CN113116977A - Bath powder for treating fungal infection and preparation method thereof - Google Patents
Bath powder for treating fungal infection and preparation method thereof Download PDFInfo
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Abstract
The invention discloses bath powder for treating fungal infection, which comprises the following raw materials in parts by weight: 0.1-0.4 part of chlorhexidine acetate, 3-10 parts of benzoic acid, 10-20 parts of salicylic acid, 10-30 parts of boric acid, 2-8 parts of phellodendron extract, 2-8 parts of cortex dictamni extract, 2-8 parts of radix sophorae flavescentis extract, 2-8 parts of cortex pseudolaricis extract, 0.001-0.004 part of essence and 30-60 parts of talcum powder, wherein the fungal infection bath powder reduces the proportion of acidic substances in the fungal infection bath powder and reduces the irritation to the skin by controlling the content of the acidic substances such as benzoic acid, salicylic acid, boric acid and the like, enhances the antifungal effect by the combined action of the acidic substances such as benzoic acid, salicylic acid, boric acid and the like and the traditional Chinese medicines such as phellodendron, cortex dictamni, radix sophorae flavescentis, cortex pseudolaricis and the like, and increases the antibacterial effect to the skin by the cooperation of chlorhexidine acetate and the traditional Chinese medicine extract, especially an inhibitory effect on fungal infections.
Description
Technical Field
The invention relates to the technical field of skin antibacterial powder, in particular to bath powder for treating fungal infection and a preparation method thereof.
Background
Various skin antibacterial powders in the market at present are mainly used for inhibiting escherichia coli, staphylococcus aureus and candida albicans on the skin, and are directly scattered on the skin or act on the skin after being dissolved in a proper amount of warm water during use, but most of the skin antibacterial powders have unreasonable components, so that a phenomenon of serious desquamation can occur when a user uses the skin antibacterial powder, the skin is damaged, and particularly after various fungi used on the skin of a foot are infected and inhibited, the skin is seriously desquamated, the epidermis is damaged, pain is caused, and the skin can not walk, so that secondary infection is caused.
Disclosure of Invention
The bath powder for treating fungal infection is used for enhancing the bacteriostatic effect on foot skin, preventing a user from peeling during use, is convenient to use and can effectively solve the problems in the background art.
In order to achieve the purpose, the invention provides the following technical scheme: a bath powder for treating fungal infection comprises the following raw materials in parts by weight: 0.1-0.4 part of chlorhexidine acetate, 3-10 parts of benzoic acid, 10-20 parts of salicylic acid, 10-30 parts of boric acid, 2-8 parts of phellodendron extract, 2-8 parts of cortex dictamni extract, 2-8 parts of sophora flavescens extract and 2-8 parts of cortex pseudolaricis extract.
As a preferred technical scheme of the invention, the raw materials further comprise the following components in parts by weight: 0.001-0.004 parts of essence and 30-60 parts of talcum powder.
As a preferable technical scheme of the invention, the method comprises the following steps:
(1) selecting proper amounts of chlorhexidine acetate, benzoic acid, salicylic acid and boric acid according to the weight parts, sterilizing to enable the chlorhexidine acetate, the benzoic acid, the salicylic acid and the boric acid to reach the medicinal grade, and filtering by a filter sieve with the filtering fineness of 100 meshes;
(2) selecting appropriate amount of cortex Phellodendri, radix Sophorae Flavescentis, cortex Dictamni Radicis and cortex pseudolaricis decoction pieces, respectively decocting and reflux-extracting with modern Chinese medicine, single-cycle vacuum concentrating, and spray drying to obtain Chinese medicinal extract, and fine powder;
(3) coarsely mixing the chlorhexidine acetate and the talcum powder obtained in the step (1), and then putting the mixture into a small-sized high-speed mixing pulverizer (35000 r/min) for pulverizing and mixing for 8-10 seconds to obtain a material A for later use;
(4) weighing fine powder of the extracts of the golden cypress, the radix sophorae flavescentis, the cortex dictamni and the cortex pseudolaricis prepared in the step (2) according to the parts by weight, respectively putting the fine powder into a high-efficiency mixer, then adding the benzoic acid, the salicylic acid and the boric acid obtained in the step (1), starting the transverse low-speed stirring for 1min, then starting the high-speed transverse stirring, carrying out the high-speed dispersion stirring and the longitudinal cutting knife for 5min, and fully and uniformly stirring the materials to obtain bath powder for treating fungal infection;
(5) sampling and inspecting the obtained bath powder for treating fungal infection;
(6) adding the obtained bath powder for treating fungal infection into a filling machine, and packaging with composite film into bags.
