CN112717088A - Traditional Chinese medicine composition, pharmaceutical preparation, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition, pharmaceutical preparation, and preparation method and application thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/75—Rutaceae (Rue family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a pharmaceutical preparation, a preparation method and an application thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 0.6-11 parts of phellodendron extract, 1.2-12 parts of fructus cnidii extract, 6-72 parts of radix sophorae flavescentis extract, 6-21 parts of radix stemonae extract, 0.6-4.5 parts of cortex dictamni extract and 0.6-6.5 parts of fructus kochiae extract. According to the traditional Chinese medicine composition provided by the invention, the common cnidium fruit extract, the sophora flavescens extract, the belvedere fruit extract, the cortex dictamni extract, the phellodendron extract and the radix stemonae extract are matched with each other, so that the traditional Chinese medicine composition has the effects of remarkably inhibiting bacteria, removing odor and relieving itching. The traditional Chinese medicine composition provided by the invention has simple raw material components, and by limiting the raw materials and the parts thereof, the raw materials play a synergistic effect, and when the traditional Chinese medicine composition is used for female sanitary products, the traditional Chinese medicine composition has the effects of inhibiting bacteria, removing odor and relieving itching.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition, a pharmaceutical preparation, and a preparation method and application thereof.
Background
The female resistance is reduced in menstrual period, menstrual blood contains abundant nutrient substances, bacteria and various pathogenic bacteria can multiply in a large amount in a short time, genital infection is caused, inflammation is induced, if the disease is not treated in time, the inflammation spreads at each physiological part, more complications are brought, and the adverse effect on an immune system, a metabolic system and an endocrine system is generated. In addition, the sanitary towel is not changed in time, or women have gynecological inflammation, and embarrassment problems such as peculiar smell, pruritus and the like can also occur.
The existing sanitary products for women such as sanitary towels mostly take absorption of menstrual blood as a main function, and researches show that 73% of women feel pruritus and burning pain in the vagina during menstrual period; dysmenorrhea and other phenomena occur in more than 80% of women. Therefore, the sanitary article which can absorb menstrual blood and effectively inhibit bacteria, relieve itching and remove odor is of great importance to the health of women.
Most of effective components in the female medicinal sanitary product disclosed in the prior art are complex in ingredients, such as bighead atractylodes rhizome, pepper, fructus cnidii, radix sophorae flavescentis, oyster, borneol, earthworm, folium artemisiae argyi, angelica sinensis, liquorice, menthol, ligusticum wallichii and the like, and the effective components are compatible with dried alum or an aqueous solution of alum and the like to use, so that the effects of inhibiting bacteria, removing odor and relieving itching are certain, but the ingredients are complex, and therefore, the development of the female medicinal sanitary product which is simple in ingredients, low in cost, good in treatment effect, small in side effect and simultaneously has the effects of inhibiting bacteria, removing odor and relieving itching is a technical problem to be solved.
Disclosure of Invention
Therefore, the invention aims to overcome the defects of complex components and high cost of the female sanitary product with the functions of inhibiting bacteria and removing odor in the prior art, and provides a traditional Chinese medicine composition, a medicinal preparation, a preparation method and application thereof.
Therefore, the invention provides the following technical scheme:
a traditional Chinese medicine composition comprises the following raw materials in parts by weight:
0.6-11 parts of phellodendron extract, 1.2-12 parts of fructus cnidii extract, 6-72 parts of radix sophorae flavescentis extract, 6-21 parts of radix stemonae extract, 0.6-4.5 parts of cortex dictamni extract and 0.6-6.5 parts of fructus kochiae extract.
Optionally, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
0.6-11 parts of phellodendron extract, 1.2-8 parts of fructus cnidii extract, 30-70 parts of radix sophorae flavescentis extract, 9-18 parts of radix stemonae extract, 0.6-3 parts of cortex dictamni extract and 0.6-3 parts of fructus kochiae extract.
