AU2021107167A4

AU2021107167A4 - Composition for moistening and relieving itching, cream and preparation method of cream

Info

Publication number: AU2021107167A4
Application number: AU2021107167A
Authority: AU
Inventors: Jinhui Wu; Yu XIANG
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-08-25
Filing date: 2021-08-25
Publication date: 2021-12-09
Anticipated expiration: 2029-08-25

Abstract

The invention relates to a composition for moistening and relieving itching, which comprises the following raw materials in parts by weight: 1-30 parts of pomelo peel extract, 0.01-10 parts of tea tree essential oil, 0.01-10 parts of Sophora flavescens, 0.01-10 parts of thymol, 0.01-10 parts of snakeskin, 0.01-10 parts of cortex dictamni, 0.01-10 parts of cortex phellodendri, 0.5-10 parts of chlorhexidine acetate . The pomelo peel extract has a Baume degree of 20-30°B6. The cream made from the above composition has good effects of moistening and relieving itching.

Description

SPECIFICATION

Composition for moistening and relieving itching,

cream and preparation method of cream

TECHNICAL FIELD

The invention relates to the field of daily chemical products, in particular to a

composition for moistening and relieving itching, cream and a preparation method of

cream.

BACKGROUND

Skin is the first barrier between human body and external environment, which

prevents human body from physical and chemical erosion. However, the skin is often

damaged, such as eczema caused by various internal and external factors and with

obvious exudation tendency; swelling, pain and itching caused by mosquito bites;

dryness, sunburn and chilblain caused by the nature's cold, the sun's radiation

. Although the above-mentioned skin injuries do not affect normal physiological

activities to a great extent, they affect people's external image and cause

psychological burden and mental pain. Therefore, it is necessary to study the products

to alleviate the above symptoms.

SUMMARY

Therefore, it is necessary to provide a composition for moistening and relieving

itching, cream and preparation method of cream.

The invention provides a composition for moistening and relieving itching.

The specific technical scheme is as follows:

A composition for moistening and relieving itching comprises the following raw

materials in parts by weight:

1-30 parts of pomelo peel extract, 0.01-10 parts of tea tree essential oil, 0.01-10

parts of Sophora flavescens, 0.01-10 parts of thymol, 0.01-10 parts of snakeskin, 0.01-

SPECIFICATION

parts of cortex dictamni, 0.01-10 parts of cortex phellodendri, 0.5-10 parts of

chlorhexidine acetate ;

The pomelo peel extract has a Baume degree of 20-30 B6.

The pomelo peel extract has antioxidant, cholesterol-lowering and antibacterial

activities, and its main antibacterial components are essential oils, lemon-like bitter

tea and flavonoids. Among them, limonin's main physiological activities are anti

cancer, antibacterial, antiviral, analgesic, anti-inflammatory, etc., which has insect

aversion and can inhibit abnormal proliferation of immune cells.

The main chemical components of tea tree essential oil are p-vinylene, pine oil

essence, lemon oil essence, eucalyptol, sesame oil brain and anisin, which have the

functions of sterilizing, diminishing inflammation, astringing pores, treating common

cold, cough, rhinitis and asthma, and improving dysmenorrhea, menoxenia and genital

infection.

Sophora flavescens is mainly composed of matrine, which has the effects of

clearing away heat and toxic materials, dispelling wind and eliminating dampness,

removing insects and relieving itching. It can be used in combination with Fructus

Cnidii to treat viral herpes, contact eczema, intractable pruritus vulvae, tinea pedis

eczema, genital herpes, various vaginitis and pudendal eczema. Matrine and

oxymatrine used alone had no inhibitory activity on Escherichia coli, Staphylococcus

aureus and Candida albicans, but when combined with Fructus Cnidii extract, they

showed good inhibitory activity on Staphylococcus aureus and Candida albicans.

Thymol has good antibacterial effect on Escherichia coli and Staphylococcus

aureus.

Chemical constituents of cortex dictamni include alkaloids, limonin, flavonoids,

sesquiterpenes and their glycosides, steroids and other compounds. Petroleum ether

SPECIFICATION

extract of tinea alba has the strongest inhibitory effect on Staphylococcus, Escherichia

coli, Proteus vulgaris and Bacillus subtilis, and the main antibacterial substances are

dictamnine and xanthone.

The chemical constituents of cortex phellodendri mainly include alkaloids,

limonin, flavonoids, sesquiterpenes and their glycosides, steroids and other

compounds. Cortex phellodendri has obvious anti-inflammatory effect on damaged

skin infected by Staphylococcus aureus, which can promote angiogenesis, improve

facial microcirculation, promote granulation growth and accelerate wound healing

while relieving fever and inflammation.