As a preferred technical solution of the present invention, the specific method of (2) is: adding cortex Phellodendri, radix Sophorae Flavescentis and cortex Dictamni Radicis into different extraction tanks respectively, adding 8 times of water for decocting under reflux for 2 hr for the first time, adding 6 times of water for decocting under reflux for 1.5 hr for the second time, mixing the decoctions to obtain a first decoction, extracting cortex pseudolaricis with appropriate amount of ethanol under reflux to obtain a second decoction, pumping the first and second decoctions into a vacuum concentration tank, heating to about 50 deg.C, concentrating under vacuum of 0.08-0.09Mpa to relative density of about 1.15, and drying to obtain fine powder by using a spray dryer.
The chlorhexidine acetate is used as a common bacteriostatic active ingredient of the skin, is efficient and safe, and can kill staphylococcus aureus, escherichia coli and candida albicans.
Benzoic acid, boric acid and salicylic acid are adopted, the pH value of the lotion is strictly controlled to achieve the effect of inhibiting fungi, and common fungal infections comprise beriberi, onychomycosis and the like.
Phellodendron bark: the phellodendron bark contains berberine, jateorhizine and tetrandrine, has a certain inhibiting effect on staphylococcus aureus, escherichia coli and the like, and has a strong inhibiting effect on skin disease curing fungi such as candida albicans, epidermophyton floccosum, microsporum and the like.
And (3) preparing cortex dictamni: bitter and cold in nature, has the effects of clearing heat, eliminating dampness, dispelling wind and removing toxicity, is commonly used for patients with damp-heat sore toxin, eczema rubella, scabies, sore and scabies, skin ulcer, yellow water dripping and the like, and achieves good effect by being compatible with traditional Chinese medicines such as lightyellow sophora root and the like; modern research proves that: the Dictamnus dasycarpus aqueous extract has different inhibitory effects on various pathogenic fungi such as Trichophyton, Trichophyton fulvum, Trichophyton epidermidis and Nocardia stellatophii.
Flavescent sophora root: bitter and cold in nature, has the effects of clearing heat, eliminating dampness, killing parasites, relieving itching and treating skin diseases, has good treatment effect on eczema and eczema, skin pruritus and mange leprosy, and the sophora flavescens mainly contains matrine, oxymatrine, isoaloperine and the like, has obvious inhibition effect on dysentery bacillus, staphylococcus aureus, escherichia coli, beta streptococcus and the like, and has different inhibition effects on dermatophytes such as tricholoma matsutake, fresh xanthomonas, fresh red epidermidis and the like.
Golden larch bark: the ointment is pungent and warm in nature, has the effects of killing parasites, treating tinea and relieving itching, and is clinically used for tinea corporis, tinea manus and pedis, tinea capitis, scabies, eczema, dermatitis, skin pruritus and the like; the golden larch bark contains organic acid and alcohol extract, has certain bacteriostasis to various common pathogenic dermatophytes and candida albicans in China, and is a special medicine for treating external dermatosis.
Compared with the prior art, the invention has the beneficial effects that: 1. the proportion of acidic substances in the fungal infection bath powder is reduced by controlling the contents of acidic substances such as benzoic acid, salicylic acid, boric acid and the like, and the irritation to the skin is reduced, so that the fungal infection bath powder cannot cause secondary damage to the skin;
2. the antifungal effect is enhanced by the combined action of acidic substances such as benzoic acid, salicylic acid, boric acid and the like and traditional Chinese medicines such as golden cypress, cortex dictamni, radix sophorae flavescentis and golden larch bark and the like;
3. the chlorhexidine acetate is matched with the traditional Chinese medicine extract to increase the bacteriostatic effect on the skin, in particular the inhibitory effect on fungal infection;
4. the fungal infection bath powder has the advantages of smoothing skin and enabling minor ulcer to be healed more easily through the talcum powder.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the invention provides a technical scheme that: a bath powder for treating fungal infection comprises the following raw materials in parts by weight: 0.2 part of chlorhexidine acetate, 5 parts of benzoic acid, 10 parts of salicylic acid, 10 parts of boric acid, 2 parts of phellodendron extract, 2 parts of cortex dictamni extract, 2 parts of radix sophorae flavescentis extract, 2 parts of cortex pseudolaricis extract, 0.001 part of essence and 67.8 parts of talcum powder.
