the sample related information and the sampling related information which are received from a scientific research personnel terminal and input by the scientific research personnel, and the extraction information and identification information of the scientific research personnel are further stored as request records; the identification information of scientific research personnel is identified by an identification part, and then the identification information is sent to a management server; judging whether the scientific research personnel have the opening authority or not at least based on the identification information by adopting a management server, and sending an opening permission signal to the sample cabinet once the scientific research personnel have the opening authority; the control module of the sample cabinet is adopted to remove the locking of the cabinet door according to the door opening permission signal, so that scientific researchers can open the cabinet door to perform extraction or storage operation; the method comprises the steps that a judging part is adopted to continuously read sample labels, an induction part is adopted to induce whether a cabinet door is closed or not, and once the fact that scientific research personnel close the cabinet door is induced, at least read sample judging information and a cabinet number of a sample cabinet are sent to a management server; the management server is adopted to judge the access condition of the biological sample according to the sent sample judgment information and the cabinet number, at least the sample position information in the sample related information is updated, the extraction frequency corresponding to the biological sample judged to be taken out is added with 1, whether the current extraction frequency of each biological sample judged to be extracted is larger than or equal to the corresponding effective frequency of the sampling information corresponding to the sample judgment information in the sampling related information is further judged in sequence, when the current extraction frequency is judged to be larger than or equal to the corresponding effective frequency of the sampling information corresponding to the sample judgment information, the biological sample is judged to be abandoned, the management server forms abandonment prompt and sends the formed abandonment prompt to a scientific research personnel terminal.

Action and Effect of the invention

According to the biological sample management method for scientific research provided by the invention, each biological sample is provided with the sample label containing the sample distinguishing information, and the placing layer of the sample cabinet is provided with the corresponding distinguishing part which can distinguish the sample label to obtain the corresponding sample distinguishing information, so that the corresponding sample distinguishing information can be read when a scientific researcher takes and places the biological sample, and the management server can update the information according to the read sample distinguishing information and the cabinet number layer number. Furthermore, the management server of the embodiment can also accumulate the extraction times of the biological samples judged to be extracted according to the access judgment result, and form a abandonment prompt to send to the corresponding scientific research personnel terminal when the accumulated extraction times is more than or equal to the effective times, so that the scientific research personnel can be prompted to abandon the biological samples which are to be abandoned after the biological samples are used for the next time, and misuse caused by putting the biological samples which are to be abandoned into the placing layer again is avoided.

Drawings

FIG. 1 is a diagram showing a system for implementing a biological specimen management method for scientific research in an embodiment of the present invention;

FIG. 2 is a schematic diagram of a sample cabinet according to an embodiment of the present invention;

FIG. 3 is a schematic view of an installation location of an RFID reader of an embodiment of the present invention;

FIG. 4 is a range diagram of an RFID reader of an embodiment of the present invention;

FIG. 5 is a functional block diagram of a sample cabinet in an embodiment of the invention;

FIG. 6 is a schematic diagram of the storage contents of the cabinet number layer number storage unit in the embodiment of the present invention;

FIG. 7 is a flowchart of a method for managing biological samples for scientific research according to an embodiment of the present invention;

FIG. 8 is a schematic diagram of sample correlation information storage according to an embodiment of the present invention;

FIG. 9 is a schematic diagram of sample correlation information storage according to an embodiment of the present invention;

FIG. 10 is a diagram illustrating a sample request screen according to an embodiment of the present invention;

FIG. 11 is a schematic diagram of request record storage in an embodiment of the invention;

FIG. 12 is a schematic diagram of extraction record storage in an embodiment of the invention; and

fig. 13 is a schematic diagram of the extraction number storage according to the embodiment of the present invention.

Detailed Description

The method for managing a biological sample for scientific research according to the present invention will be described in detail below with reference to the accompanying drawings.

As an embodiment, the present invention provides a biological sample management method for scientific research, which is characterized in that a system including a sample cabinet, a scientific research personnel terminal and a management server is used to manage a biological sample with a sample label, and the method includes: correspondingly storing the sample discrimination information, the sampling information, the sample position information and the storage requirement information as sample related information in a management server; storing the sampling information and the corresponding effective times as sampling related information in a management server; the method comprises the steps that a management server is adopted to form extraction information containing sample distinguishing information, sample position information and received sampling-required information according to the sampling-required information, the sample related information and the sampling related information which are received from a scientific research personnel terminal and input by the scientific research personnel, and the extraction information and identification information of the scientific research personnel are further stored as request records; the identification information of scientific research personnel is identified by an identification part, and then the identification information is sent to a management server; judging whether the scientific research personnel have the opening authority or not at least based on the identification information by adopting a management server, and sending an opening permission signal to the sample cabinet once the scientific research personnel have the opening authority; the control module of the sample cabinet is adopted to remove the locking of the cabinet door according to the door opening permission signal, so that scientific researchers can open the cabinet door to perform extraction or storage operation; the method comprises the steps that a judging part is adopted to continuously read sample labels, an induction part is adopted to induce whether a cabinet door is closed or not, and once the fact that scientific research personnel close the cabinet door is induced, at least read sample judging information and a cabinet number of a sample cabinet are sent to a management server; the management server is adopted to judge the access condition of the biological sample according to the sent sample judgment information and the cabinet number, at least the sample position information in the sample related information is updated, the extraction frequency corresponding to the biological sample judged to be taken out is added with 1, whether the current extraction frequency of each biological sample judged to be extracted is larger than or equal to the corresponding effective frequency of the sampling information corresponding to the sample judgment information in the sampling related information is further judged in sequence, when the current extraction frequency is judged to be larger than or equal to the corresponding effective frequency of the sampling information corresponding to the sample judgment information, the biological sample is judged to be abandoned, the management server forms abandonment prompt and sends the formed abandonment prompt to a scientific research personnel terminal.

The biological sample management method for scientific research according to the above-described embodiment may further include a feature in that the sampling-related information further includes an effective number corresponding to the sampling information, and when the management server determines that the biological sample should be discarded, the management server retrieves the sampling information corresponding to the biological sample determined to be discarded from the sampling-related information, and decreases the effective number corresponding to the sampling information in the sampling-related information by 1.

Further, the above method for managing biological samples for scientific research may further include a technical feature that the system further includes a management terminal held by an administrator, the management server determines whether the current quantity corresponding to the sampling information is less than a predetermined quantity after subtracting 1 from the effective quantity, and generates an effective quantity reminder including the sampling information and sends the reminder to the management terminal when the current quantity is less than the predetermined quantity.

