CN113015726A - 酮酰胺类化合物及其制备方法、药物组合物和用途 - Google Patents
酮酰胺类化合物及其制备方法、药物组合物和用途 Download PDFInfo
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- CN113015726A CN113015726A CN201980052674.7A CN201980052674A CN113015726A CN 113015726 A CN113015726 A CN 113015726A CN 201980052674 A CN201980052674 A CN 201980052674A CN 113015726 A CN113015726 A CN 113015726A
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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- C07D207/26—2-Pyrrolidones
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- C—CHEMISTRY; METALLURGY
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
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- C—CHEMISTRY; METALLURGY
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- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
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CN2018109030621 | 2018-08-09 | ||
CN201810903062.1A CN110818691A (zh) | 2018-08-09 | 2018-08-09 | 酮酰胺类化合物及其制备方法、药物组合物和用途 |
PCT/CN2019/100060 WO2020030143A1 (zh) | 2018-08-09 | 2019-08-09 | 酮酰胺类化合物及其制备方法、药物组合物和用途 |
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CN113181339B (zh) * | 2020-01-29 | 2022-02-22 | 中国科学院上海药物研究所 | 一种醛基类化合物的药物用途 |
JP2023513048A (ja) * | 2020-01-31 | 2023-03-30 | 中国科学院上▲海▼▲薬▼物研究所 | ケトアミド系化合物の薬学的用途 |
WO2021188620A1 (en) * | 2020-03-17 | 2021-09-23 | Cocrystal Pharma Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
US11124497B1 (en) | 2020-04-17 | 2021-09-21 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
WO2021231778A1 (en) * | 2020-05-13 | 2021-11-18 | Kymera Therapeutics, Inc. | Coronavirus protease degraders and uses thereof |
IL298529A (en) * | 2020-06-09 | 2023-01-01 | Pardes Biosciences Inc | Cysteine protease inhibitors and methods of using them |
US11174231B1 (en) | 2020-06-09 | 2021-11-16 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
IL298324A (en) * | 2020-06-10 | 2023-01-01 | Aligos Therapeutics Inc | Antiviral compounds for the treatment of coronavirus, picornavirus and novovirus infections |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
WO2022129953A1 (en) * | 2020-12-18 | 2022-06-23 | Heptares Therapeutics Limited | Sars-cov-2 mpro inhibitor compounds |
KR20240057384A (ko) | 2021-06-02 | 2024-05-02 | 아세아 테라퓨틱스 인코포레이티드 | 항바이러스제로서의 프로테아제 억제제 |
WO2023283256A1 (en) | 2021-07-09 | 2023-01-12 | Aligos Therapeutics, Inc. | Anti-viral compounds |
CN114149415A (zh) * | 2021-07-26 | 2022-03-08 | 中国药科大学 | 一种拟肽类化合物及其衍生物、制备方法、药物组合物和应用 |
WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
WO2023044509A1 (en) * | 2021-09-20 | 2023-03-23 | Pardes Biosciences, Inc. | Process for making cysteine protease inhibitors and compounds provided by that process |
WO2023044171A1 (en) * | 2021-09-20 | 2023-03-23 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
CN115557871B (zh) * | 2021-11-26 | 2024-06-04 | 杭州科巢生物科技有限公司 | 一种抗病毒化合物pf-07321332的合成方法 |
CN114249667B (zh) * | 2022-01-11 | 2023-12-26 | 衡阳师范学院 | 一种叔丁醇盐催化的两步一锅反应制备n-h酮酰胺的方法 |
CN114956934A (zh) * | 2022-01-20 | 2022-08-30 | 广州谷森制药有限公司 | 一种用于合成新型氘代氰基类化合物的中间体的制备方法 |
WO2023149982A1 (en) * | 2022-02-07 | 2023-08-10 | Purdue Research Foundation | Compounds for the treatment of sars |
WO2023249007A1 (ja) * | 2022-06-23 | 2023-12-28 | 五稜化薬株式会社 | カルパイン阻害剤 |
CN115322130B (zh) * | 2022-08-02 | 2024-05-14 | 南京正济医药研究有限公司 | 制备(s)-2-(boc-氨基)-3-[(s)-2-氧代-3-吡咯烷基]丙酸甲酯 |
CN115466225A (zh) * | 2022-08-16 | 2022-12-13 | 中国科学院上海药物研究所 | 一种酰胺类化合物及其制备方法、药物组合物和用途 |
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EP4293036A3 (en) * | 2016-10-05 | 2024-03-13 | Baylor College of Medicine | Structure of gii.4 norovirus protease -design of broad-spectrum protease inhibitors |
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2018
- 2018-08-09 CN CN201810903062.1A patent/CN110818691A/zh active Pending
-
2019
- 2019-08-09 WO PCT/CN2019/100060 patent/WO2020030143A1/zh unknown
- 2019-08-09 KR KR1020217007086A patent/KR20210043617A/ko not_active Application Discontinuation
- 2019-08-09 US US17/267,375 patent/US20220112177A1/en active Pending
- 2019-08-09 CN CN201980052674.7A patent/CN113015726B/zh active Active
- 2019-08-09 JP JP2021507010A patent/JP2021534133A/ja active Pending
- 2019-08-09 EP EP19847084.1A patent/EP3835296A4/en active Pending
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Also Published As
Publication number | Publication date |
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JP2021534133A (ja) | 2021-12-09 |
WO2020030143A1 (zh) | 2020-02-13 |
CN110818691A (zh) | 2020-02-21 |
US20220112177A1 (en) | 2022-04-14 |
CN113015726B (zh) | 2024-03-08 |
EP3835296A4 (en) | 2022-05-18 |
EP3835296A1 (en) | 2021-06-16 |
KR20210043617A (ko) | 2021-04-21 |
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