A method for preparing bath powder for treating fungal infection comprises the following steps:
(1) selecting and sterilizing 0.1 part of chlorhexidine acetate, 5 parts of benzoic acid, 10 parts of salicylic acid and 10 parts of boric acid according to the parts by weight to enable the chlorhexidine acetate, the benzoic acid, the salicylic acid and the boric acid to reach the medicinal grade, and filtering the mixture by a filter sieve, wherein the filtering fineness is 100 meshes;
(2) selecting appropriate amount of cortex Phellodendri, radix Sophorae Flavescentis, cortex Dictamni Radicis and cortex pseudolaricis decoction pieces, respectively decocting and reflux-extracting with modern Chinese medicine, single-cycle vacuum concentrating, and spray drying to obtain Chinese medicinal extract, and fine powder;
(3) coarsely mixing 0.1 part of chlorhexidine acetate obtained in the step (1) with 67.8 parts of talcum powder, and then putting the mixture into a small-sized high-speed mixing pulverizer (35000 r/min) for pulverizing and mixing for 8-10 seconds to obtain a material A for later use;
(4) weighing fine powder of 2 parts of cortex phellodendri, 2 parts of radix sophorae flavescentis, 2 parts of cortex dictamni and 2 parts of cortex pseudolaricis extracts prepared in the step (2) according to parts by weight, respectively putting the fine powder into a high-efficiency mixer, then adding 5 parts of benzoic acid, 10 parts of salicylic acid and 10 parts of boric acid obtained in the step (1), starting the material A obtained in the step (3) and 0.001 part of essence, starting transverse low-speed stirring for 1min, then starting high-speed transverse stirring, and carrying out high-speed dispersion stirring and longitudinal cutter for 5min to fully and uniformly stir the materials, thus obtaining bath powder for treating fungal infection;
(5) sampling and inspecting the obtained bath powder for treating fungal infection;
(6) adding the obtained bath powder for treating fungal infection into a filling machine, and packaging with composite film to obtain product one with a weight of 10g per bag.
The specific method of the step (2) is as follows: respectively adding 2 parts of golden cypress, 2 parts of radix sophorae flavescentis and 2 parts of cortex dictamni into different extraction tanks, adding 8 times of water for decoction, reflux extraction for 2 hours for the first time, adding 6 times of water for decoction, reflux extraction for 1.5 hours for the second time, then combining decoctions obtained by two times of extraction to obtain a first decoction, performing reflux extraction on 2 parts of cortex pseudolaricis by using ethanol to obtain a second decoction, pumping the first decoction and the second decoction into a vacuum concentration tank, heating to about 50 ℃, concentrating under vacuum of 0.08-0.09Mpa to about 1.15 of relative density, and drying to fine powder by using a spray dryer.
Example 2:
the preparation process of the bath powder for fungal infection provided by the embodiment is the same as that of the embodiment 1, and only the mass ratio of the following preparation raw materials is adjusted:
a bath powder for treating fungal infection comprises the following raw materials in parts by weight: 0.3 part of chlorhexidine acetate, 6 parts of benzoic acid, 11 parts of salicylic acid, 11 parts of boric acid, 4 parts of phellodendron extract, 4 parts of cortex dictamni extract, 4 parts of sophora flavescens extract, 4 parts of cortex pseudolaricis extract, 0.002 part of essence and 55.68 parts of talcum powder.
