CN113171314B

CN113171314B - Whitening composition and preparation method and application thereof

Info

Publication number: CN113171314B
Application number: CN202110445059.1A
Authority: CN
Inventors: 聂胜; 聂珊旎
Original assignee: Guangzhou Dechuang Biotechnology Co ltd
Current assignee: Guangzhou Dechuang Biotechnology Co ltd
Priority date: 2021-04-24
Filing date: 2021-04-24
Publication date: 2022-09-09
Anticipated expiration: 2041-04-24
Also published as: CN113171314A

Abstract

The application relates to the field of skin care products, and particularly discloses a whitening composition, and a preparation method and application thereof. The whitening composition comprises the following components in parts by weight: 0.01-0.05 parts of poria cocos extract; nonapeptide-10.02-0.06 parts; 0.3-0.6 parts of tricholoma matsutake extract; the preparation method comprises the following steps: mixing Poria extract, nonapeptide-1 and Tricholoma matsutake extract at room temperature, and stirring to obtain whitening composition. The composition/product can be used in skin care products, and has the advantages of stably improving the whitening effect of the skin; in addition, the preparation method has the advantage of simple preparation process.

Description

Whitening composition and preparation method and application thereof

Technical Field

The application relates to the field of skin care products, in particular to a whitening composition, and a preparation method and application thereof.

Background

Melanin is the most important factor for determining skin color, the formation of melanin is complicated, for example, genetic factors, excessive sunlight, improper diet, endocrine dyscrasia, improper use of cosmetics and the like all easily influence the synthesis of skin melanin, and when skin melanin is excessively synthesized, the skin melanin particles are easily unevenly distributed, so that color spots darker than normal skin color are easily generated on local parts of the skin.

Related technologies mainly use tretinoin, ursolic acid, kojic acid, vitamin C, licorice extract and the like as whitening agents to be singly or compositely added into beauty cosmetics, so that the effect of whitening skin is achieved.

However, the whitening agent has unstable whitening effect, is easily oxidized and degraded or discolored, is inconvenient to store and is easily ineffective, and thus, there is room for improvement.

Disclosure of Invention

In order to improve the whitening stability of a whitening agent, the application provides a whitening composition, a preparation method and application thereof.

In a first aspect, the present application provides a whitening composition, which adopts the following technical scheme:

the whitening composition comprises the following components in parts by mass:

0.01-0.05 parts of poria cocos extract;

nonapeptide-10.02-0.06 parts;

0.3-0.6 parts of tricholoma matsutake extract.

By adopting the technical scheme, the poria cocos extract can inhibit the generation of inflammatory factors of the skin, reduce the combination of the inflammatory factors and receptors on melanin cell membranes, ensure that the melanin cells are not easy to proliferate, simultaneously ensure that tyrosinase is not easy to activate, and is beneficial to the reduction of the generation amount of melanin; nonapeptide-1 is a bionic peptide, which has good matching property with MC1 receptor on melanocyte, and after the melanocyte-stimulating hormone in human body is combined with MC1 receptor on melanocyte, tyrosinase can be activated, nonapeptide-1 can be combined with melanocyte-stimulating hormone competitively with MC1 receptor on melanocyte, so that the entrance of receptor on melanocyte and various signal factors can be closed competitively, the activity of melanocyte can be weakened, tyrosinase can not be activated easily, and the production quantity of melanin can be reduced; the Tricholoma matsutake extract can inhibit gene level expression of important genes and main influencing factors generated by tyrosinase, reduce the content of tyrosinase, and is beneficial to reducing the generation of melanin.

The activities of the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract are high, in the practical application process, the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract are easy to cause to be difficult to exert a good skin whitening effect due to the instability of the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract, the defect can be effectively overcome, the stability of the whitening composition is improved, and the whitening composition can exert a good synergistic cooperation effect to better whiten the skin, so that the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract have a good melanin generation inhibiting effect after being jointly acted on the skin in a specific ratio, and the good skin whitening effect can be expressed in a short time.

In addition, by adding the poria extract, the nonapeptide-1 and the tricholoma matsutake extract in a specific ratio, the poria extract, the nonapeptide-1 and the tricholoma matsutake extract have better absorption capacity to the poria extract, the nonapeptide-1 and the tricholoma matsutake extract, and the poria extract, the nonapeptide-1 and the tricholoma matsutake extract are matched in a specific ratio, so that the antioxidant capacity of the skin can be better improved, collagen in the skin is not easy to lose, the firmness of the skin is improved, the content of the collagen in the skin is favorably maintained, the reduction of skin wrinkles is favorably realized, and the whitening composition has better anti-aging effect on the skin.