Chlorhexidine acetate can kill most gram-positive and gram-negative bacteria,

and is also effective against Pseudomonas aeruginosa. The antibacterial effect in vitro

is obviously improved, and the toxicity is low and the use is safe when the traditional

Chinese medicine components are compounded with chlorhexidine acetate. Its main

application mechanism is to destroy the plasma membrane of pathogenic

microorganism cell wall, and quickly kill Gram-positive bacteria, Gram-negative

bacteria, bacterial spores, fungi and viruses.

The composition for moisturizing and relieving itching containing the above raw

materials can fully exert the efficacy of each component, and can also act

synergistically after compounding, so that the compounded composition has more

excellent moisturizing, antibacterial and antipruritic effects.

In one embodiment, the composition for moisturizing and relieving itching

comprises the following raw materials in parts by weight:

5-20 parts of pomelo peel extract, 0.1-5 parts of tea tree essential oil, 0.1-5 parts

of Sophora flavescens, 0.1-5 parts of thymol, 0.1-5 parts of snakeskin, 0.1-5 parts of

SPECIFICATION

cortex dictamni, 0.1-5 parts of cortex phellodendri and 0.5-5 parts of chlorhexidine

acetate.

In one embodiment, the composition for moisturizing and relieving itching

comprises the following raw materials in parts by weight:

8-15 parts of pomelo peel extract, 0.1-1 part of tea tree essential oil, 0.1-1 part of

Sophora flavescens, 0.1-1 part of thymol, 0.1-1 part of snakeskin, 0.1-1 part of cortex

dictamni, 0.1-1 part of cortex phellodendri and 1-5 parts of chlorhexidine acetate.

In one embodiment, the preparation method of the pomelo peel extract comprises

the following steps:

Grinding dried pomelo peel, placing in 40%-80% ethanol according to the

weight ratio of 1:(3-8), and performing ultrasonic extraction for 1-3 times, each time

for 0.5-2h at the temperature of 40-80 °C to obtain an extracting solution;

Filtering and concentrating the extracting solution to 20-30 B6 to obtain pomelo

peel extract;

The invention also provides an application of the composition in preparing daily

chemical products or medicines with effects of moistening and relieving itching.

The invention also provides a cream which comprises the composition for

moisturizing and relieving itching.

In one embodiment, the cream comprises the following raw materials in parts by

weight:

10-30 parts of the composition for moisturizing and relieving itching, 5-15 parts

of urotoxin, 20-30 parts of vitamin E, 15-25 parts of menthol, 0.5-2 parts of

methylparaben, 0.5-2 parts of propyl 4-hydroxybenzoate, 60-90 parts of glycerol, 40

parts of mineral oil, 20 to 30 parts of propylene glycol, 20 to 30 parts of

polydimethylsiloxane, 40 to 60 parts of cetearyl alcohol and 600 to 800 parts of water.

SPECIFICATION

Among them, allantoin is Allantoin, which can increase and promote the

hydration ability of the binding matrix, and also act on the horny egg white, so as to

increase its ability to bind water and make the skin smooth, moist and flexible. The

urea part of allantoin also has antifungal and antibacterial effects.

Menthol, as a transdermal absorption promoter of traditional Chinese medicine

components, has the advantages of quick response, good effect and less adverse

reactions.

The above cream has obvious curative effect on skin redness and itching after

mosquito bites. It has a good repair effect on the symptoms such as dry skin and

sunburn after burning in the hot sun.

The invention also provides a preparation method of the cream, which comprises

the following steps:

1) weighing the raw materials according to the weight parts;

Step 2) adding the mineral oil, cetearyl alcohol and polydimethylsiloxane into an

oil phase pot, heating to 85-95 °C, stirring and keeping the temperature to obtain an

oil phase;

Step 3) adding the hydroxyphenyl methyl ester, propyl 4-hydroxybenzoate and

glycerol into a water phase pot, and keeping the temperature at 90-95 °C to obtain a

water phase;

14) adding the pomelo peel extract, tea tree essential oil, sophorae flavescens,

thymol, cnidium fruit, cortex dictamni and cortex phellodendri into propylene glycol,

and keeping the temperature below 70 °C to obtain a component A;

5) mixing and melting allantoin, vitamin e, menthol and chlorhexidine acetate to

obtain a component B;

SPECIFICATION

6) mixing and stirring the water phase, the oil phase, the component A and the

component B to obtain the product.

In one embodiment, in step 2), the stirring rate is 400-600rpm.

