CN112890179A - 一种解决肠内营养不耐受的半固化营养剂及其制备方法 - Google Patents
一种解决肠内营养不耐受的半固化营养剂及其制备方法 Download PDFInfo
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Abstract
本发明公开一种解决肠内营养不耐受的半固化营养剂及其制备方法,本发明中的半固化营养剂由500‑750份碳水化合物、135‑200份蛋白质、85‑100份脂肪、10‑50份低甲氧基果胶、0.1‑2份维生素复合物、5‑80份矿物质复合物;其中,矿物质复合物中包含磷酸氢钙。本发明制备的半固化营养剂用温水冲泡后在pH值为7±0.2的环境中类似于普通饮料的流动液体,便于患者(如气管关闭肌群控制力减弱的吞咽障碍患者)口服,避免现有技术中的半固化营养剂粘度过高难以下咽;该液体在饮用后在胃酸的作用下促进磷酸氢钙中的钙析出成钙离子,钙离子与低甲氧基果胶中的游离甲氧基发生架桥反应,形成“蛋壳”型较为稳定的离子结合型半固化凝胶结构,从而抑制胃食管反流、腹泻等肠内营养不耐受的反应。
Description
技术领域
本发明涉及一种营养食品,具体地,涉及一种解决肠内营养不耐受的半固化营养剂及其制备方法。
背景技术
根据大量研究表明,临床病人发生营养不良的风险较高,尤其对于糖尿病、肿瘤、创伤手术、意识障碍、厌食症等特定疾病人群更是如此。营养不良不仅导致较差的治疗效果、增加了患者并发症发生的风险以及恢复时间延长等问题的发生,进而导致更高的治疗费用和较高的病死率等。
特殊医学用途配方食品(foods for special medical purpose,FSMP,下称“特医食品”)是指为了满足进食受限、消化吸收障碍、代谢紊乱或特定疾病状态人群对营养素或膳食的特殊需要,专门加工配制而成的配方食品。临床及卫生经济学研究数据表明,特医食品能够为医院节省费用,降低病患死亡率,同时也能降低住院相关投资,是缓解全球营养不良问题的科学性解决方案,在发达国家已有近百年的使用历史。
相比肠外营养,以特医食品为代表的肠内营养因其更符合生理结构,并且可以加速术后肠道功能恢复。因此特医食品作为临床营养支持治疗首选。但是,有数据表明目前国内住院营养不良患者肠内营养比例在临床营养治疗中仅占43.7%,其原因是由于医特食品在肠内营养导致的不耐受(包括恶心、胃食管反流、腹胀、腹泻等)制约其在临床上的应用。
调查发现,肠内营养不耐受在住院患者中平均发生率为38.2%,其主要原因被指出在于目前临床上使用的特医食品多为流质营养物,粘度过低导致迅速通过胃进入肠道,从而发生不耐受反应。因此,通过对特医食品配方进行改良,在不影响正常饮用的前提下,以增加营养剂进入胃内的粘度成为解决这一难题的选择而受到关注。
针对上述问题,日本特开2008-69090号专利公开了采用液体经管营养剂给予前后通过注入低甲氧基果胶、藻朊酸及角叉菜胶等增稠剂,从而在胃内形成固态物质,以防止营养剂迅速流入肠道,以预防胃食管反流及倾倒综合症等肠内营养不耐受反应。日本专利第3516673号专利公开了一种向经肠液态营养剂直接添加琼脂、鸡蛋、果胶作为半固化剂的半固态营养剂。专利WO2004/069179公开了一种预先将液体营养剂添加增稠剂,再脱水而成的浓缩增稠糊剂。
上述专利在解决肠内不耐受的同时,但是还存在以下缺点:
缺点1、目前已有产品以管饲营养剂作为目标剂型进行增稠设计,比如使用增稠组件,患者使用时需要先管饲增稠组件,再管饲肠内营养。此种方式使用麻烦,同时也不适用于直接经口服用营养制剂的患者需求,不能解决口服营养制剂导致的胃肠不耐受的问题。与此相对应的是,目前在临床营养领域,《欧洲肠外与肠内协会(ESPEN)肠内营养指南》指出,肠内营养包括口服营养和管饲营养补充,其中,口服营养是推荐的首要肠内营养支持方式,只有当患者不具备经口摄入条件或口服营养无法满足患者营养需求时才考虑管饲营养补充。