Preferably, the whitening composition is also added with the following components in parts by weight:

0.15-0.3 part of soybean isoflavone.

By adopting the technical scheme, the soybean isoflavone with a specific proportion is added into the whitening composition, so that the content of free radicals in the skin is reduced, the firmness of the skin is further improved, wrinkles of the skin are reduced to a certain extent, and the anti-aging capability of the skin is improved.

0.05-0.1 part of glycyrrhiza glabra extract.

By adopting the technical scheme, after the glycyrrhiza glabra extract with a specific proportion is added, a better synergistic cooperation effect is generated among the components of the whitening composition, so that the melanin content of the skin is further reduced, the skin firmness is further improved, skin wrinkles are further reduced, the whitening composition obtains a better whitening effect and a better anti-aging effect, and the effect of fading color spots or whitening the skin can be observed by naked eyes after the whitening composition is continuously used for 15 days.

In a second aspect, the present application provides a method for preparing a whitening composition, which adopts the following technical scheme:

a whitening composition is prepared by mixing Poria extract, nonapeptide-1 and Tricholoma matsutake extract at room temperature, and stirring to obtain whitening composition.

By adopting the technical scheme, the components in the whitening composition can be quickly and uniformly mixed at normal temperature, so that the preparation process of the whitening composition is very simple, the components can keep better activity at low temperature, and the whitening composition can better play a role in whitening skin.

Preferably, soybean isoflavone and Glycyrrhiza glabra L.extract are added when Poria cocos extract, nonapeptide-1 and Tricholoma matsutake Mushroom extract are mixed.

By adopting the technical scheme, the soybean isoflavone and the glycyrrhiza glabra extract can be quickly mixed and dissolved with the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract at normal temperature, so that the preparation process of the whitening composition is simple and convenient, the retention effect of the preparation process on the active ingredients of each component is better, and the synergistic cooperation effect among the components can be better played.

In a third aspect, the present application provides an application of a whitening composition, which adopts the following technical scheme:

application of a whitening composition is to add the whitening composition into a skin care product.

Preferably, the skin care product is water, milk, liquid, cream, milky lotion, cream, facial mask.

By adopting the technical scheme, the whitening composition is added into the skin care product, so that the skin care product can not only help a consumer whiten the skin, but also observe the effect of fading color spots after being used for a period of time, so that the skin color of the consumer is more uniform, skin wrinkles can be reduced to a certain extent, and a better anti-aging effect is achieved while the skin is whitened.

The moisturizing cream containing the whitening composition comprises the following components in percentage by mass:

the whitening composition is 0.6-1.5%

Cetyl stearyl alcohol 1-2%

1-3% of cetearyl glucoside

Beeswax 1-1.5%

2 to 3 percent of squalane

Bisabolol 0.08-1.3%

Hydrogenated lecithin 0.2-0.5%

1.5-3% of polydimethylsiloxane

4 to 6 percent of butanediol

2.5-4% of glycerin

PEG/PPG-17/6 copolymer 0.8-1.2%

1-3% of glycerin acrylate/acrylic acid copolymer

PVM/MA copolymer 0.2-0.5%

Betaine 1.5-2.5%

2.5 to 4 percent of propylene glycol

Carbomer 0.3-0.5%

0.02-0.05% of sodium hyaluronate

0.3 to 0.6 percent of 1, 2-hexanediol

Dipotassium glycyrrhizinate 0.03-0.06%

0.03 to 0.06 percent of sodium hydroxide

Saccharide isomerate 0.8-1.3%

0.08-0.15% of caprylyl hydroximic acid

0.1 to 0.3 percent of p-hydroxyacetophenone

Centella asiatica extract 0.01-0.03%

Olibanum extract 0.01-0.03%

The balance of water.

By adopting the technical scheme, the whitening composition is added into the moisturizing cream, the whitening composition is only added by 0.6-1.5% of the total amount of the moisturizing cream, the moisturizing cream can show a better whitening effect, and the moisturizing cream has a better moisturizing effect, so that the moisturizing cream has double effects of moisturizing and whitening, and the use experience of consumers is better.

