CN113111983A

CN113111983A - Project-based biological sample management method for scientific research

Info

Publication number: CN113111983A
Application number: CN202011630289.7A
Authority: CN
Inventors: 黄景锟; 张鹏; 何杨星; 况凤超; 仓超; 李斌
Original assignee: Hangzhou Shared Experimental Technology Development Co ltd
Current assignee: Hangzhou Shared Experimental Technology Development Co ltd
Priority date: 2020-01-10
Filing date: 2020-12-31
Publication date: 2021-07-13

Abstract

The invention aims to realize rapid batch extraction of biological samples, and provides a project-based biological sample management method for scientific research, which is characterized by comprising the following steps of: inputting a required project name through a scientific research personnel terminal; forming an extraction list containing the required sample name and corresponding sample position information and extraction state information according to the required project name, project related information and sample related information, and further storing the extraction list and the identification information of scientific research personnel as request records; thereby relieve the locking of cabinet door and let scientific research personnel open the cabinet door and draw or deposit the operation, adopt the judgement portion to continuously read the action and adopt response portion response cabinet door whether to close, in case sense scientific research personnel and close the cabinet door, just send the sample judgement information that reads and the cabinet number of sample cabinet for management server at least, let management server to sample position information and draw state information and carry out the renewal processing.

Description

Project-based biological sample management method for scientific research

Technical Field

The invention relates to a biological sample management method for scientific research.

Background

The biological sample refers to organs, tissues, cells, biological macromolecules and the like derived from human bodies, other animals or plants, is usually collected and stored in environments such as low temperature (-below 30 ℃) or ultralow temperature (-below 80 ℃) and the like, and is used as a sample in scientific research work. Among them, important resource facilities in the scientific research of biological sample libraries composed of one or more types of biological samples, for example, in molecular genetics, some research projects require a large number of genetic resource samples, and thus need to utilize the human genome library for completion; pathological studies typically require a large number of pathological tissue samples and therefore rely on a library of pathological samples.

In order to ensure the rich diversity of biological samples, a large number of biological samples need to be stored and managed in the process of establishing and subsequently maintaining a biological sample library; during the operation of the biological sample library, the collection and storage of the samples are generally continued, so that a biological sample library usually has a huge number of biological samples and the number of biological samples continuously and gradually increases with time. When some scientific research projects are carried out, the number of the required related biological samples is possibly very large and the samples are stored dispersedly, and scientific research personnel need to search repeatedly when the biological samples are extracted, so that the time is wasted, and the progress of the scientific research projects is influenced.

In addition, just because quantity is big, the storage dispersion, scientific research personnel need spend the longer time to open the cabinet door and turn over when taking or returning the biological sample, draws and still need open the cabinet door again when having the omission and turn over and look for, leads to the cabinet door open time overlength, and the temperature in low temperature or the ultra-low temperature freezer is influenced by the outside and is risen, even close the cabinet door and also need the certain time cooling to resume, other biological samples in the cabinet still will receive the influence, perhaps inefficacy even. When once only extracting a large amount of biological samples, scientific research personnel still need make a round trip between each sample cabinet, and the biological sample need be kept in the refrigerated container in the temporary storage after being extracted, if the time of making a round trip to look for is longer, then the refrigerated container is difficult to effectively keep low temperature environment for the biological sample that takes out earlier unfreezes and even restores room temperature, and its validity receives the influence.

Disclosure of Invention

In order to solve the problems and realize the rapid batch extraction of biological samples, the invention provides a project-based biological sample management method for scientific research, which is characterized in that a system comprising a sample cabinet, a scientific research personnel terminal and a management server is adopted to realize the management of the biological samples with sample labels, and the method comprises the following steps: the sample discrimination information, the corresponding sample name, the sample position information and the storage requirement information are used as sample related information to be correspondingly stored in the management server; storing project related information including project names of the scientific research projects and sample names of biological samples required by the scientific research projects in a management server; enabling scientific researchers to input scientific research project names needing sample extraction as required project names through scientific research worker terminals; the management server forms a required sample name containing a required biological sample, corresponding sample position information and an extraction list of extraction state information according to a required project name, project related information and sample related information received from a scientific research personnel terminal, and further stores the extraction list and identification information of the scientific research personnel as request records; identifying the identification information of the scientific research personnel by adopting an identification part of the sample cabinet, and then sending the identification information to a management server; judging whether the scientific research personnel have the opening authority or not at least based on the identification information by adopting a management server, and sending an opening permission signal to the sample cabinet once the scientific research personnel have the opening authority; the control module of the sample cabinet is adopted to remove the locking of the cabinet door according to the door opening permission signal, so that scientific researchers can open the cabinet door to perform extraction or storage operation; the method comprises the steps that a judging part is adopted to continuously read and an induction part is adopted to induce whether a cabinet door is closed or not, and once the door is induced to be closed by scientific research personnel, at least read sample judging information and a cabinet number of a sample cabinet are sent to a management server; the management server judges the access condition of the biological sample according to the sent sample judgment information and the cabinet number, and at least updates the sample position information in the sample related information and the extraction state information requested to be recorded.

Action and Effect of the invention

According to the biological sample management method for scientific research provided by the embodiment, the sample name and the project name of the biological sample related to the scientific research project are stored as the project related information, and the sample name, the sample distinguishing information and the sample position information of the biological sample are stored as the sample related information, so that a scientific researcher can obtain the related sample name by inputting the project name, can obtain the sample position information of the biological sample related to a scientific research project at one time, and can rapidly and accurately finish extraction. The management server can generate an extraction list containing the sample name and the sample position information, and the extraction list also comprises extraction state information, so that scientific research personnel can extract according to the extraction list, and omission or errors are not easy to occur.

Drawings

FIG. 1 is a schematic diagram of a system for implementing a method for managing a biological sample for scientific research according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of a sample cabinet according to an embodiment of the present invention;

FIG. 3 is a schematic view of an installation location of an RFID reader of an embodiment of the present invention;

FIG. 4 is a range diagram of an RFID reader of an embodiment of the present invention;

FIG. 5 is a functional block diagram of a sample cabinet in an embodiment of the invention;

FIG. 6 is a schematic diagram of the storage contents of the cabinet number layer number storage unit in the embodiment of the present invention;

FIG. 7 is a flowchart of a scientific biological specimen management method according to an embodiment of the present invention;

FIG. 8 is a schematic diagram of sample correlation information storage according to an embodiment of the present invention;

FIG. 9 is a schematic diagram of sample correlation information storage according to an embodiment of the present invention;

FIG. 10 is a sample request screen diagram according to an embodiment of the invention;

FIG. 11 is a schematic diagram of an abstraction list according to an embodiment of the present invention;

FIG. 12 is a schematic diagram of extraction record storage according to an embodiment of the present invention;

FIG. 13 is a schematic diagram of the storage of the cabinet number and the location information thereof according to the embodiment of the present invention;

fig. 14 is a flow chart of a recent sample bin determination according to an embodiment of the present invention.

Detailed Description

The method for managing a biological sample for scientific research according to the present invention will be described in detail below with reference to the accompanying drawings.