Further, the above-described biological sample management method for scientific research may further include a feature in which the management server performs update processing, and then forms and stores an extraction record based on the sample discrimination information and the identification information of the biological sample determined to be extracted.

Furthermore, the biological sample management method for scientific research can also have the technical characteristics that the management server stores identification information and identity information of scientific research personnel and managers as personnel information, the management server judges whether the scientific research personnel or the managers are the scientific research personnel or the managers according to the personnel information after receiving the identification information sent by the sample cabinet, and when the scientific research personnel are judged, whether the scientific research personnel have the opening authority is further judged according to the extraction records and the request records.

The method for managing biological samples for scientific research may further include storing requirement information, verifying whether the extracted or stored biological samples are correct or not according to the determination result of the access condition, the extraction record, the sample related information and the sampling related information after the management server stores the extraction record, and sending a warning signal to the sample cabinet when the extraction or storage is determined to be incorrect.

< example >

FIG. 1 is a diagram showing a system for implementing a biological specimen management method for scientific research in an embodiment of the present invention.

As shown in fig. 1, the biological sample 2 management system 100 for scientific research of the present embodiment is used for managing biological samples 200, and includes a plurality of sample cabinets 1, a management server 2, a plurality of scientific research personnel terminals 3, a management terminal 4, and

communication networks

5a, 5b, and 5 c.

The management server 2 is in communication connection with each sample cabinet 1 through a communication network 5a, each scientific research staff terminal 3 through a communication network 5b, and the management terminal 4 through a communication network 5 c. The

communication networks

5a, 5b and 5c are all local area networks.

The scientific research personnel terminals 3 are personal computers, are respectively held by different scientific research personnel and carry out related operations, and identification information corresponding to the respective scientific research personnel is stored in each scientific research personnel terminal 3. The scientific researchers involved in the invention are scientific research experimenters who take the biological sample 200. In addition, the biological samples 200 are physiological or pathological samples of human body, other animals or plants obtained by sampling, including but not limited to organs, tissues, cells and biological macromolecules, and the forms of the biological samples 200 and the containers thereof may be the same or different according to the preservation requirement; each biological specimen 200 is a container (e.g., a test tube, centrifuge tube, specimen bag, or bottle) that contains a single specimen obtained by collecting and dispensing a sample from a sampling source (e.g., a human, other animal, plant, etc.), i.e., a plurality of biological specimens 200 from the same sampling source at the same sampling time will be obtained after each sampling action performed on one sampling source. A corresponding sample tag 201 is fixed to each container of the biological sample 200, and the sample tag 201 is a low-temperature RFID tag containing sample discrimination information and can normally operate in low-temperature and ultra-low-temperature environments. In addition, each biological sample 200 has unique sample discrimination information, which is also recorded in a corresponding RFID tag and can be read by an RFID reader. In this embodiment, the sample discrimination information is in the form of a number.

Fig. 2 is a schematic structural diagram of a sample cabinet in an embodiment of the invention. In fig. 2, the structure of the holder or the placing case for supporting the biological sample 200 is omitted for clarity of illustration.

As shown in fig. 2, the sample chamber 1 includes a chamber body 10, a placement layer 11, a chamber door 12, a locking portion 13, a sensing portion 14, a determination portion 15, an identification portion 16, a warning portion 17, and a main control chip 18. In this embodiment, the sample cabinet 1 further includes a temperature lowering mechanism including a compressor, a temperature setting mechanism for setting a temperature, a temperature detecting mechanism for detecting a temperature in the placement layer 11, and a control mechanism for controlling the operation of the temperature lowering mechanism according to a temperature detection result and a set temperature, and therefore the specific configurations and operating principles of these mechanisms are the same as those in the ultra-low temperature refrigerator in the prior art, and are not repeated herein.

The cabinet 10 has three placing layers 11 for placing the biological sample 200, and adjacent placing layers 11 are spaced apart from each other by a layer plate.

In this embodiment, the interlayer plate is a heat-insulating plate having a certain thickness. The interlayer sheet does not have any restriction structure for the specimen, and therefore the biological specimen 200, the rack or the placing case containing the biological specimen 200 can be placed on the placing layer 11 at will.

The number of the cabinet door 12, the locking portion 13, the sensing portion 14, and the determination portion 15 is three, and each corresponds to each placement layer 11.

Wherein, the cabinet door 12 is hinged on the cabinet body 10 at the side position of the placing layer 11. Cabinet door 12 is the heat preservation cabinet door, by the metal level that is located the outside and be located the heat preservation of inboard and constitute, and the layer 11 is placed to the heat preservation orientation inside to realize the heat preservation function.

The locking portion 13 is an electronic lock, and is disposed on the cabinet door 12 or on the cabinet body 10 at a position corresponding to the edge of the cabinet door 12, and can lock and unlock the cabinet door 12 according to the control electrical signal of the main control chip 18.

The sensing part 14 is a proximity switch, is arranged on the cabinet door 12 or on the cabinet body 10 at a position corresponding to the edge of the cabinet door 12, and can sense whether the cabinet door is in a closed state and generate a corresponding electric signal.

The discrimination unit 15 discriminates the specimen label 201 on the biological specimen 200 when the biological specimen 200 is taken out or placed.

Fig. 3 is a schematic view of an installation position of an RFID reader according to an embodiment of the present invention, and fig. 3 shows a partial sectional structure of a sample cabinet.

As shown in fig. 2 and 3, in the present embodiment, each determination unit 15 is constituted by two RFID readers 151. The upper interlayer board of each placement layer 11 extends outward to form a layer eaves portion 111, and the two RFID readers 151 are embedded in the layer eaves portions 111 of the upper interlayer boards of the placement layers 11 corresponding to the determination unit 15, and are located at both ends (corresponding to the left and right sides) in the width direction of the interlayer boards. Meanwhile, each RFID reader 151 is located at the outer edge position of the interlayer plate, and the position corresponds to the outer surface position of the cabinet door 12, that is, a space with a heat preservation effect is enclosed between the heat preservation layer of the cabinet door 12 and each interlayer plate of the placement layer 11, and the RFID reader is located outside the heat preservation space, so that the RFID reader is not affected by low temperature in the space and can work normally.

