CN113144195A - 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 - Google Patents

伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 Download PDF

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CN113144195A
CN113144195A CN202110182897.4A CN202110182897A CN113144195A CN 113144195 A CN113144195 A CN 113144195A CN 202110182897 A CN202110182897 A CN 202110182897A CN 113144195 A CN113144195 A CN 113144195A
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G·斯维尔戈尔德
S·梅利斯
W·J·萨赛拉
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Regeneron Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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CN202110182897.4A 2013-05-30 2014-05-29 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法 Pending CN113144195A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361828730P 2013-05-30 2013-05-30
US61/828,730 2013-05-30
US201361889553P 2013-10-11 2013-10-11
US61/889,553 2013-10-11
US201361901212P 2013-11-07 2013-11-07
US61/901,212 2013-11-07
CN201480031344.7A CN105263963B (zh) 2013-05-30 2014-05-29 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法

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CN113144195A true CN113144195A (zh) 2021-07-23

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CN201480031344.7A Active CN105263963B (zh) 2013-05-30 2014-05-29 伴pcsk9功能获得性突变的常染色体显性高胆固醇血症的治疗方法

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US (2) US20140356370A1 (enExample)
EP (1) EP3004172B1 (enExample)
JP (1) JP6423868B2 (enExample)
KR (1) KR20160013046A (enExample)
CN (2) CN113144195A (enExample)
AU (1) AU2014274077B2 (enExample)
CA (1) CA2912101A1 (enExample)
EA (1) EA201592304A1 (enExample)
IL (1) IL242251B (enExample)
TW (1) TWI682780B (enExample)
WO (1) WO2014194111A1 (enExample)
ZA (1) ZA201507798B (enExample)

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HK1216896A1 (en) 2016-12-09
CN105263963A (zh) 2016-01-20
AU2014274077B2 (en) 2019-09-26
ZA201507798B (en) 2017-04-26
EP3004172B1 (en) 2019-11-27
US20140356370A1 (en) 2014-12-04
IL242251B (en) 2020-02-27
EA201592304A1 (ru) 2016-04-29
TWI682780B (zh) 2020-01-21
CA2912101A1 (en) 2014-12-04
JP2016522211A (ja) 2016-07-28
WO2014194111A1 (en) 2014-12-04
EP3004172A1 (en) 2016-04-13
US20190330371A1 (en) 2019-10-31
AU2014274077A1 (en) 2015-11-19
TW201536315A (zh) 2015-10-01
JP6423868B2 (ja) 2018-11-14
CN105263963B (zh) 2021-03-05
KR20160013046A (ko) 2016-02-03

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Application publication date: 20210723