The invention provides a project-based biological sample management method for scientific research, which is characterized in that a system comprising a sample cabinet, a scientific research personnel terminal and a management server is adopted to realize the management of a biological sample with a sample label, and the method comprises the following steps: the sample discrimination information, the corresponding sample name, the sample position information and the storage requirement information are used as sample related information to be correspondingly stored in the management server; storing project related information including project names of the scientific research projects and sample names of biological samples required by the scientific research projects in a management server; enabling scientific researchers to input scientific research project names needing sample extraction as required project names through scientific research worker terminals; the management server forms a required sample name containing a required biological sample, corresponding sample position information and an extraction list of extraction state information according to a required project name, project related information and sample related information received from a scientific research personnel terminal, and further stores the extraction list and identification information of the scientific research personnel as request records; identifying the identification information of the scientific research personnel by adopting an identification part of the sample cabinet, and then sending the identification information to a management server; judging whether the scientific research personnel have the opening authority or not at least based on the identification information by adopting a management server, and sending an opening permission signal to the sample cabinet once the scientific research personnel have the opening authority; the control module of the sample cabinet is adopted to remove the locking of the cabinet door according to the door opening permission signal, so that scientific researchers can open the cabinet door to perform extraction or storage operation; the method comprises the steps that a judging part is adopted to continuously read and an induction part is adopted to induce whether a cabinet door is closed or not, and once the door is induced to be closed by scientific research personnel, at least read sample judging information and a cabinet number of a sample cabinet are sent to a management server; the management server judges the access condition of the biological sample according to the sent sample judgment information and the cabinet number, and at least updates the sample position information in the sample related information and the extraction state information requested to be recorded.

The biological sample management method for scientific research in the above embodiment may further have a technical feature that, after the management server completes the update processing of the sample position information and the extraction state information, the omission judgment prompt processing is also performed, the sample cabinet identified by the scientific researcher is the current sample cabinet, and the omission judgment prompt processing process is as follows: and searching the extraction list in the request record according to the cabinet number and the layer number of the current sample cabinet, judging whether extraction state information which is represented as unextracted exists in the extraction states corresponding to the cabinet number and the layer number, and forming omission prompts by the sample name, the sample distinguishing information, the cabinet number and the layer number of the biological sample corresponding to the extraction state information which is represented as unextracted when the extraction state information exists.

Further, the biological sample management method for scientific research may further have a technical feature that the cabinet number of each sample cabinet and the location information thereof are stored in the management server, the location information includes the floor number, and the room number of each sample cabinet, when it is determined that there is no missing biological sample in the current sample cabinet, the management server determines whether there is a next sample cabinet to be moved to according to the extraction list, and forms extraction path prompt information including the location information of the sample cabinet when there is a sample cabinet to be moved to.

Further, the above biological sample management method for scientific research may further have the technical feature that the process of determining whether there is a next sample cabinet to go to is as follows: and judging whether the extraction list contains the biological samples with the extraction states represented as unextracted or not according to the extraction state information of the biological samples in the extraction list, acquiring all cabinet numbers of the biological sample cabinets from the sample position information of the biological samples represented as unextracted when the biological samples contain the biological samples, and judging the sample cabinet closest to the current sample cabinet as the next sample cabinet needing to go to according to the cabinet numbers and the position information of the sample cabinets.

Further, the above method for managing biological samples for scientific research may further have a technical feature that the process of determining the nearest sample cabinet to the current sample cabinet is as follows: taking all the acquired cabinet numbers as the cabinet numbers of the sample cabinets to be judged, firstly judging whether the sample cabinets to be judged which are positioned in the same room with the current sample cabinet exist, and if so, finding out the sample cabinet to be judged which is closest to the number of the current sample cabinet as the nearest sample cabinet; when the sample cabinet to be judged with the same room number as the current sample cabinet does not exist, judging whether the sample cabinet to be judged with the same floor number as the current sample cabinet exists or not, if so, finding out the room number closest to the room number of the current sample cabinet, and taking the sample cabinet to be judged with the smallest or largest cabinet number in the room numbers as the nearest sample cabinet; and when the sample cabinet to be judged which is the same as the floor number of the current sample cabinet does not exist, judging whether the sample cabinet to be judged which is the same as the floor number of the current sample cabinet exists or not, if so, finding out the floor number which is the closest to the floor number where the current sample cabinet is located, and taking the sample cabinet to be judged which is the smallest or the largest in the floor number as the nearest sample cabinet.

The biological sample management method for scientific research in the above embodiment may further have a technical feature that the process of determining whether the scientific research personnel has the opening authority by the management server includes: searching the request records according to the received identification information and the cabinet number, judging whether matched request records exist or not, and further judging whether the sample position information in the extraction list of the matched request records exists or not when the matched request records exist; retrieving the extraction records according to the received identification information, judging whether matched extraction records exist, further acquiring corresponding storage requirement information from sample related information according to sample judgment information in the extraction records when the matched extraction records exist, judging whether the cabinet number exists in the acquired storage requirement information, and judging that the scientific research personnel have door opening permission once the final result of any judgment in the two judgments is existence.

Further, the biological sample management method for scientific research may further have a technical feature that, when the management server determines that the transmitted cabinet number exists in the sample position information in the extraction list recorded in the request, an extraction prompt corresponding to the cabinet number is generated and sent to the corresponding scientific research staff terminal to be checked by the scientific research staff, and the content of the extraction prompt is the sample name, the sample discrimination information and the corresponding layer number corresponding to all sample position information including the transmitted cabinet number in the extraction list.

< example >

FIG. 1 is a schematic diagram of a system for implementing a method for managing a biological sample for scientific research according to an embodiment of the present invention.

As shown in fig. 1, the biological sample management method for scientific research of the present embodiment is implemented based on a system 100, where the system 100 includes a plurality of sample cabinets 1, a management server 2, a plurality of scientific research personnel terminals 3, and communication networks 4a and 4 b.

The management server 2 is in communication connection with each sample cabinet 1 through a communication network 4a, and is in communication connection with each scientific research personnel terminal 3 through a communication network 4 b. In this embodiment, the communication networks 4a and 4b are both local area networks in a laboratory.

The scientific research personnel terminals 3 are terminals such as smart phones, computers and tablet computers, are respectively held by different scientific research personnel and perform related operations, and identification information corresponding to the respective scientific research personnel is stored in each scientific research personnel terminal 3. The scientific researchers involved in the present invention may be sample library management personnel who manage the biological sample 200, or may be scientific research experimenters who have access rights to the biological sample 200. In addition, the biological samples 200 are physiological or pathological samples of human body, other animals or plants obtained by sampling, including but not limited to organs, tissues, cells and biological macromolecules, and the forms of the biological samples 200 and the containers thereof may be the same or different according to the preservation requirement; either as containers containing a single sample (e.g., tubes, bags or bottles) or as containers containing multiple aliquots of the same sample (e.g., cartridges containing multiple tubes or tubes). A corresponding sample tag 201 is fixed to each container of the biological sample 200, and the sample tag 201 is a low-temperature RFID tag containing sample discrimination information and can normally operate in low-temperature and ultra-low-temperature environments.

Fig. 2 is a schematic structural diagram of a sample cabinet in an embodiment of the invention. In fig. 2, the storage rack and the storage cassette for storing the biological samples 200 are omitted to show the structure more clearly.