A method for preparing bath powder for treating fungal infection comprises the following steps:
(1) selecting and sterilizing 0.3 part of chlorhexidine acetate, 6 parts of benzoic acid, 11 parts of salicylic acid and 11 parts of boric acid according to the parts by weight to enable the chlorhexidine acetate, the benzoic acid, the salicylic acid and the boric acid to reach the medicinal grade, and filtering the mixture by a filter sieve, wherein the filtering fineness is 100 meshes;
(2) selecting appropriate amount of cortex Phellodendri, radix Sophorae Flavescentis, cortex Dictamni Radicis and cortex pseudolaricis decoction pieces, respectively decocting and reflux-extracting with modern Chinese medicine, single-cycle vacuum concentrating, and spray drying to obtain Chinese medicinal extract, and fine powder;
(3) coarsely mixing 0.3 part of chlorhexidine acetate obtained in the step (1) with 55.68 parts of talcum powder, and then putting the mixture into a small-sized high-speed mixing pulverizer (35000 r/min) for pulverizing and mixing for 8-10 seconds to obtain a material A for later use;
(4) weighing fine powder of 4 parts of cortex phellodendri, 4 parts of radix sophorae flavescentis, 4 parts of cortex dictamni and 4 parts of cortex pseudolaricis extracts prepared in the step (2) according to parts by weight, respectively putting the fine powder into a high-efficiency mixer, then adding 6 parts of benzoic acid, 11 parts of salicylic acid and 11 parts of boric acid obtained in the step (1), starting the material A obtained in the step (3) and 0.002 part of essence, starting transverse low-speed stirring for 1min, then starting high-speed transverse stirring, and carrying out high-speed dispersion stirring and longitudinal cutter for 5min to fully and uniformly stir the materials, thus obtaining bath powder for treating fungal infection;
(5) sampling and inspecting the obtained bath powder for treating fungal infection;
(6) adding the obtained bath powder for treating fungal infection into a filling machine, and packaging with a composite film to obtain a second product 10g per bag.
The specific method of the step (2) is as follows: respectively adding 4 parts of golden cypress, 4 parts of radix sophorae flavescentis and 4 parts of cortex dictamni into different extraction tanks, adding 8 times of water for decoction, reflux extraction for 2 hours for the first time, adding 6 times of water for decoction, reflux extraction for 1.5 hours for the second time, then combining decoctions obtained by two times of extraction to obtain a first decoction, performing reflux extraction on 4 parts of cortex pseudolaricis by using ethanol to obtain a second decoction, pumping the first decoction and the second decoction into a vacuum concentration tank, heating to about 50 ℃, concentrating under vacuum of 0.08-0.09Mpa to about 1.15 of relative density, and drying to fine powder by using a spray dryer.
Example 3:
the preparation process of the bath powder for fungal infection provided by the embodiment is the same as that of the embodiment 1, and only the mass ratio of the following preparation raw materials is adjusted:
a bath powder for treating fungal infection comprises the following raw materials in parts by weight: 0.35 part of chlorhexidine acetate, 7 parts of benzoic acid, 12 parts of salicylic acid, 12 parts of boric acid, 5 parts of phellodendron extract, 5 parts of cortex dictamni extract, 5 parts of radix sophorae flavescentis extract, 5 parts of cortex pseudolaricis extract, 0.002 part of essence and 48.63 parts of talcum powder.
A method for preparing bath powder for treating fungal infection comprises the following steps:
(1) selecting and sterilizing 0.35 parts of chlorhexidine acetate, 7 parts of benzoic acid, 12 parts of salicylic acid and 12 parts of boric acid according to the parts by weight to enable the chlorhexidine acetate, the benzoic acid, the salicylic acid and the boric acid to reach the medicinal grade, and filtering the mixture by a filter sieve, wherein the filtering fineness is 100 meshes;
(2) selecting appropriate amount of cortex Phellodendri, radix Sophorae Flavescentis, cortex Dictamni Radicis, and cortex pseudolaricis decoction pieces, respectively decocting and reflux-extracting with modern Chinese medicine, single-cycle vacuum concentrating, and spray drying to obtain Chinese medicinal extract, and fine powder;
(3) coarsely mixing 0.35 part of chlorhexidine acetate obtained in the step (1) with 48.63 parts of talcum powder, and then putting the mixture into a small-sized high-speed mixing pulverizer (35000 r/min) for pulverizing and mixing for 8-10 seconds to obtain a material A for later use;
(4) weighing fine powder of 5 parts of cortex phellodendri, 5 parts of radix sophorae flavescentis, 5 parts of cortex dictamni and 5 parts of cortex pseudolaricis extracts prepared in the step (2) according to parts by weight, respectively putting the fine powder into a high-efficiency mixer, then adding 7 parts of benzoic acid, 12 parts of salicylic acid and 12 parts of boric acid obtained in the step (1), starting the material A obtained in the step (3) and 0.002 part of essence, starting transverse low-speed stirring for 1min, then starting high-speed transverse stirring, and carrying out high-speed dispersion stirring and longitudinal cutter for 5min to fully and uniformly stir the materials, thus obtaining bath powder for treating fungal infection;
(5) sampling and inspecting the obtained bath powder for treating fungal infection;
(6) adding the obtained bath powder for treating fungal infection into a filling machine, and packaging with a composite film to obtain a third product with a weight of 10g per bag.