缺点2、目前已有产品通过直接向液体管饲营养剂中添加琼脂、鸡蛋、果胶等增稠剂的形式使之呈现半固态状。但是此种产品极可能在生产过程中由于加热杀菌等工序导致增稠力减弱甚至消失,或者产品在长期保存或运输过程中出现脱水,导致经管给予时出现堵管等情况发生。同时,目前存在的添加增稠剂(尤其针对添加低甲氧基果胶)的液体管饲营养剂由于难以解决其他蛋白液体制剂难以均质,容易发生蛋白质析出的问题,故而均选用酪蛋白作为蛋白质来源,更易导致患者耐受性差,消化吸收率低,容易引发腹泻、呕吐等反应。
缺点3、目前存在部分添加增稠剂的口服营养制剂产品,但该类产品首先是用于气管关闭肌群控制力减弱的吞咽障碍患者,目的是为了防止吞咽营养剂时误吸风险,针对经口摄入功能正常的患者反而易因为粘度过高或口感较差而难以下咽,即使通过调整增稠剂添加比例来降低粘度的方式又无法起到防止胃肠不耐受的预期效果。
发明内容
为了克服现有技术中存在的问题,本发明的目的之一是提供一种便于食用并且同时还能防止胃肠不耐受的一种解决肠内营养不耐受的半固化营养剂。
为实现上述目的,本发明采用的技术方案如下:
一种解决肠内营养不耐受的半固化营养剂,按重量份计,包括以下组份:
其中,所述矿物质复合物中包含1-20份的磷酸氢钙。
优选地,所述低甲氧基果胶的酯化度为20%-50%。
优选地,按重量份计,还包括0.2-5份的香味剂和0.1-1份的三氯蔗糖。
优选地,按重量份计,所述维生素复合物包括维生素A醋酸酯0.01-0.10份、胆钙化醇0.02-0.08份、dl-α-醋酸生育酚0.03-0.15份、植物甲萘醌0.004-0.016份、烟酸硫胺素0.008-0.015份、核黄素0.008-0.015份、盐酸吡哆醇0.008-0.015份、氰钴胺0.001-0.006份、L-抗坏血酸0.05-0.2份、叶酸0.001-0.006份和烟酸0.005-0.04份。
优选地,按重量份计,所述矿物质复合物还包括D-泛酸钙0.01-0.06份、D-生物素0.003-0.018份、氯化钠2-15份、氧化镁1-13份、焦磷酸铁0.1-0.6份、氧化锌0.1-0.8份、碘化钾3-17份、亚硒酸钠0.0005-0.003份、硫酸铜0.015-0.05份、硫酸锰0.05-0.3份和柠檬酸1-13份。
优选地,所述香味剂为乳类香精、水果类香精、蔬菜类香精和坚果类香精中的一种或多种。
优选地,所述碳水化合物为麦芽糊精,所述麦芽糊精的DE值为18;所述蛋白质包括植物性蛋白质和动物性蛋白;所述脂肪为植物油、饱和脂肪酸和不饱和脂肪酸中一种或多种,其中,所述植物油中含有亚油酸和/或α-亚麻酸。
优选地,所述半固化营养剂与温度为50℃±2的蒸馏水按质量比为15-25:90-110混合后形成粘度为50-250mPa·s的流体。
本发明的目的之二是提供一种解决肠内营养不耐受的半固化营养剂的方法,具体包括以下步骤:
步骤1、原料制备
混料1的制备:将维生素复合物和一部分的麦芽糊精中均过60目振荡筛后再进行混合20min,充分混合后得到混料1;其中,混料1中的维生素复合物与麦芽糊精的质量比为1:5~1:10;
混料2的制备:将矿物质复合物和另有一部分的麦芽糊精中均过60目振荡筛后再进行混合20min,充分混合后得到混料2;其中,混料2中的矿物质复合物与麦芽糊精的质量比为1:3~1:5;
步骤2、混料3的制备
将步骤1获得的混料1和混料2进行混合20min,充分混合后得到混料3;
步骤3、产品的制备
将步骤2获得混料3与剩余的麦芽糊精一起混合30min,充分混合后得到产品半固化营养剂;