The repair cream containing the whitening composition comprises the following components in percentage by mass:

the whitening composition is 0.6-1.5%

5 to 8 percent of butanediol

2-4% of glycerin

2 to 4 percent of isohexadecane

1 to 3 percent of betaine

2-3% of polydimethylsiloxane

PEG/PPG-17/6 copolymer 1.5-3%

Liquid paraffin 5-7%

Ethylhexyl palmitate 1.5-2.5%

Cetostearyl alcohol 1-2%

Myristyl glucoside 0.5-1%

Cetearyl glucoside 0.5-1%

Tocopherol acetate 0.1-0.5%

Bisabolol 0.05-0.2%

Carbomer 0.1-0.5%

0.3 to 0.8 percent of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer

Allantoin 0.08-0.2%

Arginine 0.2-0.5%

Herba Selaginellae extract 0.2-0.8%

Nipagin methyl ester 0.1-0.3%

0.1 to 0.3 percent of phenoxyethanol

0.05 to 0.2 percent of chlorphenesin

0.02 to 0.08 percent of essence

The balance being water.

By adopting the technical scheme, the whitening composition is added into the repair cream, the whitening composition is only added into the repair cream by 0.6-1.5% of the total amount of the repair cream, the repair cream can show a better whitening effect, and the repair cream has a better repairing effect on skin, so that the skin is helped to fade pigment when the skin is repaired, and pigmentation is not easy to generate after the skin is repaired.

A make-up cream containing the whitening composition comprises the following components in percentage by mass:

whitening composition 0.6-1.5%

4-6% of glycerin

4 to 6 percent of cyclopentadecylidene dimethyl siloxane

5 to 7 percent of titanium dioxide

1-3% of polymethylsilsesquioxane

2 to 4 percent of butanediol

Octyl methicone 2-4%

Caprylic/capric triglyceride 1-3%

Cetyl PEG/PPG-10/1 Dimethicone 1-2%

Tocopherol 0.1-0.5%

Distearyl dimethyl ammonium hectorite 0.3-0.8%

Ultramarine blue 0.2-0.5%

Sorbitan isostearate 0.5-0.8%

Sodium chloride 0.5-1.2%

0.08 to 0.12 percent of methyl hydroxybenzoate

0.15 to 0.25 percent of phenoxyethanol

0.01 to 0.05 percent of chlorphenesin

0.008 to 0.012 percent of essence

0.01 to 0.05 percent of sodium hyaluronate

Centella asiatica extract 0.01-0.03%

Olibanum extract 0.01-0.03%

The balance of water.

By adopting the technical scheme, 0.6-1.5% of whitening composition is added into the makeup base cream, so that the makeup base cream has a better whitening effect, and the skin of a consumer is more white and bright.

In summary, the present application has the following beneficial effects:

1. the whitening composition is formed by combining the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract according to a specific proportion, the defect that the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract are difficult to be well combined with skin due to insufficient stability of the poria cocos extract, the nonapeptide-1 and the tricholoma matsutake extract can be overcome, active components in the whitening composition can keep better stability before acting on the skin and can be well absorbed by the skin after contacting the skin, so that the active components in the whitening composition and the skin have better acting effect, and after the whitening composition acts on the skin together, the synergistic effect can be stably exerted, so that the skin is effectively whitened.

2. The soybean isoflavone and the glycyrrhiza glabra extract are preferably added in the composition, so that the skin whitening effect is achieved, and meanwhile, the anti-aging effect is further improved.

3. The preparation method of the whitening composition has the characteristics of simple production process and convenience.

Detailed Description

The components in the present application are commercially available, and the following is information on the source of each component in each of the examples and comparative examples.

Bisabolol, ethylhexyl palmitate, tocopheryl acetate, and tocopherols were obtained from Kyoto Biotech, Inc., Guangzhou.

PEG/PPG-17/6 copolymer was purchased from Kyowa Kangchi Chemicals, Inc. and was designated 75-H-450.

Hydrogenated lecithin was purchased from Guangzhou, Mass, Daxing chemical Co., Ltd, model S-10

The viscosity of the polydimethylsiloxane was 1.5cst-500000cst, available from Australian trade company, Guangzhou. Model number PMX-200 Fluid.

Allantoin, nipagin methyl ester, chlorphenesin, caprylhydroxamic acid and p-hydroxyacetophenone were purchased from Kunshan, Shuangyou daily chemical Co., Ltd.

