CN115252678B

CN115252678B - Traditional Chinese medicine antibacterial itching-relieving gel and preparation method thereof

Info

Publication number: CN115252678B
Application number: CN202110483670.3A
Authority: CN
Inventors: 段秀梅; 王洪玲; 海丽娜; 卢子睿; 张红强
Original assignee: Shanxi Zhendong Health Care Technology Co ltd
Current assignee: Shanxi Zhendong Health Care Technology Co ltd
Priority date: 2021-04-30
Filing date: 2021-04-30
Publication date: 2023-12-29
Anticipated expiration: 2041-04-30
Also published as: CN115252678A

Abstract

The invention provides a traditional Chinese medicine antibacterial itching-relieving gel and a preparation method thereof, belonging to the technical field of external pharmaceutical preparations. The traditional Chinese medicine antibacterial itching-relieving gel mainly comprises radix isatidis, dandelion, flos caryophylli, cortex acanthopanacis, borneol and peppermint oil. The gel has simple components, good antibacterial effect, obvious inhibition effect on staphylococcus aureus, escherichia coli, candida albicans and the like, can effectively prevent bacteria from breeding, and meanwhile, the gel texture can stay and be absorbed on the surface of the skin, so that the purposes of bacteriostasis, pain relieving, detumescence and the like are achieved.

Description

Traditional Chinese medicine antibacterial itching-relieving gel and preparation method thereof

Technical Field

The invention belongs to the technical field of external pharmaceutical preparations, and relates to a traditional Chinese medicine antibacterial itching-relieving gel and a preparation method thereof.

Background

The skin discomfort, dermatitis and eczema caused by the biting of mosquitoes and insects are common skin diseases, the skin damage is various, the itching is severe, and a great deal of inconvenience and pain are brought to patients. These skin disorders often have the following common pathologies: the skin injury is the secondary skin inflammation on the basis of more seborrhea secretion, namely, normal flora on the surface of the skin is greatly propagated into opportunistic pathogenic bacteria to attack the skin due to the increase of sebum secretion and the change of chemical composition; the sweat glands are not smooth to secrete, so that the skin cannot breathe normally, and the subcutaneous superfluous moisture cannot be secreted and excreted normally.

For these troubles, chemical disinfectants, antibiotics and the like which are widely used by people in the past are used for prevention and treatment, but the chemical disinfectants and antibiotics often cause drug resistance of pathogenic bacteria, secondary environmental pollution is caused, and people are increasingly invaded and threatened by microorganisms and pathogenic bacteria. In view of the above, the study of novel formulations that are non-irritating, non-toxic or low-toxic and pollution-free is now an important research topic.

At present, the skin diseases are mainly treated by single symptoms in treatment, such as eczema, sweat rash, seborrheic dermatitis, skin itch, beriberi and the like, and the traditional treatment method is to take symptomatic drugs orally or apply various treatment ointments on the surface of focus skin. The ointment is characterized in that the ointment matrix is formed by emulsifying oil and water, contains more grease components, the unified symptom of skin diseases is sweat gland obstruction, bacteria infiltrate into the skin, and according to the theory of 'pain caused by no-go' of traditional Chinese medicine, the grease components contained in the ointment can aggravate blockage of sweat glands of the skin, and form a seal on the skin surface, so that the expected curative effect is difficult to achieve even if the ointment contains're-effective medicine', the treatment result is influenced, and even the ointment can play a role in reaction.

For example, chinese patent application CN111184844A discloses an herbal antibacterial cream for treating dermatitis and eczema and a preparation method thereof. The cream comprises the following components in parts by weight: 1-2 parts of musk, 1-2 parts of radix sophorae flavescentis, 1-2 parts of wintergreen oil, 5-6 parts of silicone oil, 1-2 parts of dried ginger, 1-2 parts of myrrh, 1-3 parts of garden balsam stem, 1-2 parts of radix aconiti, 3-4 parts of pseudo-ginseng, 12 parts of radix angelicae pubescentis, 4-5 parts of black ant, 1-2 parts of safflower, 2-3 parts of borneol, 1-2 parts of camphor, 2-3 parts of kuh-seng, 1-2 parts of wormwood, 2-3 parts of hedyotis diffusa, 1-2 parts of golden cypress, 1-2 parts of honeysuckle, 1-2 parts of tea tree essential oil, 1-2 parts of herba violae, 3-4 parts of wild chrysanthemum, 1-2 parts of radix euphorbiae Fischerianae, 2-3 parts of dandelion, 1-3 parts of paris polyphylla, 1-2 parts of borneol, 1-4 parts of radix stemonae, 2-5 parts of rheum officinale, 2-5 parts of peppermint and 20-30 parts of castor oil. When in treatment, a proper amount of the antibacterial cream is smeared on an affected part, and can be basically cured once or twice a day for 1-3 months, and the wound is not easy to relapse after curing, and has no toxic or side effect. However, the product uses tens of Chinese herbal medicines, has complex preparation and high cost, adopts the cream texture, has poor medication compliance for patients with dermatitis and eczema, and has a treatment effect to be improved.

