CN108478736A - A kind of Chinese herbal medicine extraction solution and preparation method thereof for treating tinea of feet and hands - Google Patents
A kind of Chinese herbal medicine extraction solution and preparation method thereof for treating tinea of feet and hands Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The Chinese herbal medicine that the present invention relates to a kind of for treating tinea of feet and hands extracts solution and preparation method thereof, and bulk pharmaceutical chemicals include kuh-seng, Golden Larch Bark, Chinese prickly ash, rheum officinale, the tuber of stemona, the root bark of shaggy-fruited dittany, chlorhexidine acetate, benzoic acid and vinegar, and raw material medicaments in part by weight is made：Kuh-seng 5% 20%, Golden Larch Bark 1% 35%, Chinese prickly ash 7% 20%, rheum officinale 5% 40%, the tuber of stemona 5% 30%, chlorhexidine acetate 0.01% 0.5%, benzoic acid 0.05% 0.7% and vinegar 35% 70%.This is used to treat Chinese herbal medicine extraction solution of tinea of feet and hands and preparation method thereof, can treat pachyderma, damp and hot blister, bitterly more than etc. symptoms of itching, inhibition Escherichia coli, skin discomfort problem caused by staphylococcus aureus and Candida albicans etc., and significant in efficacy.
Description
Technical field
The invention belongs to Chinese herbal medicine ointment technical fields, and in particular to a kind of Chinese herbal medicine for treating tinea of feet and hands carries
Take solution and preparation method thereof.
Background technology
Currently on the market treatment tinea of feet and hands symptom product effect it is single, frequent recurrence and using high dose chemical drugs at
Point, drug resistance increases, and leads to exacerbation of symptoms.The product Chinese herbal medicine extraction process and active drug concentration of draft class are not achieved
Effective therapeutic effect.
Invention content
The purpose of the present invention is that solve the above-mentioned problems and provides a kind of Chinese herbal medicine for treating tinea of feet and hands and carry
Solution and preparation method thereof is taken, for treating pachyderma, damp and hot blister, the symptoms such as pain of itching is more than.
The present invention is achieved through the following technical solutions above-mentioned purpose：
It is a kind of for treat tinea of feet and hands Chinese herbal medicine extraction solution, bulk pharmaceutical chemicals include kuh-seng, Golden Larch Bark, Chinese prickly ash, rheum officinale,
The tuber of stemona, the root bark of shaggy-fruited dittany, chlorhexidine acetate, benzoic acid and vinegar.
As a further optimization solution of the present invention, raw material medicaments in part by weight is made：Kuh-seng 5%-20%, Golden Larch Bark
1%-35%, Chinese prickly ash 5%-20%, rheum officinale 5%-40%, tuber of stemona 5%-30%, chlorhexidine acetate 0.01%-0.5%, benzoic acid
0.05%-0.7% and vinegar 35%-70%.
As a further optimization solution of the present invention, raw material medicaments in part by weight is made：Kuh-seng 5%, Golden Larch Bark 5%, flower
Green pepper 5%, rheum officinale 5%, the tuber of stemona 5%, chlorhexidine acetate 0.2%, benzoic acid 0.2% and vinegar 69.6%.
The preparation method of solution is extracted according to the above-mentioned Chinese herbal medicine for treating tinea of feet and hands, step is,
S1, by kuh-seng, Golden Larch Bark, rheum officinale, the tuber of stemona, the root bark of shaggy-fruited dittany, Chinese prickly ash Six-element medicinal material, add alcohol reflux to extract 2 times, first
Secondary to add 6-10 times to measure ethyl alcohol extraction 1-5 hours, for the second time plus 4-8 times is measured ethyl alcohol and extracted 1-4 hours；
S2, merge ethanol solution, filter the dregs of a decoction, recycle ethanol；
S3, the dregs of a decoction add 5-10 times to measure water boiling and extraction 1-6 hours, and filtration stands 24-54 hours, supernatant taken, with ethyl alcohol
Liquid merges, and is concentrated into the clear cream that relative density is 0.5-2 (60 DEG C), vinegar, chlorhexidine acetate, benzoic acid, mixing is added.
Pharmacological action：
Kuh-seng：Kuh-seng heat-clearing and damp-drying drug, desinsection control pruitus, scabies leprosy malignant sore.
Golden Larch Bark：Golden Larch Bark nature and flavor are acrid in flavour and warm in nature, can desinsection, it is antipruritic, for controlling mange itch, there is heat-clearing and damp-drying drug, purging intense heat to remove
The effect of steaming, detoxification sore treatment.
Chinese prickly ash：Chinese prickly ash warming spleen and stomach for dispelling cold dehumidifies, analgesic, desinsection, solution fish raw meat poison.It controls having indigestion to stop drinking, trusted subordinate's crymodynia, vomit,
Oh, cough with dyspnea, wind-cold-dampness arthralgia, diarrhea, dysentery, colic, dentalgia, roundworm disease, enterobiasis, pruritus vulvae, sore scabies.
