CN113041190A - Antioxidant composition, preparation method and application - Google Patents
Antioxidant composition, preparation method and application Download PDFInfo
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- CN113041190A CN113041190A CN202110298168.5A CN202110298168A CN113041190A CN 113041190 A CN113041190 A CN 113041190A CN 202110298168 A CN202110298168 A CN 202110298168A CN 113041190 A CN113041190 A CN 113041190A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
Abstract
The invention relates to the field of skin care products, and particularly discloses an antioxidant composition, a preparation method and application, wherein the antioxidant composition comprises the following components in percentage by mass: wisteria extract: 0.5 to 5.0 percent; isoprene glycol: 0.5 to 3.0 percent. The isoprene glycol adopted by the invention can temporarily open the lipid between the cutin layers of the skin, so that more water-soluble components which are difficult to enter the skin can enter the skin. Can improve the penetration effect of water soluble components into stratum corneum, and enhance the use effect of cosmetic. The wisteria extract contains more phenolic substances and flavonoid compounds, and also contains volatile oil, allantoin, allantoic acid, heptacosane, dihydrostigmasterol and other components, can clear free radicals in the initiation stage of an oxidation reaction chain, can directly capture free radicals in the free radical reaction chain, and has double effects of preventing and breaking the chain. And the wisteria extract is easy to obtain and low in price.
Description
Technical Field
The invention relates to the field of skin care products, in particular to an antioxidant composition, a preparation method and application.
Background
Aging is a direct manifestation of functional aging of the human body and is a natural process. The human cells are in continuous contact with the outside, including respiration, light, pollution, etc., so that free radicals are continuously generated in the human body. Free radicals can damage human cells, causing numerous diseases, most of which are associated with the production of excess free radicals, cancer, aging or other diseases. The formation of lipofuscin, the mutation of mitochondrial DNA, the induction of apoptosis and the synthesis of protein are deeply influenced from the generation to the quenching of free radicals, and the relationship between the free radicals and the aging is close. Therefore, the antioxidation is a hot topic in the beauty industry in recent years, and the antioxidation is short for antioxidation free radicals, namely the removal of excessive free radicals. The activity of antioxidant enzymes in the human body decreases with the increasing age, so that it is required to help reduce the generation of free radicals by supplementing antioxidant substances, and the use of antioxidant cosmetics is one of effective means for preventing aging.
At present, the antioxidant cosmetics on the market are expensive in price and mostly have poor antioxidant effect, so that the problem of seeking for preparing the antioxidant cosmetics by using raw materials with obvious antioxidant effect and high price for people is urgent to solve.
Disclosure of Invention
The invention aims to provide an antioxidant composition to solve the problems of unobvious antioxidant effect and high price of the antioxidant composition in the current market.
In order to achieve the purpose, the invention adopts the following technical scheme:
an antioxidant composition, comprising by mass percent: wisteria extract: 0.5 to 5.0 percent;
isoprene glycol: 0.5 to 3.0 percent;
the preparation method of the wisteria extract comprises the following steps:
the first step is as follows: cleaning the sorted wisteria florbunda, placing the cleaned wisteria florda in a sterilized stainless steel tray, spreading the cleaned wisteria florda, and freeze-drying the cleaned wisteria florda for 16 hours;
the second step is that: grinding the freeze-dried wisteria flowers obtained in the step one by using a grinder, and sieving by using a 100-mesh sieve;
the third step: adding wisteria, ethanol and water in a weight ratio of 1:2:1 into a stainless steel heating reflux pot, starting heating, setting the temperature to 98 ℃, carrying out reflux cooking for 2 hours, then cooling, naturally cooling to 50 ℃, filtering, pouring out a first decoction, remaining residues in the pot, repeating the decocting step of the first decoction for 2 hours, pouring out a second decoction, and combining the first and second decoctions to obtain an extracting solution;
the fourth step: filtering the extracting solution by using 200-mesh clean gauze, after filtering, transferring the filtrate into a rotary evaporator for vacuumizing, setting the temperature at 62 ℃, distilling at low temperature, adding butanediol equivalent to the filtrate when the filtrate is distilled to be 20 percent of the rest, and uniformly stirring to obtain a mixed solution;
the fifth step: transferring the mixed solution to a rotary evaporator in batches, vacuumizing, setting the temperature to 58 ℃, and continuously steaming the rest ethanol to obtain the wisteria floribunda extract.
