CN108354870A - Moisten the preparation method of anti-pruritic compositions, emulsifiable paste and emulsifiable paste - Google Patents
Moisten the preparation method of anti-pruritic compositions, emulsifiable paste and emulsifiable paste Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to a kind of moist anti-pruritic compositions, include the raw material of following parts by weight：1 30 parts of pummelo peel extract, 0.01 10 parts of tea tree ethereal oil, 0.01 10 parts of kuh-seng, 0.01 10 parts of thymol, 0.01 10 parts of snakeskin, 0.01 10 parts of dittany bark, 0.01 10 parts of Cortex Phellodendri, 0.5 10 parts of acetic acid chlorhexidine；The Baume degrees of the pummelo peel extract is 20 30 ° of B é.The emulsifiable paste made of above-mentioned composition has preferably moist antipruritic effect.
Description
Technical field
The present invention relates to daily chemical product fields, more particularly to a kind of preparation of moist anti-pruritic compositions, emulsifiable paste and emulsifiable paste
Method.
Background technology
Skin is first of barrier that human body is contacted with external environment, and human body is avoided to receive the erosion of physics, chemistry.But
Skin also when be subjected to infringement, such as：Eczema caused by a variety of internal and external factors, with apparent exudation tendency；Bite by mosquitos
It is caused to swell, pain, itch；Cold of the Nature, dry and cracked caused by the irradiation of burning sun, sunburn, pernio.Though above-mentioned various skin injuries
Normal physiological activity is not influenced largely, but influences the external image of people, to psychological burden caused by people and spirit pain
It is bitter.Therefore, research slow down the product of above-mentioned symptom very it is necessary to.
Invention content
Based on this, it is necessary in view of the above-mentioned problems, providing a kind of preparation side for moistening antipruritic composition, emulsifiable paste and emulsifiable paste
Method.
The present invention provides a kind of moist anti-pruritic compositions.
Specific technical solution is：
A kind of moist anti-pruritic compositions include the raw material of following parts by weight：
1-30 parts of pummelo peel extract, 0.01-10 parts of tea tree ethereal oil, 0.01-10 parts of kuh-seng, 0.01-10 parts of thymol, snake
0.01-10 parts of leather, 0.01-10 parts of dittany bark, 0.01-10 parts of Cortex Phellodendri, 0.5-10 parts of acetic acid chlorhexidine；
The Baume degrees of the pummelo peel extract is 20-30 ° of B é.
It is essential oil, class lemon that pummelo peel extract, which has anti-oxidant, norcholesterol, antibacterial isoreactivity, main antipathogenic composition,
Lemon herb mixtures tea, flavone compound.Wherein, the main physiological activity of limonin has anticancer, antibacterial, antiviral, analgesia, anti-inflammatory
Deng having insect antifeedant, have inhibiting effect to immunocyte abnormality proliferation.
The main chemical composition of tea tree ethereal oil is to Meng's ethylene, dipentene, limonene, cineol, sesame oil brain, fennel
Element has bactericidal antiphlogistic, convergence pore, treatment cold, cough, rhinitis, asthma, improves dysmenorrhoea, irregular menstruation and reproduction
Device infection and other effects.
The main component of kuh-seng be matrine, have it is clearing heat and detoxicating, dispel pathogenic wind and remove dampness, effect that worming is antipruritic.With frutus cnidii
Compatible use, to virus infected herpes, contact eczema, intractable pudendal pruritus, tinea pedis eczema, genital herpes and various the moon
Road is scorching, eczema genitalium has fine curative effect.Matrine and oxymatrine are used alone to Escherichia coli, staphylococcus aureus
With Candida albicans all without inhibitory activity, and to staphylococcus aureus and Candida albicans after being combined with common cnidium fruit P.E
All show good inhibitory activity.
Thymol has good fungistatic effect to Escherichia coli, staphylococcus aureus.
The chemical composition of dittany bark includes the compounds such as alkaloid, limonin, flavones, sequiterpene and its glycoside, steroidal.
Favus skin ligroin extraction is most strong to the inhibiting effect of staphylococcus, Escherichia coli, proteus vulgaris, hay bacillus, main
Want antibacterial substance be tinea alba Jian He fraxinellone.