Caprylic/capric triglyceride, sorbitan isostearate were purchased from Hemiami Chemicals (Shanghai) Co., Ltd.

Polymethylsilsesquioxane was purchased from Batai chemical Co., Ltd, Guangzhou under model number BT-9271.

Octyl methicone was purchased from Batai chemical Co., Ltd, Guangzhou under model number BT-6034.

Cyclopenta-polydimethylsiloxane is available from Batai chemical Co., Ltd, Guangzhou under model number BT-1346.

PVM/MA copolymer/Glycerol acrylate/acrylic acid copolymer was purchased from Gemba gum oil, sold by Polyocerization, Engineers, Inc., Guangzhou.

Blue AS, a model number of the ocean chemical engineering technology Co., Ltd, Guangzhou, ultramarine.

Myristyl glucoside, cetearyl glucoside were purchased from baihabo ltd, guangzhou.

Beeswax, cetearyl alcohol, and liquid paraffin were purchased from Guangzhou, Chengyi chemical Co., Ltd.

Soybean isoflavone and Poria extract are obtained from Shanghai Kai Biotech limited.

The hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer is purchased from Ostrin chemical Co., Ltd, Guangzhou, and the model is AVC.

Centella asiatica extract and boswellia serrata extract were purchased from tostei trade ltd, guangzhou.

The matsutake Mushroom extract is available from Sichuan perfume peanut science and technology Co.

Glycyrrhiza glabra extract was purchased from Oalli, Inc. of Shanghai.

Nonapeptide-1 was purchased from biosciences, Inc. of Kingsu Jinsri, Jiangsu.

Squalane is available from Bioho, Guangzhou trade, Inc.

Betaine was purchased from Hengtauo, Guangzhou trade company, Inc.

Carbomer was purchased from guangzhou megabalance trade ltd.

Sodium hyaluronate was purchased from Shandong Anhua biomedical corporation, Inc.

The saccharide isomers were purchased from Korsaway commerce, Inc., Guangzhou.

Arginine was purchased from shanghai shi science development ltd.

Selaginella tamariscina extract was purchased from WANGCHEMICAL Co., Guangzhou flower.

Titanium dioxide was purchased from Yangzhou Fine chemical Co., Ltd.

Disteardimonium hectorite was purchased from aoyun trade, guangzhou.

The essence is daily essence of Guangzhou Fenghao essence, and the specific embodiment adopts cherry blossom essence.

The present application will be described in further detail with reference to examples and comparative examples.

Examples 1 to 3

A whitening composition comprising the following components, the amounts (kg) of each component in examples 1-3 are detailed in Table 1.

TABLE 1

	Example 1	Example 2	Example 3
				Poria extract	0.01	0.03	0.05
Nonapeptide-1	0.02	0.04	0.06
				Tricholoma matsutake extract	0.3	0.45	0.6

In examples 1 to 3, the whitening composition was prepared by the following method: adding Poria extract, nonapeptide-1 and Tricholoma matsutake extract into a stirring kettle at room temperature, stirring at 80r/min for 3min, and stirring to obtain whitening composition.

Examples 4 to 5

The difference from example 2 is that: the whitening composition also included soy isoflavones, and the amounts (kg) of the ingredients of examples 4-5 are detailed in table 2.

TABLE 2

	Example 4	Example 5
			Poria extract	0.03	0.03
Nonapeptide-1	0.04	0.04
			Tricholoma matsutake extract	0.45	0.45
Soy isoflavone	0.15	0.3

In examples 4 to 5, the whitening composition was prepared by: adding soybean isoflavone, Poria extract, nonapeptide-1 and Tricholoma matsutake extract into a stirring kettle at room temperature, stirring at 60r/min for 5min, and stirring to obtain whitening composition.

Examples 6 to 7

The difference from example 4 is that: the whitening composition also includes glycyrrhiza glabra extract, and the amounts (kg) of the ingredients in examples 6-7 are detailed in table 3.

TABLE 3

	Example 6	Example 7
			Poria extract	0.03	0.03
Nonapeptide-1	0.04	0.04
			Tricholoma matsutake extract	0.45	0.45
Soy isoflavone	0.15	0.15
			Glycyrrhiza glabra extract	0.05	0.1

In examples 6 to 7, the whitening composition was prepared by: adding soybean isoflavone, Poria extract, nonapeptide-1 and Tricholoma matsutake extract into a stirring kettle at room temperature, stirring at 100r/min for 2min, and stirring to obtain whitening composition.