The specific method of the step (2) is as follows: adding 5 parts of golden cypress, 5 parts of radix sophorae flavescentis and 5 parts of cortex dictamni into different extraction tanks respectively, adding 8 times of water for decoction, reflux extraction for 2 hours for the first time, adding 6 times of water for decoction, reflux extraction for 1.5 hours for the second time, then combining decoctions obtained by two times of extraction to obtain a first decoction, performing reflux extraction on 5 parts of cortex pseudolaricis by using ethanol to obtain a second decoction, pumping the first decoction and the second decoction into a vacuum concentration tank, heating to about 50 ℃, concentrating under vacuum of 0.08-0.09Mpa to about 1.15 of relative density, and drying to fine powder by using a spray dryer.
Example 4:
the preparation process of the bath powder for fungal infection provided by the embodiment is the same as that of the embodiment 1, and only the mass ratio of the following preparation raw materials is adjusted:
a bath powder for treating fungal infection comprises the following raw materials in parts by weight: 0.1 part of chlorhexidine acetate, 4 parts of benzoic acid, 11 parts of salicylic acid, 11 parts of boric acid, 6 parts of phellodendron extract, 6 parts of cortex dictamni extract, 6 parts of sophora flavescens extract, 6 parts of cortex pseudolaricis extract, 0.003 part of essence and 49.87 parts of talcum powder.
A method for preparing bath powder for treating fungal infection comprises the following steps:
(1) selecting and sterilizing 0.1 part of chlorhexidine acetate, 4 parts of benzoic acid, 11 parts of salicylic acid and 11 parts of boric acid according to the parts by weight to enable the chlorhexidine acetate, the benzoic acid, the salicylic acid and the boric acid to reach the medicinal grade, and filtering the mixture by a filter sieve, wherein the filtering fineness is 100 meshes;
(2) selecting appropriate amount of cortex Phellodendri, radix Sophorae Flavescentis, cortex Dictamni Radicis and cortex pseudolaricis decoction pieces, respectively decocting and reflux-extracting with modern Chinese medicine, single-cycle vacuum concentrating, and spray drying to obtain Chinese medicinal extract, and fine powder;
(3) coarsely mixing 0.1 part of chlorhexidine acetate obtained in the step (1) with 49.87 parts of talcum powder, and then putting the mixture into a small-sized high-speed mixing pulverizer (35000 r/min) for pulverizing and mixing for 8-10 seconds to obtain a material A for later use;
(4) weighing fine powder of 6 parts of cortex phellodendri, 6 parts of radix sophorae flavescentis, 6 parts of cortex dictamni and 6 parts of cortex pseudolaricis extracts prepared in the step (2) according to parts by weight, respectively putting the fine powder into a high-efficiency mixer, then adding 4 parts of benzoic acid, 11 parts of salicylic acid and 11 parts of boric acid obtained in the step (1), starting the material A obtained in the step (3) and 0.003 part of essence, starting transverse low-speed stirring for 1min, then starting high-speed transverse stirring, and carrying out high-speed dispersion stirring and longitudinal cutting for 5min to fully and uniformly stir the materials, thus obtaining bath powder for treating fungal infection;
(5) sampling and inspecting the obtained bath powder for treating fungal infection;
(6) adding the obtained bath powder for treating fungal infection into a filling machine, and packaging with a composite film to obtain product IV with a weight of 10g per bag.