Optionally, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
0.6-3 parts of phellodendron extract, 1.2-8 parts of fructus cnidii extract, 30-65 parts of radix sophorae flavescentis extract, 9-18 parts of radix stemonae extract, 0.6-3 parts of cortex dictamni extract and 0.6-3 parts of fructus kochiae extract.
Optionally, the method for extracting any one of the phellodendron amurense extract, the cnidium monnieri fruit extract, the sophora flavescens extract, the stemona japonica root extract, the cortex dictamni extract and the fructus kochiae extract comprises the following steps:
adding solvent into one of cortex Phellodendri, fructus Cnidii, radix Sophorae Flavescentis, radix Stemonae, cortex Dictamni Radicis and Kochiae fructus, reflux extracting, mixing extractive solutions, concentrating, and drying to obtain corresponding extract.
Optionally, the mass volume ratio of any one of the phellodendron, the fructus cnidii, the radix sophorae flavescentis, the radix stemonae, the cortex dictamni and the fructus kochiae to the solvent is 1 (5-10).
Optionally, the solvent is water or ethanol.
Optionally, reflux-extracting at 90-100 deg.C for 1-3 times, each for 1-2 hr.
Optionally, concentrating under reduced pressure to density of 1.29-1.33.
Optionally, vacuum drying at 75 deg.C and-95-99 KPa for 8-10 h.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: weighing cortex Phellodendri extract, fructus Cnidii extract, radix Sophorae Flavescentis extract, radix Stemonae extract, cortex Dictamni Radicis extract and Kochiae fructus extract according to selected weight parts, and mixing well to obtain the final product.
The invention also provides a pharmaceutical preparation, which comprises the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method,
the traditional Chinese medicine composition is added with conventional auxiliary materials, and is prepared into clinically acceptable solutions, sprays, ointments, emplastrums, films, pastes and tinctures according to a conventional process.
Optionally, when the pharmaceutical formulation is a solution, the pharmaceutical formulation further comprises a solvent; the solvent is water.
Optionally, the mass ratio of the solvent to the traditional Chinese medicine composition is 1000 (5-20).
The invention also provides the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method, or the application of the medicinal preparation in preparing products for inhibiting bacteria, removing peculiar smell or relieving itching.
The invention also provides a bacteriostatic and deodorant sanitary towel chip, and the medicinal preparation is sprayed on the sanitary towel chip;
preferably, the spraying amount of the medicinal preparation on the bacteriostatic and deodorant sanitary towel chip is 5-20g/m2。
Optionally, the sanitary napkin core is made of non-woven fabric.
Optionally, the non-woven fabric contains chitin and/or silver ions.
The technical scheme of the invention has the following advantages:
1. according to the traditional Chinese medicine composition provided by the invention, the common cnidium fruit extract, the sophora flavescens extract, the belvedere fruit extract, the cortex dictamni extract, the phellodendron extract and the radix stemonae extract are matched with each other, so that the traditional Chinese medicine composition has the effects of remarkably inhibiting bacteria, removing odor and relieving itching. The traditional Chinese medicine composition provided by the invention has the advantages of simple raw material components and low cost; by limiting the raw materials and the parts thereof and exerting the synergistic effect among the raw materials, the Chinese medicinal composition has the effects of inhibiting bacteria, removing odor and relieving itching when being used for female sanitary articles, and has good treatment effect and small side effect.
2. In order to improve the bacteriostatic effect of the medicinal sanitary products for women disclosed in the prior art, the active ingredients of the medicinal sanitary products for women mostly contain traditional Chinese medicine alum or dried alum, which is also called calcined alum. The Chinese medicinal components such as gentian, common cnidium fruit and lightyellow sophora root are matched with dried alum or an aqueous solution of the dried alum for use, so that the effects of inhibiting bacteria, removing odor and relieving itching are excellent, and the inventor finds that part of women are allergic to medical sanitary products containing the alum or the dried alum through research.