Further, the antioxidant composition further comprises an emulsifier, wherein the emulsifier comprises one or more of polyglycerol-10 dipalmitate, hydrogenated lecithin, steareth-2, steareth-21, potassium cetyl phosphate, ceteareth-20, glyceryl stearate, methylglucose sesquistearate, PEG-20 methylglucose sesquistearate, polysorbate-60, polysorbate-20, PEG-40 hydrogenated castor oil.
Further, the antioxidant composition also comprises a thickening agent, wherein the thickening agent comprises one or more of hydroxyethyl cellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate cross-linked polymer-6, ammonium acryloyldimethyl taurate/VP copolymer, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and agarose.
Further, the antioxidant composition further comprises an emollient comprising one or more of cetostearyl alcohol, squalane, hydrogenated polydecene, neopentyl glycol diheptanoate, ethylhexyl palmitate, polydimethylsiloxane, cyclomethicone, octyl methicone, glycerol tri (ethyl hexanoate), pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, mineral oil, prinsepia utilis royle oil, octyldodecanol, jojoba seed oil, grape seed oil, isopropyl myristate, phenyl methicone, shea butter.
Further, the antioxidant composition also comprises a humectant, wherein the humectant comprises one or more of glycerol, butanediol, 1, 3-propylene glycol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propylene glycol, hydroxyethyl urea, sodium polyglutamate, bis-PEG-18 methyl ether dimethylsilane, panthenol, levan and trehalose.
Further, the antioxidant composition further comprises a skin conditioner, wherein the skin conditioner comprises one or more of bisabolol, tocopherol (vitamin E), beta-glucan, niacinamide, biogum-1, sodium polyaspartate, glycerol glucoside, dipotassium glycyrrhizinate, glutathione, matrine, corn gluten amino acids, purslane extract, carnosine, acetyl chitosamine, madecassoside, sodium polyglutamate, lactobacillus fermentation lysate, and aloe vera leaf juice.
Further, the antioxidant composition also comprises a pH regulator, wherein the pH regulator comprises one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid and sodium citrate.
Further, the antioxidant composition further comprises a preservative, wherein the preservative comprises one or more of methyl hydroxybenzoate, propyl hydroxybenzoate, chlorphenesin, phenoxyethanol, ethylhexyl glycerol, hexamidine di (isethionate) salt, and benzyl alcohol.
A second object of the present invention is to provide a method for preparing the antioxidant composition as described above, which comprises the step of mixing the components of the antioxidant composition.
The third purpose of the invention is to provide the application of the antioxidant composition in skin care products, wherein the skin care products comprise water-type skin care products, gel-type skin care products, emulsion-type skin care products or cream-type skin care products.
The invention has the beneficial effects that:
the invention provides an antioxidant composition, which comprises the following components in percentage by mass: wisteria extract: 0.5 to 5.0 percent; isoprene glycol: 0.5 to 3.0 percent. The invention reasonably mixes the wisteria extract and the isoamyl glycol according to a specific proportion to obtain the antioxidant composition which can be applied to cosmetics. Wherein the isoprene glycol temporarily opens lipids in the stratum corneum of the skin, thereby allowing more of the water-soluble components that are not accessible to the skin. Can improve the penetration effect of water soluble components into stratum corneum, and enhance the use effect of cosmetic. The wisteria extract contains more phenolic substances and flavonoid compounds, and also contains volatile oil, allantoin, allantoic acid, heptacosane, dihydrostigmasterol and other components, can clear free radicals in the initiation stage of an oxidation reaction chain, can directly capture free radicals in the free radical reaction chain, and has double effects of preventing and breaking the chain. And the wisteria extract is easy to obtain and low in price. Under the compound scheme provided by the invention, the isoprene glycol can promote the transdermal absorption of the wisteria florbunda extract and enhance the effect of the wisteria florda extract on scavenging free radicals and resisting oxidation. Compared with the existing antioxidant cosmetics, the antioxidant composition to be protected has more excellent antioxidant effect and is priced to the relatives.
Detailed Description
The invention provides an antioxidant composition and a preparation method and application thereof. In order that the invention may be more readily understood, reference will now be made to the following more particular description of the invention, examples of which are set forth below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. These embodiments are provided so that this disclosure will be thorough and complete. The various starting materials used in the examples are, unless otherwise indicated, conventional commercial products.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The numerical values set forth in the examples of the present invention are approximations, not necessarily values. All values within the error range may be included without limiting to the specific values disclosed in the embodiments of the present invention, where the error or experimental conditions allow.