In one embodiment, in step 6), the technological parameters of mixing and

stirring are as follows: adding oil phase into a preparation pot, stirring, adding water

phase, vacuum emulsifying, cooling to 60-80°C, adding component A, cooling to 60

°C, adding component B, and cooling to 40-45C to obtain the product.

Compared with the existing scheme, the invention has the following beneficial

effects:

In the composition for moisturizing and relieving itching, the pomelo peel extract

has antioxidant, cholesterol-lowering and bacteriostatic activities, and the effective

components in the pomelo peel extract have better bacteriostatic effects on various

microorganisms such as Bacillus subtilis, Escherichia coli, molds and yeasts, and are

compounded with tea tree essential oil, Sophora flavescens and thymol, which have

obvious bactericidal, anti-inflammatory, antipruritic and analgesic effects. The above

mentioned traditional Chinese medicine components can be used in combination with

chlorhexidine acetate, which can significantly improve the antibacterial effect in vitro.

Furthermore, the pomelo peel extract with 20-30 B6 has moderate content of effective

substances, which is more beneficial to exert the effects of moistening and relieving

itching of the composition after being mixed with tea tree essential oil, Sophora

flavescens and thymol in a specific proportion.

The cream prepared from the above composition is applied to skin as a daily

chemical product, which has the functions of bacteriostasis, nourishing and repairing,

and has obvious curative effect on skin redness, itching and other symptoms after

mosquito bites; It has a good repair effect on skin dryness and sunburn after burning

SPECIFICATION

in the hot sun. At the same time, the cream can also be used as a medicine for treating

dermatitis, eczema, podophyllosis, etc., relieving skin discomfort and other symptoms

without side effects.

BRIEF DESCRIPTION OF THE FIGURES

Fig. 1 is a flow chart of a preparation method of cream in one embodiment of the

present invention.

DESCRIPTION OF THE INVENTION

The composition for moistening and relieving itching, cream and the preparation

method of cream of the present invention will be further explained in detail with

specific examples.

In a specific embodiment, all raw materials are from the market.

Example 1

The embodiment provides a cream which is prepared from the following raw

materials in parts by weight:

10 parts of pomelo peel extract, 0.5 parts of tea tree essential oil, 0.5 parts of

Sophora flavescens, 0.5 parts of thymol, 0.5 parts of snakeskin, 0.5 parts of cortex

dictamni, 0.5 parts of cortex phellodendri, 5 parts of chlorhexidine acetate,10 parts of

urotoxin, 25 parts of vitamin e, 20 parts of menthol, 1 part of methylparaben, 1 part of

propyl 4-hydroxybenzoate, 80 parts of glycerol, 50 parts of mineral oil,25 parts of

propylene glycol, 25 parts of polydimethylsiloxane, 50 parts of cetearyl alcohol and

700 parts of water.

The preparation method of the cream comprises the following steps:

1) weighing the raw materials according to the weight parts;

2) Preparation of oil phase: put the mineral oil, cetearyl alcohol and

polydimethylsiloxane into an oil phase pot, turn on the interlayer steam switch and

SPECIFICATION

heat to 90-95°C, the oil phase is completely melted, start stirring at a speed of 500rpm,

mix all components evenly, and keep the temperature at 85-90°C for later use.

3) preparation of water phase: adding water into a water phase pot, boiling, and

discharging a proper amount of hot water for later use; adding hydroxyphenyl methyl

ester and propyl 4-hydroxybenzoate into a water phase pot, stirring and dissolving;

put glycerol in a stainless steel barrel, dilute it with hot water for later use, add it into

a water phase pot, stir until it is fully miscible, adjust the amount of interlayer steam,

and keep the temperature at 90-95C for later use.

4) preparation of component A: putting propylene glycol in a stainless steel

barrel, heating to above 80 °C in a water bath, adding pomelo peel extract, tea tree

essential oil, Sophora flavescens, thymol, fructus Cnidii, cortex dictamni and cortex

Phellodendri, stirring until completely dissolved, and keeping the temperature below

°C for later use; set aside a part of propylene glycol for later use.

5) preparation of component B: allantoin, vitamin e, menthol and chlorhexidine

acetate are mixed and melted for later use.

6) Mixing and emulsifying: keep a certain degree of vacuum in the preparation

pot, pump the oil phase into the preparation pot, stir slowly, add the water phase into

the preparation pot, start vacuum emulsification, stir slowly, slowly add component A

when the temperature drops to 70°C, rinse the container with standby propylene

glycol, and add it into the vacuum emulsifying machine. Start vacuum emulsification,

stir slowly, add component B slowly when the temperature drops to 60°C, start

vacuum emulsification, stir slowly, close the steam valve, adjust the amount of

cooling circulating water, when the temperature drops below 45C and the paste

becomes paste, stop stirring and discharge, and put it in a clean container.

