CN102641375A - Medicament for treating tinea capitis, tinea pedis, tinea manuum, onychomycosis, tinea corporis and tinea cruris and preparation method thereof - Google Patents
Medicament for treating tinea capitis, tinea pedis, tinea manuum, onychomycosis, tinea corporis and tinea cruris and preparation method thereof Download PDFInfo
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- CN102641375A CN102641375A CN2012100417701A CN201210041770A CN102641375A CN 102641375 A CN102641375 A CN 102641375A CN 2012100417701 A CN2012100417701 A CN 2012100417701A CN 201210041770 A CN201210041770 A CN 201210041770A CN 102641375 A CN102641375 A CN 102641375A
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Abstract
The invention discloses a medicament for treating tinea capitis, tinea pedis, tinea manuum, onychomycosis, tinea corporis and tinea cruris and a preparation method thereof. The medicament is prepared from the following materials according to the optimal weight ratio: impatiens balsamina herb, shrubalthea bark, radix sophorae flavescentis, rhizoma atractylodis, golden cypress, picrorhiza kurroa, chenopodium ambrosioides, sweet wormwood, alums, borax, fructus cnidii, tinea capitis skin, pericarpium zanthoxyli and vinegar. The dosage forms such as powder, lotion, medicinal extract, cream, spray and the like can be prepared by adopting different processes. The medicament is used for treating the various ringworms caused by dermatophyte infection. The medicament is prepared by a pure-traditional-Chinese-medicine formula, does not contain hormone and other western medicines, the medicinal herbs resource is easy to obtain, the application is wide, the curative effect is obvious through continuous clinical research and application for more than 20 years, the toxic and side effects do not occur.
Description
The present invention is a kind of medicine of treating tinea capitis, tinea pedis, the tinea manuum, tinea unguium, tinea corporis, tinea cruris, and it is to use Chinese herbal medicine to be the topical agent that feedstock production forms, and the invention still further relates to the method for preparing of this medicine.
One, technical field:
The present invention is a kind of medicine of treating tinea capitis, tinea pedis, the tinea manuum, tinea unguium, tinea corporis, tinea cruris and preparation method thereof, belongs to the health protection with Chinese medicine medicine field.
Two, background technology
Head, foot, hands, first, body, tinea cruris all belong to the fungal infection dermatoses, and the tinea capitis pathogenic bacterium mainly are achorion, Microsporum ferrugineum, microsporum canis, purple tinea bacterium and trichophyton tonsurans.Foot, hands, first, body, its main source of disease bacterium of tinea cruris are dermatophytess such as trichophyton, acrothesium floccosum, trichophyton gypseum, candida albicans.More than these tinea infect mutually.For seeing, the sickness rate of tinea pedis is the highest more with the child for tinea capitis.Sickness rate is high in south, mine or underwater work and army, and reason is that local environment is sultry, moist and wear air-locked rubber overshoes, bucket footwear, plastic shoes, glove etc. for a long time, cause damp and hot accumulate to steam help the fungi growth breeding.Barber shop, lido, bathing pool, foot washing basin, slippers, bath towel, put foot cloth on the skin and all become the source of infection easily.Again because of these funguses are extremely obstinate, difficulty is killed, thus the normal obstinate of above tinea, the lifelong difficult hysteria that has, and infecting each other among the household, self cross infection, serious harm physical and mental health.
Tinea capitis is divided into tinea alba, tinea favosa, black tinea, and the traditional Chinese medical science is claimed tinea capitis, tinea capitis, thinks that primary disease mainly is that damp and hot the going up of spleen lung steamed scalp, accumulates long-pending infestedly, or dirt is held in hand, and the evil infections of poison such as head, medicated pillow are unclean, haircut form.The tinea pedis traditional Chinese medical science is called tinea pedis, river snail-like blebs, tinea pedis.The title tinea manuum is fungal infection of hand and foot.Tinea unguium is tinea unguium, tinea unguium.Tinea corporis is tinea circinata, Folium Nelumbinis tinea, tinea circinata.Tinea cruris is called inguinals tinea, originates from top, groin, pudendum, crissum and buttocks in the thigh.The common symptom of above tinea all be pruritus unbearably, yellow fluid incrustation or hemorrhage incrustation behind the skin of scratching brokenly, infect the back and suppurate and forms a scab into skin ulcer, touching difficult hysteria.