Comparative example 1

The only difference from example 2 is:

in the preparation method of the whitening composition, the extract of the pine mushroom is replaced by the extract of the tuckahoe with equal quantity.

Comparative example 2

The only difference from example 2 is:

the preparation method of the whitening composition adopts the pine mushroom extract to replace the tuckahoe extract in equal amount.

Comparative example 3

The only difference from example 2 is:

in the preparation method of the whitening composition, the tricholoma matsutake extract is used for replacing nonapeptide-1 in equal amount.

Comparative example 4

The only difference from example 2 is:

the dosage of the whitening composition comprises Poria extract 0.005kg, nonapeptide-1 0.01kg, and Tricholoma matsutake extract 0.4 kg.

Comparative example 5

The only difference from example 2 is:

the input amount of the whitening composition is 0.3kg of tuckahoe extract, 0.3kg of nonapeptide-1 and 0.4kg of tricholoma matsutake extract.

Application examples 1 to 8

A moisturizing cream containing a whitening composition comprises the following components, and the dosage of each component is detailed in Table 4.

In addition, the whitening compositions prepared in examples 1 to 7 were used for the whitening combinations in examples 1 to 7, respectively, and the whitening composition prepared in example 1 was used for the whitening composition in example 8.

TABLE 4

The preparation method of application examples 1 to 8 is as follows:

step (1), mixing raw materials;

adding cetyl stearyl alcohol, cetyl glucoside, beeswax, squalane, bisabolol, hydrogenated lecithin, polydimethylsiloxane and PEG/PPG-17/6 copolymer into an emulsifying pot, heating to 80 ℃ under stirring at the rotation speed of 30r/min, homogenizing at the rotation speed of 2800r/min for 2min, and keeping the temperature for 15min to obtain a phase B mixture.

And (1-2) adding water, butanediol, glycerol, a glycerol acrylate/acrylic acid copolymer, a PVM/MA copolymer, betaine, propylene glycol, carbomer, sodium hyaluronate, 1, 2-hexanediol, dipotassium glycyrrhizinate, sodium hydroxide and saccharide isomerate into an oil phase pot, stirring until the materials are dissolved at the rotating speed of 60r/min, heating to 75 ℃, and preserving heat for 15min to obtain a phase A mixture.

And (2) reducing the pressure of the emulsifying pot to 0.06MPa, stirring the B-phase mixture at the rotating speed of 50r/min, pumping the A-phase mixture into the emulsifying pot in which the B-phase mixture is positioned while stirring, and obtaining the C-phase mixture after pumping.

And (3) intermittently homogenizing the phase C mixture in an emulsifying pot for 4 times, controlling the homogenization temperature of the two-phase mixture to be 75 ℃, the homogenization rotation speed to be 1400r/min, 1min each time and the interval time to be 30s, then stirring for 1min at the rotation speed of 60r/min, then reducing the temperature of the phase C mixture to 45 ℃, then adding the octanoyl hydroximic acid, the p-hydroxyacetophenone, the centella asiatica extract, the boswellia serrata extract and the whitening composition into the phase C mixture, stirring for 2min at the rotation speed of 45r/min, and then cooling to room temperature to obtain the moisturizing cream.

Application examples 9 to 10

A repair cream containing a whitening composition comprises the following components, and the dosage of each component is detailed in Table 5.

The whitening composition prepared in example 1 was used as the whitening composition in application example 9, and the whitening composition prepared in example 1 was used as the whitening composition in application example 10.

TABLE 5

The preparation method of application examples 9 to 10 is as follows:

step 1), mixing raw materials;

step 1-1), adding water, butanediol, glycerol, isohexadecane, betaine, polydimethylsiloxane, PEG/PPG-17/6 copolymer, liquid paraffin, myristyl glucoside and tocopherol acetate into an emulsifying pot, heating to 80 ℃ under stirring at a rotating speed of 60r/min, homogenizing at a rotating speed of 2800r/min for 10min, and preserving heat for 15min to obtain a mixture of group B.

Step 1-2), adding ethylhexyl palmitate, cetyl alcohol, cetyl glucosyl agent, bisabolol, carbomer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, allantoin, water, arginine, herba Selaginellae extract, essence and methyl paraben into an oil phase pot, heating to 75 ℃ under stirring at a rotation speed of 60r/min, and keeping the temperature for 15min to obtain a group A mixture.