As shown in fig. 2, the sample chamber 1 includes a chamber body 10, a placement layer 11, a chamber door 12, a locking portion 13, a sensing portion 14, a determination portion 15, an identification portion 16, a warning portion 17, and a main control chip (not shown). In this embodiment, sample cabinet 1 still is equipped with cooling mechanism such as compressor, is used for carrying out the temperature setting mechanism that the temperature set for, is used for detecting the temperature detection mechanism who places layer 11 internal temperature and controls the control mechanism who realizes the control by temperature change according to temperature detection result and the work of setting for the temperature to cooling mechanism, thereby the specific constitution and the theory of operation of these mechanisms are the same with among the ultra-low temperature refrigerator among the prior art, and it is no longer repeated here.

The cabinet 10 has three placing layers 11 for placing the biological sample 200, and adjacent placing layers 11 are spaced apart from each other by a layer plate.

In this embodiment, the interlayer plate is a heat-insulating plate having a certain thickness. The interlayer sheet does not have any restriction structure for the specimen, and therefore the biological specimen 200, the rack or the placing case containing the biological specimen 200 can be placed on the placing layer 11 at will.

The number of the cabinet door 12, the locking portion 13, the sensing portion 14, and the determination portion 15 is three, and each corresponds to each placement layer 11.

Wherein, the cabinet door 12 is hinged on the cabinet body 10 at the side position of the placing layer 11. Cabinet door 12 is the heat preservation cabinet door, by the metal level that is located the outside and be located the heat preservation of inboard and constitute, and the layer 11 is placed to the heat preservation orientation inside to realize the heat preservation function.

The locking portion 13 is used to lock the cabinet door 12. In this embodiment, the locking portion 13 is an electronic lock, and is disposed on the cabinet door 12 or on the cabinet body 10 at a position corresponding to the edge of the cabinet door 12, and can lock or unlock the cabinet door 12 according to the control electrical signal of the main control chip.

The sensing part 14 is a proximity switch, is disposed on each cabinet door 12 or on the cabinet body 10 at a position corresponding to the edge of each cabinet door 12, and can sense whether the corresponding cabinet door 12 is in a closed state and generate a corresponding electrical signal. The discrimination unit 15 discriminates the specimen label 201 on the biological specimen 200 when the biological specimen 200 is taken out or placed.

Fig. 3 is a schematic view of an installation position of an RFID reader according to an embodiment of the present invention, and fig. 3 shows a partial sectional structure of a sample cabinet.

As shown in fig. 2 and 3, in the present embodiment, each determination unit 15 is constituted by two RFID readers 151. The upper interlayer board of each placement layer 11 extends outward to form a layer eaves portion 111, and the two RFID readers 151 are embedded in the layer eaves portions 111 of the upper interlayer boards of the placement layers 11 corresponding to the determination unit 15, and are located at both ends (corresponding to the left and right sides) in the width direction of the interlayer boards. Meanwhile, each RFID reader 151 is located at the outer edge position of the interlayer plate, and the position corresponds to the outer surface position of the cabinet door 12, that is, a space with a heat preservation effect is enclosed between the heat preservation layer of the cabinet door 12 and each interlayer plate of the placement layer 11, and the RFID reader is located outside the heat preservation space, so that the RFID reader is not affected by low temperature in the space and can work normally.

FIG. 4 is a range diagram of an RFID reader of an embodiment of the present invention. Wherein, fig. 4(B) is a schematic range diagram in the width direction, fig. 4(a) is a schematic range diagram in the depth direction, and the broken lines in the diagram each indicate the read range of the RFID reader; in addition, in fig. 4(B), the cabinet door 12 is omitted.

As shown in fig. 4(a), in the present embodiment, the read range D of the RFID reader 151 in width is greater than one-half of the width L of the interlayer board and smaller than the width L. Since the RFID readers 151 are respectively located at both ends of the interlayer sheet, when the biological sample 200 is stored from a position near one end of the interlayer sheet (for example, placed in the placement layer 11 from a position near the left or right), only one RFID reader 151 near the biological sample 200 can read the sample label 201 thereon, and when the biological sample 200 is picked up or placed from a position near the middle of the interlayer sheet, both RFID readers 151 can read the sample label 201 thereon. For example, in fig. 4(a), a biological sample 200a is put in from the right area, and its biological tag 201a is read only by the RFID reader 151 on the right side during the putting in; the biological sample 200b is put in from the middle area, so that the biological tag 201a thereof can be read by two RFID readers 151 at the same time during the putting in process; the biological specimen 200a is put in from the left area, and the biological tag 201a thereof is read only by the RFID reader 151 on the left side during the putting in. Thus, the sample rack control unit can determine the approximate location (left area, right area, or middle area) where the biological sample 200 is stored, based on the fact that the two RFID readers 151 read the biological tags.

In addition, as shown in fig. 4(B), the reading direction of the RFID reader 151 in the present embodiment is not directed inward (i.e., is not directed toward the inside of the setting layer 11) when viewed from the depth direction, so that the RFID reader 151 cannot read the sample label 201 on the biological sample 200 in the setting layer 11 regardless of the opened or closed state of the cabinet door 12.

Specifically, the RFID reader 151 of the present embodiment is a directional RFID reader, and the directional RFID reader is installed slightly obliquely outward, that is, the reading direction of the directional RFID reader faces outward, so that the sample tag 201 is read only in the picking and placing process. For example, in fig. 4(B), once the cabinet door 12 is opened, the RFID reader 151 can read the bio-tag 201d on the biological sample 200d being put in, but cannot read the bio-tag 201e on the biological sample 200e already positioned in the setting layer 11. That is, since the reading directions of the RFID readers 151 are all facing outward, the sample tags 201 on the biological samples 200 in the placement layer 11 are not read, and the biological samples 200 can only pass through the reading area of the RFID readers 151 in the taking and placing processes, so that the sample tags 201 thereon are read.

In addition, in this embodiment, the interlayer plate further has a metal interlayer 112, and the metal interlayer 112 forms a shielding effect, so the RFID reader 151 does not read the sample tag 201 on the biological sample 200 in the adjacent placement layer 11. The recognition unit 16 is provided on the cabinet 10 and recognizes recognition information of a researcher.

In this embodiment, the identification information is door opening information, a password, two-dimensional code information corresponding to the identity of a scientific researcher, fingerprint information of the scientific researcher, or face information in a door opening card held by the scientific researcher, and the identification portion is a door card reading device, a password input device, a two-dimensional code scanning device, a fingerprint identification device, or a face identification device corresponding to the identification information. The scientific researchers can operate the identification part 16 in a corresponding mode (namely, the operations of swiping a card, inputting a password, scanning a two-dimensional code, verifying a fingerprint, shooting a human face and the like) so that the identification part 16 can identify the identification information of the scientific researchers.

In this embodiment, the identification information corresponds to the identity of each scientific research personnel, that is, each scientific research personnel has unique identification information, and the identity of each scientific research personnel can be directly and correspondingly determined through the identification information.

The warning section 17 is used to generate warning information. In this embodiment, the warning portion 17 is a warning light disposed on the front surface of the cabinet 10, and is configured to generate a light flash when receiving the warning message.

Fig. 5 is a functional block diagram of a sample cabinet in an embodiment of the invention.