Rheum officinale：Bitter is trembled with fear,
Can heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.It stagnates constipation for real heat, blood-head
Hematemesis, hot eyes pharynx swelling, carbuncle swells furunculosis, abdominalgia with intestinal abscess, blood stasis closed, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice,
Stranguria, oedema；Externally treating burns and scalds.
The tuber of stemona：The tuber of stemona is sweet, bitter, tepor.
Can moistening lung to lower qi cough-relieving, desinsection.It coughs for new chronic cough, pulmonary tuberculosis cough, pertussis；It is used for head louse, body louse, pinworm outside
Disease, private parts, which is disturbed, itches.The sweet tuber of stemona moistens the lung and relieve the cough.For deficiency of yin and overstrain cough.
Chlorhexidine acetate：Chlorhexidine acetate is a kind of cationic surfactant, has a broad antifungal spectrum, to most gram-positives and
Negative bacteria has killing effect, also effective to Pseudomonas aeruginosa, and antibacterial action is better than benzalkonium bromide, and effect is rapid and lasting, poison
Low, the no local irritant effect of property.
Benzoic acid：Benzoic acid, which has, to be softened and dissolves cutin, inhibits fungi, antipruritic effect.
Vinegar：Vinegar digestible fat and lipid peroxidation in sugar, the intake for reducing salinity, inhibition and reduction human aging process
The formation of matter has diuresis..
The beneficial effects of the present invention are：
The symptoms such as medicament categories proportioning of the present invention is reasonable, and invention can treat pachyderma, damp and hot blister, and pain of itching is more than, suppression
Skin discomfort problem caused by Escherichia coli processed, staphylococcus aureus and Candida albicans etc., and it is significant in efficacy.
Specific implementation mode
With reference to embodiment, the invention will be further described：
The normal of dawn it should be noted that embodiment method therefor is known to those skilled in the art unless otherwise instructed
Rule method, the materials such as reagent used are commercially available products unless otherwise instructed.
Embodiment one, a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands, raw material medicaments in part by weight are made：Kuh-seng
20%, Golden Larch Bark 1%, Chinese prickly ash 20%, rheum officinale 5%, the tuber of stemona 5%, chlorhexidine acetate 0.01%, benzoic acid 0.05% and vinegar
48.94%.
Embodiment two, a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands, raw material are formed according to following percentage：It is former
Material is formed according to following percentage：Kuh-seng 12.5%, Golden Larch Bark 16%, Chinese prickly ash 14%, rheum officinale 10%, the tuber of stemona 10%, acetic acid chlorine
Oneself determines 0.03%, benzoic acid 0.37% and vinegar 37.1%.
Embodiment three, a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands, raw material are formed according to following percentage：It is bitter
Ginseng 5%, Golden Larch Bark 5%, Chinese prickly ash 9%, rheum officinale 5%, the tuber of stemona 5%, chlorhexidine acetate 0.5%, benzoic acid 0.5% and vinegar
70%.
Example IV, a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands, raw material are formed according to following percentage：It is bitter
Ginseng 5%, Golden Larch Bark 5%, Chinese prickly ash 5%, rheum officinale 5%, the tuber of stemona 5%, chlorhexidine acetate 0.2%, benzoic acid 0.2% and vinegar
69.6%.
Embodiment five, a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands, raw material are formed according to following percentage：It is bitter
Ginseng 5%, Golden Larch Bark 1%, Chinese prickly ash 7%, rheum officinale 40%, the tuber of stemona 5%, chlorhexidine acetate 0.5%, benzoic acid 0.5% and vinegar
41%.
Embodiment six, a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands, raw material are formed according to following percentage：It is bitter
Ginseng 5%, Golden Larch Bark 1%, Chinese prickly ash 7%, rheum officinale 5%, the tuber of stemona 30%, chlorhexidine acetate 0.5%, benzoic acid 0.5% and vinegar
51%.
Above-described embodiment is all made of following methods and is prepared：
S1, Asian puccoon, garden burnet, Radix Angelicae Sinensis, twice with ethyl alcohol extraction, extracting solution concentration, dry dry extract；
S2, dry extract low-temperature grinding are spare；
S3, dragon's blood are co-melting with matrix heating after crushing, and other compositions reconcile uniform with matrix.
Choose pachyderma 60, damp and hot blister 60, pain of itching more than 60 and Escherichia coli cause skin discomfort 60
Example, staphylococcus aureus cause skin discomfort 60, Candida albicans to cause skin 60 uncomfortable, are divided into 6 groups, including reality
A group 1-6 is tested, every group of various symptoms there are 10.
