CN112891616A - 一种甲壳胺透明质酸钠抗菌液体膜及其制备方法 - Google Patents
一种甲壳胺透明质酸钠抗菌液体膜及其制备方法 Download PDFInfo
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- CN112891616A CN112891616A CN202110126191.6A CN202110126191A CN112891616A CN 112891616 A CN112891616 A CN 112891616A CN 202110126191 A CN202110126191 A CN 202110126191A CN 112891616 A CN112891616 A CN 112891616A
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- chitosan
- sodium hyaluronate
- antibacterial
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Abstract
本发明涉及医用液体敷料技术领域，公开了一种甲壳胺透明质酸钠抗菌液体膜，包括甲壳胺、细胞生长因子、透明质酸钠、甘油磷脂、椰子油、丙二醇、乙酸丁酯、乙酸乙酯。本发明成膜迅速，成膜后紧贴皮肤，不但可杀菌、抑菌、促进伤口愈合，防止伤口感染，还具有隔离紫外线和有害物质及污染物侵入、深层滋润皮肤的优点；本发明防水、透气，肌肤亲和性好，皮肤舒适度佳，并且保护膜具有良好的延展性，不影响关节部位的灵活性，使用方便，易于观察伤口情况及促进伤口恢复等特点，后期可自然脱落，无后顾之忧。
Description
技术领域
本发明涉及医用液体敷料技术领域，具体涉及一种甲壳胺透明质酸钠抗菌液体膜及其制备方法。
背景技术
生活中皮肤损伤的情况时有发生，伤口修复是一个复杂过程，敷料的使用在促进伤口愈合中起到十分重要的作用，其可保护伤口免受外界侵害，机体也利用自身的愈合修复能力等待伤口愈合。伤口愈合也是组织修复的过程，组织修复过程中细胞外基质(Extracellular matrix,ECM)与细胞间的相互作用能够明显影响组织形态的发生或重建。
敷料是临床上广泛应用的一种用以覆盖疮、伤口或其他损害的医用材料。传统的敷料主要包括天然纱布、合成纤维内敷料、发泡多聚体类敷料、水胶体类敷料等，其生物相容性和降解性较差，这些敷料很容易为细菌等微生物的入侵提供温床，因此对灭菌要求极高；另外，传统敷料黏贴不紧密，胶布包扎会导致皮肤发白，且防水透气性差。虽然市面上出现了类似液体创可贴的产品，但这些产品不能兼顾伤口防水透气性、滋润皮肤、抵抗紫外线的作用。因此，发明人发明了一种甲壳胺透明质酸钠抗菌液体膜及其制备方法。
发明内容
基于以上问题，本发明提供一种甲壳胺透明质酸钠抗菌液体膜及其制备方法，本发明成膜迅速，使用方便，不影响工作生活，同时还具有美容润肤功能。
为解决以上技术问题，本发明提供了一种甲壳胺透明质酸钠抗菌液体膜，包括如下重量份数的组分：甲壳胺4-6份，细胞生长因子1-2份，透明质酸钠10-12份，甘油磷脂2-4份，椰子油6-8份，丙二醇2-4份，乙酸丁酯48-52份，乙酸乙酯12-15份。
进一步的，还包括如下重量份数的组分：抗菌纳米粒子3-5份，活性保护剂10-12份和聚乙二醇1-2份。
进一步的，所述抗菌纳米粒子为纳米银，所述活性保护剂为海藻糖。
进一步的，包括如下重量份数的组分：乙酸丁酯48份，乙酸乙酯12份，甲壳胺6份，椰子油8份，丙二醇3份，聚乙二醇2份，其中聚乙二醇的分子量为4000，细胞生长因子2份，抗菌纳米粒子5份，活性保护剂12份，甘油磷脂4份。