The numerical ranges disclosed in the examples of the present invention are intended to indicate the relative amounts of the components in the mixture and the ranges of temperatures or other parameters recited in the other method examples.
The invention provides an antioxidant composition, which comprises the following components in percentage by mass:
wisteria extract: 0.5 to 5.0 percent;
isoprene glycol: 0.5 to 3.0 percent.
In this embodiment, the antioxidant composition comprises a wisteria extract and isoprene glycol.
The wisteria floribunda (WISTERIA SINENSIS) flower extract contains more phenolic substances and flavonoid compounds, and also contains volatile oil, allantoin, allantoic acid, heptacosane, dihydrostigmasterol and other components, can clear free radicals in an oxidation reaction chain initiation stage, can directly capture free radicals in a free radical reaction chain, and has double effects of preventing and breaking the chain. Wisteria is a common traditional Chinese medicine, is distributed in all provinces of northwest China, North China and Yangtze river watershed, and is easy to obtain and low in price.
The isoprene glycol is an amphiphilic molecular structure, has good skin-friendly property, and can temporarily open lipid between cuticles of the skin, so that more water-soluble components which are difficult to enter the skin can enter the skin. Can improve the penetration effect of water soluble components into stratum corneum, and enhance the use effect of cosmetic.
The preparation method of the wisteria extract comprises the following steps:
the first step is as follows: cleaning the sorted wisteria florbunda, placing the cleaned wisteria florda in a sterilized stainless steel tray, spreading the cleaned wisteria florda, and freeze-drying the cleaned wisteria florda for 16 hours;
the second step is that: grinding the freeze-dried wisteria flowers obtained in the step one by using a grinder, and sieving by using a 100-mesh sieve;
the third step: adding wisteria, ethanol and water in a weight ratio of 1:2:1 into a stainless steel heating reflux pot, starting heating, setting the temperature to 98 ℃, carrying out reflux cooking for 2 hours, then cooling, naturally cooling to 50 ℃, filtering, pouring out a first decoction, remaining residues in the pot, repeating the decocting step of the first decoction for 2 hours, pouring out a second decoction, and combining the first and second decoctions to obtain an extracting solution;
the fourth step: filtering the extracting solution by using 200-mesh clean gauze, after filtering, transferring the filtrate into a rotary evaporator for vacuumizing, setting the temperature at 62 ℃, distilling at low temperature, adding butanediol equivalent to the filtrate when the filtrate is distilled to be 20 percent of the rest, and uniformly stirring to obtain a mixed solution;
the fifth step: transferring the mixed solution to a rotary evaporator in batches, vacuumizing, setting the temperature to 58 ℃, and continuously steaming the rest ethanol to obtain the wisteria floribunda extract.
In a further embodiment of the present invention, the antioxidant composition further comprises 0.1-5.0% of an emulsifier, the emulsifier comprises one or more of hydroxyethylcellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate/VP copolymer, ammonium acryloyldimethyl taurate/behenyl alcohol polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, TAMARINDUS INDICA seed polysaccharide, acrylic acid/C10-30 alkanol acrylate crosspolymer, agarose.
In a further embodiment of the present invention, the antioxidant composition further comprises 0.1-2.0% of a thickener comprising one or more of hydroxyethylcellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate/VP copolymer, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, TAMARINDUS INDICA seed polysaccharide, acrylic acid/C10-30 alkanol acrylate crosspolymer, agarose.
In a further embodiment of the present invention, the antioxidant composition further comprises 1.0-30.0% of an emollient comprising one or more of cetostearyl alcohol, squalane, hydrogenated polydecene, neopentyl glycol diheptanoate, ethylhexyl palmitate, dimethicone, cyclomethicone, octyl methicone, glycerol tri (ethyl hexanoate), pentaerythritol tetra (ethyl hexanoate), isononyl isononanoate, mineral oil, prinus utilis (PRINSEPIA UTILIS) oil, octyldodecanol, jojoba (simdsia CHINENSIS) seed oil, grape (VITIS VINIFERA) seed oil, isopropyl myristate, phenyl methicone, BUTYROSPERMUM PARKII (butyphylla PARKII) tallow oil.
In a further embodiment of the present invention, the antioxidant composition further comprises 5.0-20.0% of a humectant comprising one or more of glycerin, butylene glycol, 1, 3-propanediol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propanediol, hydroxyethyl urea, sodium polyglutamate, bis-PEG-18 methyl ether dimethylsilane, panthenol, levan, trehalose.
