CN113105475B - 布鲁顿氏酪氨酸激酶的抑制剂及其使用方法 - Google Patents
布鲁顿氏酪氨酸激酶的抑制剂及其使用方法 Download PDFInfo
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- CN113105475B CN113105475B CN202110404344.9A CN202110404344A CN113105475B CN 113105475 B CN113105475 B CN 113105475B CN 202110404344 A CN202110404344 A CN 202110404344A CN 113105475 B CN113105475 B CN 113105475B
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Classifications
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- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| CN201680072147.9A CN109071563A (zh) | 2015-12-10 | 2016-12-09 | 布鲁顿氏酪氨酸激酶的抑制剂及其使用方法 |
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| CN201680072147.9A Pending CN109071563A (zh) | 2015-12-10 | 2016-12-09 | 布鲁顿氏酪氨酸激酶的抑制剂及其使用方法 |
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| JP3003987B2 (ja) | 1996-08-20 | 2000-01-31 | 篠▲崎▼ 晴彦 | 合成樹脂管内に施設されるケーブルの支持装置及びそのケーブル支持具を取付ける方法 |
| JO3793B1 (ar) * | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | مثبطات تيروزين كاينيز بروتون وأساليب استخدامها |
| JO3794B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
| EP3596087A1 (en) * | 2017-03-15 | 2020-01-22 | Janssen Sciences Ireland Unlimited Company | Methods of selective aryl- and heteroaryl-nitrogen bond formation |
| CN110028525A (zh) * | 2018-04-13 | 2019-07-19 | 太仓运通新材料科技有限公司 | 一种2-氟磷酰基乙酸三乙酯的合成方法 |
| JP7449242B2 (ja) | 2018-05-17 | 2024-03-13 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的ペプチダーゼ３０（ｕｓｐ３０）阻害剤として有用な縮合二環化合物 |
| JP7530889B2 (ja) * | 2018-10-05 | 2024-08-08 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ３０（ｕｓｐ３０）阻害剤として作用する縮合ピロリン |
| AU2019395201A1 (en) | 2018-12-06 | 2021-05-20 | Daiichi Sankyo Company, Limited | Cycloalkane-1,3-diamine derivative |
| WO2021043200A1 (zh) * | 2019-09-04 | 2021-03-11 | 正大天晴药业集团股份有限公司 | 一种喹唑啉衍生物的制备方法及其结晶 |
| CN111635368B (zh) * | 2020-06-12 | 2021-06-29 | 东莞市东阳光仿制药研发有限公司 | 一种胺化合物的制备方法 |
| CN114478346A (zh) * | 2021-12-31 | 2022-05-13 | 和鼎（南京）医药技术有限公司 | 一种制备乌帕替尼中间体的方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2006118749A1 (en) * | 2005-05-04 | 2006-11-09 | Janssen Pharmaceutica, N.V. | Thia-tetraazaacenaphthylene kinase inhibitors |
| WO2007092879A2 (en) * | 2006-02-08 | 2007-08-16 | Janssen Pharmaceutica, N.V. | Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors |
| WO2010056875A1 (en) * | 2008-11-12 | 2010-05-20 | Cgi Pharmaceuticals, Inc. | Pyridazinones and their use as btk inhibitors |
| WO2015089337A1 (en) * | 2013-12-11 | 2015-06-18 | Biogen Idec Ma Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
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| DE3112415A1 (de) | 1981-03-28 | 1982-10-07 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur chlorierung von cyclischen amiden und cyclischen vinylogen amiden |
| US5430150A (en) | 1992-12-16 | 1995-07-04 | American Cyanamid Company | Retroviral protease inhibitors |
| US5300478A (en) | 1993-01-28 | 1994-04-05 | Zeneca Limited | Substituted fused pyrazolo compounds |
| JP2008513463A (ja) | 2004-09-15 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チアゾロピリジンキナーゼ阻害剤 |
| AU2006278627B2 (en) | 2005-08-08 | 2011-08-18 | Janssen Pharmaceutica, N.V. | Thiazolopyrimidine kinase inhibitors |
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| US9371567B2 (en) | 2010-04-19 | 2016-06-21 | The Translational Genomics Research Institute | Methods and kits to predict therapeutic outcome of BTK inhibitors |
| US20140249105A1 (en) | 2011-07-25 | 2014-09-04 | Diverchim | Novel ceramide analogues, processes for preparing same and uses thereof |
| CA2901510C (en) | 2013-03-15 | 2022-11-29 | Janssen Pharmaceutica Nv | Processes for preparing ibrutinib derivatives and intermediates thereof |
| JO3794B1 (ar) * | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
| JO3793B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | مثبطات تيروزين كاينيز بروتون وأساليب استخدامها |
| WO2018103060A1 (en) | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
| WO2018103058A1 (en) | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006118749A1 (en) * | 2005-05-04 | 2006-11-09 | Janssen Pharmaceutica, N.V. | Thia-tetraazaacenaphthylene kinase inhibitors |
| WO2007092879A2 (en) * | 2006-02-08 | 2007-08-16 | Janssen Pharmaceutica, N.V. | Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors |
| WO2010056875A1 (en) * | 2008-11-12 | 2010-05-20 | Cgi Pharmaceuticals, Inc. | Pyridazinones and their use as btk inhibitors |
| WO2015089337A1 (en) * | 2013-12-11 | 2015-06-18 | Biogen Idec Ma Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
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| US20170283431A1 (en) | 2017-10-05 |
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| TW201734020A (zh) | 2017-10-01 |
| JP7110097B2 (ja) | 2022-08-01 |
| JO3793B1 (ar) | 2021-01-31 |
| AR107041A1 (es) | 2018-03-14 |
| AU2016366546A1 (en) | 2018-05-31 |
| UY37016A (es) | 2017-06-30 |
| JP2022141851A (ja) | 2022-09-29 |
| BR112018011525A2 (pt) | 2018-11-21 |
| JP2018536684A (ja) | 2018-12-13 |
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| AU2016366546B2 (en) | 2021-08-12 |
| IL259862A (en) | 2018-07-31 |
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| IL259862B (en) | 2022-04-01 |
| EP3386992A1 (en) | 2018-10-17 |
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| CN113105475A (zh) | 2021-07-13 |
| US10822348B2 (en) | 2020-11-03 |
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| EA038031B1 (ru) | 2021-06-25 |
| US20190284203A1 (en) | 2019-09-19 |
| US10800792B2 (en) | 2020-10-13 |
| JP7471348B2 (ja) | 2024-04-19 |
| CN109071563A (zh) | 2018-12-21 |
| BR112018011525B1 (pt) | 2023-10-24 |
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