进一步的，包括如下重量份数的组分：乙酸丁酯51份，乙酸乙酯14份，甲壳胺4份，椰子油6份，丙二醇4份，聚乙二醇1份，其中聚乙二醇的分子量为3500，细胞生长因子1份，抗菌纳米粒子3份，活性保护剂10份，甘油磷脂2份。
为解决以上技术问题，本发明还提供了甲壳胺透明质酸钠抗菌液体膜的制备方法，包括如下步骤：
S1：将乙酸丁酯、乙酸乙酯和丙二醇置于容器中混合均匀，得到混合溶液；
S2：向步骤S1中的混合溶液中加入按配比称量的聚乙二醇，搅拌均匀，待组分稳定；
S3：向经步骤S2处理后的溶液中加入按配比称量的细胞生长因子、透明质酸钠、抗菌纳米粒子、甘油磷脂、椰子油及活性保护剂，超声溶解，使各组分完全溶解形成溶液A；
S4：使用乳酸溶解甲壳胺，将PH调节至5.5-6.5后加入步骤S3中的溶液A中，加热至35～40℃，搅拌溶解后，静置1-2h即得液体膜制剂。
与现有技术相比，本发明的有益效果是：本发明是由成膜材料制成的液体产品，通过涂抹或喷洒在皮肤上而紧密粘附于皮肤创伤部位，从而形成透明保护膜；本发明成膜迅速，成膜后紧贴皮肤，不但可杀菌、抑菌、促进伤口愈合，防止伤口感染，还具有隔离紫外线和有害物质及污染物侵入、深层滋润皮肤的优点；本发明防水、透气，肌肤亲和性好，皮肤舒适度佳，并且保护膜具有良好的延展性，不影响关节部位的灵活性，使用方便，易于观察伤口情况及促进伤口恢复等特点，后期可自然脱落，无后顾之忧。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚明白，下面结合实施例，对本发明作进一步的详细说明，本发明的示意性实施方式及其说明仅用于解释本发明，并不作为对本发明的限定。
实施例1：
一种甲壳胺透明质酸钠抗菌液体膜，包括如下重量份数的组分：甲壳胺4-6份，细胞生长因子FGF 1-2份，透明质酸钠10-12份，甘油磷脂2-4份，椰子油6-8份，丙二醇2-4份，乙酸丁酯48-52份，乙酸乙酯12-15份。
上述甲壳胺透明质酸钠抗菌液体膜的制备方法如下：
S1：将乙酸丁酯、乙酸乙酯和丙二醇置于容器中混合均匀，得到混合溶液；
S2：向混合溶液中加入按配比称量的细胞生长因子、透明质酸钠、甘油磷脂、椰子油，超声溶解，使各组分完全溶解形成溶液A；
S4：使用乳酸溶解甲壳胺，将PH调节至5.5-6.5后加入步骤S3中的溶液A中，加热至35～40℃，搅拌溶解后，静置1-2h即得液体膜制剂。
本实施例的原料甲壳胺，也称甲壳质，其主要来源于甲壳动物的表皮以及真菌和一些低等植物的细胞壁，可由甲壳中的壳聚糖脱乙酰化而得到，也在某些微生物和酵母菌中天然存在。其具有在微酸条件下溶解成可被吸收的凝胶状，具有凝胶性和成膜特性。甲壳胺具有如下功能：止血、防止渗血、止痛的作用；具有美容护肤的功效，活化细胞可产生大量胶原纤维，具有快速愈合伤口、促进组织再生、减轻伤口疤痕的作用；防紫外线。
透明质酸钠俗称玻尿酸，广泛存在于结缔组织、上皮组织和神经组织中，具有保湿、促进伤口愈合和组织再生的作用。
椰子油为从椰子肉中提取得到的，含有脂肪酸、月桂酸、多酚等成分，其主要功能如下：抗菌，可以杀死引发疾病的细菌、病毒、真菌和寄生虫；抗氧化；美容护肤，具有很强的清洁效果，而且不会伤害皮肤，可以保护皮肤不受紫外线伤害。
乙酸丁酯和乙酸乙酯作为溶剂可起到快速干燥的作用，丙二醇作为增塑剂，具有助溶和增强成膜的韧性的作用，细胞生长因子FGF为成纤维细胞生长因子，是一种可以促进成纤维细胞生长的细胞因子。
实施例2：