In a further embodiment of the present invention, the antioxidant composition further comprises 3.0-10.0% of a skin conditioning agent comprising one or more of bisabolol, tocopherol (vitamin E), β -glucan, niacinamide, bioglycan-1, sodium polyaspartate, glycerol glucoside, dipotassium glycyrrhizinate, glutathione, matrine, corn gluten amino acids, purslane (PORTULACA OLERACEA) extract, carnosine, acetyl chitosamine, madecassoside, sodium polyglutamate, lactic acid bacteria fermentation lysate, ALOE vera (ALOE BARBADENSIS) leaf juice.
In a further embodiment of the present invention, the antioxidant composition further comprises 0.1-0.6% of a pH adjusting agent, wherein the pH adjusting agent comprises one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid, and sodium citrate.
In a further embodiment of the present invention, the antioxidant composition further comprises 0.1-1.0% of a preservative comprising one or more of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, ethylhexylglycerin, hexamidine bis (isethionate), benzyl alcohol.
In a further embodiment of the present invention, the antioxidant composition further comprises a solvent, such as water.
According to the invention, the wisteria extract and the isoprene glycol are reasonably mixed according to a specific proportion to obtain the antioxidant composition which can be applied to cosmetics. Wherein the isoprene glycol temporarily opens lipids in the stratum corneum of the skin, thereby allowing more of the water-soluble components that are not accessible to the skin. Can improve the penetration effect of water soluble components into stratum corneum, and enhance the use effect of cosmetic. The wisteria extract contains more phenolic substances and flavonoid compounds, and also contains volatile oil, allantoin, allantoic acid, heptacosane, dihydrostigmasterol and other components, can clear free radicals in the initiation stage of an oxidation reaction chain, can directly capture free radicals in the free radical reaction chain, and has double effects of preventing and breaking the chain. And the wisteria extract is easy to obtain and low in price. Under the compound scheme provided by the invention, the isoprene glycol can promote the transdermal absorption of the wisteria florbunda extract and enhance the effect of the wisteria florda extract on scavenging free radicals and resisting oxidation. Compared with the existing antioxidant cosmetics, the antioxidant composition to be protected has more excellent antioxidant effect and is priced to the relatives.
The whitening composition provided by the invention can be applied to various product forms of whitening cosmetics, and has the characteristics of simple preparation method, wide application and capability of meeting market demands.
In another aspect, the present invention also provides a method for preparing an antioxidant composition, which comprises the step of mixing the components of the antioxidant composition.
The invention also provides the application of the antioxidant composition in skin care products, wherein the skin care products comprise water-type skin care products, gel-type skin care products, emulsion-type skin care products or cream-type skin care products.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Embodiments of the present invention will be described in detail below with reference to examples 1 to 3 and comparative examples 1 to 3, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Examples 1-3 and comparative examples 1-3 provide an antioxidant essence, which comprises the following raw materials in parts by weight as shown in table 1:
TABLE 1
The preparation method comprises the following steps:
(1) accurately weighing various raw materials in the formula, and placing the raw materials in a clean and sterilized vessel;
(2) adding phase A raw materials (water, carbomer, sodium polyglutamate, methyl hydroxybenzoate, butanediol and glycerol) into a vacuum emulsifying pot, stirring, heating to 80-85 deg.C, stirring, and keeping the temperature for use;
(3) adding phase B raw materials (steareth-2, steareth-21, squalane, bisabolol and octyl polymethylsiloxane) into an oil pan, stirring and heating to 80-85 ℃, fully and uniformly stirring, and keeping the temperature for later use;
(4) pumping the phase B raw material into a vacuum emulsifying pot, mixing and stirring uniformly, homogenizing and emulsifying for 5-8 minutes, stirring uniformly, stirring at constant temperature for defoaming for 10 minutes, and cooling;
(5) cooling to below 40 deg.C, adding C phase raw materials (tocopherol (vitamin E), erythritol, arginine, corn gluten amino acids, herba Portulacae extract, caulis et folium wisteria extract and/or isoprene glycol), stirring, and cooling;
(6) cooling to below 35 deg.C, adding D phase material (phenoxyethanol), stirring, discharging, and standing;
(7) after the inspection is qualified, filling, packaging and code spraying are carried out;
(8) and warehousing after the inspection is qualified.
Test example I, physical and chemical index detection
And testing the physicochemical indexes of the antioxidant essence prepared according to QB/T2660. The results are as follows:
1. appearance: white or yellowish translucent mucus.
