CN112972287A - Protein compound liquid for improving skin elasticity and preparation method and application thereof - Google Patents
Protein compound liquid for improving skin elasticity and preparation method and application thereof Download PDFInfo
- Publication number
- CN112972287A CN112972287A CN202110322438.1A CN202110322438A CN112972287A CN 112972287 A CN112972287 A CN 112972287A CN 202110322438 A CN202110322438 A CN 202110322438A CN 112972287 A CN112972287 A CN 112972287A
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- CN
- China
- Prior art keywords
- skin elasticity
- improving skin
- collagen
- vitamin
- elastin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Abstract
The invention provides a protein compound liquid for improving skin elasticity and a preparation method and application thereof, wherein the protein compound liquid comprises the following components in parts by weight: 1.2-4.75 parts of collagen, 0.05-0.84 part of elastin, 0.24-0.46 part of sodium ascorbate, 0.02-0.12 part of tranexamic acid and 88-95 parts of normal saline. The collagen, the elastin, the sodium ascorbate and the tranexamic acid are combined to play a synergistic interaction role among different components, so that the composition is used for improving the elasticity of skin, has excellent effect, quick response, high acceptable price degree and low risk in the using process, and has an application prospect obviously superior to other products in the prior art; it is convenient to use, and can improve the elasticity of the skin of the whole body comprehensively; the preparation process is simple and controllable, the main active ingredients are easy to obtain, the application effect is obvious, and the actual application prospect is wide.
Description
Technical Field
The invention relates to the technical field of medical cosmetology, in particular to a protein compound liquid for improving skin elasticity and a preparation method and application thereof.
Background
Along with environmental pollution, temperature change and pressure caused by season change, and comprehensive influence of factors such as ultraviolet irradiation, age increase, metabolism slowing and the like, various problems such as skin elasticity loss and the like can be caused. For the vast women who love beauty, the skin elasticity is an important factor for maintaining beautiful skin, and whitening, sun protection, speckle lightening, water replenishing and the like are all completed on the basis of the elasticity of the skin. Therefore, it is necessary to maintain and improve the elasticity of skin, and further achieve the purposes of moisturizing and anti-wrinkle.
In the prior art, the following approaches are mainly adopted for maintaining and improving the skin elasticity:
(1) using skin care products with the function of improving skin elasticity;
(2) medical treatment and beauty treatment;
(3) can be taken orally for conditioning.
How to select the skin care product which is suitable for the user and has the function of improving the elasticity of the skin is difficult, and the effect is not good; although the medical cosmetology is generally good in effect, the process has certain risks and is high in price; although oral conditioning has certain improvement effect and lower risk, the effect is slower.
By inquiring the existing market products, no relevant report of the protein compound liquid for improving the skin elasticity by injection, which has the advantages of excellent effect, quick response, high acceptable price degree and low risk in the use process, is seen.
Disclosure of Invention
The invention aims to provide a protein compound liquid for improving skin elasticity and a preparation method and application thereof.
The invention adopts the following technical scheme:
a protein compound liquid for improving skin elasticity comprises the following components in parts by weight:
further, in the above technical scheme, the collagen is an injection-grade small molecule polypeptide or oligopeptide with a molecular weight of less than 4000 Da.
Preferably, in the above technical solution, the collagen is one or more of fish skin collagen, fish scale collagen, fish bone collagen, bovine bone collagen and porcine bone collagen.
Further, in the above technical means, the elastin is bovine cartilage elastin and/or bonito arterial ball elastin.
Still further, in the above technical solution, the protein complex liquid for improving skin elasticity further comprises:
0.3 to 4.8 portions of vitamin B
0.05-0.42 part of vitamin C.
Specifically, in the above technical scheme, the vitamin B comprises the following components in parts by weight:
in a specific embodiment of the invention, the protein compound liquid for improving skin elasticity consists of the following components in parts by weight:
in a preferred embodiment of the invention, the protein compound liquid for improving skin elasticity consists of the following components in parts by weight:
in another preferred embodiment of the invention, the protein compound liquid for improving skin elasticity consists of the following components in parts by weight:
the invention also provides a preparation method of the protein compound liquid for improving skin elasticity, which comprises the following steps:
weighing and preparing the required components according to the mass ratio, adding the collagen, the elastin and the tranexamic acid into normal saline, uniformly mixing, adding the sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving the skin elasticity.
