CN112996562A - 治疗阿尔茨海默病的方法 - Google Patents

治疗阿尔茨海默病的方法 Download PDF

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Publication number
CN112996562A
CN112996562A CN201980071651.0A CN201980071651A CN112996562A CN 112996562 A CN112996562 A CN 112996562A CN 201980071651 A CN201980071651 A CN 201980071651A CN 112996562 A CN112996562 A CN 112996562A
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CN
China
Prior art keywords
hydroxypropyl
beta
cyclodextrin
cyclodextrin composition
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980071651.0A
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English (en)
Chinese (zh)
Inventor
S.H.海恩科夫
J.L.塔特
N.S.法恩
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Secro Treatment Co ltd
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Secro Treatment Co ltd
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Application filed by Secro Treatment Co ltd filed Critical Secro Treatment Co ltd
Publication of CN112996562A publication Critical patent/CN112996562A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
CN201980071651.0A 2018-10-29 2019-10-24 治疗阿尔茨海默病的方法 Pending CN112996562A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862752131P 2018-10-29 2018-10-29
US62/752,131 2018-10-29
US201962885053P 2019-08-09 2019-08-09
US62/885,053 2019-08-09
PCT/US2019/057784 WO2020092107A1 (en) 2018-10-29 2019-10-24 Methods for treating alzheimer's disease

Publications (1)

Publication Number Publication Date
CN112996562A true CN112996562A (zh) 2021-06-18

Family

ID=68583503

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980071651.0A Pending CN112996562A (zh) 2018-10-29 2019-10-24 治疗阿尔茨海默病的方法

Country Status (10)

Country Link
US (3) US11925659B2 (https=)
EP (1) EP3873604B1 (https=)
JP (1) JP7446322B2 (https=)
KR (1) KR20210084480A (https=)
CN (1) CN112996562A (https=)
BR (1) BR112021008139A2 (https=)
CA (1) CA3114021C (https=)
ES (1) ES2992137T3 (https=)
PT (1) PT3873604T (https=)
WO (1) WO2020092107A1 (https=)

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WO2025214478A1 (zh) * 2024-04-12 2025-10-16 北京华昊中天生物医药股份有限公司 一种优替德隆药物组合物及其制备方法

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CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
US11466008B2 (en) 2017-09-18 2022-10-11 Eip Pharma, Llc Co-crystals of neflamapimod (VX-745)
CN113490691A (zh) 2019-01-03 2021-10-08 劣势者药物有限公司 环糊精二聚体、其组合物及其用途
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING
EP4157290A4 (en) * 2020-06-02 2024-06-05 National University of Singapore COMPOSITIONS, THEIR USES IN THERAPY AND METHODS THEREFOR
WO2022051631A1 (en) 2020-09-03 2022-03-10 University Of Notre Dame Du Lac Therapy to stimulate hippocampal neural progenitors and adult neurogenesis
WO2022099094A1 (en) * 2020-11-06 2022-05-12 Eip Pharma, Inc. Compositions and methods for treating depression
EP4240486A4 (en) * 2020-11-06 2024-05-22 EIP Pharma, Inc. TREATMENT OF GALKING DYSFUNCTION IN THE CONTEXT OF A NEURODEGENERATIVE DISEASE
US12285440B2 (en) 2021-03-14 2025-04-29 Massachusetts Institute Of Technology APOE4 impairs myelination via altered cholesterol biosynthesis and transport in oligodendroglia
WO2023089062A1 (en) * 2021-11-18 2023-05-25 Vib Vzw Improved gamma-secretase inhibitor screening assays
WO2023156966A1 (en) 2022-02-18 2023-08-24 Beren Therapeutics P.B.C. Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same
WO2023191425A1 (ko) * 2022-03-28 2023-10-05 주식회사 비엔에이치리서치 약물의 전기생리학적 스크리닝 방법
CN114569742B (zh) * 2022-05-09 2022-07-19 北京剂泰医药科技有限公司 一种组合物及其制备方法和应用
CA3259307A1 (en) * 2022-06-13 2023-12-21 Beren Therapeutics P.B.C. SYSTEMS AND METHODS FOR MANUFACTURING HYDROXYPROPYL-BETA-CYCLODEXTRIN
EP4561566A1 (en) * 2022-07-29 2025-06-04 Anavex Life Sciences Corp. Compositions and methods for prevention of cognitive decline caused by degenerative diseases
KR20250073473A (ko) * 2022-09-30 2025-05-27 싸이클로 테라퓨틱스, 아이엔씨. 조기 알츠하이머병 치료 방법

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US4877778A (en) 1987-07-01 1989-10-31 The Children's Medical Center Corporation Method of enhancing lipophile transport using cyclodextrin derivatives
US5569756A (en) 1995-03-21 1996-10-29 American Maize-Products Company Purification of chemically modified cyclodextrins
US8883494B2 (en) 2003-11-14 2014-11-11 Adil A. KHAN In vitro model for neuronal death
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Publication number Priority date Publication date Assignee Title
WO2025214478A1 (zh) * 2024-04-12 2025-10-16 北京华昊中天生物医药股份有限公司 一种优替德隆药物组合物及其制备方法

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EP3873604B1 (en) 2024-08-21
CA3114021A1 (en) 2021-05-07
KR20210084480A (ko) 2021-07-07
BR112021008139A2 (pt) 2021-08-03
WO2020092107A1 (en) 2020-05-07
US20220008453A1 (en) 2022-01-13
JP2022509358A (ja) 2022-01-20
EP3873604A1 (en) 2021-09-08
CA3114021C (en) 2025-05-27
ES2992137T3 (es) 2024-12-09
JP7446322B2 (ja) 2024-03-08
PT3873604T (pt) 2024-10-22
US11925659B2 (en) 2024-03-12
US20240415871A1 (en) 2024-12-19
US20250302864A1 (en) 2025-10-02

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