CN113121510A - 一种萘并呋喃邻醌化合物及其制备方法和应用、抗肿瘤药物组合物、抗菌药物组合物 - Google Patents
一种萘并呋喃邻醌化合物及其制备方法和应用、抗肿瘤药物组合物、抗菌药物组合物 Download PDFInfo
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- CN113121510A CN113121510A CN202110324537.3A CN202110324537A CN113121510A CN 113121510 A CN113121510 A CN 113121510A CN 202110324537 A CN202110324537 A CN 202110324537A CN 113121510 A CN113121510 A CN 113121510A
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- naphthofuran
- quinone compound
- intermediate product
- compound
- reaction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN202110377953.XA CN113116882B (zh) | 2021-03-26 | 2021-03-26 | 一种萘并呋喃邻醌化合物在制备抗菌药物中的应用 |
CN202110324537.3A CN113121510B (zh) | 2021-03-26 | 2021-03-26 | 一种萘并呋喃邻醌化合物及其制备方法和应用、抗肿瘤药物组合物、抗菌药物组合物 |
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CN202110324537.3A CN113121510B (zh) | 2021-03-26 | 2021-03-26 | 一种萘并呋喃邻醌化合物及其制备方法和应用、抗肿瘤药物组合物、抗菌药物组合物 |
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CN202110377953.XA Division CN113116882B (zh) | 2021-03-26 | 2021-03-26 | 一种萘并呋喃邻醌化合物在制备抗菌药物中的应用 |
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CN113121510A true CN113121510A (zh) | 2021-07-16 |
CN113121510B CN113121510B (zh) | 2023-04-14 |
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CN202110324537.3A Active CN113121510B (zh) | 2021-03-26 | 2021-03-26 | 一种萘并呋喃邻醌化合物及其制备方法和应用、抗肿瘤药物组合物、抗菌药物组合物 |
CN202110377953.XA Active CN113116882B (zh) | 2021-03-26 | 2021-03-26 | 一种萘并呋喃邻醌化合物在制备抗菌药物中的应用 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824700A (en) * | 1996-02-20 | 1998-10-20 | Wisconsin Alumni Research Foundation | Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth |
CN101274925A (zh) * | 2007-03-29 | 2008-10-01 | 中国科学院上海药物研究所 | 一类萘并呋喃邻醌化合物及其制备方法和用途 |
CN103554117A (zh) * | 2013-10-16 | 2014-02-05 | 苏州大学张家港工业技术研究院 | 一种手性螺萘醌并吡喃羟吲哚化合物的制备方法 |
CN105130936A (zh) * | 2015-09-01 | 2015-12-09 | 中国药科大学 | 一类邻萘醌化合物、其制备方法和医药用途 |
CN105884723A (zh) * | 2014-12-25 | 2016-08-24 | 上海三帆生物医药科技有限公司 | 丹参酮衍生物、其制备方法及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020161959A1 (ja) * | 2019-02-06 | 2020-08-13 | タヒボジャパン株式会社 | 抗菌及び抗ウイルス活性を有するナフトキノン化合物及びその医薬用途 |
CN110859845B (zh) * | 2019-12-10 | 2021-02-02 | 南京医科大学 | 丹参酮类化合物的应用 |
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2021
- 2021-03-26 CN CN202110324537.3A patent/CN113121510B/zh active Active
- 2021-03-26 CN CN202110377953.XA patent/CN113116882B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824700A (en) * | 1996-02-20 | 1998-10-20 | Wisconsin Alumni Research Foundation | Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth |
CN101274925A (zh) * | 2007-03-29 | 2008-10-01 | 中国科学院上海药物研究所 | 一类萘并呋喃邻醌化合物及其制备方法和用途 |
CN103554117A (zh) * | 2013-10-16 | 2014-02-05 | 苏州大学张家港工业技术研究院 | 一种手性螺萘醌并吡喃羟吲哚化合物的制备方法 |
CN105884723A (zh) * | 2014-12-25 | 2016-08-24 | 上海三帆生物医药科技有限公司 | 丹参酮衍生物、其制备方法及其应用 |
CN105130936A (zh) * | 2015-09-01 | 2015-12-09 | 中国药科大学 | 一类邻萘醌化合物、其制备方法和医药用途 |
Non-Patent Citations (6)
Title |
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ELISA BONANDI ET AL.: ""The 1,2,3-triazole ring as a bioisostere in medicinal chemistry"", 《DRUG DISCOVERY TODAY》 * |
SHENG-YOU LI ET AL.: ""Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis"", 《MOLECULES》 * |
伍勇 等: ""松香基Schiff碱杂环衍生物的合成及抑菌活性"", 《精细化工中间体》 * |
国家药典委员会 编著: "《中华人民共和国药典 注释 1部》", 30 March 2016, 中国医药科技出版社 * |
李建恒 等: ""丹参脂溶性有效成分丹参酮研究进展"", 《河北大学学报(自然科学版)》 * |
赵桂森 等主编: "《新药设计与开发基础》", 30 November 2015, 山东大学出版社 * |
Also Published As
Publication number | Publication date |
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CN113121510B (zh) | 2023-04-14 |
CN113116882B (zh) | 2023-04-07 |
CN113116882A (zh) | 2021-07-16 |
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Inventor after: Chen Chao Inventor after: Li Shengyou Inventor after: Li Ke Inventor after: Pan Weidong Inventor after: Lou Huayong Inventor after: Song Junrong Inventor after: Li Jinyu Inventor before: Chen Chao Inventor before: Li Shengyou Inventor before: Li Ke Inventor before: Pan Weidong Inventor before: Lou Huayong Inventor before: Song Junrong Inventor before: Li Jinyu |
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