For example, chinese patent application CN101396507B discloses a traditional Chinese medicine antibacterial liquid, which is prepared by taking 15-18 parts of glabrous greenbrier rhizome, 15-18 parts of lightyellow sophora root, 145-155 parts of radix isatidis, 12-15 parts of amur corktree bark, 110-120 parts of dandelion, 5-8 parts of baical skullcap root, 7-10 parts of gentian, 75-80 parts of flos caryophylli, 60-65 parts of cortex caryophylli, 10-12 parts of peppermint oil and 0.3-0.5 part of borneol as raw materials, soaking and extracting glabrous greenbrier rhizome, lightyellow sophora root, radix isatidis, amur corktree bark, dandelion, baical skullcap root, gentian, flos caryophylli and cortex caryophylli with ethanol solution, blending peppermint oil and borneol in filtrate, and filling. The invention selects natural traditional Chinese medicines with aromatic smell and sterilization and bacteriostasis effects as raw materials to prepare the traditional Chinese medicine bacteriostasis liquid, can be used for treating skin diseases, is sprayed on the surface of focus skin, can not prevent normal respiratory metabolism of skin, can enable medicines contained in the liquid to be rapidly delivered to the subcutaneous focus part, and has quick curative effect and high bioavailability. However, the traditional Chinese medicine antibacterial liquid has the advantages of more traditional Chinese medicine components, more complex prescription, high preparation cost and higher difficulty; the dosage form of filling spray is adopted, compressed air is added in the filling process, the preparation requirement is high, the spray needs to be increased to achieve the required dosage, the dosage is large, the treatment effect is difficult to achieve, and in addition, the filling spray has the safety problem, so that the filling spray cannot pass through the security inspection of vehicles such as trains, airplanes, high-speed rails and the like.

The existing medicines for treating dermatitis and eczema dermatosis mainly have the following problems:

1. in the dosage form adopted by the medicine, the cream has poor texture medication compliance, poor effect, large dosage of spray preparation and safety problem;

2. the medicine contains antibiotic components, so that pathogenic bacteria are easy to generate drug resistance, and further treatment is influenced;

3. the preparation process is complex, the cost of raw materials is high, and the price of the medicine is high, but the treatment effect cannot be satisfied by patients.

Disclosure of Invention

Aiming at the problems existing in the prior art, the invention provides the traditional Chinese medicine antibacterial itching-relieving gel and the preparation method thereof, wherein the gel mainly comprises four traditional Chinese medicines of radix isatidis, flos caryophylli, dandelion and cortex mori, can effectively inhibit various bacteria and fungi, improves the health degree of skin and the defensive ability against pathogenic bacteria by the improvement of the preparation method according to a specific proportion, has fresh and cool use sense due to the adoption of gel, has the effects of relieving itching, spasmolysis, resisting inflammation, easing pain and the like, and has good medication compliance for patients.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

a traditional Chinese medicine antibacterial itching-relieving gel comprises the following components in parts by weight: 10-50 parts of main medicine solution, 10-50 parts of gel matrix, 0.05-0.1 part of antibacterial solution and 0.5-5 parts of pH regulator.

Further, the traditional Chinese medicine gel main medicine solution comprises the following components in parts by weight: 30-45 parts of radix isatidis, 20-35 parts of dandelion, 15-25 parts of flos caryophylli, 10-20 parts of cortex caryophylli, 5-12 parts of borneol and 15-25 parts of peppermint oil, wherein the weight ratio of the dandelion to the flos caryophylli to the cortex caryophylli is 4-7:3-5:2-4.

Further, the traditional Chinese medicine gel main medicine solution comprises the following components in parts by weight: 35-40 parts of radix isatidis, 25-30 parts of dandelion, 17-22 parts of flos caryophylli, 12-18 parts of cortex caryophylli, 6-10 parts of borneol and 18-22 parts of peppermint oil.