The chemical composition of Cortex Phellodendri based on alkaloid, further include limonin, phenolic acid class, terpene, lignanoids, sterol and
Its glycoside.Cortex Phellodendri has apparent anti-inflammatory effect to the damaged skin of infection of staphylococcus aureus, while antipyretic anti-inflammatory also
It can promote angiogenesis, improve face microcirculation, promote granulation growth, accelerating wound healing.
Acetic acid chlorhexidine has killing effect to most Grain-positives and negative bacteria, also effective to Pseudomonas aeruginosa.It will be upper
It states traditional Chinese medicine ingredients to be compounded with chlorhexidine acetate, In Vitro Bacteriostasis significant effect improves and toxicity is low, safe to use.It is mainly made
With mechanism be destroy pathogenic microorganism cell wall plasmalemma, quickly kill gram positive bacteria, gram-negative bacteria, bacterial spore,
Fungi and virus etc..
The moist anti-pruritic compositions for including the above raw material, while giving full play to a component and effect, moreover it is possible to after compounding
Synergistic effect makes the composition after compounding have superior moist, antibacterial and itching-relieving efficacies.
Above-mentioned moist anti-pruritic compositions in one of the embodiments, include the raw material of following parts by weight：
5-20 parts of pummelo peel extract, 0.1-5 parts of tea tree ethereal oil, 0.1-5 parts of kuh-seng, 0.1-5 parts of thymol, snakeskin
0.1-5 parts, 0.1-5 parts of dittany bark, 0.1-5 parts of Cortex Phellodendri, 0.5-5 parts of acetic acid chlorhexidine.
Above-mentioned moist anti-pruritic compositions in one of the embodiments, include the raw material of following parts by weight：
8-15 parts of pummelo peel extract, 0.1-1 parts of tea tree ethereal oil, 0.1-1 parts of kuh-seng, 0.1-1 parts of thymol, snakeskin
0.1-1 parts, 0.1-1 parts of dittany bark, 0.1-1 parts of Cortex Phellodendri, 1-5 parts of acetic acid chlorhexidine.
The preparation method of the pummelo peel extract includes the following steps in one of the embodiments,：
Dry pomelo peel is crushed, by 1:The weight ratio of (3-8) is placed in the ethyl alcohol of a concentration of 40%-80%, ultrasonic extraction
1-3 times, each extraction time is 0.5-2h, and temperature is 40-80 DEG C, obtains extracting solution；
By extracting solution filtering, it is concentrated into 20-30 Baume degrees, obtains pummelo peel extract；
The present invention also provides a kind of above-mentioned compositions to prepare the application moistened in antipruritic class daily chemical product or drug.
The present invention also provides a kind of emulsifiable pastes, include above-mentioned moist anti-pruritic compositions.
Above-mentioned emulsifiable paste includes the raw material of following parts by weight in one of the embodiments,：
Above-mentioned moist anti-pruritic compositions 10-30 parts, 5-15 parts of urotoxin, 20-30 parts of vitamin E, 15-25 parts of menthol,
0.5-2 parts of methyl hydroxybenzoate, 0.5-2 parts of Nipasol, 60-90 parts of glycerine, 40-60 parts of dormant oil, 20-30 parts of propylene glycol, poly- diformazan
600-800 parts of 20-30 parts of radical siloxane, 40-60 parts of cetostearyl alcohol and water.
Wherein, allantoin is urine base glycolylurea, it can increase and promote to engage the hydratability of matrix, moreover it is possible to act on angle egg
In vain, the ability for making it combine water increases, and skin is made to become smooth, moist and flexible.The urea part of allantoin also has antifungi
With antibacterial effect.
Menthol has many advantages, such as that rapid-action, effect is good, adverse reaction is small as traditional Chinese medicine ingredients skin penetration enhancer.
After above-mentioned emulsifiable paste is to bite by mosquitos, the symptoms such as redness, itch that skin occurs have notable curative effect；It burns to burning sun
Afterwards, the symptoms such as chapped skin, sunburn have preferable reparation curative effect.