Preferably, in the above technical solution, the method for preparing the protein complex liquid for improving skin elasticity further comprises:
vitamin B and vitamin C are added and mixed well before the sodium ascorbate is added.
The invention also provides application of the protein compound liquid or the preparation method in preparing an injection preparation for improving skin elasticity.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention creatively combines collagen, elastin, sodium ascorbate and tranexamic acid, exerts the synergistic interaction effect among different components, is used for improving the elasticity of skin, has excellent effect, quick effect, high acceptable price degree and low risk in the using process, and has application prospect obviously superior to other products in the prior art;
(2) the protein compound liquid for improving the skin elasticity for injection provided by the invention is convenient to use, can comprehensively improve the elasticity of the skin of the whole body, and has a wide range of applicable people;
(3) the preparation process of the protein compound liquid for improving skin elasticity for injection provided by the invention is simple and controllable, the main active ingredients are easy to obtain, the application effect is obvious, and the actual application prospect is wide.
Detailed Description
The present invention is further described in detail below with reference to specific examples so that those skilled in the art can more clearly understand the present invention.
The following examples are given for the purpose of illustration only and are not intended to limit the scope of the invention.
All other embodiments obtained by a person skilled in the art based on the specific embodiments of the present invention without any inventive step are within the scope of the present invention.
In the examples of the present invention, all the raw material components are commercially available products well known to those skilled in the art unless otherwise specified.
In the examples of the present invention, unless otherwise specified, all technical means used are conventional means well known to those skilled in the art.
In the examples of the present invention, the raw material sources used were as follows:
collagen was purchased from bio-technologies ltd, yi ta, beijing;
elastin was purchased from biotechnology limited of yi ta, beijing;
sodium ascorbate was purchased from Shanghai-resistant industries, Inc.;
tranexamic acid was purchased from Shanxi Depu liquid medicine, Inc.;
the other raw materials are conventional commercial products.
Example 1
The embodiment provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fish scale collagen), elastin (bovine cartilage elastin and bonito arterial ball elastin) and tranexamic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B2 and vitamin B6) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Example 2
The embodiment provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade bovine bone collagen and injection-grade fish skin collagen), elastin (bovine cartilage elastin and bonito arterial ball elastin) and tranexamic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B2, vitamin B6 and vitamin B12) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Example 3
The embodiment provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fish bone collagen, injection-grade fish scale collagen and injection-grade pig bone collagen), elastin (bovine cartilage elastin) and tranexamic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B2, vitamin B6 and vitamin B12) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Example 4
The embodiment provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade pig bone collagen and injection-grade fish skin collagen), elastin (bovine cartilage elastin) and tranexamic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B2, vitamin B6 and vitamin B12) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Example 5
The embodiment provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fishbone collagen and injection-grade fish scale collagen), elastin (bonito arterial ball elastin) and tranexamic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B2, vitamin B6 and vitamin B12) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Example 6
The embodiment provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and mixing the required raw materials according to the mass ratio, adding collagen (injection-grade fish bone collagen, injection-grade fish scale collagen and injection-grade pig bone collagen), elastin (bovine cartilage elastin) and tranexamic acid into physiological saline, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Comparative example 1
The comparative example provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fish bone collagen, injection-grade fish scale collagen and injection-grade pig bone collagen), elastin (bovine cartilage elastin) and tranexamic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B2, vitamin B6 and vitamin B12) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Comparative example 2
The comparative example provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade bovine bone collagen and injection-grade fish skin collagen), elastin (bovine cartilage elastin and bonito arterial ball elastin) and tranexamic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B2, vitamin B6 and vitamin B12) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Comparative example 3
The embodiment provides a protein compound liquid for improving skin elasticity and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fishbone collagen and injection-grade fish scale collagen) and elastin (skipjack arterial globulin) into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B2, vitamin B6 and vitamin B12) and vitamin C, uniformly mixing, and finally adding sodium ascorbate, and uniformly mixing to obtain the protein compound liquid for improving skin elasticity.