SPECIFICATION

The preparation method of the pomelo peel extract comprises the following steps:

Step 1) Dry the fresh pomelo peel in the sun or use an oven to evaporate the

water.

Step 2) take 500g of dried pomelo peel with normal color and no enzyme rot, add

it to 3kg of 60% ethanol, and extract it with ultrasonic wave for 1h at 60°C to obtain a

first extract, then add 2.5kg of 60% ethanol into the ultrasonic wave extraction tank,

carry out secondary leaching, and extract it with ultrasonic wave at 60°C for 1h to

obtain a second extract; mixing the first extracting solution and the second extracting

solution to obtain an extracting solution.

Step 3) cooling the extracting solution to room temperature, allowing impurities

to settle naturally, filtering with a 40-mesh filter screen, adding the extracting solution

into a vacuum concentrator, and concentrating to 28 B6 to obtain the pomelo peel

extract.

Example 2

The embodiment provides a cream which is prepared from the following raw

materials in parts by weight:

15 parts of pomelo peel extract, 1 part of tea tree essential oil, 1 part of Sophora

flavescens, 1 part of thymol, 1 part of snakeskin, 1 part of cortex dictamni, 1 part of

cortex phellodendri, 5 parts of chlorhexidine acetate, 10 parts of urotoxin, 25 parts of

vitamin E, 20 parts of menthol, 1 part of methylparaben, 1 part of propyl 4

hydroxybenzoate, 80 parts of glycerol, 50 parts of mineral oil, 25 parts of propylene

glycol, 25 parts of polydimethylsiloxane, 50 parts of cetearyl alcohol and 700 parts of

water.

The preparation method of cream and pomelo peel extract in this example is the

same as that in Example 1.

SPECIFICATION

Example 3

The embodiment provides a cream which is prepared from the following raw

materials in parts by weight:

18 parts of pomelo peel extract, 2 parts of tea tree essential oil, 2 parts of

Sophora flavescens, 2 parts of thymol, 2 parts of snakeskin, 2 parts of cortex dictamni,

2 parts of cortex phellodendri, 6 parts of chlorhexidine acetate, 10 parts of urotoxin,

parts of vitamin E, 20 parts of menthol, 1 part of methylparaben, 1 part of propyl

4-hydroxybenzoate, 80 parts of glycerol, 50 parts of mineral oil, 25 parts of propylene

water.

The preparation method of cream and pomelo peel extract in this example is the

same as that in Example 1.

Example 4

The embodiment provides a cream which is prepared from the following raw

materials in parts by weight:

4 parts of pomelo peel extract, 0.1 part of tea tree essential oil, 0.1 part of

Sophora flavescens, 0.1 part of thymol, 0.1 part of snakeskin, 0.1 part of cortex

dictamni, 0.1 part of cortex phellodendri, 4 parts of chlorhexidine acetate, 10 parts of

propyl 4-hydroxybenzoate, 80 parts of glycerol, 50 parts of mineral oil , 25 parts of

700 parts of water.

The preparation method of cream and pomelo peel extract in this example is the

same as that in Example 1.

Comparative example 1

SPECIFICATION

This comparative example provides a cream and its preparation method, which is

basically the same as Example 1, except that the composition for moistening and

relieving itching does not contain pomelo peel extract.

Comparative example 2

This comparative example provides a cream and its preparation method, which is

basically the same as Example 1, with the difference that thymol is replaced by

lavender in the composition for moisturizing and relieving itching.

Comparative example 3

This comparative example provides a cream and a preparation method thereof,

which are basically the same as those in Example 1, except that the composition for

moistening and relieving itching does not contain cortex dictamni.

Clinical trial

Clinical trials were conducted on the creams of Examples 1-4 and Comparative

Examples 1-3. The specific method is:

1. Clinical case selection: Randomly select 160 volunteers who have just been

bitten by mosquitoes and have redness and itching at the bite.

2. Test method: 20 people were divided into A-H groups. Groups A-D

correspond to groups 1-4, respectively, and the cream of examples 1-4 is applied to

mosquito bites; Group E-G respectively corresponds to groups 1-3 of comparative

examples, and the cream of comparative examples 1-3 is applied to mosquito bites.

Group H was the control group, without applying cream, and the time of applying

cream in each group was 3 times a day.

3. Efficacy standard:

(1) Healing: The symptoms of redness and itching at the bite completely

disappeared.