Further, the components and the weight parts of the traditional Chinese medicine gel main medicine solution are most preferably as follows: 37 parts of radix isatidis, 28 parts of dandelion, 19 parts of flos caryophylli, 15 parts of cortex caryophylli, 8 parts of borneol and 20 parts of peppermint oil.

Further, the gel matrix is prepared from carbomers and purified water; wherein the carbomer is selected from one or more of carbomer 971NF, carbomer 974P, carbomer 940, carbomer U20, carbomer 980 NF; the mass ratio of carbomer to purified water is 1-5:25-100.

Further, the antibacterial liquid is prepared from a bacteriostatic agent and a humectant; wherein the antibacterial agent is selected from one or more of ethyl hydroxybenzoate, methyl hydroxybenzoate, propyl hydroxybenzoate, potassium sorbate, methyl salicylate, and ethyl hydroxybenzoate; the humectant is one or more selected from propylene glycol, glycerol, ethanol, propanol and butanol; the mass ratio of the bacteriostatic agent to the humectant is 5-20:1000.

Further, the pH regulator is one or more selected from triethanolamine, ethylenediamine, laurylamine and sodium bicarbonate.

The preparation method of the traditional Chinese medicine gel is characterized by comprising the following steps:

(1) Preparation of a main drug solution: extracting radix Isatidis, herba Taraxaci, flos Caryophylli and cortex Periplocae Radicis with ethanol to obtain extractive solution; adding Borneolum Syntheticum and oleum Menthae Dementholatum into the extractive solution, stirring, and making into main medicinal solution;

(2) Preparation of gel matrix: swelling carbomer in purified water to prepare gel matrix with mass concentration of 2.5-5.0%;

(3) Preparation of antibacterial liquid: heating and dissolving the formula amount of bacteriostatic agent in the formula amount of humectant to prepare bacteriostatic liquid with the mass concentration of 0.5-2%;

(4) Preparation: and (3) adding the formula amount of the antibacterial liquid obtained in the step (3) into the gel matrix obtained in the step (2), uniformly stirring, adjusting the pH to 6.5-6.8 by using a pH regulator, and adding the main medicine solution obtained in the step (1) to 100 parts to obtain the antibacterial itching-relieving gel.

Further, the preparation method, step (1) specifically comprises: soaking radix Isatidis, herba Taraxaci, flos Caryophylli and cortex Periplocae Radicis in 50% ethanol solution with 5-6 times of the total mass at normal temperature for 7 days, filtering, and collecting the residue and filtrate; soaking the residue in 45% ethanol solution 4-5 times of the total mass of the four Chinese medicinal materials at normal temperature for 7 days, and filtering to obtain filtrate; mixing the two filtrates, adding Borneolum Syntheticum and oleum Menthae Dementholatum, and stirring to obtain main medicinal solution.

The application of the traditional Chinese medicine gel in preparing medicines for preventing and treating skin discomfort, dermatitis and eczema caused by mosquito bite and insect bite.

Compared with the prior art, the invention has the following beneficial effects:

1. the preparation method is improved, the treatment effect is ensured, and meanwhile, the formula is simple and the cost is low.

2. The medicine preparation is improved, gel texture and skin feel are fresh and cool, and the medicine preparation can stay and absorb on the surface of skin, so that the active ingredients can directly reach the skin damage, the purposes of bacteriostasis, pain relieving, detumescence and the like are achieved, the medication compliance of patients is improved, and the treatment effect is improved.

Detailed Description

In order to make the technical means, the creation features, the achievement of the purpose and the effect of the present invention easy to understand, the present invention will be further elucidated with reference to the specific embodiments, but the following embodiments are only preferred embodiments of the present invention, not all of them. Based on the examples in the embodiments, those skilled in the art can obtain other examples without making any inventive effort, which fall within the scope of the invention. In the following examples, unless otherwise specified, the methods of operation used were conventional, the equipment used was conventional, and the raw materials used were commercially available, without limiting the present application.

The following raw material sources are exemplary illustrations:

carbomer 974P was purchased from lubo management (Shanghai) limited;

propylene glycol was purchased from Yu Fuchen (Tianjin) chemical company, lot 20200427;

the ethyl hydroxybenzoate was purchased from Shanghai microphone Biochemical technology Co., ltd, batch number C10114068;

triethanolamine was purchased from Shanghai Michelia Biochemical technologies Co., ltd. Under the lot number C10103251.