Experimental example functional verification of improvement of skin elasticity
And (3) comparing test effects:
screening the protein complex liquid of the examples and the comparative examples were tested for those without allergy, 200 of the operators, 100 of the men and 100 of the women, the age range of which was 20-45 years, were divided into 10 groups of five men and women.
In the experiments 1 to 6, the protein solutions of examples 1 to 6 were injected, the protein solutions of comparative examples 1 to 3 were injected, and the blank control group was injected with physiological saline.
Specifically, subjects in each experimental group were injected 5 times, each time with a weekly interval, and after two weeks after the last injection, the subjects were scored according to skin elasticity (1-10 points), wherein: scores of 1 are worst, scores of 10 are best, and all are scored by the same person.
The evaluation results are shown in table 1 below.
TABLE 1 evaluation results of improvement of skin elasticity
Finally, the method of the present invention is only a preferred embodiment and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A protein compound liquid for improving skin elasticity is characterized in that,
the paint comprises the following components in parts by weight:
2. the protein complex liquid for improving skin elasticity according to claim 1,
the collagen is injection-grade small molecular polypeptide or oligopeptide with the molecular weight of less than 4000 Da;
preferably, the collagen is one or more of fish skin collagen, fish scale collagen, fish bone collagen, bovine bone collagen and porcine bone collagen.
3. The protein complex liquid for improving skin elasticity according to claim 1,
the elastin is bovine cartilage elastin and/or bonito arterial ball elastin.
4. The protein complex liquid for improving skin elasticity according to any one of claims 1 to 3,
further comprising:
0.3 to 4.8 portions of vitamin B
0.05-0.42 part of vitamin C.
5. The protein complex liquid for improving skin elasticity according to claim 4,
the vitamin B comprises the following components in parts by weight:
6. the protein complex liquid for improving skin elasticity according to any one of claims 1 to 5,
the composition comprises the following components in parts by weight:
7. the protein complex liquid for improving skin elasticity according to claim 6,
the composition comprises the following components in parts by weight:
8. the protein complex liquid for improving skin elasticity according to claim 6,
the composition comprises the following components in parts by weight:
9. the method for preparing a protein complex liquid for improving skin elasticity according to any one of claims 1 to 8,
the method comprises the following steps: weighing and preparing the required components according to the mass ratio, adding collagen, elastin and tranexamic acid into normal saline, uniformly mixing, adding sodium ascorbate, and uniformly mixing to obtain a protein compound liquid for improving skin elasticity;
preferably, the method further comprises adding vitamin B and vitamin C and mixing uniformly before adding the sodium ascorbate.
10. Use of the protein complex liquid according to any one of claims 1 to 8 or the preparation method according to claim 9 for preparing an injection preparation for improving skin elasticity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110322438.1A CN112972287A (en) | 2021-03-25 | 2021-03-25 | Protein compound liquid for improving skin elasticity and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110322438.1A CN112972287A (en) | 2021-03-25 | 2021-03-25 | Protein compound liquid for improving skin elasticity and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112972287A true CN112972287A (en) | 2021-06-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110322438.1A Withdrawn CN112972287A (en) | 2021-03-25 | 2021-03-25 | Protein compound liquid for improving skin elasticity and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848527A (en) * | 2022-06-02 | 2022-08-05 | 浙江珂瑞康生物医疗科技有限公司 | Collagen composite solution for injection and preparation method thereof |
-
2021
- 2021-03-25 CN CN202110322438.1A patent/CN112972287A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848527A (en) * | 2022-06-02 | 2022-08-05 | 浙江珂瑞康生物医疗科技有限公司 | Collagen composite solution for injection and preparation method thereof |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210618 |
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| WW01 | Invention patent application withdrawn after publication |