The traditional Chinese medicine composition provided by the invention does not add alum or dried alum, but adopts specific phellodendron extract, fructus cnidii extract, radix sophorae flavescentis extract, radix stemonae extract, cortex dictamni extract and fructus kochiae extract, and all the raw materials are matched with each other to play a synergistic effect. When the antibacterial deodorant is used for female sanitary articles, the antibacterial deodorant has the effects of inhibiting bacteria, removing odor and relieving itching, and no allergy phenomenon exists in the using process.
3. The traditional Chinese medicine composition provided by the invention comprises the following raw materials in parts by weight: 0.6-11 parts of phellodendron extract, 1.2-8 parts of fructus cnidii extract, 30-70 parts of radix sophorae flavescentis extract, 9-18 parts of radix stemonae extract, 0.6-3 parts of cortex dictamni extract and 0.6-3 parts of fructus kochiae extract. By further limiting the parts of the raw materials, the prepared traditional Chinese medicine composition has remarkable effects of inhibiting bacteria, removing odor and relieving itching when being used for female hygienic products.
4. The traditional Chinese medicine composition provided by the invention comprises the following raw materials in parts by weight: 0.6-3 parts of phellodendron extract, 1.2-8 parts of fructus cnidii extract, 30-65 parts of radix sophorae flavescentis extract, 9-18 parts of radix stemonae extract, 0.6-3 parts of cortex dictamni extract and 0.6-3 parts of fructus kochiae extract. By further limiting the parts of the raw materials, the prepared traditional Chinese medicine composition has more remarkable effects of inhibiting bacteria, removing odor and relieving itching when being used for female sanitary products.
5. The pharmaceutical preparation provided by the invention is a solution and also comprises a solvent; by limiting the mass ratio of the solvent to the traditional Chinese medicine composition to be 1000 (5-20), the prepared medicinal preparation has good effects of inhibiting bacteria, removing odor and relieving itching when being used for female sanitary articles, and has good treatment effect and small side effect.
6. The preparation method of the traditional Chinese medicine composition provided by the invention is simple and convenient; when the prepared traditional Chinese medicine composition is used for female sanitary articles, the traditional Chinese medicine composition has the effects of bacteriostasis, odor removal and itching relieving, does not have allergy phenomenon in the using process, and has good treatment effect and small side effect.
7. The bacteriostatic and deodorant sanitary towel chip provided by the invention has the effects of bacteriostasis, deodorization and itching relieving, and does not have an allergy phenomenon in the using process. The spraying amount of the traditional Chinese medicine composition on the sanitary towel chip for inhibiting bacteria and removing odor is limited to 5-20g/m2The obtained sanitary towel core sheet has more excellent effects of bacteriostasis, odor removal and itching relief.
Detailed Description
The following examples are provided to further understand the present invention, not to limit the scope of the present invention, but to provide the best mode, not to limit the content and the protection scope of the present invention, and any product similar or similar to the present invention, which is obtained by combining the present invention with other prior art features, falls within the protection scope of the present invention.
The examples do not show the specific experimental steps or conditions, and can be performed according to the conventional experimental steps described in the literature in the field. The reagents or instruments used are not indicated by manufacturers, and are all conventional reagent products which can be obtained commercially.
The specification of the pure cotton nonwoven fabrics used in the examples and the comparative examples was the same.