The present invention also provides the preparation methods of above-mentioned emulsifiable paste, include the following steps：
Step 1) weighs each raw material by above-mentioned parts by weight；
The dormant oil, cetostearyl alcohol and dimethyl silicone polymer is added in step 2) in oil phase pot, is heated to 85-95
DEG C, it stirs, heat preservation obtains oil phase；
The methyl hydroxybenzoate, Nipasol and glycerine is added in step 3) in water phase pot, keeps the temperature 90-95 DEG C, obtains water phase；
The pummelo peel extract, tea tree ethereal oil, kuh-seng, thymol, frutus cnidii, dittany is added in step 4) in propylene glycol
Skin and Cortex Phellodendri, 70 DEG C or less heat preservations, obtain component A；
The allantoin, vitamin E, menthol and acetic acid chlorhexidine mixing congruent melting are obtained B component by step 5)；
Step 6) by the water phase, oil phase, component A and B component be mixed to get.
In one of the embodiments, in step 2), the stir speed (S.S.) is 400-600rpm.
In one of the embodiments, in step 6), the technological parameter of the mixing is：Oil is added in pot in preparing
Phase, stirring add water phase, and vacuum emulsification is cooled to 60-80 DEG C, and component A is added, and are cooled to 60-65 DEG C, then add B component,
Be cooled to 40-45 DEG C to get.
Compared with existing scheme, the invention has the advantages that：
In above-mentioned moist anti-pruritic compositions, there is pummelo peel extract anti-oxidant, norcholesterol, antibacterial isoreactivity, shaddock ped to carry
Active ingredient in object is taken to have preferable antibacterial effect to multiple-microorganism such as bacillus subtilis, Escherichia coli, yeast and mold
Fruit compounds with traditional Chinese medicine ingredients such as tea tree ethereal oil, kuh-seng, thymols, has the effect of significant bactericidal antiphlogistic, itching analgesic.
Above-mentioned traditional Chinese medicine ingredients are used cooperatively with acetate chlorhexidine, are remarkably improved In Vitro Bacteriostasis effect.Further, 20-30 Baumes
In the pummelo peel extract of degree, substance content is moderate, with the traditional Chinese medicine ingredients such as the tea tree ethereal oil, kuh-seng, thymol of special ratios
After mixing, it is more advantageous to performance composition and moistens antipruritic effect.
Using the emulsifiable paste that above-mentioned composition is prepared as raw material, be applied on skin as daily chemical product, have it is antibacterial, nourish,
The effect of reparation, after bite by mosquitos, the symptoms such as redness, itch that skin occurs have notable curative effect；After burning to burning sun, skin
The symptoms such as the dry and cracked, sunburn of skin have preferable reparation curative effect.Meanwhile above-mentioned emulsifiable paste also has and can be used as treatment dermatitis, eczema, sufficient moss silver
It considers the drug of disease etc. to be worth doing, alleviates the symptoms such as skin discomfort, generation without side-effects.
Description of the drawings
Fig. 1 is the preparation method flow chart of emulsifiable paste in one embodiment of the invention.
Specific implementation mode
The preparation method of the moist anti-pruritic compositions of the present invention, emulsifiable paste and emulsifiable paste is made into one below in conjunction with specific embodiment
Step detailed description.
In specific implementation mode, all raw materials derive from commercially available.
Embodiment 1
The present embodiment provides a kind of emulsifiable pastes, are prepared by following raw material in parts by weight：
10 parts of pummelo peel extract, 0.5 part of tea tree ethereal oil, 0.5 part of kuh-seng, 0.5 part of thymol, snakeskin 0.5 part, dittany
0.5 part of skin, 0.5 part of Cortex Phellodendri, 5 parts of acetic acid chlorhexidine, 10 parts of urotoxin, 25 parts of vitamin E, 20 parts of menthol, methyl hydroxybenzoate 1
Part, 1 part of Nipasol, 80 parts of glycerine, 50 parts of dormant oil, 25 parts of propylene glycol, 25 parts of dimethyl silicone polymer, 50 parts of cetostearyl alcohol
With 700 parts of water.