其中,所述步骤1中的混料1和混料2以及步骤3中的产品半固化营养剂中均可加入蛋白质、脂肪、低甲氧基果胶、香味剂和三氯蔗糖中的一种或多种。
与现有技术相比,本发明具有以下的有益效果:
1、首先,本发明中半固化营养剂与温水(50℃±2的蒸馏水)冲泡后在pH值为7±0.2的环境中是一种类似普通饮料的流动液体,如此,便于患者(如气管关闭肌群控制力减弱的吞咽障碍患者)口服,避免现有技术中的半固化营养剂粘度过高存在难以下咽的问题。其次,由于本发明中的半固化营养剂与温水冲泡后形成的液体的流动性较好,因此,有利于增稠剂低甲氧基果胶在液体中分散均匀,并且有利于后期在胃中形成稳定的半固化凝胶。
其次,本发明中的半固化营养剂与温水冲泡形成的液体进入胃中,在胃酸的作用下促进矿物质复合物中的磷酸氢钙中的钙析出成钙离子,生成的钙离子与低甲氧基果胶中的游离甲氧基发生架桥反应,引起半固化营养剂粘度增加至1Pa·s以上,使其接近食糜的性状,形成“蛋壳”型较为稳定的离子结合型半固化凝胶结构,从而实现抑制胃食管反流、腹泻等肠内营养不耐受反应。
此外,由于增稠剂低甲氧基果胶在液体中均匀分散,形成的半固化凝胶结构相对较为稳定,一方面,有利于延长半固化凝胶在肠内的停留时间,利于患者对半固化营养剂中的各营养组分的充分吸收;另一方面,避免粘度过低导致迅速通过胃进入肠道,从而发生不耐受反应。
并且,由于本发明中的半固化营养剂是在胃中形成半固化凝胶结构,其避免了现有技术中通过直接向液体管饲营养剂中添加琼脂、鸡蛋、果胶等增稠剂的形式使之呈现半固态状会发生蛋白质析出的问题;如此,一方面避免了患者出现不耐受的问题,另一方面避免了本发明制备的半固化营养剂中的营养组分的流失。
2、首先,本发明中的蛋白质为植物性蛋白和动物性蛋白的组合,其中植物性蛋白为大豆分离蛋白,动物性蛋白为分离乳清蛋白,通过将分离乳清蛋白与大豆分离蛋白联合应用,可以实现蛋白质互补作用,优化氨基酸模式,提高整体消化吸收率。
其次,本发明中的碳水化合物选用DE值为18的麦芽糊精,一方面确保本发明制备的半固化营养剂冲泡时的溶解性,即确保了半固化营养剂冲泡形成的液体的流动性,同时还不影响本发明中的半固化营养剂在长期保存过程中的吸湿性。
3、本发明中的半固化营养剂中还加入了香味剂和三氯蔗糖,通过香味剂增加了冲泡后的半固化营养剂从嗅觉上对患者食欲的刺激,从而增加患者的食欲。此外,通过加入三氯蔗糖增加了冲泡后的半固化营养剂的口感,从味觉上刺激患者的食欲。因此,本发明中的半固化营养剂从多个角度对患者食欲的进行刺激,利于患者进食,从而有利于患者康复,降低患者的死亡率。
4、本发明中的半固化营养剂在制备过程中,首先是将维生素复合物和矿物质复合物先分别与麦芽糊精等物质进行混合,然后再将与麦芽糊精等物质混合后的维生素复合物和与麦芽糊精等物质混合后的矿物质复合物进行混合(混料3的制备),从而避免在混料3制备的过程出现高浓度的维生素复合物和矿物质复合物直接接触引发副产物的生成。如此,通过将维生素复合物和矿物质复合物先分别与麦芽糊精等物质进行混合,一方面提高了本发明中的半固化营养剂的安全性,另一方面也避免了本发明中的半固化营养剂中的各营养素降低。
5、本发明中的磷酸氢钙1-20份和低甲氧基果胶10-50份确保了本发明中半固化营养剂与温水冲泡后形成粘度为50-250mPa·s的流体,并且确保该流体在胃酸的作用下能够形成稳定的离子结合型半固化凝胶。
附图说明
图1为本发明中样品1在初始态(pH=7.2)的流动性图;
图2为本发明中样品1在pH=2的流动性图;
图3为本发明中样品1在pH=4的流动性图;
图4为本发明中样品2在初始态(pH=7.2)的流动性图;
图5为本发明中样品2在pH=2的流动性图;
图6为本发明中样品2在pH=4的流动性图。
具体实施方式
1、植物性蛋白质:
本发明中的植物性蛋白质是从大豆、谷物(米)中分离出的蛋白质,在本发明中优选从大豆中分离出的蛋白质,即大豆分离蛋白。
此外,植物性蛋白质还可以是将从大豆中分离的蛋白质进行酶解后得到的大豆低聚肽。
2、动物性蛋白:
本发明中的动物蛋白质是从牛奶、蛋、鱼和贝类中分离出的蛋白质,在本发明中优选从牛奶中分离出的乳清蛋白质,即分离乳清蛋白质。
3、植物油:
本发明中的植物油来源于高油酸葵花籽油粉、大豆油粉、亚麻籽油粉、芝麻油粉、菜籽油粉、橄榄油粉、腰果油粉、榛子油粉、松子油粉和花生油粉中的任意多种。
4、饱和脂肪酸:
本发明中的饱和脂肪酸为:辛酸、月桂酸、棕榈酸、硬脂酸和中链甘油三酯粉中的一种或多种。
5、不饱和脂肪酸:
本发明中的不饱和脂肪酸来源于油酸、二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)中的一种或多种。
6、碳水化合物:
本发明中的碳水化合物来源于糖类(葡萄糖、果糖、半乳糖等)、二糖类(乳糖、蔗糖、麦芽糖等)及多糖类(淀粉、糊精)。本发明中优选DE值为18的麦芽糊精。
实施例
下面结合实施例对本发明的技术方案进一步进行清楚、完整地描述,其中,本发明实施例中所用原材料均为市售。
实施例1
一种解决肠内营养不耐受的半固化营养剂,按重量份计,包括以下组分:
麦芽糊精500份、分离乳清蛋白质69份、大豆分离蛋白质69份、高油酸葵花籽油粉30份、大豆油粉28份、亚麻籽油粉29份、低甲氧基果胶28份、香味剂1.6份、三氯蔗糖0.1份、维生素复合物0.5份和矿物质复合物30份。
其中,香味剂为乳类香精、水果类香精、蔬菜类香精、坚果类香精中的一种或几种的组合;本实施例中的香味剂为花生香精。
按重量份计,维生素复合物包括:维生素A醋酸酯0.02份、胆钙化醇0.02份、dl-α-醋酸生育酚0.03份、植物甲萘醌0.006份、烟酸硫胺素0.1份、核黄素0.1份、盐酸吡哆醇0.008份、氰钴胺0.003份、L-抗坏血酸0.2份、叶酸0.003份和烟酸0.01份。
按重量份计,矿物质复合物包括:D-泛酸钙0.02份、D-生物素0.003份、磷酸氢钙5份、氯化钠16份、氧化镁3.5份、焦磷酸铁0.283份、氧化锌0.38份、碘化钾2.6份、亚硒酸钠0.012份、硫酸铜0.012份、硫酸锰0.09份和柠檬酸钠2.1份。
该解决肠内营养不耐受的半固化营养剂的制备具体包括以下步骤:
步骤1、原料准备
混料1的制备:将维生素复合物、花生香精、三氯蔗糖和5份麦芽糊精过60目振荡筛后投入三维混合机中并混合20min,得到混料1并将其装入袋中备用;
混料2的制备:将矿物质复合物和90份的麦芽糊精过60目振荡筛后投入三维混合机中并混合20min,得到混料2;
步骤2、混料3的制备
将步骤1获得的混料1与混料2投入三维混合机中并混合20min,获得混料3,并装入袋中备用。
步骤3、产品的制备
将步骤2获得的混料3与分离乳清蛋白质69份、大豆分离蛋白质69份、高油酸葵花籽油粉30份、大豆油粉28份、亚麻籽油粉29份、低甲氧基果胶28份和剩余405份麦芽糊精一起在锥形混合机中混合30min,最后得到产品半固化营养剂。其中,剩余组份在进行步骤3混合之前需要经过60目的振动筛进行筛分。
实施例2
一种解决肠内营养不耐受的半固化营养剂,按重量份计,包括以下组分:
麦芽糊精643份、蛋白质150份、脂肪95份、低甲氧基果胶10份、食用香精1份、三氯蔗糖0.1份、维生素复合物0.5份和矿物质复合物40份。
具体地,蛋白质由65份的分离乳清蛋白质、65份的大豆分离蛋白质和20份的大豆低聚肽组成;脂肪由15份中链甘油三酯粉、25份高油酸葵花籽油粉、25份大豆油粉和30份菜籽油粉组成;
其中,香味剂为乳类香精、水果类香精、蔬菜类香精、坚果类香精中的一种或几种的组合;本实施例中的香味剂由乳味香精和红枣香精组成。