The phellodendron extract, the fructus cnidii extract, the radix sophorae flavescentis extract, the radix stemonae extract, the cortex dictamni extract and the fructus kochiae extract obtained by the existing extraction method can meet the implementation requirements of the scheme in the invention. For comparison, in each of the following examples and comparative examples, the extracts of phellodendron amurense, cnidium monnieri, sophora flavescens, stemona, dictamnus dasycarpus and kochia scoparia were obtained by the following methods:
and (3) golden cypress extract: weighing 10kg of phellodendron amurense, adding into 5 times of pure water, carrying out reflux extraction for 3 times, each time for 2 hours, combining the extracting solutions, carrying out reduced pressure concentration at 65 ℃ until the density is 1.32, and carrying out vacuum drying for 10 hours at 75 ℃ and-95 to-99 KPa in a vacuum drying oven to obtain the phellodendron amurense extract;
extracting fructus cnidii: weighing 10kg of fructus cnidii, adding into 6 times of ethanol (volume fraction is 5%), carrying out reflux extraction for 2 times at 95 ℃ for 1 hour each time, combining the extracting solutions, carrying out reduced pressure concentration at 65 ℃ until the density is 1.32, and carrying out vacuum drying for 9 hours at 75 ℃ and-95 to-99 KPa in a vacuum drying oven to obtain the fructus cnidii extract;
and (3) sophora flavescens extract: weighing 10kg of radix sophorae flavescentis, adding the radix sophorae flavescentis into 7 times of ethanol (the volume fraction is 10%), carrying out reflux extraction at 95 ℃ for 1.5 hours, collecting an extracting solution, carrying out reduced pressure concentration at 65 ℃ until the density is 1.32, and carrying out vacuum drying in a vacuum drying oven at 75 ℃ and under-95 KPa to-99 KPa for 9 hours to obtain a radix sophorae flavescentis extract;
radix stemonae extract: weighing 10kg of radix stemonae, adding into 8 times of ethanol (volume fraction is 20%), carrying out reflux extraction for 2 times at 90 ℃ for 1 hour each time, combining the extracting solutions, carrying out reduced pressure concentration at 65 ℃ until the density is 1.32, and carrying out vacuum drying for 8 hours at 75 ℃ under-95 to-99 KPa in a vacuum drying oven to obtain the radix stemonae extract;
extract of cortex Dictamni Radicis: weighing 10kg of cortex dictamni, adding into 9 times of ethanol (volume fraction is 15%), carrying out reflux extraction for 2 times at 90 ℃, each time for 2 hours, combining the extracting solutions, concentrating under reduced pressure at 65 ℃ until the density is 1.32, and carrying out vacuum drying for 8 hours in a vacuum drying oven at 75 ℃ under-95 to-99 KPa to obtain the cortex dictamni extract;
the fructus kochiae extract: weighing 10kg of fructus kochiae, adding 10 times of pure water, reflux-extracting for 3 times, each time for 1.5h, combining the extracting solutions, concentrating under reduced pressure at 65 ℃ until the density is 1.32, and vacuum-drying in a vacuum drying oven at 75 ℃ and under-95 to-99 KPa for 10h to obtain the fructus kochiae extract.
Example 1
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing 1g of cortex Phellodendri extract, 3g of fructus Cnidii extract, 6g of radix Sophorae Flavescentis extract, 6g of radix Stemonae extract, 2g of cortex Dictamni Radicis extract and 2g of Kochiae fructus extract, and mixing.
Preparation of a solution:
adding the above Chinese medicinal composition into 4kg pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 15g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting pure cotton non-woven fabric containing Chinese medicinal composition to obtain sanitary towel core (each sheet is 30mm × 75 mm).
Example 2
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing 6g of phellodendron extract, 12g of fructus cnidii extract, 50g of radix sophorae flavescentis extract, 21g of radix stemonae extract, 4.5g of cortex dictamni extract and 6.5g of fructus kochiae extract, and mixing to obtain the traditional Chinese medicine.
Preparation of a solution:
adding the above Chinese medicinal composition into 5kg pure water, ultrasonic mixing at normal temperature and 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 10g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting the above pure cotton nonwoven fabric containing the Chinese medicinal composition to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Example 3
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing 11g of phellodendron extract, 5g of fructus cnidii extract, 70g of radix sophorae flavescentis extract, 10g of radix stemonae extract, 2g of cortex dictamni extract and 2g of fructus kochiae extract, and mixing to obtain the traditional Chinese medicine.