And 2), reducing the pressure of an emulsifying pot to 0.06MPa, stirring the B-phase mixture at the rotating speed of 50r/min, pumping the A-group mixture into the emulsifying pot in which the B-group mixture is positioned while stirring, and forming a C-group mixture after pumping.

And 3) intermittently homogenizing the mixture in the group C for 4 times in an emulsifying pot, controlling the homogenizing temperature of the mixture in the group C to be 75 ℃, the homogenizing rotating speed to be 1400r/min, 1min each time and the interval time to be 30s, then stirring for 1min at the rotating speed of 60r/min, then reducing the temperature of the mixture in the group C to 45 ℃, then adding phenoxyethanol, chlorphenesin and the whitening composition into the mixture in the group C, stirring for 2min at the rotating speed of 45r/min, and then cooling to room temperature to obtain the repair cream.

Application examples 11 to 12

A make-up base containing a whitening composition, the make-up base comprising the following components in amounts specified in Table 6.

The whitening composition prepared in example 1 was used as the whitening composition in application example 11, and the whitening composition prepared in example 1 was used as the whitening composition in application example 12.

TABLE 6

The preparation method of application examples 9 to 10 is as follows:

step 1, mixing raw materials;

step 1-1, adding cyclopentadimethylsiloxane, titanium dioxide, polymethylsilsesquioxane, octyl methicone, caprylic/capric triglyceride, cetyl PEG/PPG-10/1 polydimethylsiloxane, tocopherol, distearyl dimethylammonium hectorite, ultramarine and sorbitan isostearate into an emulsifying pot, heating to 75 ℃ at the rotating speed of 60r/min while stirring, homogenizing at the rotating speed of 2800r/min for 10min, and then preserving heat at 75 ℃ for 15min to obtain a B-type mixture.

Step 1-2, adding water, glycerol, butanediol, sodium chloride, methyl hydroxybenzoate, sodium hyaluronate and the whitening composition into a water phase pot, heating to 75 ℃ while stirring at a rotating speed of 60r/min, and preserving heat for 15min to obtain a mixture A.

And 2, reducing the pressure of the emulsifying pot to 0.06MPa, stirring the B-phase mixture at the rotating speed of 50r/min, pumping the A-class mixture into the emulsifying pot in which the B-class mixture is positioned while stirring, and obtaining the C-class mixture after pumping.

And 3, intermittently homogenizing the C mixture in an emulsifying pot for 4 times, controlling the homogenization temperature of the C mixture to be 75 ℃, the homogenization rotation speed to be 1400r/min, 1min each time and the interval time to be 30s, stirring at the rotation speed of 60r/min for 1min, then reducing the temperature of the C mixture to 40 ℃, then adding phenoxyethanol, chlorophenyl glycoside ether, essence, centella asiatica extract, boswellia serrata extract and the whitening composition into the C mixture, stirring at the rotation speed of 40r/min for 2min, and then cooling to room temperature to obtain the sun screen.

Application comparative example 1

The difference from application example 2 is that: the whitening composition prepared in comparative example 1 was used in equal amounts instead of the whitening composition prepared in example 2.

Application comparative example 2

The difference from application example 2 is that: the whitening composition prepared in comparative example 2 was used in equal amounts instead of the whitening composition prepared in example 2.

Application comparative example 3

The difference from application example 2 is that: the whitening composition prepared in comparative example 3 was used in equal amounts instead of the whitening composition prepared in example 2.

Application comparative example 4

The difference from application example 2 is that: the whitening composition prepared in comparative example 4 was used in equal amounts instead of the whitening composition prepared in example 2.

Application comparative example 5

The difference from application example 2 is that: the whitening composition prepared in comparative example 5 was used in equal amounts instead of the whitening composition prepared in example 2.

Experiment 1

Test object(s): the experiment consisted of 36 adult volunteers with spots on their cheeks, divided into 12 groups, averaging 3 persons in each group, corresponding to the samples tested in application examples 1-7 and in application comparative examples 1-5.

The test method comprises the following steps: after cleaning the face in the morning and evening every day, 1ml of the test sample prepared in each application example is smeared on the left cheek, the right cheek is not smeared as a blank control, the blank control is continuously used for 30 days, and the skin melanin content MI values of the left cheek and the right cheek of each group of volunteers are detected by using an MX18 melanin determinator of Germany CK company on the 15 th day and the 30 th day, wherein the higher the measurement value is, the higher the melanin content of the skin is. The difference between the MI values of the right cheek minus the left cheek indicates that the whitening effect of the test sample is more significant if the difference between the MI values is larger.

