CN112842928A - Protein compound liquid for removing skin wrinkles and preparation method and application thereof - Google Patents
Protein compound liquid for removing skin wrinkles and preparation method and application thereof Download PDFInfo
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- CN112842928A CN112842928A CN202110322436.2A CN202110322436A CN112842928A CN 112842928 A CN112842928 A CN 112842928A CN 202110322436 A CN202110322436 A CN 202110322436A CN 112842928 A CN112842928 A CN 112842928A
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- growth factor
- collagen
- skin wrinkles
- removing skin
- stem cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Abstract
The invention provides a protein compound liquid for removing skin wrinkles and a preparation method and application thereof, wherein the protein compound liquid comprises the following components in parts by weight: 1.45-5.88 parts of collagen, 0.03-036 parts of stem cell growth factor, 0.21-0.54 part of rhodiola rosea extract, 0.08-0.26 part of hyaluronic acid and 85-96 parts of physiological saline. The collagen, the stem cell growth factor, the rhodiola rosea extract and the hyaluronic acid are combined to play a synergistic interaction role among different components, so that the collagen-based rhodiola rosea extract can be used for removing wrinkles of skin, and has the advantages of excellent effect, quick response, high price acceptable degree, low risk in the using process and application prospect obviously superior to other products in the prior art; it is convenient to use, and can completely remove wrinkles of the skin of the whole body; the preparation process is simple and controllable, the main active ingredients are easy to obtain, the application effect is obvious, and the actual application prospect is wide.
Description
Technical Field
The invention relates to the technical field of medical cosmetology, in particular to a protein compound liquid for removing skin wrinkles and a preparation method and application thereof.
Background
Although facial aging is a normal natural physiological process of people, the facial aging causes great psychological stress to people due to people's natural beauty; in addition, various problems such as wrinkles on the skin of the face are further caused by environmental pollution, temperature changes and stress caused by season changes, and comprehensive influences of factors such as ultraviolet irradiation, aging, and metabolism slowing. For the majority of beauty lovers, it is necessary to remove skin wrinkles and achieve the purposes of moisturizing and improving the elasticity of the skin wrinkles.
In the prior art, the following approaches are mainly adopted for removing skin wrinkles:
(1) skin care products with the function of removing skin wrinkles are used;
(2) medical treatment and beauty treatment;
(3) can be taken orally for conditioning.
Wherein, how to select the skin care product which is suitable for the user and has the function of removing skin wrinkles is difficult, and the effect is not good; although the medical cosmetology is generally good in effect, the process has certain risks and is high in price; although oral conditioning has certain improvement effect and lower risk, the effect is slower.
By inquiring the existing market products, no relevant report of the protein compound liquid for removing skin wrinkles by injection with excellent effect, quick response, high acceptable price degree and low risk in the using process is found.
Disclosure of Invention
The invention aims to provide a protein compound liquid for removing skin wrinkles and a preparation method and application thereof.
The invention adopts the following technical scheme:
a protein compound liquid for removing skin wrinkles comprises the following components in parts by weight:
further, in the above technical scheme, the collagen is an injection-grade small molecule polypeptide or oligopeptide with molecular weight of 2500-.
Preferably, in the above technical solution, the collagen is one or more of fish scale collagen, fish skin collagen, pig skin collagen, bovine bone collagen and sheep bone collagen.
Further, in the above technical solution, the stem cell growth factor includes epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor.
Specifically, in the above technical solution, the mass ratio of the epidermal growth factor, the fibroblast growth factor, the platelet-derived growth factor and the vascular endothelial growth factor is (18-34): (6-12.8): (2.4-7.6): (4.8-8.5).
Further, in the above technical scheme, the content of salidroside in the rhodiola rosea extract is 2.4-5.8 wt%.
Still further, in the above technical solution, the protein complex liquid for removing skin wrinkles further comprises:
0.36 to 3.5 portions of vitamin B
0.08 to 0.25 portion of dextrovitamin E.
