CN113144195A - 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 - Google Patents
伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 Download PDFInfo
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| HRP20180959T1 (hr) | 2011-01-28 | 2018-07-27 | Sanofi Biotechnology | Ljudska protutijela za pcsk9 za uporabu u postupcima liječenja određenih skupina subjekata |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| CA2848201C (en) | 2011-09-16 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) |
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| CN111920954A (zh) | 2013-06-07 | 2020-11-13 | 再生元制药公司 | 通过施用pcsk9抑制剂抑制动脉粥样硬化的方法 |
| CN115192704A (zh) * | 2013-10-11 | 2022-10-18 | 赛诺菲生物技术公司 | Pcsk9抑制剂用于治疗高血脂症的用途 |
| CN106062003A (zh) | 2013-11-12 | 2016-10-26 | 赛诺菲生物技术公司 | 用于与pcsk9抑制剂一起使用的给药方案 |
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| US9045548B1 (en) | 2014-07-15 | 2015-06-02 | Kymab Limited | Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment |
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| US9023359B1 (en) | 2014-07-15 | 2015-05-05 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
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| US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
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| US9139648B1 (en) | 2014-07-15 | 2015-09-22 | Kymab Limited | Precision medicine by targeting human NAV1.9 variants for treatment of pain |
| KR20170029613A (ko) | 2014-07-16 | 2017-03-15 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
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| WO2016100615A2 (en) * | 2014-12-18 | 2016-06-23 | The University Of Chicago | Methods and composition for neutralization of influenza |
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| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
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| KR102401796B1 (ko) | 2017-04-13 | 2022-05-25 | 카딜라 핼쓰캐어 리미티드 | 신규의 펩타이드 기재 pcsk9 백신 |
| AU2018291702A1 (en) * | 2017-06-30 | 2020-02-06 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising PCSK-9 antibody and use thereof |
| MY203415A (en) | 2017-09-19 | 2024-06-27 | Regeneron Pharma | Methods of reducing particle formation and compositions formed thereby |
| CA3084155A1 (en) | 2017-12-13 | 2019-06-20 | Regeneron Pharmaceuticals, Inc. | Devices and systems for chromatography column bed support management and related methods |
| TW202448568A (zh) | 2018-07-02 | 2024-12-16 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| DK3911648T3 (da) | 2019-01-18 | 2025-01-13 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf |
| CA3160071A1 (en) * | 2019-11-18 | 2021-05-27 | Ad Pharmaceuticals Co., Ltd. | Anti-pcsk9 antibody and use thereof |
| EP4072672A1 (en) * | 2019-12-10 | 2022-10-19 | Regeneron Pharmaceuticals, Inc. | Use of a pcsk9 inhibitor to treat homozygous familial hypercholesterolemia |
| KR20230057410A (ko) | 2020-08-25 | 2023-04-28 | 리제너론 파마슈티칼스 인코포레이티드 | Pcsk9 및 ldlr 조절인자를 사용한 패혈증 치료 |
| CN116189765B (zh) * | 2023-02-23 | 2023-08-15 | 上海捷易生物科技有限公司 | 一种iPS细胞遗传学风险评估系统及应用 |
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|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP1471152A1 (en) * | 2003-04-25 | 2004-10-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Mutations in the human PCSK9 gene associated to hypercholesterolemia |
| US8357371B2 (en) | 2008-12-15 | 2013-01-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to PCSK9 |
| JO3672B1 (ar) * | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| AR079336A1 (es) * | 2009-12-11 | 2012-01-18 | Irm Llc | Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9) |
| AR088782A1 (es) * | 2011-04-29 | 2014-07-10 | Sanofi Sa | Sistemas de ensayo y metodos para identificar y caracterizar farmacos hipolipemiantes |
| AR087305A1 (es) * | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| CA2848201C (en) * | 2011-09-16 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipoprotein(a) levels by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9) |
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2014
- 2014-05-28 TW TW103118526A patent/TWI682780B/zh not_active IP Right Cessation
- 2014-05-29 US US14/290,462 patent/US20140356370A1/en not_active Abandoned
- 2014-05-29 WO PCT/US2014/040050 patent/WO2014194111A1/en not_active Ceased
- 2014-05-29 CA CA2912101A patent/CA2912101A1/en not_active Abandoned
- 2014-05-29 AU AU2014274077A patent/AU2014274077B2/en not_active Ceased
- 2014-05-29 EA EA201592304A patent/EA201592304A1/ru unknown
- 2014-05-29 JP JP2016516825A patent/JP6423868B2/ja active Active
- 2014-05-29 KR KR1020157033966A patent/KR20160013046A/ko not_active Ceased
- 2014-05-29 CN CN202110182897.4A patent/CN113144195A/zh active Pending
- 2014-05-29 CN CN201480031344.7A patent/CN105263963B/zh active Active
- 2014-05-29 EP EP14739600.6A patent/EP3004172B1/en active Active
-
2015
- 2015-10-19 ZA ZA2015/07798A patent/ZA201507798B/en unknown
- 2015-10-25 IL IL242251A patent/IL242251B/en not_active IP Right Cessation
-
2019
- 2019-03-28 US US16/367,795 patent/US20190330371A1/en not_active Abandoned
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| RHAINDS D等: "PCSK9 inhibition and LDL cholesterol lowering: The biology of an attractive therapeutic target and critical review of the latest clinical trials", 《CLINICAL LIPIDOLOGY》 * |
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| Publication number | Publication date |
|---|---|
| EP3004172B1 (en) | 2019-11-27 |
| CN105263963A (zh) | 2016-01-20 |
| US20190330371A1 (en) | 2019-10-31 |
| JP2016522211A (ja) | 2016-07-28 |
| US20140356370A1 (en) | 2014-12-04 |
| TW201536315A (zh) | 2015-10-01 |
| AU2014274077B2 (en) | 2019-09-26 |
| EA201592304A1 (ru) | 2016-04-29 |
| AU2014274077A1 (en) | 2015-11-19 |
| TWI682780B (zh) | 2020-01-21 |
| HK1216896A1 (en) | 2016-12-09 |
| WO2014194111A1 (en) | 2014-12-04 |
| ZA201507798B (en) | 2017-04-26 |
| IL242251B (en) | 2020-02-27 |
| CN105263963B (zh) | 2021-03-05 |
| EP3004172A1 (en) | 2016-04-13 |
| CA2912101A1 (en) | 2014-12-04 |
| KR20160013046A (ko) | 2016-02-03 |
| JP6423868B2 (ja) | 2018-11-14 |
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