FIG. 4 is a range diagram of an RFID reader of an embodiment of the present invention. Wherein, fig. 4(B) is a schematic range diagram in the width direction, fig. 4(a) is a schematic range diagram in the depth direction, and the broken lines in the diagram each indicate the read range of the RFID reader; in addition, in fig. 4(B), the cabinet door 12 is omitted.

As shown in fig. 4(a), in the present embodiment, the read range D of the RFID reader 151 in width is greater than one-half of the width L of the interlayer board and smaller than the width L of the interlayer board. Since the RFID readers 151 are respectively located at both ends of the interlayer sheet, when the biological sample 200 is stored from a position near one end of the interlayer sheet (for example, placed in the placement layer 11 from a position near the left or right), only one RFID reader 151 near the biological sample 200 can read the sample label 201 thereon, and when the biological sample 200 is picked up or placed from a position near the middle of the interlayer sheet, both RFID readers 151 can read the sample label 201 thereon. For example, in fig. 4(a), a biological sample 200a is put in from the right area, and its biological tag 201a is read only by the RFID reader 151 on the right side during the putting in; the biological sample 200b is put in from the middle area, so that the biological tag 201a thereof can be read by two RFID readers 151 at the same time during the putting in process; the biological specimen 200a is put in from the left area, and the biological tag 201a thereof is read only by the RFID reader 151 on the left side during the putting in. Thus, the sample rack control unit can determine the approximate location (left area, right area, or middle area) where the biological sample 200 is stored, based on the fact that the two RFID readers 151 read the biological tags.

In addition, as shown in fig. 4(B), the reading direction of the RFID reader 151 of the present embodiment is directed inward as viewed from the depth direction. Specifically, the RFID reader of the present embodiment is a directional RFID reader, and the directional RFID reader 151 is installed to be slightly inclined inward, that is, the reading direction thereof is directed inward. Meanwhile, in the present embodiment, the layer eaves portion 111 at the position of the RFID reader 151 is provided with an inward inclined slope portion 111A, so that the electromagnetic wave of the RFID reader 151 enters the placing layer to read the sample tag 201 on the biological sample 200 therein. For example, in fig. 4(B), once the cabinet door 12 is opened, the RFID reader 151 can read the bio-tag 201e on the bio-sample 200e placed in the placement layer 11, but cannot read the bio-tag 201d on the bio-sample 200d that has not been placed in the placement layer 11. That is, since the reading directions of the RFID readers 151 are all inward, only the sample tag 201 on the biological sample 200 in the placement layer 11 will be read, and the biological sample 200 will not be read during the taking and placing process.

The procedure of reading the sample label 201 by the determination section 15 in this embodiment is as follows: the main control chip 18 controls the determination part to continuously read and temporarily store the read sample determination information contained in the sample label 201 according to the opening condition of the cabinet door 12 sensed by the sensing part 14 when the cabinet door 12 is opened, and sends the last read sample determination information, layer number and cabinet number of all the sample labels 201 to the management server 2 after the cabinet door 12 is closed, and at this time, the sample determination information corresponds to the biological sample 200 actually existing in the layer 11 and currently placed after the scientific research personnel completes the picking and placing actions.

In addition, in this embodiment, the interlayer plate further has a metal interlayer 112, and the metal interlayer 112 forms a shielding effect, so the RFID reader 151 does not read the sample tag 201 on the biological sample 200 in the adjacent placement layer 11.

The identity recognition part 16 is arranged on the cabinet 10 and used for recognizing the recognition information of scientific research personnel.

In this embodiment, the identification information is door opening information, a password, two-dimensional code information corresponding to the identity of a scientific researcher, fingerprint information of the scientific researcher, or face information in a door opening card held by the scientific researcher, and the identity identification unit is a door card reading device, a password input device, a two-dimensional code scanning device, a fingerprint identification device, or a face identification device corresponding to the identification information. The scientific researcher can operate the identity recognition part 16 in a corresponding mode (namely, the operations of swiping a card, inputting a password, scanning a two-dimensional code, verifying a fingerprint, shooting a human face and the like) so that the identity recognition part 16 recognizes the identification information of the scientific researcher.

In this embodiment, the identification information corresponds to the identity of each scientific research personnel, that is, each scientific research personnel has unique identification information, and the identity of each scientific research personnel can be directly and correspondingly determined through the identification information.

The warning portion 17 is a warning lamp disposed on the front surface of the cabinet 10, and is configured to generate a light flashing when receiving the warning message so as to warn the employee that an incorrect sample is taken.

Fig. 5 is a functional block diagram of a sample cabinet in an embodiment of the invention.

As shown in fig. 5, the main control chip 18 is electrically connected to the locking portion 13, the sensing portion 14, the determination portion 15, the identification portion 16, and the warning portion 17, respectively, and controls the operations of these components. The main control chip 18 includes a sample cabinet communication section 181 and a cabinet number layer number storage section 182.

The sample chamber communication unit 181 is a communication module connected to the main control chip 18, and is used to perform data communication between the sample chamber 1 and the management server 2. In this embodiment, the cabinet number layer number storage unit 182 records the respective cabinet number, and the scientific research personnel can find the corresponding sample cabinet 1 through the cabinet number. Meanwhile, in each sample cabinet 1, the respective placement layers 11 also have respective unique layer numbers. Since the determination unit 15 corresponds to each placement layer 11, actually, the determination unit 15 also corresponds to each layer number, so that when the determination unit 15 reads the sample label 201, the main control chip 18 can determine which determination unit 15 of which placement layer 11 has read the sample label according to the correspondence. For convenience of description, hereinafter, the three set layers 11 are referred to as a set layer 11a, a set layer 11b, and a set layer 11c, and the determination units 15 corresponding to the set layer 11a, the set layer 11b, and the set layer 11c are referred to as a determination unit 15a, a determination unit 15b, and a determination unit 15c, respectively.

Fig. 6 is a schematic diagram of the storage contents of the cabinet number layer number storage unit in the embodiment of the present invention.

As shown in fig. 6, the sample tank 1 having the tank number "GH 1" shown in fig. 6 is exemplified by having three receiving layers 11, the layer numbers of which are "Cha", "Chb" and "Chc", respectively, and the numbers of the three discrimination sections 15 are "PBa", "PBb" and "PBc", respectively.