Specifically, in the above technical scheme, the vitamin B comprises the following components in parts by weight:
in a specific embodiment of the invention, the protein compound liquid for removing skin wrinkles consists of the following components in parts by weight:
in a preferred embodiment of the invention, the protein compound liquid for removing skin wrinkles consists of the following components in parts by weight:
wherein:
in the stem cell growth factor, the mass ratio of the epidermal growth factor, the fibroblast growth factor, the platelet-derived growth factor and the vascular endothelial growth factor is (24.5-32.8): (7.2-10.5): (3.6-6.5): (5.6-7.8);
the content of salidroside in the rhodiola rosea extract is 3.2-4.6 wt%.
In another preferred embodiment of the invention, the protein compound liquid for removing skin wrinkles consists of the following components in parts by weight:
wherein:
in the stem cell growth factor, the mass ratio of the epidermal growth factor, the fibroblast growth factor, the platelet-derived growth factor and the vascular endothelial growth factor is (22.8-31.36): (6.8-11.8): (3.5-6.8): (5.4-8.2);
the content of salidroside in the rhodiola rosea extract is 3.6-5.2 wt%.
The invention also provides a preparation method of the protein compound liquid for removing skin wrinkles, which comprises the following steps:
weighing and preparing the required components according to the mass ratio, adding the collagen, the rhodiola rosea extract and the hyaluronic acid into normal saline, uniformly mixing, adding the stem cell growth factor, and uniformly mixing to obtain the protein compound liquid for removing skin wrinkles.
Preferably, in the above technical solution, the preparation method of the protein compound liquid for removing skin wrinkles further comprises:
before the stem cell growth factor is added, vitamin B and dextrorotatory vitamin E are added and mixed uniformly.
The invention also provides the application of the protein compound liquid or the preparation method in preparing an injection preparation for removing skin wrinkles.
Compared with the prior art, the invention has the beneficial effects that:
(1) the collagen, the stem cell growth factor, the rhodiola rosea extract and the hyaluronic acid are creatively combined to play a synergistic interaction role among different components, so that the collagen, the stem cell growth factor, the rhodiola rosea extract and the hyaluronic acid can be used for removing wrinkles of skin, and the collagen, the stem cell growth factor, the rhodiola rosea extract and the hyaluronic acid have the advantages of excellent effect, quick response, high acceptable price degree, low risk in the using process and obvious application prospect superior to other products in the prior art;
(2) the protein compound liquid for removing skin wrinkles by injection provided by the invention is convenient to use, can completely remove wrinkles of the whole skin, and has a wide range of applicable groups;
(3) the preparation process of the protein compound liquid for removing skin wrinkles by injection provided by the invention is simple and controllable, the main active ingredients are easy to obtain, the application effect is obvious, and the actual application prospect is wide.
Detailed Description
The present invention is further described in detail below with reference to specific examples so that those skilled in the art can more clearly understand the present invention.
The following examples are given for the purpose of illustration only and are not intended to limit the scope of the invention.
All other embodiments obtained by a person skilled in the art based on the specific embodiments of the present invention without any inventive step are within the scope of the present invention.
In the examples of the present invention, all the raw material components are commercially available products well known to those skilled in the art unless otherwise specified.
In the examples of the present invention, unless otherwise specified, all technical means used are conventional means well known to those skilled in the art.
In the examples of the present invention, the raw material sources used were as follows:
collagen was purchased from bio-technologies ltd, yi ta, beijing;
stem cell growth factors were purchased from semer feishel;
the rhodiola rosea extract is purchased from West Anruin biotechnology limited, and the content of salidroside is 4.5 wt%;
hyaluronic acid was purchased from Guangzhou jump-over commerce, Inc.;
the other raw materials are conventional commercial products.
Example 1
The embodiment provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
Wherein the stem cell growth factor is prepared from the following components in a mass ratio of 20.5: 12.6: 2.5: 8.4 epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor.
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade pigskin collagen), rhodiola rosea extract and hyaluronic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B3, vitamin B9 and vitamin B12) and dextrovitamin E, uniformly mixing, and finally adding dry cell growth factor, and uniformly mixing to obtain the protein compound liquid for removing skin wrinkles.