Example 1

(1) Preparation of a main drug solution: accurately weighing 37g of radix isatidis, 28g of dandelion, 19g of flos caryophylli and 15g of cortex caryophylli, adding 6 times of 50% ethanol, soaking for 7 days, and filtering to obtain filter residues and filtrate;

adding 4 times of 45% ethanol into the filter residue, soaking for 7 days, and filtering to obtain filtrate;

combining the two filtrates to obtain soaking solution for standby.

And adding 8g of borneol and 20g of peppermint oil into the obtained soaking solution, and uniformly stirring to obtain the traditional Chinese medicine antibacterial extract.

(2) Preparation of gel matrix: 3.0g of carbomer 974P and 100.0g of purified water are weighed, carbomer 974P is added into the purified water for multiple times, stirring is carried out while adding, and after complete dissolution, the carbomer 974P is swelled overnight to a shade place, thus obtaining the 3% carbomer 974P matrix.

(3) Preparation of antibacterial liquid: 0.1g of ethylparaben and 10.0g of propylene glycol are weighed, and the ethylparaben is added into the propylene glycol, heated and dissolved, and uniformly mixed to obtain the ethylparaben antibacterial liquid.

(4) Preparation: weighing 40.0g of the gel matrix obtained in the step (2), adding 0.1g of the ethylparaben antibacterial solution obtained in the step (3), stirring while adding, regulating the pH to 6.5-6.8 with triethanolamine, finally adding 50.0g of the main medicine solution obtained in the step (1), and uniformly mixing to obtain the traditional Chinese medicine antibacterial itching-relieving gel.

The results show that: the gel prepared by taking carbomer 974P as a matrix has good uniformity and clarity, contains uniform small bubbles and can be removed by using a vacuum homogenizer in the later production process; using purified water to swell carbomer 974P to obtain uniform stable carbomer 974P matrix, adding auxiliary materials in the later period, and adding main medicine solution after the matrix is stable to obtain stable gel; when propylene glycol is used as a humectant, the ethylparaben can be completely dissolved under the condition of proper heating, and meanwhile, the propylene glycol has similar properties with glycerol, but the viscosity, toxicity and irritation of the propylene glycol are smaller than those of the glycerol; triethanolamine is a common neutralizing agent containing acid polymer gel such as carbomer as pH regulator, and is neutralized with carboxyl of carbomer to form stable preparation.

Example 2

(1) Preparation of a main drug solution: accurately weighing 35g of radix isatidis, 30g of dandelion, 17g of flos caryophylli and 18g of cortex caryophylli, adding 6 times of 50% ethanol, soaking for 7 days, and filtering to obtain filter residues and filtrate;

combining the two filtrates to obtain soaking solution for standby.

And 6g of borneol and 22g of peppermint oil are added into the obtained soaking liquid, and the traditional Chinese medicine antibacterial extracting solution is obtained after uniform stirring.

(2) Preparation of gel matrix: 3.0g of carbomer 974P is weighed, 100.0g of purified water is added into the water for multiple times, the carbomer 974P is stirred while being added, and after complete dissolution, the carbomer 974P is swelled overnight to a shade place, so as to obtain the 3% carbomer 974P matrix.

(4) Preparation: weighing 10g of the gel matrix obtained in the step (2), adding 0.1g of the ethylparaben antibacterial solution obtained in the step (3), stirring while adding, regulating the pH to 6.5-6.8 with triethanolamine, finally adding 50.0g of the main medicine solution obtained in the step (1), and uniformly mixing to obtain the traditional Chinese medicine antibacterial itching-relieving gel.

Example 3

(1) Preparation of a main drug solution: accurately weighing 40g of radix isatidis, 25g of dandelion, 22g of flos caryophylli and 12g of cortex caryophylli, adding 6 times of 50% ethanol, soaking for 7 days, and filtering to obtain filter residues and filtrate;

combining the two filtrates to obtain soaking solution for standby.

And adding 10g of borneol and 18g of peppermint oil into the obtained soaking liquid, and uniformly stirring to obtain the traditional Chinese medicine antibacterial extract.

(3) Preparation of antibacterial liquid: 0.05g of ethylparaben and 10.0g of propylene glycol are weighed, and the ethylparaben is added into the propylene glycol, heated and dissolved, and uniformly mixed to obtain the ethylparaben antibacterial liquid.

(4) Preparation: weighing 50.0g of the gel matrix obtained in the step (2), adding 0.1g of the ethylparaben antibacterial solution obtained in the step (3), stirring while adding, regulating the pH to 6.5-6.8 with triethanolamine, finally adding the main medicine solution obtained in the step (1) to 100.0g, and uniformly mixing to obtain the traditional Chinese medicine antibacterial itching-relieving gel.