In addition, similarly, since the locking part 13 and the sensing part 14 also correspond to the placing layer 11, the main control chip 18 can also perform corresponding control of locking or unlocking according to the corresponding relationship, or obtain the sensing result of the opening/closing state of the corresponding cabinet door 12.

In this embodiment, the main control chip 18 of each sample cabinet 1 records its own cabinet number, and the scientific research personnel can find the corresponding sample cabinet 1 through the cabinet number. Meanwhile, in each sample cabinet 1, the respective placement layers 11 also have respective unique layer numbers. Since the determination unit 15 corresponds to each placement layer 11, actually, the determination unit 15 also corresponds to each layer number, so that when the determination unit 15 reads the sample label 201, the main control chip 18 can determine which determination unit 15 of which placement layer 11 has read the sample label according to the correspondence. Similarly, since the locking portion 13 and the sensing portion 14 correspond to the placing layer 11, the main control chip 18 can also control the corresponding locking or unlocking according to the corresponding relationship, or obtain the sensing result of the opening/closing state of the corresponding cabinet door 12.

FIG. 7 is a flowchart of a method for managing a biological specimen for scientific research according to an embodiment of the present invention.

As shown in fig. 7, the biological sample management method for scientific research according to the present embodiment is implemented based on the system 100 including the sample cabinet 1, the server 2, the researcher terminal 3, the management terminal 4, and the communication network 5, and is configured to manage information of a biological sample 200 based on a sample tag 201 including an RFID tag, and specifically includes the following steps.

In step S1, the sample discrimination information 211, the sampling information 212, the sample position information 213, and the valid number information 214 are stored in association with each other as the sample-related information 21. Specifically, these pieces of information are stored in the management server 2.

Fig. 8 is a schematic diagram of sample related information storage according to an embodiment of the present invention.

As shown in fig. 8, in the present embodiment, the specimen discrimination information 211 is unique number information of the biological specimen 200, which is also stored in the chip of the specimen tag 201, and thus, once the specimen tag 201 is read, the number information can be obtained by the RFID reader.

The sampling information 212 includes the source name of the sampling source and the sampling time. In practical use, the sampling time may be replaced by a sampling batch/lot number, as long as the sampling information of different dispensed biological samples 200 obtained from the same sampling source in the same sampling is the same.

The sample position information 213 includes the cabinet number of the sample cabinet 1 and the layer number of the placement layer 11, for example, the first several bits of each sample position information are the corresponding cabinet numbers, so as to avoid the same layer number of the placement layers 11 of the same layer number of different sample cabinets.

In this embodiment, the plurality of sample discrimination information 211 may have the same sampling information 212 (for example, if a sample from the same source "cell sample source 1" is sampled at time t1 and dispensed to form a plurality of biological samples 200, the plurality of biological samples 200 all have the same sampling information "cell sample source 1-sampling time t 1"). Meanwhile, the plurality of sample discrimination information may correspond to the same sample position information (for example, a plurality of biological samples 200 are carried on a placement layer of the same sample cabinet). The sampling information may also include some information in number form, such as sampling numbers, etc., according to naming requirements, but the number information in the sampling information and the number of the sample discrimination information may be independent of each other and have no correspondence.

The valid times information 214 is valid times corresponding to each biological sample 200. That is, if the number of times exceeds the above number, the corresponding biological sample 200 cannot be used any more, and the disposal operation should be performed in accordance with the sample management use specification. Similar to the storage requirement information 221, the effective number of times of biological samples 200 obtained from the same batch of samples is the same.

In step S2, the sampling information 212, the corresponding storage request information 221, and the valid number 222 are stored as the sampling-related information 22. These pieces of sampling-related information 22 are also stored in the management server 2, as are the pieces of sampling-related information 21.

Fig. 9 is a schematic diagram of storage of sampling related information according to an embodiment of the present invention.

As shown in fig. 9, the storage request information 221 includes the number of sample cases 1 where the biological samples 200 obtained by the same sampling can be stored. Due to different storage requirements of different biological samples 200, the samples may be stored in the sample cabinets 1 with different set temperatures due to temperature requirements, and the samples with the same storage temperature may be stored separately due to sample storage safety requirements (for example, a physiological sample and a pathological sample should be stored separately, and a sample containing an infectious pathogen should be completely isolated from other samples). In addition, the placing layers 11 are separated by the layer plates, so that the placing layers can be regarded as independent storing environments. The biological samples 200 obtained from the same sampling source at the same time are the same, so the storage requirements of the biological samples 200 of the same sampling information are necessarily the same, and the storage requirement information includes the number of the sample cabinet 1 in which all the biological samples 200 of a certain sampling can be stored (i.e., the number of the sample cabinet 1 that meets the storage requirements of the biological samples 200 in various aspects such as temperature requirement, isolation requirement, etc.).

The effective number 223 is the effective number (i.e., the number that can be used) of biological samples 200 obtained for the same sampling from the same sampling source. The initial value of the effective number is the number of sub-packages in storage at the time of sampling.

In this embodiment, the sample-related information 21 and the sampling-related information 22 may be input when the biological sample 200 is put in storage after the sampling is completed.

The reader/writer provided in the administrator terminal 4 is an RFID reader/writer, and can write discrimination information into the RFID tag. When a certain batch of biological samples 200 are put into storage, the administrator can input information (including sample discrimination information, acquisition information, storage request information, and the like) of the biological samples to be put into storage through the human-computer interaction screen displayed on the input display section of the administrator terminal 4, and then write the input sample discrimination information into the RFID tag by using the RFID reader/writer and transmit the input information to the management server 2, so that the management server 2 stores the input information as sample-related information. Then, the administrator unlocks the lock section 14 to open the cabinet door 12 so as to make the identification section 16 of the specimen cabinet 1 identify, inserts the biological specimen 200 with the specimen label 201 in which the specimen discrimination information is written, and makes the management server 200 perform a corresponding process, that is, an update process of writing the positional information at the time of insertion.

In this embodiment, after the preliminary storage of the information is completed, scientific researchers can apply for and extract the biological sample 200, thereby managing the biological sample 200.

Fig. 10 is a diagram illustrating a sample request screen according to an embodiment of the present invention.

As shown in fig. 10, the sample request screen 31 includes a text box 311 for the researcher to input characters and an enter button 312 for making an enter content determination. When a scientific research staff applies for extracting a sample, the scientific research staff terminal 3 is required to input identification information to log in the management server 2, and the scientific research staff terminal 3 is required to input required sampling information through a human-computer interaction picture of the scientific research staff terminal 3, so that the input required sampling information and the input identification information are sent to the management server 2 by the scientific research staff terminal 3.