Example 2
The embodiment provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
Wherein the stem cell growth factor is prepared from the following components in a mass ratio of 32.5: 9.6: 6.4: 5.6 consisting of epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor.
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fish scale collagen, injection-grade pig skin collagen and injection-grade sheep bone collagen), rhodiola rosea extract and hyaluronic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B3, vitamin B9 and vitamin B12) and dextrovitamin E, uniformly mixing, and finally adding a dry cell growth factor, and uniformly mixing to obtain the protein compound liquid for removing skin wrinkles.
Example 3
The embodiment provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
Wherein the stem cell growth factor is prepared from the following components in a mass ratio of 23.7: 11.6: 5.8: 7.5 of epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor.
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fish skin collagen and injection-grade sheep bone collagen), rhodiola rosea extract and hyaluronic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B3, vitamin B9 and vitamin B12) and dextrovitamin E, uniformly mixing, and finally adding and uniformly mixing the dry cell growth factor to obtain the protein compound liquid for removing skin wrinkles.
Example 4
The embodiment provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade bovine bone collagen and injection-grade pig skin collagen), rhodiola rosea extract and hyaluronic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B3, vitamin B9 and vitamin B12) and dextrovitamin E, uniformly mixing, and finally adding and uniformly mixing the dry cell growth factor to obtain the protein compound liquid for removing skin wrinkles.
Example 5
The embodiment provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
Wherein the stem cell growth factor is prepared from the following components in a mass ratio of 32.8: 6.5: 4.5: 6.4 epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor.
2. Preparation method
Weighing and mixing the required raw materials according to the mass ratio, adding collagen (injection-grade sheep bone collagen), rhodiola rosea extract and hyaluronic acid into physiological saline, uniformly mixing, and finally adding the stem cell growth factor into the mixture, and uniformly mixing to obtain the protein compound liquid for removing skin wrinkles.
Comparative example 1
The comparative example provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
Wherein the stem cell growth factor is prepared from the following components in a mass ratio of 24.5: 10.8: 4.9: 6.9 epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor.
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fish skin collagen and injection-grade sheep bone collagen) and hyaluronic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B3, vitamin B9 and vitamin B12) and dextrovitamin E, uniformly mixing, and finally adding and uniformly mixing the dry cell growth factor to obtain the protein compound liquid for removing skin wrinkles.
Comparative example 2
The comparative example provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade bovine bone collagen and injection-grade pig skin collagen), rhodiola rosea extract and hyaluronic acid into physiological saline, uniformly mixing, and finally adding vitamin B (vitamin B1, vitamin B3, vitamin B9 and vitamin B12) and dextrovitamin E and uniformly mixing to obtain the protein compound liquid for removing skin wrinkles.
Comparative example 3
The embodiment provides a protein compound liquid for removing skin wrinkles and a preparation method thereof.
1. Composition of raw materials
Wherein the stem cell growth factor is prepared from the following components in a mass ratio of 31.8: 8.6: 5.7: 6.2 consisting of epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor.
2. Preparation method
Weighing and preparing the required raw materials according to the mass ratio, adding collagen (injection-grade fish scale collagen, injection-grade pig skin collagen and injection-grade sheep bone collagen), rhodiola rosea extract and hyaluronic acid into normal saline, uniformly mixing, adding vitamin B (vitamin B1, vitamin B3, vitamin B9 and vitamin B12) and dextrovitamin E, uniformly mixing, and finally adding a dry cell growth factor, and uniformly mixing to obtain the protein compound liquid for removing skin wrinkles.
Experimental example functional verification for removing skin wrinkles
And (3) comparing test effects:
screening the protein complex liquid of the examples and the comparative examples were tested for non-allergic subjects, including 450 patients, 225 male patients and 225 female patients, wherein the age range of the patients is 35-65 years, and the patients are divided into 9 groups, and each group has 25 male and female patients.
In the experiment 1-5 groups, the protein complex liquid of example 1-5 was injected, the protein complex liquid of comparative example 1-3 was injected, and the blank control group was injected with physiological saline.
Specifically, subjects in each experimental group were injected 5 times with a one-week interval, and the wrinkle-reducing effect of the subjects was evaluated two weeks after the last injection.