Preparation of a solution:
adding the above Chinese medicinal composition into 10kg of pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 5g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting the above pure cotton nonwoven fabric containing the Chinese medicinal composition to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Example 4
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing cortex Phellodendri extract 0.6g, fructus Cnidii extract 1.2g, radix Sophorae Flavescentis extract 48g, radix Stemonae extract 9g, cortex Dictamni Radicis extract 0.6g and Kochiae fructus extract 0.6g, and mixing.
Preparation of a solution:
adding the above Chinese medicinal composition into 4kg of pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 20g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 3 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting pure cotton non-woven fabric containing Chinese medicinal composition to obtain sanitary towel core (each sheet is 30mm × 75 mm).
Example 5
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing 1g of cortex Phellodendri extract, 5g of fructus Cnidii extract, 30g of radix Sophorae Flavescentis extract, 10g of radix Stemonae extract, 2g of cortex Dictamni Radicis extract and 2g of Kochiae fructus extract, and mixing.
Preparation of a solution:
adding the above Chinese medicinal composition into 5kg pure water, ultrasonic mixing at normal temperature and 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 10g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting pure cotton non-woven fabric containing Chinese medicinal composition to obtain sanitary towel core (each sheet is 30mm × 75 mm).
Example 6
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing and mixing 3g of phellodendron extract, 8g of fructus cnidii extract, 65g of radix sophorae flavescentis extract, 18g of radix stemonae extract, 3g of cortex dictamni extract and 3g of fructus kochiae extract.
Preparation of a solution:
adding the above Chinese medicinal composition into 8kg pure water, ultrasonic mixing at normal temperature and 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 15g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 3 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting pure cotton non-woven fabric containing Chinese medicinal composition to obtain sanitary towel core (each sheet is 30mm × 75 mm).
Example 7
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing 9.5g of phellodendron extract, 3.5g of fructus cnidii extract, 46g of radix sophorae flavescentis extract, 27g of radix stemonae extract, 9g of cortex dictamni extract and 5g of fructus kochiae extract, and mixing to obtain the traditional Chinese medicine.
Preparation of a solution:
adding 5kg pure water into the above Chinese medicinal composition, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 10g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting pure cotton non-woven fabric containing Chinese medicinal composition to obtain sanitary towel core (each sheet is 30mm × 75 mm).
Example 8
The embodiment provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing 1.5g of cortex Phellodendri extract, 11g of fructus Cnidii extract, 72g of radix Sophorae Flavescentis extract, 12.5g of radix Stemonae extract, 1.3g of cortex Dictamni Radicis extract, and 1.7g of Kochiae fructus extract, and mixing.
Preparation of a solution:
adding 8kg pure water into the above Chinese medicinal composition, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 15g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 3 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting pure cotton non-woven fabric containing Chinese medicinal composition to obtain sanitary towel core (each sheet is 30mm × 75 mm).
Comparative example 1
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
30g of radix sophorae flavescentis, 20g of fructus cnidii, 20g of cortex phellodendri, 20g of rhizoma atractylodis, 30g of cortex dictamni, 30g of radix stemonae, 20g of pepper, 30g of angelica sinensis, 20g of oyster, 20g of fructus kochiae, 20g of folium artemisiae argyi, 20g of ligusticum wallichii, 20g of rhizoma atractylodis macrocephalae, 20g of earthworm, 10g of borneol, 10g of menthol, 15g of dried alum and 10g of liquorice are respectively weighed.
The preparation method comprises the steps of firstly removing impurities and dust from the medicinal materials, removing borneol and menthol, mixing and crushing the other medicinal materials into fine powder according to the dosage (passing through a five-mesh sieve), separately grinding borneol and menthol into fine powder, adding the fine powder into the other medicinal powder, stirring to obtain traditional Chinese medicine antibacterial powder, uniformly adding the traditional Chinese medicine antibacterial powder into pure cotton non-woven fabrics, and preparing the sanitary towel according to a conventional production method, wherein 1000 sanitary towel chips (each 30mm multiplied by 75mm) can be produced by one kilogram of the medicinal powder.