As shown in fig. 5, the main control chip 18 is electrically connected to the locking portion 13, the sensing portion 14, the determination portion 15, the identification portion 16, and the warning portion 17, respectively, and controls the operations of these components. The main control chip includes a sample cabinet communication section 181 and a cabinet number layer number storage section 182.

The sample chamber communication unit 181 is a communication module connected to the main control chip 18, and is used to perform data communication between the sample chamber 1 and the management server 2. In this embodiment, the cabinet number layer number storage unit 182 records the respective cabinet number, and the scientific research personnel can find the corresponding sample cabinet 1 through the cabinet number. Meanwhile, in each sample cabinet 1, the respective placement layers 11 also have respective unique layer numbers. Since the determination unit 15 corresponds to each placement layer 11, actually, the determination unit 15 also corresponds to each layer number, so that when the determination unit 15 reads the sample label 201, the main control chip 18 can determine which determination unit 15 of which placement layer 11 has read the sample label according to the correspondence. For convenience of description, hereinafter, the three set layers 11 are referred to as a set layer 11a, a set layer 11b, and a set layer 11c, and the determination units 15 corresponding to the set layer 11a, the set layer 11b, and the set layer 11c are referred to as a determination unit 15a, a determination unit 15b, and a determination unit 15c, respectively.

Fig. 6 is a schematic diagram of the storage contents of the cabinet number layer number storage unit in the embodiment of the present invention.

As shown in fig. 6, the sample tank 1 having the tank number "GH 1" shown in fig. 6 is exemplified by having three receiving layers 11, the layer numbers of which are "Cha", "Chb" and "Chc", respectively, and the numbers of the three discrimination sections are "PBa", "PBb" and "PBc", respectively.

In addition, similarly, since the locking part 13 and the sensing part 14 also correspond to the placing layer 11, the main control chip 18 can also perform corresponding control of locking or unlocking according to the corresponding relationship, or obtain the sensing result of the opening/closing state of the corresponding cabinet door 12.

FIG. 7 is a flowchart of a scientific biological sample management method according to an embodiment of the present invention.

As shown in fig. 7, the biological sample management method for scientific research according to the present embodiment is implemented based on the system 100 of the sample cabinet 1, the server 2, the researcher terminal 3, and the communication network 4, and is used for managing information of a biological sample 200 based on a sample tag 201 including an RFID tag, and specifically includes the following steps.

In step S1, the sample discrimination information 211, the corresponding sample name 212, the sample position information 213, and the storage request information 214 are stored in association with each other as the sample-related information 21. Specifically, these pieces of information are stored in the management server 2.

Fig. 8 is a schematic diagram of sample related information storage according to an embodiment of the present invention.

As shown in fig. 8, in the present embodiment, the specimen discrimination information 211 is unique number information of the biological specimen 200, which is also stored in the chip of the specimen tag 201, and thus, once the specimen tag 201 is read, the number information can be obtained by the RFID reader.

The specimen name 212 is the name of the specimen contained in the specimen bottle.

The sample position information 213 includes the cabinet number of the sample cabinet 1, the layer number of the placement layer 11, and the position in the placement layer 11. Each sample position information 213 takes the form of a bin number and a layer number. Taking 1 having a bin number GH1 and including three placement levels 11 as an example, as shown in fig. 8, the first few bits of each sample position information 213 are the corresponding bin number, the last few bits are the level number, and the last few bits are the positions (left, middle, or right) in the placement level 11, thereby avoiding the situation where the same sample position information 213 occurs in the same number of placement levels 11 of different sample bins 1.

The storage request information 214 includes the bin number and the layer number of the sample bin 1 in which the biological sample 200 can be stored. Due to different storage requirements of different biological samples 200, the samples may be stored in the sample cabinets 1 with different set temperatures due to temperature requirements, and the samples with the same storage temperature may be stored separately due to sample storage safety requirements (for example, a physiological sample and a pathological sample should be stored separately, and a sample containing an infectious pathogen should be completely isolated from other samples). In addition, since the placing layers 12 are separated by the layer plates, they can be regarded as an independent storing environment, and the storage requirement information includes the number of the sample cabinet 1 in which a certain biological sample 200 can be stored (i.e., the number of the sample cabinet 1 that satisfies various storage requirements such as temperature requirement and isolation requirement of the biological sample 200).

In this embodiment, the sample discrimination information 211 may have the same sample name 212 (for example, if the same type of sample from the same source is dispensed to form a plurality of biological samples 200, the biological samples 200 all have the same sample name 212). Meanwhile, the plurality of sample discrimination information 211 may correspond to the same sample position information 213 (for example, a plurality of biological samples 200 are carried on the placement layer 11 of the same sample cabinet 1). The sample name 212 may also include some information in the form of numbers, such as a sampling number, according to the naming requirement, but the number information in the sample name and the number of the sample identification information may be independent of each other and have no correspondence. In addition, the storage request information 214 corresponding to each sample discrimination information 211 may have a plurality of numbers of the cabinet numbers, for example, if a certain biological sample 200 may be stored in a plurality of storage levels 11 of different sample cabinets 1, the storage request information 214 includes all the cabinet numbers and the layer numbers thereof that satisfy the storage request.

In step S2, the project names 221 including the respective scientific research projects and the sample names 212 of the biological samples 200 required for the scientific research projects are stored as the project-related information 22. Like the sample-related information 21, these pieces of information are also stored in the management server 2.

Fig. 9 is a schematic diagram of sample related information storage according to an embodiment of the present invention.

As shown in fig. 9, the biological sample 200 required by each scientific research project is the biological sample 200 required by the scientific research project at the current progress, and after the scientific research project supervisor establishes a communication connection with the management server 2 through the supervisor terminal, the supervisor terminal views the scientific research project within the authority range, searches the currently required biological sample 200 from the sample related information 21, and sets the biological sample 200 as the biological sample 200 related to the scientific research project. After the supervisor completes the setting, the management server 2 stores the corresponding sample name 212 and the project name 221 of the scientific research project in association with each other according to the setting.

In this embodiment, after the initial storage of the information is completed, the scientific researchers may extract or store the biological sample 200.

FIG. 10 is a sample request screen diagram according to an embodiment of the invention.

As shown in fig. 10, the sample request screen 31 includes a text box 311 for the researcher to input characters and an enter button 312 for making an enter content determination. When the scientists apply for the sample, the scientist terminal 3 is required to log in the management server 2 by using the identification information, and the research project name 221 required to extract the sample is input as the required project name through the sample request picture 31 displayed by the scientist terminal 3.

FIG. 11 is a schematic diagram of an abstraction list according to an embodiment of the present invention.