The preparation method of above-mentioned emulsifiable paste, includes the following steps：
Step 1) weighs each raw material according to above-mentioned parts by weight；
The preparation of step 2) oil phase：Dormant oil, cetostearyl alcohol, dimethyl silicone polymer are set in oil phase pot, interlayer is opened
Vapour tug is heated to 90~95 DEG C, and oil phase melts completely, starts stirring, and rate 500rpm makes each component be uniformly mixed, heat preservation
85~90 DEG C spare.
The preparation of step 3) water phase：Water is added into water phase pot, boils, it is spare to release appropriate hot water；By methyl hydroxybenzoate, hydroxyl
Phenylpropyl alcohol ester is added in water phase pot, stirring and dissolving；Glycerine is placed in stainless steel barrel, water phase pot is added after being diluted with spare hot water
In, to fully miscible, adjusting jacket steam intake, 90-95 DEG C of heat preservation is spare for stirring.
The preparation of step 4) component A：Propylene glycol is placed in stainless steel barrel, heating water bath adds shaddock to 80 DEG C or more
Bark extract, tea tree ethereal oil, kuh-seng, thymol, frutus cnidii, dittany bark and Cortex Phellodendri stir to being completely dissolved, and 70 DEG C or less are protected
Warm standby is used；It is spare to reserve a part of propylene glycol.
The preparation of step 5) component B：It will be spare after allantoin, vitamin E, menthol and acetic acid chlorhexidine mixing congruent melting.
Step 6) mixing and emulsifying：It prepares pot and keeps certain vacuum degree, oil phase is pumped into configuration pot, opens and mixes slowly, by water
It is added to configuration pot, opens vacuum emulsification, is mixed slowly, when temperature is down to 70 DEG C, is slowly added to component A, with spare propylene glycol
Eluant container, and be added into vacuum emulsifying machine.Vacuum emulsification is opened, is mixed slowly, temperature is slowly added into B groups when being down to 60 DEG C
Point, vacuum emulsification is opened, is mixed slowly, steam off valve adjusts cooling circulating water intake, waits for that temperature is down to 45 DEG C or less lotions
When at cream, stop stirring discharging.Loaded in clean container.
Wherein, the preparation method of pummelo peel extract includes the following steps：
Step 1) is dried fresh pomelo peel under sunlight or moisture content is evaporated using baker.
Step 2) take 500g color and lusters it is normal, without the rotten dry pomelo peel of enzyme, be added into the ethyl alcohol of 3kg a concentration of 60%,
Ultrasonic extraction 1h in ultrasonic extraction tank, temperature are 60 DEG C, obtain the first extracting solution, then 2.5kg is added into ultrasonic extraction tank
A concentration of 60% ethyl alcohol, carries out secondary extraction, and ultrasonic extraction 1h at 60 DEG C obtains the second extracting solution, by the first extracting solution and
Two extracting solutions mix, and obtain extracting solution.
Extracting solution is cooled to room temperature by step 3), allows impurity natural subsidence, is filtered with 40 mesh filter screens, and by extracting solution
It is added in vacuum concentrator, is concentrated into 28 Baume degrees, obtains pummelo peel extract.
Embodiment 2
The present embodiment provides a kind of emulsifiable pastes, are prepared by following raw material in parts by weight：
15 parts of pummelo peel extract, 1 part of tea tree ethereal oil, 1 part of kuh-seng, 1 part of thymol, 1 part of snakeskin, 1 part of dittany bark, Huang
1 part of cypress, 5 parts of acetic acid chlorhexidine, 10 parts of urotoxin, 25 parts of vitamin E, 20 parts of menthol, 1 part of methyl hydroxybenzoate, Nipasol 1
Part, 80 parts of glycerine, 50 parts of dormant oil, 25 parts of propylene glycol, 25 parts of dimethyl silicone polymer, 50 parts of cetostearyl alcohol and 700 parts of water.
The preparation method of emulsifiable paste and pummelo peel extract is same as Example 1 in the present embodiment.