Example 4

(1) Preparation of a main drug solution: accurately weighing 30g of radix isatidis, 35g of dandelion, 15g of flos caryophylli and 20g of cortex caryophylli, adding 6 times of 50% ethanol, soaking for 7 days, and filtering to obtain filter residues and filtrate;

combining the two filtrates to obtain soaking solution for standby.

And adding 5g of borneol and 15g of peppermint oil into the obtained soaking solution, and uniformly stirring to obtain the traditional Chinese medicine antibacterial extract.

(4) Preparation: weighing 40.0g of the gel matrix obtained in the step (2), adding 0.05g of the ethylparaben antibacterial solution obtained in the step (3), stirring while adding, regulating the pH to 6.5-6.8 with triethanolamine, finally adding the main medicine solution obtained in the step (1) to 100.0g, and uniformly mixing to obtain the traditional Chinese medicine antibacterial itching-relieving gel.

Example 5

(1) Preparation of a main drug solution: accurately weighing 45g of isatis root, 20g of dandelion, 25g of flos caryophylli and 10g of cortex caryophylli, adding 6 times of 50% ethanol, soaking for 7 days, and filtering to obtain filter residues and filtrate;

combining the two filtrates to obtain soaking solution for standby.

And adding 12g of borneol and 15g of peppermint oil into the obtained soaking liquid, and uniformly stirring to obtain the traditional Chinese medicine antibacterial extract.

(4) Preparation: weighing 40.0g of the gel matrix obtained in the step (2), adding 0.1g of the ethylparaben antibacterial solution obtained in the step (3), stirring while adding, regulating the pH to 6.5-6.8 with triethanolamine, finally adding the main medicine solution obtained in the step (1) to 100.0g, and uniformly mixing to obtain the traditional Chinese medicine antibacterial itching-relieving gel.

Comparative example 1 selection of different gel matrices

The difference from example 1 is that a different gel matrix is chosen, the remainder being the same. Wherein, the step (2) specifically comprises:

(2) Preparation of gel matrix: 2.0g of carbomer 974P is weighed, 100.0g of purified water is added into the water for multiple times, and the carbomer 974P is stirred while being added, and is fully dissolved and swelled overnight at a shade place to obtain 2% carbomer 974P matrix;

weighing 6.7g of xanthan gum and 1000g of water, placing the water at 90 ℃ for heat preservation, adding the xanthan gum into the water for multiple times, stirring while adding, completely dissolving, and swelling overnight at a shade and dark place to obtain 0.67% of xanthan gum matrix;

35g of 2% carbomer 974P matrix and 5g of 0.67% xanthan gum are weighed and evenly mixed to obtain a gel matrix.

The result shows that after the xanthan gum is added into the carbomer 974P matrix, the prepared finished product has better uniformity, fewer bubbles and better clarity, but the PH is more complicated to adjust, and the addition amount of the main medicine is smaller.

Comparative example 2

The difference with the embodiment 1 is that the main medicine quality in the step (1) is changed into 48g of radix isatidis, 15g of dandelion, 28g of flos caryophylli and 8g of cortex caryophylli, and the rest are the same.

Comparative example 3

The difference from example 1 is that the radix Isatidis in step (1) is replaced with rhizoma Smilacis Glabrae, and the rest are the same.

Comparative example 4

The difference from example 1 is that the mass ratio of dandelion, flos caryophylli and cortex caryophylli in step (1) is 18:27:22 (the total weight of dandelion, flos caryophylli and cortex caryophylli is the same as that of example 1), and the rest is the same.

Comparative example 5

The difference from example 1 is that the main ingredient in step (1) does not contain dandelion (replaced by isatis root, flos caryophylli and cortex caryophylli), and the weight ratio of the main ingredient to the cortex caryophylli is the same as that of example 1), and the rest is the same.

Comparative example 6

The difference from example 1 is that the main drug components in step (1) are: 35g of radix isatidis, 25g of dandelion, 15g of flos caryophylli, 15g of cortex caryophylli and 15g of radix sophorae flavescentis, and the rest are the same.

Experimental example

Sensory index

Appearance: yellow uniform gel

Smell: peppermint smell, no other peculiar smell

Stability test

Measured according to the accelerated test method of the disinfection technical Specification (2002 edition).