Western modern medicine is treated above tinea and is adopted medicine for external use such as sulfur ointment, iodine tincture, 10% ice vinegar liquor to soak more, wipes the stupid formic acid liniment of compound recipe outward, or with borate, rivanoli solution, potassium permanganate solution, soak or immersion.Other controls outer being coated with such as the hot liniment in medicine for external use such as the stupid formic acid ointment of compound recipe, unguentum acidi salicylici, salicylate compound tincture, Zinc Undecylenate foot-powder, compound recipe thunder town, clotrimazole cream, miconazole of tinea.
Outer putting on the skin such as No. 1, No. 2 tinea liquid of the many employings of Chinese medicine external curing, econazole, Realgar cream, sebum cream, crazy ointment, Indigo Naturalis cream, tinea ointment, Lithargyrum's cream.
Above Chinese medicine and western medicine external agent, relief of symptoms in various degree, but be difficult to cure.
Consult " the Chinese medicine patent is complete works of " Chinese medicine patent documentation and collect the 278th page; Application number: 9310557.1; Publication number CN1082420A, open day: 94.2.23; Denomination of invention: a kind of curing dermatomycosis looses, and mixes being made into Chinese medicine and western medicine, dermatosiss such as treatment psoriasis, exudative dermatitis, neurodermatitis scabies, beriberi.Application number: 87105078, publication number 1031798, the day for announcing: 890322, denomination of invention: suppress the manufacture method of fungus tinea liquid, formulated with Chinese medicine Radix Rumicis Crispi, Cortex Phellodendri, acetic acid.The 283rd page of application number: 89105071, notification number: 1037654, the day for announcing: 89.12.06, denomination of invention: a kind of compound method of tinea curing medicine water, adopt the Rhizoma Atractylodis Macrocephalae, Cortex cercis chinensis, salicylic acid, stupid formic acid to process, treat various ringworms.The 286th page of application number: 91100294, notification number: 1063412, the day for announcing: 920812, denomination of invention: the manufacturing approach of Yiwohu tinea-curing medicine is mixed and made into by a brood of tiger of Chinese medicine and mineral property Chinese medicine and Western medicine.The 279th page of application number 85104517, notification number: 1007784, the day for announcing: 87.01.28, denomination of invention: a kind of manufacturing approach of treating foot, tinea manuum liquid medicine, prescription is glacial acetic acid, Pericarpium Zanthoxyli, sodium chloride, distilled water.The 282nd page of application number: 89103022, notification number: 1047033, the day for announcing: 90.11.21, denomination of invention: the manufacturing approach of one-time efficacious jiaoqijing: ethanol, water, Chinese medicine, chemical substance manufacturing form.The 282nd page of application number: 89103252; Notification number: 1047451, the day for announcing: 90.12.05, denomination of invention: the manufacturing approach of one-time efficacious ezhangjing; Be sick Chinese medicine and western medicine tincture such as a kind of treatment tinea manuum (the goose palm), tinea palmaris nigra, form by ethanol, water, Chinese medicine, chemical substance manufacturing.284 pages of application numbers 9010344, notification number: 1057783, the day for announcing: the compound method of 92.01.15 denomination of invention treatment body, hands, tinea pedis liquid medicine, form by Radix Sophorae Flavescentis, Cortex Dictamni, Cortex Phellodendri, Rhizoma Arisaematis, the Radix Angelicae Dahuricae, salicylic acid, benzoic