As shown in fig. 11, after the scientific research personnel terminal 3 sends the input required project name to the management server 2, the management server 2 retrieves the project-related information 22 according to the received required project name to obtain a corresponding sample name 212 as a required sample name 212 ', further retrieves the sample-related information 21 to obtain corresponding sample position information 213, generates corresponding extraction lists for all the retrieved required sample names 212' and sample position information 213, and then sends the extraction lists to the scientific research personnel terminal 3. In the extraction list 23, each requirement sample name 212' also has corresponding extraction status information 231, and the extraction status is recorded as not extracted when the extraction list 23 is generated. Taking fig. 10 as an example, fig. 10 shows the list 23 of "genetic item 1" in fig. 9, where the sample name 212 corresponding to "genetic item 1" includes "cell sample 1", "serum sample 1" and "DNA sample 1", and the three biological samples 200 are classified into three types according to the bin numbers, the first type includes "cell sample 1" and "serum sample 1" located at the same placement level 11 "Cha" (the bin number is GH1-Cha) of the sample bin 1 "GH 1", and "cell sample 1" and "serum sample 1" with the sample discrimination information 211 being "P1" and "P4", respectively; the second type is "DNA sample 1" in which the set layer 11 "Cha" (the cabinet number layer number is GH2-Cha) and the sample discrimination information 211 is "P5" are located in the sample cabinet 1 "GH 2"; the third type is "DNA sample 1" in which the sample discrimination information 211 is "P6" and the sample discrimination information 211 is "GH 2-Chb" at the placement level 11 "Chb" of the sample chamber 1 "GH 2". Wherein, the two requirement sample names 212' in the first class are different, and therefore have respective extraction states; the second and third types are both "DNA sample 1", so the demand sample name 212' is the same for both types, and they have the same extraction status. When the extraction list 23 is generated, the extraction state corresponding to each demand sample name 212' is not extracted.

The management server 2 sends the extraction list to the scientific research worker terminal 3, and stores the extraction list 23 and the corresponding identification information as one request record. In each request record, each demand sample name is also provided with corresponding extraction state information 231, and the extraction state is recorded as not extracted when the extraction list is generated.

Step S3, when the scientific research personnel selects one sample cabinet 1 to take and place the biological sample, the identification information of the scientific research personnel is identified by the identification part, and then the identification information is sent to the management server through the sample cabinet communication part 181, and then the process goes to step S4.

In step S4, the management server 2 determines whether the scientific research personnel has the opening authority or not according to the extraction record, the request record and the received identification information, and sends an opening permission signal to the sample cabinet 1 once the scientific research personnel has the opening authority, and then the process goes to step S5.

FIG. 12 is a schematic diagram of an extraction record storage according to an embodiment of the present invention.

As shown in fig. 12, in the present embodiment, when a scientific researcher takes out a certain biological sample 200, the management server 2 stores the corresponding sample discrimination information 211 and the identification information received from the sample cabinet 1 as one extraction record 241. In addition, when a certain biological sample 200 is returned, the management server 2 deletes the corresponding extraction record 241.

In this embodiment, when the scientific researcher operates the recognition unit 16 to make the recognition unit 16 recognize the identification information, the sample cabinet communication unit 181 transmits the identification information and the cabinet number of the sample cabinet to the management server 2, and at this time, the management server 2 searches the request record and the extraction record 241, respectively, to complete the determination of the opening authority.

Specifically, on the one hand, the management server 2 searches the request records based on the received identification information and the cabinet number and determines whether or not there is a matching request record, and further determines whether or not there is the cabinet number in the sample position information 213 in the extraction list 23 of the matching request record when there is.

On the other hand, the management server 2 searches the extracted record based on the received identification information and determines whether or not there is a matching extracted record 241, and further, if there is any, acquires the corresponding storage request information 214 from the sample-related information 21 based on the sample discrimination information 211 in the extracted record 241, and determines whether or not the counter number is present in the acquired storage request information 214.

Once the final result of any one of the two determinations is present (i.e. the extraction list 23 of the request record contains the transmitted cabinet number or the storage request information 214 of the biological sample 200 in the extraction record 241 contains the cabinet number), the management server 2 sends a door opening permission signal to the sample cabinet 1, so as to allow the scientific research staff to open the cabinet door. The door opening permission signal contains a layer number, and the layer number is all layer numbers corresponding to the cabinet number in the extraction list 23 of the request record under the condition that the request records are matched; in the case where the extraction records 241 match, the layer number is one or more layer numbers corresponding to the cabinet number in the storage requirement information 214. When it is determined that the door opening authority exists and the management server 2 transmits the door opening signal, the sample rack 1 to which the door opening signal is transmitted is a place where the current extraction or storage operation is performed, and the sample rack 1 is hereinafter referred to as a current sample rack 1'.

If neither of the above determinations is determined to exist, the management server 2 sends a warning signal to the corresponding sample cabinet 1, so that the warning unit 17 sends a warning to remind the scientific research personnel, wherein the warning may be in the form of a short red light emitted by the warning unit 17.

Further, step S4 includes the following steps:

when the management server 2 judges that the transmitted cabinet number exists in the sample position information in the extraction list, an extraction prompt corresponding to the cabinet number is generated and transmitted to the corresponding scientific research personnel terminal 3 to be checked by the scientific research personnel.

Specifically, when it is determined that the sample position information 213 of the extraction list 23 has the sent cabinet number (i.e., when the scientific researcher has the biological sample 200 that needs to be extracted from the current sample cabinet 1'), the sample names 212, the sample discrimination information 211, and the corresponding layer numbers corresponding to all the sample position information 213 of the cabinet number in the extraction list 23 are used to form an extraction prompt. After the extraction prompt is generated, the management server 2 sends a door opening signal to the sample cabinet 1, and meanwhile, the extraction prompt is sent to the scientific research personnel terminal 3, so that the scientific research personnel can check the extraction prompt through the man-machine interaction picture of the scientific research personnel terminal 3, and all biological samples 200 needing to be extracted in each layer are sequentially extracted according to the extraction prompt, and therefore omission is avoided.

In step S5, the main control chip 18 controls the corresponding locking part 13 to unlock the cabinet door 12 according to the layer number in the door opening permission signal, so that the scientific research staff can open the cabinet door 12 to perform the extraction or storage operation, and once the scientific research staff opens the cabinet door 12 and the sensing part 14 senses that the cabinet door 12 is opened, the process goes to step S6. In addition, if the sensing part 14 does not sense that the cabinet door 12 is opened within a predetermined time, the main control chip 18 controls the locking part 13 to lock the cabinet door 12 again.

In step S6, the main control chip 18 controls the determination unit 15 to continuously perform the reading operation and temporarily store the read sample determination information 211 and the number of times, and once the scientific research personnel complete the extraction or storage and close the cabinet door 12 so that the sensing unit 14 senses that the cabinet door 12 is closed, the process proceeds to step S7. In addition, if the closing of the cabinet door 12 is not sensed after the predetermined time, the main control chip 18 controls the warning part 17 to give a warning (for example, continuously give a red light, etc.), thereby prompting the scientific research personnel to close the cabinet door 12 in time.

In this embodiment, the main control chip 18 controls the determination unit 15 to continuously perform the reading action after the sensing unit 14 senses that the cabinet door 12 is opened, so that the sample tag 201 can be read by the determination unit 15 when the biological sample 200 is taken and placed; meanwhile, the main control chip 18 also temporarily stores all the sample discrimination information read during the continuous reading operation and the number of times of reading.

In step S7, the main control chip 18 controls the lock section 13 to lock the cabinet door 12, and controls the sample cabinet communication section 181 to transmit the identification number, the cabinet number, the layer number corresponding to the determination section 15, and all the sample determination information and the number of readings read by the layer number to the management server 2, and then the process proceeds to step S8.