一种甲壳胺透明质酸钠抗菌液体膜，包括如下重量份数的组分：甲壳胺4-6份，细胞生长因子1-2份，透明质酸钠10-12份，甘油磷脂2-4份，椰子油6-8份，丙二醇2-4份，乙酸丁酯48-52份，乙酸乙酯12-15份，抗菌纳米粒子3-5份，活性保护剂10-12份，聚乙二醇1-2份。本实施例的抗菌纳米粒子为纳米银，本实施例的活性保护剂为海藻糖。
上述甲壳胺透明质酸钠抗菌液体膜的制备方法，包括如下步骤：
S1：将乙酸丁酯、乙酸乙酯和丙二醇置于容器中混合均匀，得到混合溶液；
S2：向步骤S1中的混合溶液中加入按配比称量的聚乙二醇，搅拌均匀，待组分稳定；
S3：向经步骤S2处理后的溶液中加入按配比称量的细胞生长因子、透明质酸钠、抗菌纳米粒子、甘油磷脂、椰子油及活性保护剂，超声溶解，使各组分完全溶解形成溶液A；
S4：使用乳酸溶解甲壳胺，将PH调节至5.5-6.5后加入步骤S3中的溶液A中，加热至35～40℃，搅拌溶解后，静置1-2h即得液体膜制剂。
本实施例的活性保护剂为海藻糖，可起到活性保护的作用，可增加制剂的稳定性和活性；抗菌纳米粒子为纳米银，具有强效广谱杀菌、修复再生的特点；所述聚乙二醇的分子量为3500-4000，其具有调节粘度、成膜后不易脱落的特点。进一步提高了液体膜制剂的抗菌性能、成膜性能。
本实施例的甲壳胺透明质酸钠抗菌液体膜(后文统一称为抗菌液体膜)为液体制剂，可通过直接涂抹或喷洒在皮肤上而紧密粘附于皮肤创伤部位，使用方便，片刻成膜，不影响工作生活，同时还具有润肤功能。
抗菌液体膜中的甲壳胺具有除菌、镇痛止血的效果，可活化细胞，促使细胞产生大量胶原纤维迅速形成细致皮肤，具有预防疤痕形成、防紫外线等护肤美容功效，甲壳胺还具有成膜特性；透明质酸钠可促进皮肤营养供给，保湿抗皱，有很强的润滑感和成膜性，可协同减少紫外线的透过，并可对透过的少量紫外线造成的皮肤损伤进行修复；乙酸丁酯和乙酸乙酯在体温条件下易挥发，将其作为溶剂，达到了快速干燥的效果；丙二醇作为增塑剂，达到了增加成膜的韧性和助溶的效果；聚乙二醇作为粘合剂达到了使抗菌液体膜不易脱落的效果；细胞生长因子、抗菌纳米粒子(纳米银)和活性保护剂使活性得到保护的细胞因子与抗菌纳米粒子直接作用于伤口，达到了高效抗菌和选择性地快速修复皮肤损伤的效果；椰子油可减少细胞老化，促进新陈代谢和减少疤痕的生成的效果，可阻挡紫外线的辐射，且安全无刺激作用。
本实施例的抗菌液体膜的适用范围如下：可应用于多种外伤，例如皮肤创伤、割伤、擦伤、龟裂、皲裂、晒伤、灼伤等。本实施例的抗菌液体膜为当下创伤敷料的应用提供了一个更加便捷、有效的方法，发明人在原有液体创可贴最佳配方的基础上，对其在创伤愈合过程中的作用进行研究，为今后液体创可贴在临床及日常生活中的应用推广提供了技术支持和产品选择。
本实施例的抗菌液体膜只需在受损皮肤上涂/喷两下，1分钟内便可形成一层紧密贴合皮肤的透明膜，可将原有的污染面细菌杀死，完全覆盖创面皮肤，起到隔离消毒的作用。抗菌液体膜形成膜还具有抑制细菌生长的作用，从空气飘落或接触污染带来的细菌，在膜体上无法繁衍生存，起到了保持表面清洁的目的。这种膜与机体表面结合牢度很高，在一般摩擦力下不脱落，只要膜体存在，膜上细菌就无法存活，从而达到了持续杀菌保持皮肤干净的目的。抗菌液体膜形成膜具有透气性好、滋润皮肤、防御紫外线的作用，具有良好的护肤功效，舒适度佳，不需要清除，数天后可自然脱落。
实施例3：
一种甲壳胺透明质酸钠抗菌液体膜，包括如下重量份数的组分：乙酸丁酯48份，乙酸乙酯12份，甲壳胺6份，椰子油8份，丙二醇3份，聚乙二醇2份(分子量为4000)，细胞生长因子2份，抗菌纳米粒子5份，活性保护剂12份，甘油磷脂4份。本实施例的细胞生长因子为FGF，抗菌纳米粒子为纳米银，活性保护剂为海藻糖。
上述液体膜的制备方法包括以下步骤：
S1：将乙酸丁酯、乙酸乙酯和丙二醇置于容器中混合均匀，得到混合溶液；