acid.The 287th page of application number 91100678, notification number: 1063820, day for announcing 92.08.26, denomination of invention: the manufacturing approach of tinea unguium dissolving cream refers to medicament by formulated external applications of seven flavor botanical herbses such as nine flavor mineral property Chinese medicines, white Flos Impatientis such as Plumbum preparatium.The 287th page of application number: 91100878; Notification number: 1063821; The day for announcing: 92.08.26, denomination of invention: a kind of method for preparing of treating tinea pedis liquid medicine, process by immersions such as Gelsemium elegans Benth., Rhizoma Coptidis, Herba Typhonii gigantei, Semen Strychni, potassium permanganate, the acid of salicylic acid benzene Turbo cornutus Solander, phenol, ethanol.The 288th page of application number 91106738, notification number: 1068038, the day for announcing: 93.01.20, denomination of invention: the prescription of athlete's foot ointment and manufacture method.Composition: treatment such as prednisone, metronidazole, Nystatin, clotrimazole ointment, fluocinonide ointment, Galla Chinensis, Os Sepiae tinea pedis.The 290th page of application number: 92106149, notification number: 1078147, the day for announcing: 93.11.10, denomination of invention: a kind of method for preparing of liquid for treating tinea pedis and foot odour, formulated by Radix Sophorae Flavescentis, Cortex Hibisci Flos Carthami, vinegar essence, glacial acetic acid, Alumen Calamina etc.Medicine for external use such as the more than prescription of tinea such as an invention treatment trick, and JIAOXIAN YICIJING, Compound Flavescent Sophora and Salicylic Acid Powder, its prescription contains western medicine composition more, and curative effect is as one wishes not to the utmost.
The present invention is sheerly Chinese herbal and crude drugs preparations, does not contain hormone, and the medicine source is easy to get, and is applied widely, easy to use, surplus the clinical practice 20 year, constantly observes, research, sums up and form, and is evident in efficacy, without any side effects.
Three, summary of the invention:
The present invention is to be raw material by following medicine and weight proportion thereof, the topical agent that is prepared from:
Herba Impatientis 10-50 part, Cortex Hibisci 10-50 part, Radix Sophorae Flavescentis 10-50 part, Rhizoma Atractylodis 10-50 part, Cortex Phellodendri 10-50 part, Rhizoma Picrorhizae 10-50 part, Herba Chenopodii 10-50 part, Herba Artemisiae Annuae 10-40 part, Alumen 10-60 part, Borax 10-60 part, Fructus Cnidii 10-50 part, Cortex Dictamni 10-50 part, Fructus Zanthoxyli 10-40 part, vinegar 10-60 part.
The weight proportion scope of medicine of the present invention is:
Herba Impatientis 10-40 part, Cortex Hibisci 10-40 part, Radix Sophorae Flavescentis 10-50 part, Rhizoma Atractylodis 10-40 part, Cortex Phellodendri 10-30 part, Rhizoma Picrorhizae 10-50 part, Herba Chenopodii 10-40 part, Herba Artemisiae Annuae 10-40 part, Alumen 10-50 part, Borax 10-50 part, Fructus Cnidii 10-40 part, Cortex Dictamni 10-40 part, Fructus Zanthoxyli 10-30 part, vinegar 10-50 part.
The optimum weight proportioning of pharmaceutical formulation of the present invention is:
40 parts of Herba Impatientis, 40 parts of Cortex Hibiscis, cover 50 parts of ginsengs, 50 parts of Rhizoma Atractylodis, 40 parts of Cortex Phellodendris, 40 parts of Rhizoma Picrorhizae, 40 parts of Herba Chenopodiis, 40 parts of Herba Artemisiae Annuaes, 50 parts in Alumen, 50 parts of Boraxs, 40 parts of Fructus Cnidiis, 50 parts of Cortex Dictamni, 30 parts of Fructus Zanthoxylis, 50 parts of vinegar with mat.