In this embodiment, when the cabinet door 12 is opened by a scientific researcher after being unlocked, so that the sensing portion 14 senses that the cabinet door 12 is opened, and then the sensing portion 14 senses that the cabinet door 12 is closed again, the main control chip 18 controls the sample cabinet communication portion 181 to send the identification number, the cabinet number, the layer number corresponding to the determination portion 15, and all the sample determination information and the reading times read by the layer number to the management server 2 while controlling the locking portion 13 to lock the cabinet door 12.

In step S8, the management server 2 determines the access status of the biological sample 200 based on the identification number, the cabinet number, the layer number, the sample discrimination information, and the number of readings transmitted from the sample cabinet 1, updates the sample position information 211 in the sample-related information and the extraction state information 231 in the request record, and then proceeds to step S9.

The specific process of the management server 2 for judging the access condition of the biological sample 200 according to the identification number, the cabinet number, the layer number, the sample discrimination information and the reading times sent by the sample cabinet 1 is as follows:

when the same sample discrimination information is read for odd times, it is first determined whether the cabinet number and the layer number already exist in the sample position information corresponding to the sample discrimination information.

If there is any, it is determined that the biological sample 200 has been taken out, and the sample position information corresponding to the sample discrimination information in the sample-related information is rewritten to "taken out" or the like indicating that it has been taken out, and the extraction state information 231 corresponding to the sample discrimination information in the request record is rewritten to extracted.

If there is no cabinet number and layer number (i.e., it has been marked as "taken out"), it is determined that the biological sample 200 is placed, and at this time, the corresponding sample position information is rewritten into the cabinet number and layer number corresponding to the determination section 15 (which can be obtained from the information sent from the sample cabinet 1), and further, the position information read by the determination section 15 (for example, the left, right, or middle area) is added to the sample position information.

In addition, when the same sample discrimination information is read for an even number of times, the corresponding biological sample 200 is considered to be taken out and put back or put in and then taken out, and at this time, the biological sample 200 is judged not to be put in or taken out, and the rewriting of the corresponding information is not performed any more; when a certain biological sample 200 is determined to be taken out, the management server 2 also stores the corresponding sample discrimination information 211 and the identification information received from the current sample rack 1' as one extraction record 241. In this embodiment, the management server 2 also deletes the corresponding extraction record 241 when determining that a certain biological sample 200 is returned.

In step S9, the management server 2 verifies and confirms whether the extracted biological sample 200 is correct or not according to the result of the access determination and the extraction record, and proceeds to step S10 when it is determined that the extraction error is not made by the researcher, and proceeds to step S11 when it is determined that the extraction error is not made by the researcher.

Specifically, in the present embodiment, once the management server 2 has completed the determination of the access condition of the biological sample 200, the name of the sample corresponding to the cabinet number and the layer number is acquired as the name to be extracted from the extraction list of the request record based on the identification information, and the corresponding sample name 212 is acquired as the actual extraction name from the sample-related information 21 based on the received sample discrimination information 211 determined to be extracted, and it is further determined whether the name to be extracted and the actual extraction name match, and if not, it is determined that the scientific researcher has extracted the wrong sample.

In step S10, the management server 2 sends a warning signal to the current sample cabinet 1', so that the warning unit 17 activates a warning to remind the scientific research personnel of taking out the wrong sample, and then the process goes to step S11. Wherein the warning may be in the form of a continuous emission of red light at a specific emission frequency.

In step S11, it is determined whether or not the unextracted biological sample 200 is still present in the placement layer 11 of the current sample holder 1', a omission indication is formed when it is determined to be present, and the process proceeds to step S12, and the process proceeds to step S13 when it is determined to be absent.

In this embodiment, the determination process for determining whether there is any unextracted biological sample 200 in the current sample cabinet 1' and the process for forming the omission indication are as follows:

after the access condition determination and the request record update are completed, the management server 2 searches the extraction list in the request record according to the current cabinet number and layer number, determines whether "unextracted" exists in the extraction state corresponding to the cabinet number and layer number, and if so, forms the sample name of the "unextracted" biological sample 200, the corresponding sample discrimination information, and the cabinet number and layer number into a omission prompt.

And step S12, the management server 2 sends the omission prompt to the corresponding scientific research personnel terminal 3, so that the scientific research personnel can check the omission condition and extract again. Then, the process proceeds to step S13.

In step S13, the management server 2 determines whether there is a next sample cabinet 1 to be moved to, and if there is any, forms an extraction route prompt, and then proceeds to step S14, and if not, proceeds to an end state.

Fig. 13 is a schematic diagram of cabinet numbers and storage of location information thereof according to an embodiment of the present invention.

As shown in fig. 13, in this embodiment, the management server 2 further stores the cabinet number of each sample cabinet 1 and the location information thereof, where the location information includes the floor number, and room number of each sample cabinet 1.

Specifically, the management server 2 determines whether the extraction list 23 includes a biological sample 200 whose extraction state is "unextracted" or not based on the extraction state information 231 of each biological sample 200 in the extraction list 23, acquires all the bin numbers from the sample position information 213 of the unextracted biological sample 200 when the biological sample is included, and determines the sample bin 1 bin number in which the biological sample 200 to be extracted exists, which is closest to the current sample bin 1', based on the bin number and the location information of the sample bin; when the biological sample 200 is not contained, it means that all the biological samples 200 to be extracted are completely extracted, and the state is entered into the end state.

In general, the sample cabinets 1 are arranged in the same room according to the cabinet number, similarly, the rooms on the same floor are arranged according to the room number, and the floors on the same building are arranged according to the floor number, so that the sample cabinet with the biological sample 200 to be extracted nearest to the current sample cabinet 1' can be found out by utilizing the rule. That is, all the cabinet numbers including the biological sample 200 whose extraction state is "unextracted" are obtained from the extraction list 23 as the cabinet number of the sample cabinet to be determined, the position information of the corresponding sample cabinet is obtained according to the cabinet number of the sample cabinet to be determined, and then the sample cabinet 1 closest to the current sample cabinet 1' is determined.

As shown in fig. 14, when the extraction list 23 includes the extraction status of "not extracted", the process of further determining the nearest sample rack of the current sample rack 1' is as follows:

step S13-1-1, judging whether a sample cabinet to be judged with the same room number as the current sample cabinet 1' exists, if so, entering step S13-1-2, and if not, entering step S13-1-3;

step S13-1-2, the sample cabinet to be judged with the number closest to the number of the current sample cabinet 1 'is taken as a new current sample cabinet 1', and then an extraction path prompt is formed;

step S13-1-3, judging whether a sample cabinet to be judged with the same floor number as the current sample cabinet 1' exists, if so, entering step S13-1-4, and if not, entering step S13-1-5;

step S13-1-4, finding out the room number closest to the current room number of the sample cabinet 1' from the sample cabinets to be judged, taking the sample cabinet to be judged with the smallest cabinet number in the room numbers as the nearest sample cabinet, and then forming an extraction path prompt;

step S13-1-5, judging whether a sample cabinet to be judged with the same floor number as the current sample cabinet 1' exists, if so, entering step S13-1-6, and if not, entering step S13-1-7;

step S13-1-6, finding out the floor number closest to the floor number where the current sample cabinet 1' is located, taking the sample cabinet to be judged with the smallest cabinet number in the sample cabinet 1 with the smallest room number in the floor number as the nearest sample cabinet, and then forming an extraction path prompt;

and S13-1-7, finding out the floor number closest to the floor number of the current sample cabinet 1', taking the sample cabinet to be judged with the smallest floor number and room number in the floor number and the sample cabinet with the smallest cabinet number in the sample cabinet 1 as the nearest sample cabinet, and then forming an extraction path prompt.