SPECIFICATION

(2) Significant effect: the symptoms of redness and itching are alleviated, the use

time is prolonged, and the symptoms disappear.

(3) ineffectiveness: redness and itching are relieved or aggravated.

4. Statistics of curative effect: after 2 days, respectively, the skin curative effect

of mosquito bites of members of each group is counted, and the results are shown in

the following table.

Table 1 Effect of applying cream on bite after 2 days

Number of Effective n Invalid Proportion of patients umber of number of recovery and cured people people effectiveness

A 18 2 0 100% B 17 3 0 100% C 17 3 0 100% D 15 3 1 95% E 3 5 12 40% F 8 5 7 65% G 9 5 6 70% H 1 2 17 15%

It can be seen from the above table that the creams of Examples 1-4 have

effective antipruritic and anti-inflammatory effects.

The technical features of the above-mentioned embodiments can be combined

arbitrarily. In order to make the description concise, all possible combinations of the

technical features in the above-mentioned practical embodiments are not described.

However, as long as there is no contradiction between the combinations of these

technical features, they should be considered as the scope recorded in this

specification.

The above examples only express several embodiments of the present invention,

and their descriptions are specific and detailed, but they cannot be understood as

limiting the scope of the patent of the present invention. It should be pointed out that,

SPECIFICATION

for those of ordinary skill in the field, without departing from the concept of the

present invention, several modifications and improvements can be made, which

belong to the protection scope of the present invention. Therefore, the scope of

protection of the patent of the present invention shall be subject to the appended

claims.

Claims

1. A composition for moistening and relieving itching is characterized by

comprising the following raw materials in parts by weight:

parts of Sophora flavescens, 0.01-10 parts of thymol, 0.01-10 parts of snakeskin, 0.01

parts of cortex dictamni, 0.01-10 parts of cortex phellodendri, 0.5-10 parts of

chlorhexidine acetate ;

The pomelo peel extract has a Baume degree of 20-30 B6.

2. The composition for moistening and relieving itching according to claim 1 is

characterized by comprising the following raw materials in parts by weight:

acetate.

3. The composition for moistening and relieving itching according to claim 2 is

characterized by comprising the following raw materials in parts by weight:

4. The composition for moistening and relieving itching according to any one of

claims 1-3 is characterized in that the preparation method of the pomelo peel extract

comprises the following steps:

grinding dried pomelo peel, placing in 40%-80% ethanol according to the weight

ratio of 1:(3-8), and performing ultrasonic extraction for 1-3 times, each time for 0.5

2h at the temperature of 40-80 °C to obtain the extracting solution;

peel extract.

5. Application of the composition according to any one of claims 1-3 in

preparing daily chemical products or medicines for moistening and relieving itching.

6. A cream is characterized by comprising the composition for moisturizing and

relieving itching according to any one of claims 1-3.

7. The cream according to claim 6 is characterized by comprising the following

raw materials in parts by weight:

10-30 parts of the composition for moisturizing and relieving itching according

to any one of claims 1-3, 5-15 parts of urotoxin, 20-30 parts of vitamin E, 15-25 parts

of menthol, 0.5-2 parts of methylparaben, 0.5-2 parts of propyl 4-hydroxybenzoate,

-90 parts of glycerol, 40-60 parts of mineral oil and 20-30 parts of propylene glycol,

-30 parts of polydimethylsiloxane, 40-60 parts of cetearyl alcohol and 600-800

parts of water.

8. The preparation method of the cream according to claim 7 is characterized by

comprising the following steps:

(1) weighing the raw materials according to the parts by weight of claim 7;

2) adding the mineral oil, cetearyl alcohol and polydimethylsiloxane into an oil

phase pot, heating to 85-95 °C, stirring, and keeping the temperature to obtain an oil

phase;

3) adding the hydroxyphenyl methyl ester, propyl 4-hydroxybenzoate and

water phase;

4) adding the pomelo peel extract, tea tree essential oil, Sophora flavescens,

and keeping the temperature below 70 °C to obtain component A;

5) mixing and melting allantoin, vitamin e, menthol with chlorhexidine acetate to

obtain a component B;

6) mixing and stirring the water phase, the oil phase, the component A and the

component B to obtain the product.

9. The preparation method according to claim 8 is characterized in that in step 2),

the stirring speed is 400- 600rpm.

10. the preparation method according to claim 8 is characterized in that in step 6),

the technological parameters of mixing and stirring are as follows: adding oil phase

into a preparation pot, stirring, adding water phase, emulsifying in vacuum, cooling to

-80°C, adding component A, cooling to 60-65°C, adding component B, and cooling

to 40-45°C.

Figure 1 DRAWING