Four, practical implementation method:
(1) method for preparing of powder:
1. with said medicine by optimum weight proportioning preparation, wherein Alumen, the other splendid attire of Borax, vinegar is by patient's own adding when the medication.
2. except that Alumen, Borax, other medicines adopt Exposure to Sunlight or drying room drying.
3. with dried medicine and Alumen, Borax close even, pulverize and be coarser powder powder.
4. powder is divided into 100g, 150g, three kinds of dosage of 200g, is divided in the gauze bag that varies in size, plastic bag is sealed, and per 10 pouch-packaged are a sack, promptly process external decocting lotion.
(2) method for preparing of washing liquid
1. said medicine is prepared by the optimum weight proportioning, wherein the other splendid attire of vinegar treats that the back adds.
2. the crude drug for preparing is closed the drinking water that adds 12 times of amounts in the even dress pot and soaked 24 hours, whenever stirred once at a distance from 8 hours.
3. the medicine diuretic heating that will soak after 24 hours decocted the leaching medicinal liquid 2 hours.
4. medicinal residues are added water once more and decoct 2 hours leaching medicinal liquids for 10 times.
5. with mixing after twice medicinal liquid clarification, the stirring of adding vinegar is closed even, deposition, filtration.
6. will filter the back medicinal liquid branch bottle of packing into, every bottled 500ml adds a cover encapsulation.
(3) pharmaceutical formulation of the present invention also can adopt different process to be prepared into dosage forms such as externally used paste, cream, spray, and more convenient patient uses.
(4) preparation of medicaments method of the present invention has only been narrated powder, washing liquid, and its unguentum, cream, spray preparing process are discussed, but still requires to use the rights protection of this formulation unguentum, cream, spray.
Claims (7)
1. an external used medicine of treating tinea capitis, tinea pedis, the tinea manuum, tinea unguium, tinea corporis, tinea cruris is characterized in that it is the topical agent of being processed by the following weight proportion raw material.
Herba Impatientis 10-50 part, Cortex Hibisci 10-50 part, Radix Sophorae Flavescentis 10-50 part, Rhizoma Atractylodis 10-50 part, Cortex Phellodendri 10-50 part, Rhizoma Picrorhizae 10-50 part, Herba Chenopodii 10-50 part, Herba Artemisiae Annuae 10-40 part, Alumen 10-60 part, Borax 10-60 part, Fructus Cnidii 10-50 part, Cortex Dictamni 10-50 part, Fructus Zanthoxyli 10-40 part, vinegar 10-60 part.
2. the medicine of treatment head according to claim 1, foot, hands, first, body, tinea cruris, wherein the weight proportion of each raw material is:
Herba Impatientis 10-40 part, Cortex Hibisci 10-40 part, Radix Sophorae Flavescentis 10-50 part, Rhizoma Atractylodis 10-40 part, Cortex Phellodendri 10-30 part, Rhizoma Picrorhizae 10-50 part, Herba Chenopodii 10-40 part, Herba Artemisiae Annuae 10-40 part, Alumen 10-50 part, Borax 10-50 part, Fructus Cnidii 10-40 part, Cortex Dictamni 10-40 part, Fructus Zanthoxyli 10-30 part, vinegar 10-50 part.
3. the medicine of treatment head according to claim 1, foot, hands, first, body, tinea cruris, wherein the optimum weight proportioning of each raw material is:
40 parts of Herba Impatientis, 40 parts of Cortex Hibiscis, 50 parts of Radix Sophorae Flavescentiss, 50 parts of Rhizoma Atractylodis, 40 parts of Cortex Phellodendris, 40 parts of Rhizoma Picrorhizae, 40 parts of Herba Chenopodiis, 40 parts of Herba Artemisiae Annuaes, 50 parts in Alumen, 50 parts of Boraxs, 40 parts of Fructus Cnidiis, 50 parts of Cortex Dictamni, 30 parts in Pericarpium Zanthoxyli, 50 parts of vinegar
4. according to the medicine of claim 1,2,3 described treatment foots, hands, first, body, tinea cruris, it is characterized in that said medicament is a said dosage form on any pharmaceutics.