When receiving the required sampling information and the identification information sent by the terminal 3 of the scientific research personnel, the management server 2 retrieves the relevant information of the sample according to the received required sampling information, obtains the corresponding sample discrimination information 211 and the sample position information 213, sends the retrieved sample discrimination information 211, the retrieved sample position information 213 and the received required sampling information as extraction information to the terminal 3 of the scientific research personnel, and enables the scientific research personnel to check the information through the man-machine interaction picture of the terminal 3 of the scientific research personnel. In the extracted information, there may be a plurality of biological samples 200 corresponding to one piece of sampling-required information, and accordingly, there may be a plurality of pieces of sample position information 213.

Fig. 11 is a schematic diagram of request record storage in the embodiment of the present invention.

As shown in fig. 11, the management server 2 transmits the extracted information and stores the extracted information and the identification information received from the terminal 3 of the scientific research worker as one request record 231, thereby forming a plurality of request records 231. When the scientific research personnel selects a plurality of pieces of required sampling information, the management server 2 also stores each piece of required sampling information and the corresponding extraction information and identification information thereof as different request records 231.

Then, the scientific researcher can select one sample cabinet 1 to take and place the biological sample 200, and the identification part 16 is used for identification.

In step S3, when a researcher or a manager selects one sample cabinet 1 to pick and place a biological sample, the identification information of the researcher or the manager is identified by the identification unit 16, and then the identification information is transmitted to the management server 2 through the sample cabinet communication unit 181, and the process proceeds to step S4.

Step S4, the management server 2 determines whether the identification information corresponds to a researcher or a manager, and when the identification information corresponds to a researcher, searches the request record 231 and the extraction record 241, respectively, and further determines whether the researcher has an opening right; when the administrator is judged, the administrator directly judges that the administrator has the opening authority. If it is determined that the sample cabinet 1 has the opening authority, the control device transmits a door opening permission signal to the sample cabinet 1, and then proceeds to step S5.

In this embodiment, the management server 2 further stores an extraction record 241.

Fig. 12 is a schematic diagram of extraction record storage in the embodiment of the present invention.

As shown in fig. 12, when a researcher takes a certain biological sample 200, the management server 2 stores the corresponding sample discrimination information and the identification information received from the sample cabinet 1 as one extraction record 241.

In this embodiment, the management server 2 also stores the personal information. That is, the related information of the researchers and the managers is stored, including the identification information, the personal information (name, department, etc.) and the identity information of each of the researchers and the managers. The identity information represents whether the person is a scientific research person or an administrator. The management server 2 determines whether the identification information corresponds to the scientific research personnel or the administrator based on the stored personnel information, and further determines whether the scientific research personnel has the door opening authority when determining that the scientific research personnel exists.

The judgment of whether the scientific research personnel have the door opening permission is carried out based on the identification information, the extraction record and the request record, and the specific process is as follows:

the respective request records 231 are sequentially searched based on the received identification information and the cabinet number, and it is determined whether or not there is a matching request record 231, and if so, it is determined whether or not the cabinet number exists in the sample position information 213 of the matching request record.

The respective extracted records 241 are sequentially retrieved based on the received identification information to determine whether there is a matching extracted record 241, and if so, the corresponding sample position information 213 is retrieved from the sample-related information 21 based on the sample discrimination information 211 in the extracted record 241 and it is determined whether the obtained sample position information 213 is "taken out". If it is determined that the sample identification information 211 corresponds to the storage request information 221 of the sampling information 212, it is further determined whether the cabinet number is present in the acquired storage request information 221.

Once the final result of any one of the two search determinations is that the cabinet is present (i.e. the transmitted cabinet number is present in the sample position information 213 requested to be recorded or the cabinet number is present in the storage request information 221), the management server 2 sends a door opening permission signal to the sample cabinet 1, so that the scientific research staff opens the cabinet door. The door open permission signal includes a layer number, which is the layer number in the request record in the case where the request records 231 match; in the case where the extraction records 241 match, the layer number is one or more layer numbers corresponding to the cabinet number in the storage requirement information.

If neither of the above determinations is determined to exist, no response is made (alternatively, the management server 2 may send a warning signal to the corresponding sample cabinet 1 to cause the warning unit 17 to issue a warning to remind the scientific research personnel, where the warning may be in the form of a short red light emitted by the warning unit 17).

In addition, if the administrator is determined to have the door opening authority of all the doors, the door opening permission signal sent at this time includes all the layer numbers corresponding to the cabinet numbers, and the main control chip 18 can control all the locking parts 13 to be unlocked according to the signal. In this embodiment, the main control chip 18 is provided with an automatic locking mechanism, that is, after a certain locking portion 13 is controlled to be unlocked, if the corresponding sensing portion 14 does not sense that the cabinet door 12 is opened within a certain time, the main control chip 18 controls the locking portion 13 to unlock again, so as to avoid that the locking portion 13 keeps an unlocking state all the time under the condition that the cabinet door 12 is not opened.

In step S5, the main control chip 18 controls the corresponding locking part 13 to unlock the cabinet door 12 according to the layer number in the door opening permission signal, so that a scientific researcher or administrator can open the cabinet door 12 to perform an extraction or storage operation, and once the sensing part 14 senses that the cabinet door 12 is opened, the process goes to step S6.

In step S6, the main control chip 18 controls the determination unit 15 to continuously perform the reading operation and temporarily store the read sample determination information, and once the scientific researchers complete the extraction or storage and close the cabinet door 12, so that the sensing unit 14 senses that the cabinet door 12 is closed, the process goes to step S7.

In step S7, the main control chip 18 controls the lock section 13 to lock the cabinet door 12, and controls the sample cabinet communication section 181 to transmit the identification number, the cabinet number, the layer number corresponding to the determination section 15, and the last read identification information and the number of readings of all samples to the management server 2, and then the process proceeds to step S8.

In step S8, the management server 2 determines the access situation of the biological sample 200 according to the identification number, the cabinet number, the layer number sample discrimination information and the reading frequency sent from the sample cabinet 1, updates the sample position information in the sample related information and forms a corresponding extraction record, and then proceeds to step S9.