Comparative example 2
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
respectively weighing 15g of common cnidium fruit, 15g of lightyellow sophora root, 15g of amur corktree bark, 15g of Chinese gentian, 15g of raw sessile stemona root, 15g of dittany bark, 15g of golden larch bark, 15g of belvedere fruit, 15g of dandelion and 10g of Chinese mugwort leaf, respectively crushing the medicinal materials at low temperature (15 ℃), mixing, soaking in 0.87kg of cold water (5 ℃) for 3 hours, and filtering to obtain soaking dregs A and soaking liquid A;
adding 8 times of pure water into the residues obtained in the above steps, and decocting at 70 deg.C for 1.5h to obtain water decoction B and water decoction residue B; extracting to obtain volatile oil substance C in the water decoction dregs B to obtain extracted dregs C, and performing distillation extraction on the water decoction dregs B to obtain volatile oil substance C; extracting the residue C with ethanol to obtain ethanol extract D; mixing the volatile oil substance C and the alcohol extract D to obtain a mixture E; mixing the soak solution A and the water decoction B to obtain a mixture solution F, extracting the mixture solution by absolute ethyl alcohol to obtain effective components, and adding an alum solution after the mixture solution F is extracted to ensure that the mass ratio of alum is 10%; the mixture E was added to the mixed solution F obtained in the above step, and thoroughly mixed to obtain a final formulation. The final preparation is a solution type Chinese medicinal composition.
Spraying the obtained solution type Chinese medicinal composition on pure cotton non-woven fabric uniformly, spraying 10g of solution type Chinese medicinal composition per square meter of non-woven fabric, and oven drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting the above pure cotton nonwoven fabric containing the Chinese medicinal composition to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Comparative example 3
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
the preparation of the traditional Chinese medicine composition comprises the following steps:
weighing 6g of cortex Phellodendri extract, 50g of radix Sophorae Flavescentis extract, 21g of radix Stemonae extract, 4.5g of cortex Dictamni Radicis extract and 6.5g of Kochiae fructus extract, and mixing.
Preparation of a solution:
adding the above Chinese medicinal composition into 4.4kg pure water, ultrasonic mixing at normal temperature and 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 10g of solution per square meter of non-woven fabric, and oven drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing Chinese medicinal composition. Cutting the above pure cotton nonwoven fabric containing the Chinese medicinal composition to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Comparative example 4
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
preparation of a solution:
weighing 20g of cortex Phellodendri extract, adding into 1kg of pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
uniformly spraying the solution on pure cotton non-woven fabric, spraying 10g of the solution on per square meter of non-woven fabric, and drying at 60 ℃ for 2h to obtain the pure cotton non-woven fabric containing the phellodendron extract. Cutting the above pure cotton nonwoven fabric containing cortex Phellodendri extract to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Comparative example 5
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
preparation of a solution:
weighing 20g fructus Cnidii extract, adding into 1kg pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
and uniformly spraying the solution on a pure cotton non-woven fabric, spraying 10g of the solution on each square meter of the non-woven fabric, and drying at 60 ℃ for 2h to obtain the pure cotton non-woven fabric containing the fructus cnidii extract. Cutting the pure cotton non-woven fabric containing fructus Cnidii extract to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Comparative example 6
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
preparation of a solution:
weighing 20g radix Sophorae Flavescentis extract, adding into 1kg pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
spraying the solution on pure cotton non-woven fabric uniformly, spraying 10g of the solution on per square meter of non-woven fabric, and drying at 60 deg.C for 2 hr to obtain pure cotton non-woven fabric containing radix Sophorae Flavescentis extract. Cutting the above pure cotton nonwoven fabric containing radix Sophorae Flavescentis extract to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Comparative example 7
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
preparation of a solution:
weighing 20g radix Stemonae extract, adding into 1kg pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
and uniformly spraying the solution on a pure cotton non-woven fabric, spraying 10g of the solution on each square meter of the non-woven fabric, and drying at 60 ℃ for 2h to obtain the pure cotton non-woven fabric containing the stemona root extract. Cutting the pure cotton non-woven fabric containing radix Stemonae extract to obtain sanitary towel chips (each 30mm × 75 mm).