2. pH value: 5.5-6.8.
3. And (3) investigating heat resistance stability: keeping the temperature at (40 +/-1) ℃ for 24h, and ensuring that no obvious character difference exists between the temperature after the temperature is restored to the room temperature and the temperature before the test, so that the product is qualified.
4. And (3) cold resistance stability investigation: keeping the temperature of minus 5 ℃ to minus 10 ℃ for 24h, and having no obvious character difference after the temperature is restored to the room temperature and before the test, and being qualified.
Test example two, application Performance test
1) And (3) product safety test:
the skin care compositions obtained in examples and comparative examples were subjected to a human patch test according to the method described in technical specification for cosmetic safety (2015 edition).
The experimental population is as follows: total 36, 30 women, 6 men, age 21-59, 6 per group, composite subject volunteer enrollment criteria;
the test method comprises the following steps: the selection area is not more than 50mm2Of a depth of about 1mmAdding about 0.020-0.025ml of the tested substance into a proper spot tester by a closed spot test method; the plaque test device is pasted on the curved side of the forearm of a subject, the subject is removed after 24h, the skin reaction is observed for 0.5h, 24h and 48h after the removal respectively, and the result is recorded according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
And (3) test results: the 36 subjects scored 0 at 3 observation time points 0.5h, 24h, 48h after removal of the patch (negative response).
2) And (3) product efficacy test:
and (3) carrying out efficacy tests on the prepared antioxidant essence, including skin texture tests and skin wrinkle resistance tests, wherein the specific scheme is as follows:
skin texture test
(1) Taking the antioxidant essence of examples 1-3 and comparative examples 1-3.
(2) The left and right cheekbones of the face, the left and right cheeks at the intersection of the nose tip and the pupil, and the left and right sides at the intersection of the temple and the mouth corner of the subject were selected as the test areas.
(3) Skin texture was first determined by a technician using a Skin image analysis system (Skin visualizer SV600) at the experimental site prior to application of the example and comparative cosmetics five times per spot and averaged.
(4) Subjects after four weeks of continuous use of the example or comparative example cosmetics, Skin texture was tested using the Skin image analysis system (Skin visualizer SV 600).
(5) The skin texture change pattern of the example and comparative example cosmetics was analyzed by counting the number of test sites of the subjects and analyzing the change pattern of the skin texture (each subject was measured by the same technician each time).
3) Anti-wrinkle experiment on human skin
The anti-wrinkle test of human skin is the most direct method for testing the anti-wrinkle effect.
The changes in the elasticity values of the applied part were measured by a test person group using the example and comparative cosmetics and then using a skin elasticity tester (current meter dual MPA580) under the direction of the skilled person (each subject was measured by the same skilled person each time).
(1) Take the example and comparative example cosmetics.
(2) The left and right cheekbones of the face, the left and right cheeks at the intersection of the nose tip and the pupil, and the left and right sides at the intersection of the temple and the mouth corner of the subject were selected as the test areas.
(3) The gel is applied twice a day in the morning and at night, and the photo before application is used as a control. During the experiment, the subject was unable to apply any other cosmetic.
(4) After the subjects continued to use the example and comparative example cosmetics for four weeks, the skin elasticity values before and after use were counted.
(5) And counting the values measured at each time of the experimental part of the subject, and analyzing the skin elasticity change rule of the subject to evaluate the skin elasticity change condition of the subject.
The test population: 60 wrinkled persons with the average age of 35-45 years old. Among them, 20 men and 40 women had no damage to their skin. Each example and comparative example had 10 subjects.
After four weeks (28 days) of use of the product, the data are shown in tables 2 and 3.