The specific method of the step (2) is as follows: respectively adding 6 parts of golden cypress, 6 parts of radix sophorae flavescentis and 6 parts of cortex dictamni into different extraction tanks, adding 8 times of water for decoction, reflux extraction for 2 hours for the first time, adding 6 times of water for decoction, reflux extraction for 1.5 hours for the second time, then combining decoctions obtained by two times of extraction to obtain a first decoction, performing reflux extraction on 6 parts of cortex pseudolaricis by using ethanol to obtain a second decoction, pumping the first decoction and the second decoction into a vacuum concentration tank, heating to about 50 ℃, concentrating under vacuum of 0.08-0.09Mpa to about 1.15 of relative density, and drying to fine powder by using a spray dryer.
Example (b): 5:
the preparation process of the bath powder for fungal infection provided by the embodiment is the same as that of the embodiment 1, and only the mass ratio of the following preparation raw materials is adjusted:
a bath powder for treating fungal infection comprises the following raw materials in parts by weight: 0.1 part of chlorhexidine acetate, 3 parts of benzoic acid, 10 parts of salicylic acid, 10 parts of boric acid, 3 parts of phellodendron extract, 3 parts of cortex dictamni extract, 3 parts of sophora flavescens extract, 3 parts of cortex pseudolaricis extract, 0.001 part of essence and 64.89 parts of talcum powder.
A method for preparing bath powder for treating fungal infection comprises the following steps:
(1) selecting and sterilizing 0.1 part of chlorhexidine acetate, 3 parts of benzoic acid, 10 parts of salicylic acid and 10 parts of boric acid according to the parts by weight to enable the chlorhexidine acetate, the benzoic acid, the salicylic acid and the boric acid to reach the medicinal grade, and filtering the mixture by a filter sieve, wherein the filtering fineness is 100 meshes;
(2) selecting appropriate amount of cortex Phellodendri, radix Sophorae Flavescentis, cortex Dictamni Radicis and cortex pseudolaricis decoction pieces, respectively decocting and reflux-extracting with modern Chinese medicine, single-cycle vacuum concentrating, and spray drying to obtain Chinese medicinal extract, and fine powder;
(3) coarsely mixing 0.1 part of chlorhexidine acetate obtained in the step (1) with 64.89 parts of talcum powder, and then putting the mixture into a small-sized high-speed mixing pulverizer (35000 r/min) for pulverizing and mixing for 8-10 seconds to obtain a material A for later use;
(4) weighing 3 parts of cortex phellodendri, 3 parts of radix sophorae flavescentis, 3 parts of cortex dictamni and 3 parts of cortex pseudolaricis extract prepared in the step (2) according to parts by weight, respectively putting the fine powders into a high-efficiency mixer, then adding 3 parts of benzoic acid, 10 parts of salicylic acid and 10 parts of boric acid obtained in the step (1), starting the transverse low-speed stirring for 1min, then starting the high-speed transverse stirring, and carrying out high-speed dispersion stirring and longitudinal cutting for 5min to fully and uniformly stir the materials to obtain bath powder for treating fungal infection;
(5) sampling and inspecting the obtained bath powder for treating fungal infection;
(6) adding the obtained bath powder for treating fungal infection into a filling machine, and packaging with a composite film to obtain product five with a weight of 10g per bag.
The specific method of the step (2) is as follows: respectively adding 3 parts of golden cypress, 3 parts of radix sophorae flavescentis and 3 parts of cortex dictamni into different extraction tanks, adding 8 times of water for decoction, reflux extraction for 2 hours for the first time, adding 6 times of water for decoction, reflux extraction for 1.5 hours for the second time, then combining decoctions obtained by two times of extraction to obtain a first decoction, performing reflux extraction on 3 parts of cortex pseudolaricis by using ethanol to obtain a second decoction, pumping the first decoction and the second decoction into a vacuum concentration tank, heating to about 50 ℃, concentrating under vacuum of 0.08-0.09Mpa to about 1.15 of relative density, and drying to fine powder by using a spray dryer.
Effect embodiment: the bath powder for treating fungal infection prepared in the first to fifth examples of the present invention was subjected to activity test to observe the effect.
The experimental number of each bath powder for treating fungal infection is 100, 50 men and 50 women, and all the bath powder has fungal infection symptoms, age: 19-47 years old.