The experimental method (viscosity parameter setting: rotation speed: 2rpm; temperature: 25 ℃ and torque: 78.3%) at 54 ℃ and 14d was adopted, and the characteristics, pH value and viscosity before and after the stability test were examined with emphasis, and the results showed that other indexes were not significantly changed except that the characteristics were changed into transparent gel (the reason was bubble escape, a vacuum homogenizer was considered in production, and the final characteristics were transparent yellow gel), and the specific results are shown in Table 1.

TABLE 1 gel stability test results Table

Stability tests show that: the traditional Chinese medicine gel has good stability performance in an acceleration test and a bacteriostasis test

TABLE 2 gel bacteriostasis test results table

Antibacterial experiments show that the gel has good antibacterial effect. When the mass parts of the main medicine components are changed, the antibacterial effect is obviously reduced; when the composition of the main medicine is changed and one of the medicines is increased or reduced, the antibacterial effect is greatly reduced.

Finally, it should be noted that the above description is only for illustrating the technical solution of the present invention, and not for limiting the scope of the present invention, and that the simple modification and equivalent substitution of the technical solution of the present invention can be made by those skilled in the art without departing from the spirit and scope of the technical solution of the present invention.

Claims

1. A traditional Chinese medicine gel is characterized in that: the composite material consists of the following components in parts by weight: 10-50 parts of main medicine solution, 10-50 parts of gel matrix, 0.05-0.1 part of antibacterial solution and 0.5-5 parts of pH regulator;

the main medicine solution is prepared from the following components in parts by weight: 35-40 parts of radix isatidis, 25-30 parts of dandelion, 17-22 parts of flos caryophylli, 12-18 parts of cortex caryophylli, 6-10 parts of borneol and 18-22 parts of peppermint oil; the weight ratio of dandelion to flos caryophylli to cortex caryophylli is 4-7:3-5:2-4;

the gel matrix is prepared from carbomer and purified water;

the carbomer is carbomer 974P; the mass ratio of carbomer to purified water is 3:100; the antibacterial liquid is prepared from a bacteriostatic agent and a humectant, wherein the bacteriostatic agent is ethyl hydroxybenzoate; the humectant is propylene glycol; the mass ratio of the bacteriostatic agent to the humectant is 5-20:1000;

the pH regulator is triethanolamine;

the preparation method of the traditional Chinese medicine gel comprises the following steps:

(2) Preparation of gel matrix: swelling carbomer in purified water to prepare a gel matrix;

(3) Preparation of antibacterial liquid: heating and dissolving a bacteriostatic agent in a humectant to prepare a bacteriostatic liquid;

(4) Preparation: taking the formula amount of the gel matrix obtained in the step (2), adding the formula amount of the antibacterial liquid obtained in the step (3), uniformly stirring, adding the formula amount of the pH regulator to regulate the pH, and adding the formula amount of the main medicine solution obtained in the step (1) to obtain the traditional Chinese medicine gel;

the pH in the step (4) is 6.5-6.8;

the conditions of the ethanol extraction in the step (1) are as follows: extracting with ethanol twice, wherein the addition amount of ethanol for the first time is 5-6 times of the total mass of radix Isatidis, herba Taraxaci, flos Caryophylli and cortex Periplocae Radicis, the concentration of ethanol is 50%, and filtering to obtain residue and filtrate 1; extracting the residue with 45% ethanol for the second time, wherein the amount of ethanol is 4-5 times of the mass of the residue, filtering to obtain filtrate 2, and mixing filtrate 1 and filtrate 2 to obtain extractive solution.

2. The method for preparing the traditional Chinese medicine gel according to claim 1, which is characterized by comprising the following steps:

(4) Preparation: and (3) adding the formula amount of the antibacterial liquid obtained in the step (3) into the gel matrix obtained in the step (2), uniformly stirring, adding the formula amount of the pH regulator to regulate the pH, and adding the formula amount of the main medicine solution obtained in the step (1) to obtain the traditional Chinese medicine gel.

3. The preparation method according to claim 2, wherein the step (1) is specifically: soaking radix Isatidis, herba Taraxaci, flos Caryophylli and cortex Periplocae Radicis in ethanol solution at normal temperature, filtering, and collecting residue and filtrate; soaking the filter residue in ethanol solution at normal temperature, and filtering to obtain filtrate; mixing the two filtrates, adding Borneolum Syntheticum and oleum Menthae Dementholatum, and stirring to obtain main medicinal solution.

4. The use of the traditional Chinese medicine gel in claim 1 for preparing medicines for preventing and treating skin discomfort, dermatitis and eczema caused by mosquito bite and insect bite.