Comparative example 8
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
preparation of a solution:
weighing 20g cortex Dictamni Radicis extract, adding into 1kg pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
and uniformly spraying the solution on a pure cotton non-woven fabric, spraying 10g of the solution on each square meter of the non-woven fabric, and drying at 60 ℃ for 2h to obtain the pure cotton non-woven fabric containing the cortex dictamni extract. Cutting the pure cotton non-woven fabric containing cortex Dictamni Radicis extract to obtain sanitary napkin chips (each sheet is 30mm × 75 mm).
Comparative example 9
The comparative example provides a bacteriostatic and deodorant sanitary towel chip, and the preparation method comprises the following steps:
preparation of a solution:
weighing 20g Kochiae fructus extract, adding into 1kg pure water, ultrasonic mixing at normal temperature of 50Hz for 10min, and filtering to remove insoluble substances.
Preparing a sanitary towel chip:
and uniformly spraying the solution on a pure cotton non-woven fabric, spraying 10g of the solution on each square meter of the non-woven fabric, and drying at 60 ℃ for 2h to obtain the pure cotton non-woven fabric containing the fructus kochiae extract. Cutting the above pure cotton nonwoven fabric containing Kochiae fructus extract to obtain sanitary napkin chips (each 30mm × 75 mm).
Experimental example 1 bacteriostatic ratio test
The bacteriostatic performance test is carried out according to the method for testing the bacteriostatic performance of the dissoluble antibacterial (bacteriostatic) product in appendix C of GB/T15979-2002 hygienic Standard for Disposable sanitary articles, the test samples are the sanitary towel chips prepared in the embodiments and the comparative examples, escherichia coli ATCC-25922, staphylococcus aureus ATCC-6538 and candida albicans ATCC-10231 are used as test strains, the action time is 20min, each sample is repeated three times, and the average value is calculated. The specific test results are shown in table 1.
TABLE 1 results of the bacteriostatic ratio test
As can be seen from the data in the table above, the bacteriostatic rate of the sanitary napkin chip provided by the invention is more than or equal to 90%, which indicates that the sanitary napkin chip has a strong bacteriostatic action. Compared with the comparative example 1, the antibacterial effect of the extracted medicinal material is obviously better than the effect of directly crushing the medicinal material into powder; compared with the method which independently adopts the extracts of phellodendron amurense, fructus cnidii, radix sophorae flavescentis, radix stemonae, cortex dictamni and fructus kochiae, the sanitary towel chip containing the traditional Chinese medicine composition has a better antibacterial effect.
Experimental example 2 skin allergy test
Skin allergy test was performed according to 2.3.6 in "sterilized product toxicology test technical Specification" of sterilized product inspection technical Specification "of the second part of the Ministry of health (2002 edition), the test sample was the solution prepared in each example, the positive control group was given positive sensitizer 2, 4-dinitrochlorobenzene (preparation: weighing 50mg to 10ml volumetric flask of 2, 4-dinitrochlorobenzene, adding 0.5ml volume fraction 95% ethanol, ultrasonic dissolving at 50 ℃, diluting with pure water to 10ml), and 20 guinea pigs per group were purchased from Beijing Witonghui Hua Biotech limited); skin reactions were observed at 1 hour, 24 hours, and 48 hours, respectively, and skin reaction integration and stimulus intensity evaluation were performed. The results show that no erythema is formed on the skin of all experimental animals, no edema reaction exists, the integral mean value of the skin reaction of the experimental animals of the samples of the examples 1 to 8 is 0, and the skin irritation reaction of the animals is not caused by contacting the animals once, and the skin irritation reaction belongs to a non-irritant substance.