The using method comprises the following steps: a bag of the fungal infection bath powder product is sprinkled into warm water, a user soaks the affected part in the warm water for about 30 minutes, and the insoles and the socks are soaked in the warm water containing the fungal infection bath powder product for about 30 minutes, once a day, once to twice, and whether the disease recurs or not is observed after one month.
The experimental results are as follows:
the standard of curative effect is as follows: (1) the effect is shown: disappearance of fungal infection symptoms; (2) the method has the following advantages: relief of symptoms of fungal infection; (3) and (4) invalidation: there was no change before and after treatment.
| Show effect | Is effective | Invalidation | Total effective rate | Repetition rate | |
| Product 1 | 75 | 15 | 10 | 90％ | 2％ |
| Product 2 | 86 | 11 | 3 | 97％ | 5％ |
| Product 3 | 80 | 15 | 5 | 95％ | 6％ |
| Product 4 | 70 | 22 | 8 | 92％ | 4％ |
| Product 5 | 78 | 16 | 6 | 94％ | 3％ |
| Daktarin | 80 | 15 | 5 | 80％ | 79％ |
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. A bath powder for treating fungal infection, characterized in that: the raw materials comprise the following components in parts by weight: 0.1-0.4 part of chlorhexidine acetate, 3-10 parts of benzoic acid, 10-20 parts of salicylic acid, 10-30 parts of boric acid, 2-8 parts of phellodendron extract, 2-8 parts of cortex dictamni extract, 2-8 parts of sophora flavescens extract and 2-8 parts of cortex pseudolaricis extract.
2. A bath powder for use in the treatment of fungal infections according to claim 1, characterized in that: the raw materials also comprise the following components in parts by weight: 0.001-0.004 parts of essence and 30-60 parts of talcum powder.
3. A method for preparing a bath powder for treating fungal infection comprising the bath powder for fungal infection of claim 1, wherein: the method comprises the following steps:
(1) selecting proper amounts of chlorhexidine acetate, benzoic acid, salicylic acid and boric acid according to the weight parts, sterilizing to enable the chlorhexidine acetate, the benzoic acid, the salicylic acid and the boric acid to reach the medicinal grade, and filtering by a filter sieve with the filtering fineness of 100 meshes;
(2) selecting appropriate amount of cortex Phellodendri, radix Sophorae Flavescentis, cortex Dictamni Radicis and cortex pseudolaricis decoction pieces, respectively decocting and reflux-extracting with modern Chinese medicine, single-cycle vacuum concentrating, and spray drying to obtain Chinese medicinal extract, and fine powder;
(3) coarsely mixing the chlorhexidine acetate and the talcum powder obtained in the step (1), and then putting the mixture into a small-sized high-speed mixing pulverizer (35000 r/min) for pulverizing and mixing for 8-10 seconds to obtain a material A for later use;
(4) weighing fine powder of the extracts of the golden cypress, the radix sophorae flavescentis, the cortex dictamni and the cortex pseudolaricis prepared in the step (2) according to the parts by weight, respectively putting the fine powder into a high-efficiency mixer, then adding the benzoic acid, the salicylic acid and the boric acid obtained in the step (1), starting the transverse low-speed stirring for 1min, then starting the high-speed transverse stirring, carrying out the high-speed dispersion stirring and the longitudinal cutting knife for 5min, and fully and uniformly stirring the materials to obtain bath powder for treating fungal infection;
(5) sampling and inspecting the obtained bath powder for treating fungal infection;
(6) adding the obtained bath powder for treating fungal infection into a filling machine, and packaging with composite film into bags.
4. The method of preparing a bath powder for the treatment of fungal infections according to claim 3, wherein: the specific method of the step (2) is as follows: adding cortex Phellodendri, radix Sophorae Flavescentis and cortex Dictamni Radicis into different extraction tanks respectively, adding 8 times of water for decocting under reflux for 2 hr for the first time, adding 6 times of water for decocting under reflux for 1.5 hr for the second time, mixing the decoctions to obtain a first decoction, extracting cortex pseudolaricis with appropriate amount of ethanol under reflux to obtain a second decoction, pumping the first and second decoctions into a vacuum concentration tank, heating to about 50 deg.C, concentrating under vacuum of 0.08-0.09Mpa to relative density of about 1.15, and drying to obtain fine powder by using a spray dryer.
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