5. the medicament of treatment according to claim 4 head, foot, hands, first, body, tinea cruris, be that weight proportion drying by claim 3 is processed as powder, the gauze bag packing, different deals, plastic bag is sealed, and is respectively applied for above-mentioned tinea.
6. according to the medicine and the weight proportion thereof of claim 1,2,3,4 described treatment heads, foot, hands, first, body, tinea cruris, can adopt different process to process washing liquid, unguentum, cream, spray, more convenient clinical use.
7. use this prescription drug to be prepared into dosage forms such as powder, washing liquid, unguentum, cream, spray, still prescription protection.
The effect of each medicine produces synergism in the pharmaceutical formulation of the present invention; Thereby play the effect of effective treatment head, foot, hands, first, body, tinea cruris; Wherein: Flos Impatientis, this prescription adopt the flowers juice of Herba Impatientis (stem, leaf, flower), Flos Impatientis that epidermophyton rubrum, trichophyton violaceum and epidermophyton inguinale, Kaufman golf epidermophyton are all had inhibitory action.Cortex Hibisci: heat clearing away killing parasites for relieving itching, many externals are the good medicine of treatment skin scabies.Radix Sophorae Flavescentis: heat clearing and damp drying, wind dispelling insecticide, being used for skin pruritus, impetigo, scabies, leprosy, trichomonas vaginitis etc. has good effect.Rhizoma Atractylodis: drying damp and strengthening spleen wind-damp dispelling, these article fragrant is dry strong, and intensive dampness effect is arranged, with the Cortex Phellodendri compatibility be that ermiao san, damp eliminating hot merit are imitated significantly.Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever are used for sore swollen toxin, eczema, pathogenic fire purging poison damp eliminating heat.Herba Chenopodii: cure mainly ascarid, ancylostome, enterobiasis, can suppress the growth of pathogenic dermatophytes, to the skin nonirritant, external curing skin eczema, skin pruritus.Herba Artemisiae Annuae (another name Herba Acroptili repentis, Herba Artemisiae), the nature and flavor bitter cold, clearing away heat and cooling blood is used for skin pruritus, urticaria, seborrheic dermatitis, and tangible antifungic action is arranged.Alumen: worm, the dampness removing to stop itchin of dispelling that detoxify, hemostasis antidiarrheal, the heat clearing away expectorant is used for skin infection, eczema pruritus outward.Borax: the external heat-clearing and toxic substances removing, the detumescence anticorrosion.Fructus Cnidii: warming the kidney to invigorate YANG, cold expelling dispel the wind, removing dampness and killing parasites, are used for pudendum pruritus due to damp pathogen, eczema, scabies, and the external removing dampness and killing parasites is antipruritic.Cortex Dictamni: heat-clearing and toxic substances removing, dehumidifying, antipruritic, be used for the herpes simplex rash, many pus or yellow fluid drench drop, and skin is wet mashed, cards such as skin pruritus.Pericarpium Zanthoxyli (another name Fructus Zanthoxyli):, the warming middle-JIAO to relieve pain parasite killing, these article decoction being used as a lotion has dehumidifying, parasite killing, antipruritic effect.Vinegar: a Bitters, the diffusing stasis of blood detoxifcation of acid temperature, crux phlegm addiction, the yellow carbuncle of subcutaneous ulcer swell, and the surgery topical application of drug is used it more.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100417701A CN102641375A (en) | 2012-02-13 | 2012-02-13 | Medicament for treating tinea capitis, tinea pedis, tinea manuum, onychomycosis, tinea corporis and tinea cruris and preparation method thereof |