按重量份计,维生素复合物包括:生素A醋酸酯0.05份、胆钙化醇0.03份、dl-α-醋酸生育酚0.02份、植物甲萘醌0.009份、烟酸硫胺素0.1份、核黄素0.1份、盐酸吡哆醇0.008份、氰钴胺0.003份、L-抗坏血酸0.167份、叶酸0.003份和烟酸0.01份。
按重量份计,矿物质复合物包括:D-泛酸钙0.02份、D-生物素0.003份、磷酸氢钙8份、氯化钠19份、氧化镁5份、焦磷酸铁0.4份、氧化锌0.4份、碘化钾4份、亚硒酸钠0.015份、硫酸铜0.015份、硫酸锰0.147份和柠檬酸钠3份。
该解决肠内营养不耐受的半固化营养剂的制备具体包括以下步骤:
步骤1、原料准备
混料1的制备:将维生素复合物、分离乳清蛋白质、大豆分离蛋白质、大豆低聚肽和5份的麦芽糊精通过60目振荡筛后投入三维混合机中并混合20min,得到混料1,并将其装入袋中备用;
混料2:将矿物质复合物、低甲氧基果胶、红枣香精、乳味香精、三氯蔗糖、160份麦芽糊精通过60目振荡筛后投入三维混合机中并混合20min,得到混料2,并将其装入袋中备用。
步骤3、混料3的制备
将步骤1获得的混料1与混料2投入三维混合机中并混合20min,获得混料3,并装入袋中备用。
步骤4、产品的制备
将步骤3获得的混料3与中链甘油三酯粉15份、高油酸葵花籽油粉25份、大豆油粉25份、菜籽油粉30份和478份的麦芽糊精粉一起在锥形混合机中混合30min,最后得到半固化营养剂产品。其中,剩余组份在进行步骤3混合之前需要经过60目的振动筛进行筛分。
实施例3
本实施中的产品半固化营养剂的制备方法与实施例1相同,不同的是:所述半固化营养剂中的低甲氧基果胶的质量分数为1.5%。
并通过DHR-1流变仪测定该实施例制备的半固化营养剂冲泡后流体在初始态(pH=7.2)、pH值为2以及pH为4的流动性,其测试结果如图1-3所示。
实施例4
本实施中的产品半固化营养剂的制备方法与实施例1相同,不同的是:所述半固化营养剂中的低甲氧基果胶的质量分数为2.0%。
并通过DHR-1流变仪测定该实施例制备的半固化营养剂冲泡后流体在初始态(pH=7.2)、pH值为2以及pH为4的流动性,其测试结果如图4-6所示。
测试分析
从实施例3和实施例4分别取15-25g的半固化营养剂用90-110ml的50℃的蒸馏水进行冲泡,并分别记为样品1和样品2。然后在室温下用摩尔浓度为1mol/L的盐酸溶液将样品1和样品2的pH均调整为2和4,然后通过DHR-1流变仪测定样品1和样品2在初始态(pH=7.2)、pH值为2以及pH值为4的流动性。
本发明中的DHR-1流变仪在测试时温度为设定为37℃,且其夹具为40mm平行板、剪切速率为0-200s-1、浸泡时间60s、采集时间为60s以及间距为1000μm,其中测试时采用Ramp模式。
其中,样品1的测试结果如图1-3所示,样品2的测试结果如图4-6所示。
根据图1-3可以看出,样品1的初始态(pH=7.2)的流动性如图1所示,pH值为2以及pH为4流动性分别如图2和图3所示,结合图1-3可以看出,样品黏度从0.248pa.s提高到2.178pa.s(pH=4)和4.615pa.s(pH=2),流变特性明显提高,但是样品1在到pH=2时的黏度最大,这是由于较低酸度引起果胶交联结构变化有关。
根据图4-6可以看出,样品2的初始态(pH=7.2)的流动性如图4所示,pH值为2以及pH值为4流动性分别如图5和图6所示,结合图4-6可以看出样品2的黏度从0.228pa.s提高到2.863pa.s(pH=4)和4.589pa.s(pH=2),样品2黏度变化较大。