TABLE 2
TABLE 3
The examples are that the wisteria extract and the isoamyl glycol are added in different proportions; comparative example 1 was a control blank with isoprene glycol added, comparative example 2 was a control blank with wisteria flower extract added. As shown in tables 2 and 3, from the test results, it can be seen that: the skin elasticity and texture improvement effect was general after 4 weeks of use in the subjects using comparative examples 1 to 3, while the skin elasticity and texture improvement effect was significant after 4 weeks of use in the subjects using examples 1 to 3, indicating that the antioxidant effect of the product was significantly improved. After the analysis of instrument test data, the skin elasticity and texture are obviously improved after the composition is used for 4 weeks, which shows that the synergistic effect of the wisteria extract and an isoprene glycol product is obvious and is obviously better than that of singly using the wisteria extract or the isoprene glycol.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. An antioxidant composition is characterized by comprising the following components in percentage by mass:
wisteria extract: 0.5 to 5.0 percent;
isoprene glycol: 0.5 to 3.0 percent;
the preparation method of the wisteria extract comprises the following steps:
the first step is as follows: cleaning the sorted wisteria florbunda, placing the cleaned wisteria florda in a sterilized stainless steel tray, spreading the cleaned wisteria florda, and freeze-drying the cleaned wisteria florda for 16 hours;
the second step is that: grinding the freeze-dried wisteria flowers obtained in the step one by using a grinder, and sieving by using a 100-mesh sieve;
the third step: adding wisteria, ethanol and water in a weight ratio of 1:2:1 into a stainless steel heating reflux pot, starting heating, setting the temperature to 98 ℃, carrying out reflux cooking for 2 hours, then cooling, naturally cooling to 50 ℃, filtering, pouring out a first decoction, remaining residues in the pot, repeating the decocting step of the first decoction for 2 hours, pouring out a second decoction, and combining the first and second decoctions to obtain an extracting solution;
the fourth step: filtering the extracting solution by using 200-mesh clean gauze, after filtering, transferring the filtrate into a rotary evaporator for vacuumizing, setting the temperature at 62 ℃, distilling at low temperature, adding butanediol equivalent to the filtrate when the filtrate is distilled to be 20 percent of the rest, and uniformly stirring to obtain a mixed solution;
the fifth step: transferring the mixed solution to a rotary evaporator in batches, vacuumizing, setting the temperature to 58 ℃, and continuously steaming the rest ethanol to obtain the wisteria floribunda extract.
2. The antioxidant composition of claim 1, further comprising an emulsifier comprising one or more of polyglyceryl-10 dipalmitate, hydrogenated lecithin, steareth-2, steareth-21, potassium cetyl phosphate, ceteth-20, glyceryl stearate, methylgluco-sesquistearate, PEG-20 methylgluco-sesquistearate, polysorbate-60, polysorbate-20, PEG-40 hydrogenated castor oil.
3. The antioxidant composition of claim 1, further comprising a thickener comprising one or more of hydroxyethylcellulose, carbomer, xanthan gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, ammonium acryloyldimethyl taurate/VP copolymer, ammonium acryloyldimethyl taurate/behenyl polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, tamarind seed polysaccharide, acrylic acid/C10-30 alkanol acrylate crosspolymer, agarose.
4. The antioxidant composition of claim 1, further comprising an emollient comprising one or more of cetostearyl alcohol, squalane, hydrogenated polydecene, neopentyl glycol diheptanoate, ethylhexyl palmitate, polydimethylsiloxane, cyclomethicone, octyl methicone, glycerol tri (ethylhexanoate), pentaerythritol tetra (ethylhexanoate), isononyl isononanoate, mineral oil, prinsepia utilis oil, octyl dodecanol, jojoba seed oil, grape seed oil, isopropyl myristate, phenyl methicone, shea butter oil.
5. The antioxidant composition of claim 1, further comprising a humectant comprising one or more of glycerin, butylene glycol, 1, 3-propanediol, betaine, dipropylene glycol, glyceryl polyether-26, erythritol, methyl propanediol, hydroxyethyl urea, sodium polyglutamate, bis-PEG-18 methyl ether dimethylsilane, panthenol, levan, trehalose.
6. The antioxidant composition of claim 1, further comprising a skin conditioner comprising one or more of bisabolol, tocopherol (vitamin E), β -glucan, niacinamide, bioglycan-1, sodium polyaspartate, glycerol glucoside, dipotassium glycyrrhizinate, glutathione, matrine, corn gluten amino acids, purslane extract, carnosine, acetyl chitosamine, madecassoside, sodium polyglutamate, lactobacillus fermentation lysate, aloe vera leaf juice.
7. The antioxidant composition of claim 1, further comprising a pH adjusting agent comprising one or more of triethanolamine, potassium hydroxide, arginine, sodium hydroxide, citric acid, sodium citrate.
8. The antioxidant composition of claim 1, further comprising a preservative comprising one or more of methylparaben, propylparaben, chlorphenesin, phenoxyethanol, ethylhexylglycerin, hexamidine di (isethionic acid) salt, benzyl alcohol.
9. A method of preparing the antioxidant composition of any of claims 1-8 comprising the step of mixing the components of the antioxidant composition.
10. Use of the antioxidant composition of any of claims 1-8 in skin care products, including aqueous, gel, emulsion or cream type skin care products.
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