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| CN2012100417701A CN102641375A (en) | 2012-02-13 | 2012-02-13 | Medicament for treating tinea capitis, tinea pedis, tinea manuum, onychomycosis, tinea corporis and tinea cruris and preparation method thereof |
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| CN102641375A true CN102641375A (en) | 2012-08-22 |
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| CN2012100417701A Withdrawn CN102641375A (en) | 2012-02-13 | 2012-02-13 | Medicament for treating tinea capitis, tinea pedis, tinea manuum, onychomycosis, tinea corporis and tinea cruris and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550353A (en) * | 2013-10-14 | 2014-02-05 | 刘英琦 | Externally used traditional Chinese medicine liniment for treating tinea cruris on inner thigh |
| CN103735748A (en) * | 2013-12-16 | 2014-04-23 | 张圣坤 | Lotion for sore/ulcer pyogenic infection |
| WO2014071426A1 (en) * | 2012-11-06 | 2014-05-15 | Gl & Partners Og | Alum for treating skin diseases |
| CN104116747A (en) * | 2014-07-03 | 2014-10-29 | 李太玲 | Externally-applied medicine for treating dermatopathy caused by pathogenic fungi and preparation method thereof |
| CN104258271A (en) * | 2014-09-16 | 2015-01-07 | 董云 | Externally-applied traditional Chinese medicine lotion for treating tinea pedis and tinea cruris |
| CN105233144A (en) * | 2015-09-10 | 2016-01-13 | 山东宝来利来生物工程股份有限公司 | Traditional Chinese medicine preparation for treating dermatomycoses of animals and preparation method of traditional Chinese medicine preparation |
| CN105663376A (en) * | 2016-01-16 | 2016-06-15 | 杜志政 | Medicament for treating dermatophytosis and preparation method thereof |
| CN107441255A (en) * | 2017-08-23 | 2017-12-08 | 陈居旭 | A kind of Chinese medicine composition for treating skin eczema and skin tinea |
| CN114099632A (en) * | 2021-12-01 | 2022-03-01 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | Traditional Chinese medicine fermentation product and application thereof in preparation of medicine for treating fungal infection skin diseases |
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2012
- 2012-02-13 CN CN2012100417701A patent/CN102641375A/en not_active Withdrawn
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014071426A1 (en) * | 2012-11-06 | 2014-05-15 | Gl & Partners Og | Alum for treating skin diseases |
| CN103550353A (en) * | 2013-10-14 | 2014-02-05 | 刘英琦 | Externally used traditional Chinese medicine liniment for treating tinea cruris on inner thigh |
| CN103735748A (en) * | 2013-12-16 | 2014-04-23 | 张圣坤 | Lotion for sore/ulcer pyogenic infection |
| CN104116747A (en) * | 2014-07-03 | 2014-10-29 | 李太玲 | Externally-applied medicine for treating dermatopathy caused by pathogenic fungi and preparation method thereof |
| CN104258271A (en) * | 2014-09-16 | 2015-01-07 | 董云 | Externally-applied traditional Chinese medicine lotion for treating tinea pedis and tinea cruris |
| CN105233144A (en) * | 2015-09-10 | 2016-01-13 | 山东宝来利来生物工程股份有限公司 | Traditional Chinese medicine preparation for treating dermatomycoses of animals and preparation method of traditional Chinese medicine preparation |
| CN105233144B (en) * | 2015-09-10 | 2018-12-25 | 山东宝来利来生物工程股份有限公司 | A kind of Chinese materia medica preparation and preparation method thereof for treating animal fungal dermatoses |
| CN105663376A (en) * | 2016-01-16 | 2016-06-15 | 杜志政 | Medicament for treating dermatophytosis and preparation method thereof |
| CN107441255A (en) * | 2017-08-23 | 2017-12-08 | 陈居旭 | A kind of Chinese medicine composition for treating skin eczema and skin tinea |
| CN114099632A (en) * | 2021-12-01 | 2022-03-01 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | Traditional Chinese medicine fermentation product and application thereof in preparation of medicine for treating fungal infection skin diseases |
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Application publication date: 20120822 |