In this embodiment, the procedure for determining the access condition of the biological sample 200 is as follows:

when the counter number, the layer number, and the sample discrimination information 211 are received, the management server 2 first retrieves all the sample discrimination information 211 corresponding to the counter number and the layer number from the sample-related information 21 as the previous sample discrimination information, compares the sample discrimination information 211 with the received sample discrimination information 211, and if there is any sample discrimination information 211 in the previous sample discrimination information 211 but the received sample discrimination information is not present, it indicates that the biological sample 200 corresponding to the sample discrimination information 211 is taken out, and otherwise, it indicates that the biological sample 200 is put in. After the access situation determination is completed, the management server 2 rewrites the sample position information 213 corresponding to the biological sample 200 determined to be taken out of the sample-related information into the content indicating that it has been taken out (for example, "taken out"), and rewrites the sample position information 213 corresponding to the biological sample 200 determined to be put in of the sample-related information 21 into the corresponding cabinet number.

Further, when it is determined that a certain biological sample 200 has been taken out, the management server 2 stores the corresponding sample discrimination information 211 and the identification information received from the sample rack 1 as one extraction record 241.

In step S9, the management server 2 checks whether the extracted or stored biological sample 200 is correct or not based on the access determination result, the extraction log 241, the sample-related information 21, and the sampling-related information 22, and proceeds to step S10 when it is determined that the extraction or storage is incorrect, and to step S11 when it is determined that there is no error.

In this embodiment, once the determination of the access condition of the biological sample 200 is completed, the access condition may include the extracted biological sample 200 or the deposited biological sample 200.

When a certain biological sample 200 is determined to be extracted, the management server 2 acquires the corresponding sampling information 212 from the extraction record as sampling information to be extracted based on the identification information, acquires the corresponding sampling information 212 from the sample-related information 21 as actual extraction sampling information based on the received biological sample determination information 211, further determines whether the two are identical, and determines that the scientific researcher has extracted an erroneous sample if the two are not identical.

When a certain biological sample 200 is determined to be stored, the management server 2 retrieves and acquires corresponding sampling information 212 from the sample-related information 21 based on the sample discrimination information 211, retrieves and acquires corresponding storage request information 221 from the sampling-related information 22 based on the acquired sampling information 212, further determines whether or not the cabinet number and the floor number in which the biological sample 200 is stored are present in the acquired storage request information 221, and if it is determined that the biological sample 200 is not stored in the unsuitable storage floor 11, it is determined that a researcher or administrator has stored the biological sample 200 at an incorrect position.

In step S10, the management server 2 sends a warning signal to the corresponding sample cabinet 1, so that the warning section 17 starts a warning (for example, continuously emits red light at a specific light emission frequency), and then enters an end state.

In step S11, the management server 2 determines whether or not the biological sample 200 should be discarded based on the access determination result and the extraction record 241, and proceeds to step S12 when determining that the biological sample should be discarded, and proceeds to an end state when determining that the biological sample should not be discarded.

As shown in fig. 13, in the present embodiment, the management server 2 also stores the number of times 251 of extraction of each biological sample 200. Specifically, each time the access determination is completed, the management server 2 adds 1 to the number of times of extraction 251 corresponding to the biological sample 200 determined to be taken out, in accordance with the sample determination information 211.

After the access determination is completed and the accumulation of the number of extraction times is completed, the management server 2 sequentially determines whether or not the current number of extraction times of each biological sample 200 determined to be extracted is equal to or greater than the corresponding valid number 223 of times of the sampling information 212 of the sample discrimination information 211 in the sampling-related information 22. When the biological sample 200 is judged to be not less than the predetermined threshold, it is judged that the biological sample should be discarded.

In step S12, the management server 2 forms a discard prompt, transmits the formed discard prompt to the terminal 3 of the researcher, and then proceeds to step S13.

For the biological sample 200 determined to be discarded, the management server 2 searches the extraction record based on the sample discrimination information 211 thereof, acquires the identification information of the researcher corresponding to the latest extraction record 241, determines the researcher corresponding to the identification information as the presentation target, generates the discarding presentation content including the sample discrimination information 211 determined to be discarded and the corresponding sampling information 212, and sends the discarding presentation content to the corresponding researcher terminal 3. For example, the discard instruction may be a form of "sample P3 (cell sample origin 1-collection time t2) has reached the upper limit of the number of times of use, and please discard after use".

The scientific research personnel terminal 3 receives the abandonment prompt information and then displays corresponding abandonment prompt contents, so that the scientific research personnel can directly abandon the biological sample 200 after the use without returning.

In step S13, the management server 2 retrieves the sampling information 212 corresponding to the biological sample 200 determined to be discarded from the sample-related information 21, subtracts 1 from the effective amount information 222 corresponding to the sampling information 212 in the sampling-related information 22, and then proceeds to step S14.

In step S14, the management server 2 determines whether the current effective quantity corresponding to the sampling information 212 in the sampling related information 22 after subtracting 1 is less than a predetermined quantity, and if so, generates an effective quantity prompt containing the sampling information 212 and sends the prompt to the management terminal 4, and then enters an end state.

The management terminal 4 displays the effective number reminder when receiving the effective number reminder, so that the administrator performs corresponding processing according to the effective number reminder, for example, finds the corresponding remaining biological sample 200 and transfers the biological sample to a special sample storage cabinet.

In the above process, if the administrator performs the identification operation, the determination result in step S3 is the administrator, and at this time, the management server 2 further determines that the administrator has the door opening authority of all the storage levels 11, and transmits a door opening permission signal including all the level numbers to the sample cabinet 1, so that the administrator can open the cabinet door 12 of any storage level 11 to perform the operation (for example, take out the biological samples 200 to be discarded or transfer the biological samples 200 whose number is less than the predetermined effective number). Similarly, the main control chip 18 controls the determination unit 15 to continuously read the sample determination information while the cabinet door 12 is opened, and controls the sample cabinet communication unit 181 to transmit the last read sample determination information, the cabinet number, and the layer number to the management server 2 after the sensing unit 14 senses that the cabinet door 12 is locked, so that the management server 2 performs corresponding access determination and update processing.

In this embodiment, the management server 2 also periodically performs discarding check on the biological sample 200, and when the biological sample 200 that has been put in by mistake after exceeding the valid number is determined, a corresponding prompt is generated and sent to the management terminal 4, so that the administrator can go to and take out the biological sample for discarding operation.