In the above process, the management server 2 forms an extraction path prompt by using the cabinet number of the nearest sample cabinet and the position information of the corresponding sample cabinet. In addition, in the process, when the floor number or the sample cabinet to be judged with the floor number close to the floor number exists, the sample cabinet to be judged with the smallest cabinet number is used as the nearest sample cabinet; as an alternative, the one with the largest cabinet number may also be used.

In step S14, the management-side communication unit 33 sends a route extraction prompt to the terminal 3 of the scientific researcher to allow the scientific researcher to check the route through the terminal 3 of the scientific researcher, and then enters an end state.

After the above process, the scientific research personnel can go to the nearest sample cabinet according to the viewed prompting content of the extraction path, so as to perform the identification operation by using the identification part 16 of the nearest sample cabinet, that is, performing the above steps S2 to S14 again with the nearest sample cabinet as the current sample cabinet 1', until all the biological samples 200 in the extraction list are extracted, and ending the whole extraction process at step S13.

In this embodiment, when the researcher needs to return, the corresponding extraction record received from the management server 2 may be displayed through the human-computer interaction screen of the terminal 3 of the researcher, and the biological sample 200 that needs to be returned is selected from the extraction record. Then, the management server 2 sends the corresponding storage requirement information back to the scientific research personnel terminal 3 according to the selected biological sample 200, so that the scientific research personnel can check the storage requirement information through the scientific research personnel terminal 3 and go to the corresponding sample cabinet to return according to the storage requirement information.

Examples effects and effects

According to the biological sample management method for scientific research provided by the embodiment, the sample name and the project name of the biological sample related to the scientific research project are stored as the project related information, and the sample name, the sample distinguishing information and the sample position information of the biological sample are stored as the sample related information, so that a scientific researcher can obtain the related sample name by inputting the project name, can obtain the sample position information of the biological sample related to a scientific research project at one time, and can rapidly and accurately finish extraction.

Further, because the switching of the response portion response cabinet door is adopted, just control the judgement portion when the cabinet door is opened and continuously read the action, consequently can avoid the cabinet door to close, sample label is continuously read under the state that the sample cabinet does not use, reduces the operating time of judgement portion and prolongs its working life, has also avoided reading under the condition that the cabinet door is closed simultaneously and makes the cabinet door cause the problem of influence to the reading work of judgement portion. For example, if the reading is performed when the cabinet door is closed, the sample label is not easily read by the determination part due to the blockage of the cabinet door; however, if the cabinet door is arranged on the inner side of the cabinet door, the temperature in the placing layer is too low to work normally.

The management server can generate an extraction list containing the sample name and the sample position information, and the extraction list also comprises extraction state information, so that scientific research personnel can extract according to the extraction list, and omission or errors are not easy to occur. Furthermore, because the extraction state in the extraction list is updated according to the extraction operation of scientific research personnel, and meanwhile, the extraction list after the extraction state is updated can be used for judging whether an unextracted biological sample exists or not, and a omission prompt can be formed when omission occurs, so that the scientific research personnel can check the omission condition and extract again, and therefore omission can be avoided under the condition that a large amount of extraction needs to be carried out. On the other hand, even if omission occurs, the corresponding extraction state of the omitted biological sample in the extraction list is not marked as extracted, so that the scientific research personnel can make the identification part identify the identification information again and open the cabinet door again for extraction.

Furthermore, the extracted state mark in the extraction list also enables the management server to judge the next sample cabinet to be extracted according to the position information corresponding to the biological sample which is not marked as extracted in the extraction list, so that an extraction path prompt is formed, scientific researchers can be prompted to go to the nearest sample cabinet to extract after the biological sample in the current sample cabinet is extracted every time, and the time for searching the positions of the sample cabinets and the time for returning between different sample cabinet positions are saved.

In the embodiment, the management server can search the request record and the extracted record line according to the sent identification information and the cabinet number, so that whether the authority of opening the sample cabinet exists is judged, and the door opening permission signal is sent only when the authority of opening exists, so that the cabinet door can be unlocked when the scientific research personnel really needs to access, and the influence on the low-temperature environment in the placing layer due to mistaken opening is avoided. Moreover, in the embodiment, the door opening permission signal further includes a layer number in the extraction list requested to be recorded or a layer number corresponding to the cabinet number in the storage requirement information, so that the sample cabinet control part can control the locking part of the corresponding placement layer to unlock according to the layer number, and the scientific research personnel is further prevented from opening the wrong placement layer when taking and placing the sample cabinet.

In addition, in the embodiment, after the access condition is judged, the management server acquires the name to be extracted according to the identification information, acquires the actual extraction name according to the sample judgment information, and judges whether the two names are consistent, so that whether a scientific researcher extracts an incorrect biological sample can be judged. Further, because send warning signal for the sample cabinet that corresponds when judging scientific research personnel and draw the error for warning portion opens the east and warns and remind scientific research personnel, consequently can form warning suggestion effect, lets scientific research personnel return the biological sample that the error was taken out.

The above-described embodiments are merely illustrative of specific embodiments of the present invention, and the present invention is not limited to the description of the above-described embodiments.

For example, in the embodiment, the management server checks whether the extraction is correct according to the result of the access determination and the extraction record, and a similar checking mechanism does not exist during storage. However, in another embodiment of the present invention, in order to prevent the biological sample from being affected by the storage error (for example, stored in a storage layer having an inappropriate temperature), the management server may retrieve and acquire the corresponding storage request information from the sample-related information based on the sample discrimination information of the biological sample determined to be stored in the result of the access determination, further determine whether or not the tank number and the layer number for storing the biological sample are present in the acquired storage request information, and when it is determined that the tank number and the layer number are not present in the storage layer having an inappropriate storage layer, the management server may transmit a warning signal to the corresponding sample tank to cause the warning unit to activate the warning to warn the scientific research staff that the biological sample is stored in the wrong storage layer. Wherein the warning may be in the form of, for example, a continuous emission of red light at a specific emission frequency.

Further, in another aspect of the present invention, in order to ensure that the erroneously stored biological sample can be returned smoothly, the management server may further store the erroneously stored sample discrimination information, the stored position information, and the erroneously stored identification information of the researcher as an erroneously stored record when determining that the storage position is erroneous. When scientific research personnel carry out the identification operation through the identification part, the management server can judge the opening authority according to the request record and the extraction record, and can judge the opening authority according to the mis-storage record, so that the mistakenly-stored scientific research personnel can take out the mis-stored biological sample and store the mis-stored biological sample to a proper position.

In the above embodiment, the RFID reader is mounted on the layer eaves portion and the reading direction thereof faces outward, so that the sample tag can be read when leaving or entering the placement layer, and the access judgment and update portion performs corresponding access judgment and update.