S2：向步骤S1中的混合溶液中加入按配比称量的聚乙二醇，搅拌均匀，待组分稳定；
S3：向经步骤S2处理后的溶液中加入按配比称量的细胞生长因子、透明质酸钠、抗菌纳米粒子、甘油磷脂、椰子油及活性保护剂，超声溶解，使各组分完全溶解形成溶液A；
S4：使用乳酸溶解甲壳胺，将PH调节至5.5-6.0后加入步骤S3中的溶液A中，加热至35～40℃，搅拌溶解后，静置1-2h即得液体膜制剂。
实施例4：
一种甲壳胺透明质酸钠抗菌液体膜，包括如下重量份数的组分：乙酸丁酯51份，乙酸乙酯14份，甲壳胺4份，椰子油6份，丙二醇4份，聚乙二醇1份(分子量为3500)，细胞生长因子1份，抗菌纳米粒子3份，活性保护剂10份，甘油磷脂2份。本实施例的细胞生长因子为FGF，抗菌纳米粒子为纳米银，活性保护剂为海藻糖。
上述液体膜的制备方法包括以下步骤：
S1：将乙酸丁酯、乙酸乙酯和丙二醇置于容器中混合均匀，得到混合溶液；
S2：向步骤S1中的混合溶液中加入按配比称量的聚乙二醇，搅拌均匀，待组分稳定；
S3：向经步骤S2处理后的溶液中加入按配比称量的细胞生长因子、透明质酸钠、抗菌纳米粒子、甘油磷脂、椰子油及活性保护剂，超声溶解，使各组分完全溶解形成溶液A；
S4：使用乳酸溶解甲壳胺，将PH调节至6.0-6.5后加入步骤S3中的溶液A中，加热至35～40℃，搅拌溶解后，静置1-2h即得液体膜制剂。
如上即为本发明的实施例。上述实施例以及实施例中的具体参数仅是为了清楚表述发明验证过程，并非用以限制本发明的专利保护范围，本发明的专利保护范围仍然以其权利要求书为准，凡是运用本发明的说明书内容所作的等同结构变化，同理均应包含在本发明的保护范围内。
Claims (6)
1.一种甲壳胺透明质酸钠抗菌液体膜，其特征在于，包括如下重量份数的组分：甲壳胺4-6份，细胞生长因子1-2份，透明质酸钠10-12份，甘油磷脂2-4份，椰子油6-8份，丙二醇2-4份，乙酸丁酯48-52份，乙酸乙酯12-15份。
2.根据权利要求1所述的一种甲壳胺透明质酸钠抗菌液体膜，其特征在于，还包括如下重量份数的组分：抗菌纳米粒子3-5份，活性保护剂10-12份和聚乙二醇1-2份。
3.根据权利要求2所述的一种甲壳胺透明质酸钠抗菌液体膜，其特征在于，所述抗菌纳米粒子为纳米银，所述活性保护剂为海藻糖。
4.根据权利要求2所述的一种甲壳胺透明质酸钠抗菌液体膜，其特征在于，包括如下重量份数的组分：乙酸丁酯48份，乙酸乙酯12份，甲壳胺6份，椰子油8份，丙二醇3份，聚乙二醇2份，其中聚乙二醇的分子量为4000，细胞生长因子2份，抗菌纳米粒子5份，活性保护剂12份，甘油磷脂4份。
5.根据权利要求2所述的一种甲壳胺透明质酸钠抗菌液体膜，其特征在于，包括如下重量份数的组分：乙酸丁酯51份，乙酸乙酯14份，甲壳胺4份，椰子油6份，丙二醇4份，聚乙二醇1份，其中聚乙二醇的分子量为3500，细胞生长因子1份，抗菌纳米粒子3份，活性保护剂10份，甘油磷脂2份。
6.权利要求2-5中任意一项所述的甲壳胺透明质酸钠抗菌液体膜的制备方法，其特征在于，包括如下步骤：
S1：将乙酸丁酯、乙酸乙酯和丙二醇置于容器中混合均匀，得到混合溶液；
S2：向步骤S1中的混合溶液中加入按配比称量的聚乙二醇，搅拌均匀，待组分稳定；
S3：向经步骤S2处理后的溶液中加入按配比称量的细胞生长因子、透明质酸钠、抗菌纳米粒子、甘油磷脂、椰子油及活性保护剂，超声溶解，使各组分完全溶解形成溶液A；
S4：使用乳酸溶解甲壳胺，将PH调节至5.5-6.5后加入步骤S3中的溶液A中，加热至35～40℃，搅拌溶解后，静置1-2h即得液体膜制剂。
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