Specifically, at a preset time (for example, a fixed time per day), the management server 2 sequentially obtains the number of times 251 of extraction corresponding to each sample discrimination information 211, determines whether each number of times 251 of extraction is greater than the value of the corresponding valid number information 223 of the corresponding sample information 212 in the sample correlation information 22, further determines whether the sample position information 213 of the sample discrimination information 211 in the sample correlation information 21 is taken out when the number of times 251 of extraction is determined to be exceeded, and generates a discard prompt including the corresponding sample discrimination information 211 and the sample position information 213 when the number of times of extraction is not taken out, the discard prompt being sent from the management server 2 to the administrator terminal 4, so that the administrator can view the prompt through the management terminal 4. Then, the administrator can go to the corresponding sample cabinet 1 according to the discarding hint to take out the biological sample 200 that should be discarded, thereby performing a sample discarding operation.

Examples effects and effects

According to the biological sample management method for scientific research provided by the embodiment, each biological sample is provided with the sample label containing the sample identification information, and the corresponding identification part is arranged on the placing layer of the sample cabinet, so that the sample label can be identified to obtain the corresponding sample identification information, and therefore, the corresponding sample identification information can be read when the scientific research personnel take and place the biological sample, and the management server can update the information according to the read sample identification information and the cabinet number layer number. Furthermore, the management server of the embodiment can also accumulate the extraction times of the biological samples judged to be extracted according to the access judgment result, and form a abandonment prompt to send to the corresponding scientific research personnel terminal when the accumulated extraction times is more than or equal to the effective times, so that the scientific research personnel can be prompted to abandon the biological samples which are to be abandoned after the biological samples are used for the next time, and misuse caused by putting the biological samples which are to be abandoned into the placing layer again is avoided.

Furthermore, in the embodiment, the management server is used to accumulate the number of times of extraction, and periodically determines whether the number of times of extraction exceeds the valid number according to the accumulated number of times of extraction, and determines whether the corresponding biological sample is taken out when the number of times of extraction exceeds the valid number, and a discard prompt is generated to send to the administrator terminal when the number of times of extraction is not taken out, so that the administrator can be prompted to take out the biological sample to be discarded to perform a discard operation when the biological sample to be discarded is placed back by mistake, and the biological sample to be discarded is further prevented from being misused.

In addition, because the opening and closing of the induction part induction cabinet door is adopted, the judgment part is allowed to judge when the cabinet door is opened, so that the sample labels can be continuously read under the states that the cabinet door is closed and the sample cabinet is not used, the working time of the judgment part is shortened, the service life of the judgment part is prolonged, and the problem that the reading work of the cabinet door on the judgment part is influenced due to the fact that the cabinet door is read under the condition that the cabinet door is closed is also avoided. For example, if the reading is performed when the cabinet door is closed, the sample label is not easily read by the determination part due to the blockage of the cabinet door; however, if the cabinet door is arranged on the inner side of the cabinet door, the temperature in the placing layer is too low to work normally.

In the embodiment, the request records of the scientific research personnel are stored, the extraction records of the scientific research personnel are stored, whether the scientific research personnel have the permission to open the sample cabinet is further judged according to the sent identification information, the request records and the extraction records, and the door opening permission signal is sent when the scientific research personnel have the permission to open the sample cabinet, so that the cabinet door can be unlocked when the access is necessary, and the influence on the low-temperature environment in the placement layer due to the mistaken opening is avoided. Moreover, in the embodiment, the door opening permission signal further includes a layer number in the request record or a layer number corresponding to the cabinet number in the storage requirement information, so that the sample cabinet control part can control the locking part of the corresponding placing layer to unlock according to the layer number, and further the scientific research personnel is prevented from opening the wrong placing layer when taking and placing the sample cabinet. In addition, when the administrator is determined to be a manager, the door opening permission signal including all the layer numbers is sent, so that the administrator can conveniently open each placing layer to realize management work (for example, taking out a biological sample to be discarded or performing warehousing operation on a biological sample newly added after collection).

In the embodiment, the sample tag is an RFID tag, and the determination unit is an RFID reader, and is mounted on the layer eaves portion formed by the outward extension of the interlayer plate, so that the biological sample with the sample tag can be read in and out of the placement layer, and the access condition of the biological sample can be effectively determined. Furthermore, the reading direction of the RFID reader faces outwards, the corresponding sample tags in the placed layers cannot be read, meanwhile, the interlayer plate is provided with the metal interlayer, the RFID reader can be prevented from reading the adjacent sample tags in the placed layers, therefore, misreading can be prevented, and the accuracy of the management server is improved. In addition, because the length direction both ends of every layer eaves portion respectively are equipped with an RFID and read the ware, and the reading range that each RFID read the ware is greater than the half of the width of layer board between, is less than the width of layer board between, consequently can also judge biological sample and place the approximate position on the layer through the reading condition of two RFID readers, let scientific research personnel can take biological sample according to this approximate position more fast to reduce the time that the cabinet door was opened, let and place intralamellar low temperature environment and maintain stably more easily.

In addition, in the embodiment, after the access condition is judged, the management server is adopted to obtain the name to be extracted according to the identification information, obtain the actual extraction name according to the sample judgment information, and judge whether the two names are consistent, so that whether the scientific research personnel extract the wrong biological sample can be judged. Since the position information is updated after the access condition is judged, the extraction record is stored, and under the condition of mistakenly taking out, when the scientific research personnel use the identification part to read the identification information, the opening authority can be judged according to the extraction record so as to open the corresponding cabinet door, so that even under the condition of mistakenly taking out, the scientific research personnel can smoothly return the cabinet.

In the embodiment, the management server is adopted to update the effective number in the collected information storage part (namely, the effective number is reduced by 1 after being discarded every time), and an effective number prompt is formed when the number is less than the preset number and is sent to the management terminal, so that an administrator can be reminded to perform corresponding processing when the number of biological samples with the same sampling information (namely, the same sampling from the same sampling source) is too small (for example, less than the preset long-term sample remaining number).

The above-described embodiments are merely illustrative of specific embodiments of the present invention, and the present invention is not limited to the description of the above-described embodiments.

For example, in the above embodiment, the RFID reader is mounted on the layer eaves portion, the reading direction of the RFID reader faces the inner side, and the slope portion is provided, so that the RFID reader reads the sample tags in the placement layer when the sample tags are placed in the placement layer, and the management server performs corresponding access condition determination and update. However, in other aspects of the present invention, the reading direction of the RFID reader may not face inward (i.e., not face in the direction of the placement layer), so that the RFID reader cannot read the sample tag on the biological sample in the placement layer regardless of the opened or closed state of the cabinet door.