Embodiment 3
The present embodiment provides a kind of emulsifiable pastes, are prepared by following raw material in parts by weight：
18 parts of pummelo peel extract, 2 parts of tea tree ethereal oil, 2 parts of kuh-seng, 2 parts of thymol, 2 parts of snakeskin, 2 parts of dittany bark, Huang
2 parts of cypress, 6 parts of acetic acid chlorhexidine, 10 parts of urotoxin, 25 parts of vitamin E, 20 parts of menthol, 1 part of methyl hydroxybenzoate, Nipasol 1
Part, 80 parts of glycerine, 50 parts of dormant oil, 25 parts of propylene glycol, 25 parts of dimethyl silicone polymer, 50 parts of cetostearyl alcohol and 700 parts of water.
The preparation method of emulsifiable paste and pummelo peel extract is same as Example 1 in the present embodiment.
Embodiment 4
The present embodiment provides a kind of emulsifiable pastes, are prepared by following raw material in parts by weight：
4 parts of pummelo peel extract, 0.1 part of tea tree ethereal oil, 0.1 part of kuh-seng, 0.1 part of thymol, snakeskin 0.1 part, dittany
0.1 part of skin, 0.1 part of Cortex Phellodendri, 4 parts of acetic acid chlorhexidine, 10 parts of urotoxin, 25 parts of vitamin E, 20 parts of menthol, methyl hydroxybenzoate 1
Part, 1 part of Nipasol, 80 parts of glycerine, 50 parts of dormant oil, 25 parts of propylene glycol, 25 parts of dimethyl silicone polymer, 50 parts of cetostearyl alcohol
With 700 parts of water.
The preparation method of emulsifiable paste and pummelo peel extract is same as Example 1 in the present embodiment.
Comparative example 1
A kind of emulsifiable paste of this comparative example offer and preparation method thereof, it is substantially the same manner as Example 1, difference lies in：It moistens antipruritic
In composition, pummelo peel extract is not contained.
Comparative example 2
A kind of emulsifiable paste of this comparative example offer and preparation method thereof, it is substantially the same manner as Example 1, difference lies in：It moistens antipruritic
In composition, thymol is replaced with into lavender.
Comparative example 3
A kind of emulsifiable paste of this comparative example offer and preparation method thereof, it is substantially the same manner as Example 1, difference lies in：It moistens antipruritic
In composition, dittany bark is not contained.
Clinical test
The emulsifiable paste progress clinical test of Example 1-4, comparative example 1-3.Specific method is：
1, clinical case selects：160 are randomly selected just by bite by mosquitos, occur biting the volunteer of place's redness, itch.
2, test method：By one group of 20 people, it is divided into A-H groups.A-D groups difference corresponding embodiment 1-4 groups, at bite by mosquitos
Smear the emulsifiable paste of embodiment 1-4；E-G groups correspond to comparative example 1-3 groups respectively, and the emulsifiable paste of comparative example 1-3 is smeared at bite by mosquitos；
H groups are control group, do not smear emulsifiable paste, and the time that each group smears emulsifiable paste is 1 day 3 times.
3, criterion of therapeutical effect：
(1) it fully recovers：The place of biting is red and swollen, pruritis completely disappears.
(2) effective：Red and swollen, pruritis mitigates, and extends usage time, and symptom disappears.
(3) invalid：Red and swollen, itch is to mitigate or aggravate.
4, efficacy result counts, and after counting 2 days respectively, skin curative effect situation, as a result as follows at each group membership's bite by mosquitos
Shown in table.
Table 1, which is smeared emulsifiable paste and bitten after 2 days, locates curative effect situation
| Recovery from illness number | Effective number | Invalid number | Recovery from illness and effective ratio | |
| A | 18 | 2 | 0 | 100% |
| B | 17 | 3 | 0 | 100% |
| C | 17 | 3 | 0 | 100% |
| D | 15 | 3 | 1 | 95% |
| E | 3 | 5 | 12 | 40% |
| F | 8 | 5 | 7 | 65% |
| G | 9 | 5 | 6 | 70% |
| H | 1 | 2 | 17 | 15% |
As seen from the above table, the emulsifiable paste of embodiment 1-4 has effective antipruritic, anti-inflammatory effects.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of moistening antipruritic composition, which is characterized in that include the raw material of following parts by weight：
1-30 parts of pummelo peel extract, 0.01-10 parts of tea tree ethereal oil, 0.01-10 parts of kuh-seng, 0.01-10 parts of thymol, snakeskin
0.01-10 parts, 0.01-10 parts of dittany bark, 0.01-10 parts of Cortex Phellodendri, 0.5-10 parts of acetic acid chlorhexidine；
The Baume degrees of the pummelo peel extract is 20-30 ° of B é.