The evaluation results are shown in table 1 below.
TABLE 1 evaluation results of wrinkle reduction
The results show that the collagen, the stem cell growth factor, the rhodiola rosea extract and the hyaluronic acid in a specific ratio are combined, the synergistic interaction effect among different components is exerted, the skin wrinkles can be effectively removed, the effect is excellent, the effect is quick, the using process risk is low, and the application prospect is obviously better than other products in the prior art.
Finally, the method of the present invention is only a preferred embodiment and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A protein compound liquid for removing skin wrinkles is characterized in that,
the paint comprises the following components in parts by weight:
2. the protein complex liquid for removing skin wrinkles according to claim 1,
the collagen is injection-grade small molecular polypeptide or oligopeptide with the molecular weight of 2500-;
preferably, the collagen is one or more of fish scale collagen, fish skin collagen, pig skin collagen, bovine bone collagen and sheep bone collagen.
3. The protein complex liquid for removing skin wrinkles according to claim 1,
the stem cell growth factor comprises an epidermal growth factor, a fibroblast growth factor, a platelet-derived growth factor and a vascular endothelial growth factor;
preferably, the mass ratio of the epidermal growth factor to the fibroblast growth factor to the platelet-derived growth factor to the vascular endothelial growth factor is (18-34): (6-12.8): (2.4-7.6): (4.8-8.5).
4. The protein complex liquid for removing skin wrinkles according to claim 1,
the content of salidroside in the rhodiola root extract is 2.4-5.8 wt%.
5. The protein complex liquid for removing skin wrinkles according to any one of claims 1 to 4,
further comprising:
0.36 to 3.5 portions of vitamin B
0.08-0.25 part of dextrovitamin E;
preferably, the vitamin B comprises the following components in parts by weight:
6. the protein complex liquid for removing skin wrinkles according to any one of claims 1 to 5,
the composition comprises the following components in parts by weight:
7. the skin wrinkle removal protein complex liquid according to claim 6,
the composition comprises the following components in parts by weight:
wherein:
in the stem cell growth factor, the mass ratio of epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor is (24.5-32.8): (7.2-10.5): (3.6-6.5): (5.6-7.8);
the content of salidroside in the rhodiola rosea extract is 3.2-4.6 wt%.
8. The skin wrinkle removal protein complex liquid according to claim 6,
the composition comprises the following components in parts by weight:
wherein:
in the stem cell growth factor, the mass ratio of epidermal growth factor, fibroblast growth factor, platelet-derived growth factor and vascular endothelial growth factor is (22.8-31.36): (6.8-11.8): (3.5-6.8): (5.4-8.2);
the content of salidroside in the rhodiola rosea extract is 3.6-5.2 wt%.
9. The method for preparing the protein complex liquid for removing skin wrinkles according to any one of claims 1 to 8,
the method comprises the following steps: weighing and preparing the required components according to the mass ratio, adding collagen, rhodiola rosea extract and hyaluronic acid into normal saline, uniformly mixing, adding stem cell growth factor, and uniformly mixing to obtain a protein compound liquid for removing skin wrinkles;
preferably, the method further comprises adding vitamin B and dextrovitamin E and mixing uniformly before adding the stem cell growth factor.
10. Use of the protein complex liquid according to any one of claims 1 to 8 or the method according to claim 9 for preparing an injection for removing skin wrinkles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110322436.2A CN112842928A (en) | 2021-03-25 | 2021-03-25 | Protein compound liquid for removing skin wrinkles and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110322436.2A CN112842928A (en) | 2021-03-25 | 2021-03-25 | Protein compound liquid for removing skin wrinkles and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112842928A true CN112842928A (en) | 2021-05-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110322436.2A Withdrawn CN112842928A (en) | 2021-03-25 | 2021-03-25 | Protein compound liquid for removing skin wrinkles and preparation method and application thereof |
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| Country | Link |
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| CN (1) | CN112842928A (en) |
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2021
- 2021-03-25 CN CN202110322436.2A patent/CN112842928A/en not_active Withdrawn
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