Specifically, the RFID reader may be in the form of a directional RFID reader, and the directional RFID reader is installed slightly obliquely outward, that is, the reading direction of the directional RFID reader faces outward; the RFID reader may also be in the form of a general non-directional RFID reader, and when the RFID reader is mounted, the non-directional RFID reader is embedded in the interlayer board, and a shielding layer (e.g., a metal plate) is disposed at an inner side of the interlayer board, so that electromagnetic waves can be prevented from entering the placement layer when the RFID reader reads, and the reading direction faces outward. Because the reading direction of the RFID reader faces to the outside, the sample label on the biological sample in the placing layer cannot be read, and therefore the biological sample can only pass through the reading area of the RFID reader in the taking and placing process, and the sample label is read. In other embodiments, a shielding layer may be disposed at an outer side position of each directional RFID reader to prevent the reading range of the RFID reader from extending outward too much, in which case, the reading range of each RFID reader is only equivalent to the area vertically below the reading range, so as to prevent the biological sample from being repeatedly read when the biological sample is located at an outer side position close to the placement layer 11 (for example, the biological sample is held by a hand of a scientific researcher during taking and placing or temporarily placed on a taking and placing tray and thus located at the position), thereby more accurately reading the movement of the sample label in and out of the placement layer. Therefore, the management server can directly judge and update according to the situation that the label read by the judging part passes by, and the management server specifically comprises the following steps: when the same sample discrimination information is read for odd times, firstly judging whether the cabinet number and the layer number exist in the sample position information corresponding to the sample discrimination information, and if so, judging that the biological sample is taken out; if the cabinet number and the layer number do not exist (i.e., they have been marked as "taken out"), it is determined that the biological sample is placed, and at this time, the corresponding sample position information is rewritten into the cabinet number and the layer number corresponding to the determination section (which can be obtained from information sent from the sample cabinet), and further, the position information read by the determination section (for example, the left side, the right side, or the middle area) is added to the sample position information. In addition, when the same sample discrimination information is read even times, it is considered that the corresponding biological sample is taken out and put back or put in and then taken out, and the management server does not determine that the biological sample is put in or taken out at this time.

For example, in the above embodiment, the warning portion is a warning light disposed on the front surface of the cabinet door. In another aspect of the present invention, the warning unit may be an audible and visual alarm or other device having a prompt effect, and may be disposed at a position where the reagent tank is easily viewed or where sound is easily emitted, as required.

Claims

1. A biological sample management method for scientific research is characterized in that a system comprising a sample cabinet, a scientific research personnel terminal and a management server is adopted to realize the management of biological samples with sample labels, and comprises the following steps:

correspondingly storing sample distinguishing information, sampling information, sample position information and storage requirement information as sample related information in the management server;

storing the sampling information and the corresponding effective times information as sampling related information in the management server;

adopting the management server to form extraction information containing the sample distinguishing information, the sample position information and the received required sampling information according to the required sampling information input by scientific researchers, the sample related information and the sampling related information received from the scientific researchers terminal, and further storing the extraction information and the identification information of the scientific researchers as request records;

identifying the identification information of the scientific research personnel by adopting an identification part, and then sending the identification information to the management server;

judging whether the scientific research personnel have the opening authority or not at least based on the identification information by adopting the management server, and sending an opening permission signal to the sample cabinet once the scientific research personnel have the opening authority;

the control module of the sample cabinet is adopted to unlock the cabinet door according to the door opening permission signal, so that the scientific research personnel can open the cabinet door to perform extraction or storage operation;

continuously reading the sample label by using a judging part, sensing whether the cabinet door is closed or not by using a sensing part, and sending the read sample judging information and the cabinet number of the sample cabinet to the management server once the scientific research personnel are sensed to close the cabinet door;

judging the access condition of the biological sample by adopting the management server according to the sent sample distinguishing information and the cabinet number, updating at least the sample position information in the sample related information and the extraction state information recorded by the request, adding 1 to the extraction frequency corresponding to the biological sample judged to be extracted, and further sequentially judging whether the current extraction frequency of each biological sample judged to be extracted is more than or equal to the corresponding effective frequency of the sampling information corresponding to the sample distinguishing information in the sampling related information,

and when the judgment result is greater than or equal to the preset value, judging that the biological sample is to be discarded, forming a discarding prompt by the management server, and sending the formed discarding prompt to the scientific research personnel terminal.

2. The method for managing biological samples for scientific research as set forth in claim 1, wherein:

wherein the sampling related information further comprises an effective number corresponding to the sampling information,

once the management server determines that the biological sample should be discarded, the sampling information corresponding to the biological sample determined to be discarded is retrieved from the sample-related information, and the effective number corresponding to the sampling information in the sample-related information is decremented by 1.

3. The method for managing biological samples for scientific research as set forth in claim 2, wherein:

wherein the system further comprises a management terminal held by an administrator,

and the management server judges whether the current quantity corresponding to the sampling information is less than a preset quantity after subtracting 1 from the effective quantity, and generates an effective quantity prompt containing the sampling information and sends the effective quantity prompt to the management terminal when the current quantity is less than the preset quantity.

4. The method for managing biological samples for scientific research as set forth in claim 3, wherein:

wherein the management server forms and stores an extraction record based on the sample discrimination information and the identification information of the biological sample determined to be extracted after the update processing.

5. The method for managing biological samples for scientific research as set forth in claim 4, wherein:

wherein the management server further stores the identification information and the identity information of the scientific research personnel and the administrator as personnel information,

the management server receives the identification information sent by the sample cabinet and then judges whether the sample cabinet is a scientific research personnel or a manager according to the personnel information,

and when the scientific research personnel are judged to be the scientific research personnel, judging whether the scientific research personnel have the opening authority or not according to the extraction record and the request record.

6. The method for managing biological samples for scientific research as set forth in claim 4, wherein:

wherein the sampling related information further includes storage requirement information,

and after storing the extraction record, the management server further verifies and confirms whether the extracted or stored biological sample is correct or not according to the judgment result of the access condition, the extraction record, the sample related information and the sampling related information, and sends a warning signal to the sample cabinet when the extraction or storage is judged to be wrong.