Experiment 2

The adult volunteers of experiment 1 were used as test subjects, and the skin firmness of the left cheek and the right cheek was measured by MPA580 skin elastometer of CK company, germany, on the 15 th day and the 30 th day, respectively, and the lower the measurement value, the firmer the skin was. The difference in skin firmness measurements for the right cheek minus the left cheek indicates that the greater the difference in skin firmness measurements, the more pronounced the effect of the test sample on improving skin firmness.

Experiment 3

The adult volunteers of experiment 1 were used as test subjects, and skin wrinkles of the left cheek and the right cheek were detected on day 15 and day 30, respectively, using the skin rapid three-dimensional imaging system PRIMOS, and the lower the measurement value, the less wrinkles of the skin were indicated. The greater the difference in skin wrinkle measurements for the right cheek minus the left cheek indicates the more pronounced the skin wrinkle reduction effect of the test sample.

The results of the tests 1-3 are detailed in Table 7.

The differences in MI, skin firmness, and skin wrinkles measurements for experiments 1-3 are detailed in Table 8.

TABLE 7

TABLE 8

According to the results of table 7 and table 8, after 30 days from the application of the test samples, the differences of the melanin contents in the skin of the left and right cheeks of the volunteers in the application example 1-3 and the melanin content of the volunteers in the application example 2 were significantly greater than those of the volunteers in the application example 1-3, and it was proved that the combination of the tricholoma matsutake extract, the poria cocos extract and the nona-peptide-1 can produce a better synergistic effect and a better balance in the aspect of inhibiting the production of melanin, so that the melanin content in the skin can be rapidly reduced and the skin can better achieve the whitening effect. In addition, as can be seen from the experimental data of application example 2, after day 30, a significant difference is generated between the skin firmness and the skin wrinkle measurement values of the left and right cheeks of the volunteer, and as can be seen from the experimental data of application comparative examples 1 to 3, after day 30, the difference between the skin firmness and the skin wrinkle measurement values of the left and right cheeks of the volunteer is not significant, which proves that the tricholoma matsutake extract, the poria cocos extract and the nonapeptide-1 are combined in a certain proportion to generate a good anti-aging effect.

According to the volunteers of application examples 4-5 and application example 2 in tables 7 and 8, after 30 days from the application of the test samples, the difference in melanin content in the skin of the left and right cheeks of the volunteers was obtained, the difference in melanin content in the volunteers of application example 2 was significantly greater than that of the volunteers of application examples 4-5, and the ratios between the tricholoma matsutake extract, the poria cocos extract and nonapeptide-1 in application examples 4-5 and 2 were different, so it was seen that only after the tricholoma matsutake extract, the poria cocos extract and nonapeptide-1 were combined in a specific ratio, the melanin content in the skin was significantly reduced, the skin firmness and the test values of skin wrinkles were also significantly reduced, and the whitening and anti-aging effects of the skin were better.

As can be seen from comparison of the experimental data of application examples 4 to 5 and application example 2 in tables 7 and 8, the measured values of skin firmness and skin wrinkles of the left cheek of the subject were somewhat reduced and the whitening degree of the cheek was not much changed by adding soy isoflavone in combination with matsutake mushroom extract, poria cocos extract and nonapeptide-1, demonstrating that soy isoflavone was added to well help the skin to have anti-aging effect.

As can be seen from comparison of the data of application examples 6 to 7 with application example 2 in tables 7 and 8, by adding glycyrrhiza glabra extract to matsutake mushroom extract, poria cocos extract, nonapeptide-1 and soybean extract, the melanin content of the left cheek of the subject was reduced, and the skin firmness and skin wrinkle measurements were further reduced, demonstrating that glycyrrhiza glabra exhibits better whitening effect and better anti-aging effect on the skin.

The specific embodiments are only for explaining the present application and are not limiting to the present application, and those skilled in the art can make modifications to the embodiments without inventive contribution as required after reading the present specification, but all the embodiments are protected by patent law within the scope of the claims of the present application.