综合上述对样品1和样品2的测试分析,发现溶解后的2份样品在初始状态(即PH=7.2)时无明显感官差异,并且样品1和样品2的测定粘度均低于0.35pa.s,其流动性较好,类似于普通饮料。但是当用1mol/L的盐酸溶液分别对样品1和样品2的pH值进行调整时,粘度值均大于1Pa·s,初始样品1和样品2接近食糜状,从而提高营养剂的耐受性,避免腹泻、呕吐、反流等不耐受反应。其原因是因为盐酸溶液促进磷酸氢钙中的钙析出成钙离子,并与低甲氧基果胶中的游离甲氧基发生架桥反应,形成食糜的性状半固化凝胶。
以上所述仅是本发明的部分实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (9)
2.根据权利要求1所述的一种解决肠内营养不耐受的半固化营养剂,其特征在于,所述低甲氧基果胶的酯化度为20%-50%。
3.根据权利要求2所述的一种解决肠内营养不耐受的半固化营养剂,其特征在于,按重量份计,还包括0.2-5份的香味剂和0.1-1份的三氯蔗糖。
4.根据权利要求3所述的一种解决肠内营养不耐受的半固化营养剂,其特征在于,按重量份计,所述维生素复合物包括维生素A醋酸酯0.01-0.10份、胆钙化醇0.02-0.08份、dl-α-醋酸生育酚0.03-0.15份、植物甲萘醌0.004-0.016份、烟酸硫胺素0.008-0.015份、核黄素0.008-0.015份、盐酸吡哆醇0.008-0.015份、氰钴胺0.001-0.006份、L-抗坏血酸0.05-0.2份、叶酸0.001-0.006份和烟酸0.005-0.04份。
5.根据权利要求4所述的一种解决肠内营养不耐受的半固化营养剂,其特征在于,按重量份计,所述矿物质复合物还包括D-泛酸钙0.01-0.06份、D-生物素0.003-0.018份、氯化钠2-15份、氧化镁1-13份、焦磷酸铁0.1-0.6份、氧化锌0.1-0.8份、碘化钾3-17份、亚硒酸钠0.0005-0.003份、硫酸铜0.015-0.05份、硫酸锰0.05-0.3份和柠檬酸1-13份。
6.根据权利要求5所述的一种解决肠内营养不耐受的半固化营养剂,其特征在于,所述香味剂为乳类香精、水果类香精、蔬菜类香精和坚果类香精中的一种或多种。
7.根据权利要求6所述的一种解决肠内营养不耐受的半固化营养剂,其特征在于,所述碳水化合物为麦芽糊精,所述麦芽糊精的DE值为18;所述蛋白质包括植物性蛋白质和动物性蛋白;所述脂肪为植物油、饱和脂肪酸和不饱和脂肪酸中一种或多种,其中,所述植物油中含有亚油酸和/或α-亚麻酸。
8.根据权利要求7所述的一种解决肠内营养不耐受的半固化营养剂,其特征在于,所述半固化营养剂与温度为50℃±2的蒸馏水按质量比为15-25:90-110混合后形成粘度为50-250mPa·s的流体。
9.一种解决肠内营养不耐受的半固化营养剂的制备方法,其特征在于,制备权利要求7或8所述的一种解决肠内营养不耐受的半固化营养剂,具体包括以下步骤:
步骤1、原料制备
混料1的制备:将维生素复合物和一部分的麦芽糊精中均过60目振荡筛后再进行混合20min,充分混合后得到混料1;其中,混料1中的维生素复合物与麦芽糊精的质量比为1:5~1:10;
混料2的制备:将矿物质复合物和另有一部分的麦芽糊精中均过60目振荡筛后再进行混合20min,充分混合后得到混料2;其中,混料2中的矿物质复合物与麦芽糊精的质量比为1:3~1:5;
步骤2、混料3的制备
将步骤1获得的混料1和混料2进行混合20min,充分混合后得到混料3;
步骤3、产品的制备
将步骤2获得混料3与剩余的麦芽糊精一起混合30min,充分混合后得到产品半固化营养剂;
其中,所述步骤1中的混料1和混料2以及步骤3中的产品半固化营养剂中均可加入蛋白质、脂肪、低甲氧基果胶、香味剂和三氯蔗糖中的一种或多种。
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