2. according to claim 1 moisten antipruritic composition, which is characterized in that include the original of following parts by weight
Material：
5-20 parts of pummelo peel extract, 0.1-5 parts of tea tree ethereal oil, 0.1-5 parts of kuh-seng, 0.1-5 parts of thymol, the sub- 0.1-5 of snakeskin
Part, 0.1-5 parts of dittany bark, 0.1-5 parts of Cortex Phellodendri, 0.5-5 parts of acetic acid chlorhexidine.
3. according to claim 2 moisten antipruritic composition, which is characterized in that include the original of following parts by weight
Material：
8-15 parts of pummelo peel extract, 0.1-1 parts of tea tree ethereal oil, 0.1-1 parts of kuh-seng, 0.1-1 parts of thymol, the sub- 0.1-1 of snakeskin
Part, 0.1-1 parts of dittany bark, 0.1-1 parts of Cortex Phellodendri, 1-5 parts of acetic acid chlorhexidine.
4. moistening anti-pruritic compositions according to right 1-3 any one of them, which is characterized in that the preparation side of the pummelo peel extract
Method includes the following steps：
Dry pomelo peel is crushed, by 1:The weight ratio of (3-8) is placed in the ethyl alcohol of a concentration of 40%-80%, ultrasonic extraction 1-3
Secondary, each extraction time is 0.5-2h, and temperature is 40-80 DEG C, obtains extracting solution；
By extracting solution filtering, it is concentrated into 20-30 Baume degrees, obtains pummelo peel extract.
5. claim 1-3 any one of them composition is preparing the application moistened in antipruritic class daily chemical product or drug.
6. a kind of emulsifiable paste, which is characterized in that include that claim 1-3 any one of them moistens anti-pruritic compositions.
7. emulsifiable paste according to claim 6, which is characterized in that include the raw material of following parts by weight：
Claim 1-3 any one of them moistens 10-30 parts of anti-pruritic compositions, 5-15 parts of urotoxin, vitamin E 20-30
Part, 15-25 parts of menthol, 0.5-2 parts of methyl hydroxybenzoate, 0.5-2 parts of Nipasol, 60-90 parts of glycerine, 40-60 parts of dormant oil, the third two
600-800 parts of 20-30 parts of alcohol, 20-30 parts of dimethyl silicone polymer, 40-60 parts of cetostearyl alcohol and water.
8. a kind of preparation method of the emulsifiable paste described in claim 7, which is characterized in that include the following steps：
Step 1) parts by weight as described in claim 7 weigh each raw material；
The dormant oil, cetostearyl alcohol and dimethyl silicone polymer is added in step 2) in oil phase pot, is heated to 85-95 DEG C, stirs
It mixes, keeps the temperature, obtain oil phase；
The methyl hydroxybenzoate, Nipasol and glycerine is added in step 3) in water phase pot, keeps the temperature 90-95 DEG C, obtains water phase；
Step 4) be added in propylene glycol the pummelo peel extract, tea tree ethereal oil, kuh-seng, thymol, frutus cnidii, dittany bark and
Cortex Phellodendri, 70 DEG C or less heat preservations obtain component A；
The allantoin, vitamin E, menthol and acetic acid chlorhexidine mixing congruent melting are obtained B component by step 5)；
Step 6) by the water phase, oil phase, component A and B component be mixed to get.
9. preparation method according to claim 8, which is characterized in that in step 2), the stir speed (S.S.) is 400-
600rpm。
10. preparation method according to claim 8, which is characterized in that in step 6), the technological parameter of the mixing
For：Oil phase is added in preparing in pot, stirs, adds water phase, vacuum emulsification is cooled to 60-80 DEG C, and component A is added, is cooled to
60-65 DEG C, then add B component, be cooled to 40-45 DEG C to get.
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Application publication date: 20180803 |