Table one：Experimental group 1 is clinical real using the Chinese herbal medicine extraction solution for treating tinea of feet and hands prepared in embodiment one
Test result statistical form
Table two：Experimental group 2 is clinical real using the Chinese herbal medicine extraction solution for treating tinea of feet and hands prepared in embodiment two
Test result statistical form
Table three：Experimental group 3 is clinical real using the Chinese herbal medicine extraction solution for treating tinea of feet and hands prepared in embodiment three
Test result statistical form
Table three：Experimental group 3 is clinical real using the Chinese herbal medicine extraction solution for treating tinea of feet and hands prepared in embodiment three
Test result statistical form
Table four：Experimental group 4 is clinical real using the Chinese herbal medicine extraction solution for treating tinea of feet and hands prepared in example IV
Test result statistical form
Table five：Experimental group 5 is clinical real using the Chinese herbal medicine extraction solution for treating tinea of feet and hands prepared in embodiment five
Test result statistical form
Table five：Experimental group 5 is clinical real using the Chinese herbal medicine extraction solution for treating tinea of feet and hands prepared in embodiment five
Test result statistical form
Clinical trial can be seen that the extracts of Chinese herbal medicine for being used to treat skin discomfort faces, to Escherichia coli, golden yellow Portugal
Skin discomfort problem therapeutic effect caused by grape coccus and Candida albicans etc. is notable；Effective pachyderma, damp and hot blister；It is right
Pain of itching has significant therapeutic effect incessantly；Do not occur any side effect in experiment patient.
It is a kind of detailed embodiment and specific operating process of the present invention above, is before being with technical solution of the present invention
It puts and is implemented, but protection scope of the present invention is not limited to the above embodiments.
Claims (4)
1. a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands, it is characterised in that：Its bulk pharmaceutical chemicals include kuh-seng, Golden Larch Bark,
Chinese prickly ash, rheum officinale, the tuber of stemona, the root bark of shaggy-fruited dittany, chlorhexidine acetate, benzoic acid and vinegar.
2. a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands according to claim 1, it is characterised in that be, it is former
Material medicine is made by weight：Kuh-seng 5%-20%, Golden Larch Bark 1%-35%, Chinese prickly ash 5%-20%, rheum officinale 5%-40%, the tuber of stemona
5%-30%, chlorhexidine acetate 0.01%-0.5%, benzoic acid 0.05%-0.7% and vinegar 35%-70%.
3. a kind of Chinese herbal medicine extraction solution for treating tinea of feet and hands according to claim 1, which is characterized in that its raw material
Medicine is made by weight：Kuh-seng 5%, Golden Larch Bark 5%, Chinese prickly ash 5%, rheum officinale 5%, the tuber of stemona 5%, chlorhexidine acetate 0.2%, benzene first
Acid 0.2% and vinegar 69.6%.
4. the preparation method of the Chinese herbal medicine extraction solution for treating tinea of feet and hands according to claim 1-3 any one,
It is characterized in that,
S1, by kuh-seng, Golden Larch Bark, rheum officinale, the tuber of stemona, the root bark of shaggy-fruited dittany, Chinese prickly ash Six-element medicinal material, add alcohol reflux to extract 2 times, for the first time plus
It measures ethyl alcohol for 6-10 times to extract 1-5 hours, for the second time plus 4-8 times is measured ethyl alcohol and extracted 1-4 hours；
S2, merge ethanol solution, filter the dregs of a decoction, recycle ethanol；
S3, the dregs of a decoction add 5-10 times to measure water boiling and extraction 1-6 hours, and filtration stands 24-54 hours, takes supernatant, is closed with ethanol
And it is concentrated into the clear cream that relative density is 0.5-2 (60 DEG C), vinegar, chlorhexidine acetate, benzoic acid, mixing is added.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116977A (en) * | 2019-12-31 | 2021-07-16 | 郑州维谊生物科技有限公司 | Bath powder for treating fungal infection and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104043004A (en) * | 2014-07-03 | 2014-09-17 | 张胜利 | External use drug for treating skin itching |
| WO2016144979A1 (en) * | 2015-03-09 | 2016-09-15 | The Children's Mercy Hospital | Dermatophytosis prophylaxis and treatment |
-
2018
- 2018-05-17 CN CN201810476291.XA patent/CN108478736A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104043004A (en) * | 2014-07-03 | 2014-09-17 | 张胜利 | External use drug for treating skin itching |
| WO2016144979A1 (en) * | 2015-03-09 | 2016-09-15 | The Children's Mercy Hospital | Dermatophytosis prophylaxis and treatment |
Non-Patent Citations (2)
| Title |
|---|
| 吴先林: "《皮肤性病学》", 30 September 2001, 人民卫生出版社 * |
| 安徽华康药业有限公司: ""安徽华康药业有限公司企业标准-手癣康抑菌洗液"", 《企业标准信息公共服务平台》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116977A (en) * | 2019-12-31 | 2021-07-16 | 郑州维谊生物科技有限公司 | Bath powder for treating fungal infection and preparation method thereof |
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Application publication date: 20180904 |