However, in another aspect of the present invention, the reading direction of the RFID reader may be directed to the inside, for example, in the form of a directional RFID reader, the directional RFID reader is installed to be slightly inclined inward, so that the reading direction of the directional RFID reader is immediately directed to the inside, and at the same time, a slope portion inclined inward may be provided at the eaves of the layer where the directional RFID reader is located, so that the electromagnetic wave of the directional RFID reader enters the placing layer to read the sample tag on the biological sample therein. In the embodiment, the sample cabinet control part controls the judging part to continuously read and temporarily store the sample judging information contained in the read sample labels according to the opening condition of the cabinet door sensed by the sensing part when the cabinet door is opened, and sends the finally read sample judging information, the layer number and the cabinet number of all the sample labels to the management server after the cabinet door is closed, so that the sample judging information corresponds to the biological sample actually existing in the layer currently placed after the scientific research personnel finishes taking and placing actions. Then, the access judgment updating part acquires all corresponding sample judgment information (equivalent to the biological samples stored in the placing layer before the taking and the placing) from the sample related information storage part according to the cabinet number and the layer number, and compares the sample judgment information with the sample judgment information of the biological samples actually existing in the current placing layer sent by the sample cabinet, so that the taken or placed biological samples can be judged, and the sample related information storage part is updated.

For example, in the above embodiment, the warning portion is a warning light disposed on the front surface of the cabinet door. In another aspect of the present invention, the warning unit may be an audible and visual alarm or other device having a prompt effect, and may be disposed at a position where the reagent tank is easily viewed or where sound is easily emitted, as required.

For example, in the above-described embodiment, the sample-related information includes the sample discrimination information, the corresponding sample name, and the sample position information and the storage request information. In other embodiments of the present invention, the sample-related information may also include other sample-related information, for example, other related information such as a sampling source and a sampling time of the biological sample may be correspondingly stored.

Claims

1. A project-based biological sample management method for scientific research is characterized in that a system comprising a sample cabinet, a scientific research personnel terminal and a management server is adopted to realize the management of biological samples with sample labels, and the method comprises the following steps:

correspondingly storing the sample discrimination information, the corresponding sample name, the sample position information and the storage requirement information in the management server as sample related information;

storing project related information including project names of the scientific research projects and sample names of biological samples required for the scientific research projects in the management server;

inputting scientific research project names needing sample extraction as required project names by the scientific research personnel through the scientific research personnel terminal;

adopting the management server to form a required sample name of the biological sample containing the requirement, corresponding sample position information and an extraction list of extraction state information according to the required project name, the project related information and the sample related information received from the scientific research personnel terminal, and further storing the extraction list and the identification information of the scientific research personnel as request records;

identifying the identification information of the scientific research personnel by adopting an identification part of the sample cabinet, and then sending the identification information to the management server;

judging whether the scientific research personnel have the opening authority or not at least based on the identification information by adopting the management server, and sending an opening permission signal to the sample cabinet once the scientific research personnel have the opening authority;

the control module of the sample cabinet is adopted to unlock the cabinet door according to the door opening permission signal, so that the scientific research personnel can open the cabinet door to perform extraction or storage operation;

adopting a judging part to continuously read and adopting a sensing part to sense whether the cabinet door is closed or not, and sending the read sample judging information and the cabinet number of the sample cabinet to the management server once sensing that the scientific research personnel closes the cabinet door;

and judging the access condition of the biological sample by adopting the management server according to the sent sample distinguishing information and the cabinet number, and updating at least the sample position information in the sample related information and the extraction state information recorded by the request.

2. The method for managing biological samples for scientific research as set forth in claim 1, wherein:

wherein, after the management server completes the update processing of the sample position information and the extraction state information, the management server also carries out omission judgment prompt processing,

the sample cabinet identified by the scientific research personnel is the current sample cabinet,

the process of the omission judgment prompt processing is as follows:

and retrieving the extraction list in the request record according to the cabinet number and the layer number of the current sample cabinet, judging whether the extraction state information which is represented as not extracted exists in the extraction states corresponding to the cabinet number and the layer number, and forming omission prompts by the sample name, the sample distinguishing information, the cabinet number and the layer number of the biological sample corresponding to the extraction state information which is represented as not extracted when the extraction state information exists.

3. The method for managing biological samples for scientific research as set forth in claim 2, wherein:

wherein the cabinet number and the location information thereof of each sample cabinet are stored in the management server,

the position information comprises the floor number, the floor number and the room number of each sample cabinet,

when the missed biological samples do not exist in the current sample cabinet, the management server judges whether the next sample cabinet needing to go to exists according to the extraction list, and when the next sample cabinet needing to go to exists, extraction path prompt information containing the position information of the sample cabinet is formed.

4. The method for managing biological samples for scientific research as set forth in claim 3, wherein:

wherein, the process of judging whether the next sample cabinet needing to go to exists is as follows:

judging whether the biological samples with the extraction states of not extracted are contained in the extraction list according to the extraction state information of each biological sample in the extraction list,

and when the biological sample cabinet contains the sample, acquiring all cabinet numbers of the biological sample cabinet from the sample position information of the biological sample which is not extracted, and judging the sample cabinet closest to the current sample cabinet as the next sample cabinet needing to go to according to the cabinet numbers and the position information of the sample cabinet.

5. The method for managing biological samples for scientific research as set forth in claim 4, wherein:

wherein, the process of judging the nearest sample cabinet to the current sample cabinet is as follows:

taking all the acquired cabinet numbers as the cabinet numbers of the sample cabinets to be judged, firstly judging whether the sample cabinets to be judged which are positioned in the same room with the current sample cabinet exist, and if so, finding out the sample cabinet to be judged which is closest to the number of the current sample cabinet as the nearest sample cabinet;

when the sample cabinet to be judged with the same room number as the current sample cabinet does not exist, judging whether the sample cabinet to be judged with the same floor number as the current sample cabinet exists or not, if so, finding out the room number closest to the room number of the current sample cabinet, and taking the sample cabinet to be judged with the smallest or largest cabinet number in the room numbers as the nearest sample cabinet;

and when the sample cabinet to be judged with the same floor number as the current sample cabinet does not exist, judging whether the sample cabinet to be judged with the same floor number as the current sample cabinet exists, if so, finding out the floor number closest to the floor number where the current sample cabinet is located, and taking the sample cabinet to be judged with the smallest or largest floor number as the nearest sample cabinet.

6. The method for managing biological samples for scientific research as set forth in claim 1, wherein:

the process that the management server judges whether the scientific research personnel have the opening permission comprises the following steps:

searching the request records according to the received identification information and the cabinet number, judging whether matched request records exist or not, and further judging whether the sample position information in the extraction list of the matched request records exists or not when the matched request records exist;

retrieving the extracted records according to the received identification information, judging whether the matched extracted records exist, further acquiring corresponding storage requirement information from the sample related information according to the sample identification information in the extracted records when the matched extracted records exist, and judging whether the cabinet number exists in the acquired storage requirement information,

and once the final result of any one judgment in the two judgments is existence, judging that the scientific research personnel has the door opening authority.

7. The method for managing biological samples for scientific research as set forth in claim 6, wherein:

wherein, when the management server judges that the cabinet number sent by the management server exists in the sample position information in the extraction list of the request record, the management server also generates an extraction prompt corresponding to the cabinet number and sends the extraction prompt to the corresponding scientific research personnel terminal for the scientific research personnel to check,

the content of the extraction prompt is the sample name, the sample distinguishing information and the corresponding layer number corresponding to all the sample position information of the cabinet number sent from the extraction list.