Experimental example 3 odor removal test
The volume of the test working chamber is 0.1m3The test temperature is 20 ℃, the using amount of the sanitary towel chip is 1g, the surface wind speed is 0.3m/s, the test time is 3 hours, the detection item is ammonia concentration, and the ammonia concentration is detected by a portable ammonia gas detector. The ammonia removal rate (%) - (concentration of ammonia in the working chamber before the sanitary napkin chip was placed-concentration of ammonia in the working chamber 3 hours after the sanitary napkin chip was placed)/concentration of ammonia in the working chamber before the sanitary napkin chip was placed x 100%. The test samples were the sanitary napkin chips prepared in each example and comparative example.
Table 2 odor removal test results
As can be seen from the data in the above table, the present invention provides 1g hygieneThe towel core is 0.1m3The removal rate of ammonia in the working chamber within 3 hours is over 77 percent.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the spirit or scope of the invention.
Claims (10)
1. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight:
0.6-11 parts of phellodendron extract, 1.2-12 parts of fructus cnidii extract, 6-72 parts of radix sophorae flavescentis extract, 6-21 parts of radix stemonae extract, 0.6-4.5 parts of cortex dictamni extract and 0.6-6.5 parts of fructus kochiae extract.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
0.6-11 parts of phellodendron extract, 1.2-8 parts of fructus cnidii extract, 30-70 parts of radix sophorae flavescentis extract, 9-18 parts of radix stemonae extract, 0.6-3 parts of cortex dictamni extract and 0.6-3 parts of fructus kochiae extract.
3. The traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following raw materials in parts by weight:
0.6-3 parts of phellodendron extract, 1.2-8 parts of fructus cnidii extract, 30-65 parts of radix sophorae flavescentis extract, 9-18 parts of radix stemonae extract, 0.6-3 parts of cortex dictamni extract and 0.6-3 parts of fructus kochiae extract.
4. A method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized by comprising the following steps: weighing cortex Phellodendri extract, fructus Cnidii extract, radix Sophorae Flavescentis extract, radix Stemonae extract, cortex Dictamni Radicis extract and Kochiae fructus extract according to selected weight parts, and mixing well to obtain the final product.
5. A pharmaceutical preparation, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1 to 3 or the traditional Chinese medicine composition prepared by the preparation method of claim 4,
the traditional Chinese medicine composition is added with conventional auxiliary materials, and is prepared into clinically acceptable solutions, sprays, ointments, emplastrums, films, pastes and tinctures according to a conventional process.
6. The pharmaceutical formulation of claim 5, wherein when the pharmaceutical formulation is a solution, the pharmaceutical formulation further comprises a solvent; the solvent is water.
7. The pharmaceutical preparation according to claim 6, wherein the mass ratio of the solvent to the traditional Chinese medicine composition is 1000: 5-20.
8. Use of the Chinese medicinal composition of any one of claims 1 to 3, the Chinese medicinal composition prepared by the preparation method of claim 4, or the pharmaceutical preparation of any one of claims 5 to 7 in preparing bacteriostatic, odor-removing or itching-relieving products.
9. A bacteriostatic odor-removing sanitary napkin chip, which is characterized in that the medicinal preparation of claim 6 or 7 is sprayed on the sanitary napkin chip;
preferably, the spraying amount of the medicinal preparation on the bacteriostatic and deodorant sanitary towel chip is 5-20g/m2。
10. The bacteriostatic and deodorant sanitary napkin chip according to claim 9, wherein the sanitary napkin chip is made of non-woven fabric.
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