Claims

1. A whitening composition characterized by: the paint comprises the following components in parts by mass:

0.01-0.05 parts of poria cocos extract;

nonapeptide-10.02-0.06 parts;

0.3-0.6 parts of tricholoma matsutake extract;

0.15-0.3 part of soybean isoflavone;

0.05-0.1 part of glycyrrhiza glabra extract.

2. A method of preparing the whitening composition of claim 1, wherein: mixing Poria extract, nonapeptide-1 and Tricholoma matsutake extract at room temperature, and stirring to obtain whitening composition; when Poria extract, nonapeptide-1 and Tricholoma matsutake extract are mixed, soybean isoflavone and Glycyrrhiza glabra extract are also added.

3. Use of a whitening composition according to claim 1, characterized in that: adding the whitening composition to a skin care product.

4. Use of a whitening composition according to claim 3, characterized in that: the skin care product is water, lotion, cream, and facial mask.

5. A moisturizing cream containing the whitening composition of claim 1, characterized in that: the moisturizing cream comprises the following components in percentage by mass:

the whitening composition of claim 1 0.6-1.5%

Cetyl stearyl alcohol 1-2%

1-3% of cetearyl glucoside

Beeswax 1-1.5%

2 to 3 percent of squalane

Bisabolol 0.08-1.3%

Hydrogenated lecithin 0.2-0.5%

1.5-3% of polydimethylsiloxane

4 to 6 percent of butanediol

2.5-4% of glycerin

PEG/PPG-17/6 copolymer 0.8-1.2%

1-3% of glycerin acrylate/acrylic acid copolymer

PVM/MA copolymer 0.2-0.5%

Betaine 1.5-2.5%

2.5 to 4 percent of propylene glycol

Carbomer 0.3-0.5%

0.02-0.05% of sodium hyaluronate

0.3 to 0.6 percent of 1, 2-hexanediol

Dipotassium glycyrrhizinate 0.03-0.06%

0.03 to 0.06 percent of sodium hydroxide

Saccharide isomerate 0.8-1.3%

0.08-0.15% of caprylyl hydroximic acid

0.1 to 0.3 percent of p-hydroxyacetophenone

Herba Centellae extract 0.01-0.03%

Olibanum extract 0.01-0.03%

The balance of water.

6. A repair cream comprising the whitening composition of claim 1, characterized in that: the repair cream comprises the following components in percentage by mass:

the whitening composition of claim 1 0.6-1.5%

5 to 8 percent of butanediol

2-4% of glycerin

2 to 4 percent of isohexadecane

1 to 3 percent of betaine

2-3% of polydimethylsiloxane

PEG/PPG-17/6 copolymer 1.5-3%

Liquid paraffin 5-7%

Ethylhexyl palmitate 1.5-2.5%

Cetearyl alcohol 1-2%

Myristyl glucoside 0.5-1%

Cetearyl glucoside 0.5-1%

Tocopherol acetate 0.1-0.5%

Bisabolol 0.05-0.2%

Carbomer 0.1-0.5%

Allantoin 0.08-0.2%

Arginine 0.2-0.5%

Herba Selaginellae extract 0.2-0.8%

Nipagin methyl ester 0.1-0.3%

0.1 to 0.3 percent of phenoxyethanol

0.05 to 0.2 percent of chlorphenesin

0.02 to 0.08 percent of essence

The balance being water.

7. A makeup base containing the whitening composition according to claim 1, characterized in that: the makeup base comprises the following components in percentage by mass:

the whitening composition of claim 1 0.6-1.5%

4-6% of glycerin

Cyclopenta dimethyl siloxane 4-6%

Titanium dioxide 5-7%

1-3% of polymethylsilsesquioxane

2 to 4 percent of butanediol

Octyl polymethylsiloxane 2-4%

Caprylic/capric triglyceride 1-3%

Cetyl PEG/PPG-10/1 Dimethicone 1-2%

Tocopherol 0.1-0.5%

Distearyl dimethyl ammonium hectorite 0.3-0.8%

Ultramarine blue 0.2-0.5%

Sorbitan isostearate 0.5-0.8%

Sodium chloride 0.5-1.2%

0.08 to 0.12 percent of methyl hydroxybenzoate

0.15 to 0.25 percent of phenoxyethanol

0.01 to 0.05 percent of chlorphenesin

0.008-0.012% of essence

0.01 to 0.05 percent of sodium hyaluronate

Herba Centellae extract 0.01-0.03%

Olibanum extract 0.01-0.03%

The balance of water.