CN112843165A

CN112843165A - Traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animal body

Info

Publication number: CN112843165A
Application number: CN201911193845.6A
Authority: CN
Inventors: 傅体委
Original assignee: Chongqing Langfeng Biotechnology Group Co ltd
Current assignee: Chongqing Langfeng Biotechnology Group Co ltd
Priority date: 2019-11-28
Filing date: 2019-11-28
Publication date: 2021-05-28

Abstract

The invention discloses a traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animal bodies, which comprises the following raw materials in parts by weight: 8-12 parts of torreya seeds, 7-12 parts of agrimony and 10-15 parts of raw areca nuts. The technical scheme can effectively kill, inhibit and expel toxoplasma gondii in the animal body, improve the living environment of cells in the animal body, and simultaneously, the composition is matched with proper antibacterial, anti-inflammatory and antiviral medicines and medicines for improving the immune function of the animal cells, thereby achieving the purposes of repairing and restoring cell health, naturally eliminating all diseases and solving the current quarantine and epidemic problems of high epidemic situation of animals.

Description

Traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animal body

Technical Field

The invention belongs to the field of feed additives, and particularly relates to a traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animal bodies.

Background

Parasites refer to lower eukaryotes that are pathogenic and can act as pathogens and also mediate disease transmission. A parasite is characterized as being any organism within or attached to the host or host body to obtain the nutrients or refuge necessary to maintain its survival, development or reproduction.

Parasitic diseases are diseases caused by some parasites parasitizing in the human and animal body. It is a disease with the widest distribution, various varieties and serious harm in the world. Common parasites include hookworm, roundworm, schistosome, bloodworm, liver fluke, lung fluke, spore, cyst and other parasites, especially toxoplasma (also called three cadaveric worms in traditional Chinese medicine) in parasites, which are zoonosis parasites, parasitize in nucleated cells of human and animals, compete with cells for nutrition in a predatory manner, excrete a large amount of excrement and toxin, and are pathogens which harm human beings to the greatest extent; it parasitizes in cells, flows with blood, reaches all parts of the body, destroys important organs such as brain, heart, liver, eyes, lung, etc., and causes the immunity of human and animals to be reduced, and various diseases are suffered.

Over 100 years since 1900 years when existence of toxoplasma is discovered to date, scientists have found that the medicines capable of inhibiting toxoplasma comprise sulfanilamide, pyrimethamine, tetracycline, spiramycin, artemether, compound albendazole tablet, praziquantel tablet, furazolidone tablet, metronidazole tablet and the like, but the medicines can inhibit toxoplasma trophosome and are ineffective to cyst, and if the medicines are used for a long time, drug toxicity is generated, so that the aim of curing the toxoplasma cannot be achieved; moreover, the western medicines have serious toxic and side effects of damaging the liver and the kidney, are easy to cause systemic drug dermatitis and the like, and are not suitable for long-term administration.

In conclusion, the toxoplasma is extremely harmful to human bodies or animals, and the discovered medicaments only have the effect of inhibiting and nourishing the toxoplasma, have certain toxic and side effects on the human bodies, are not easy to take for a long time and cannot achieve the effect of healing.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animal bodies; the efficacy is as follows: can effectively kill, inhibit and expel toxoplasma gondii in animal bodies, improve the living environment of cells in animal bodies, and simultaneously, is matched with proper antibacterial, anti-inflammatory and antiviral medicines and improves the immune function of animal cells, thereby achieving the purposes of repairing and restoring cell health, naturally eliminating all diseases and solving the current quarantine and epidemic prevention problems of high epidemic situation of animals.

In order to achieve the technical purpose, the technical scheme adopted by the invention is as follows:

a traditional Chinese medicine biological feed additive formula for treating toxoplasma gondii in animal bodies comprises the following raw materials in parts by weight: 8-12 parts of torreya seeds, 7-12 parts of agrimony and 10-15 parts of raw areca nuts.

Further, the medicine comprises the following raw materials in parts by weight: 2-6 parts of scutellaria baicalensis, 12-15 parts of dandelion and 8-15 parts of isatis root.

Further, the medicine comprises the following raw materials in parts by weight: 15-20 parts of astragalus membranaceus, 5-9 parts of bighead atractylodes rhizome, 6-10 parts of cinnamon, 3-6 parts of clove and 3-6 parts of liquorice.

The torreya seeds, raw areca nuts and agrimony buds are monarch drugs, and pharmacological components such as torreya seeds oil, arecoline, agrimophol and the like contained in the composition have better killing effect on toxoplasma gondii through in vitro experiments;

the scutellaria baicalensis, the cinnamon, the clove and the liquorice are ministerial drugs, and the baicalin, the cinnamyl phenol, the clove oil, the glycyrrhizin and the like contained in the composition have better killing, anaesthetizing, inhibiting and expelling effects on hookworm, winged insect, roundworm, schistosome, bloodworm, sporulate worm, liver fluke, lung fluke, flagellate, fasciola, trichomonas, acarid and the like, and further strengthen and supplement the insecticidal effect of monarch drugs;

the astragalus, the white atractylodes rhizome and the like are adjuvant drugs and have the functions of strengthening body resistance, consolidating the constitution and improving the immunity of the organism; the dandelion and the isatis root are used as guiding drugs and have the effects of clearing away heat and toxic materials, resisting bacteria and inflammation and resisting viruses.

In the invention, 3 medicines in the monarch drug can have the effect of the invention; the effect of the invention can be further enhanced by monarch and minister collocation; in addition, the drugs in the monarch drug can also be directly matched with adjuvant drugs and messenger drugs for use; and the monarch, the minister, the assistant and the guide can be matched together for use, so that a better effect is achieved.

Due to the adoption of the technical scheme, the invention has the following advantages: can effectively paralyze the muscle of the parasite and block the conduction function of the central nervous system of the brain, inhibit and cut off the synthesis of parasite protein to completely lose the activity and even die, and finally is discharged out of the body through metabolite, thereby effectively killing, inhibiting and expelling the parasite in the human body and the livestock, repairing and restoring the health of cells, and naturally eliminating all diseases.

The medicine properties of the components of the invention are as follows:

chinese torreya seeds:

alias: chinese torreya, yu torreya, and Chinese torreya.

Nature and taste: sweet and neutral.

Meridian tropism: it enters lung, stomach and large intestine meridians.

The functions are mainly as follows: killing parasites, removing food retention, moistening lung, relieving cough, moistening dryness, and relaxing bowels; can be used for treating ancylostomiasis, ascariasis, taeniasis, abdominal pain due to parasitic infestation, infantile malnutrition, cough due to lung dryness, and constipation.

Raw areca nuts:

alias: jade, Bingmen and youth

Nature and taste: bitter, pungent and warm.

Meridian tropism: it enters stomach and large intestine meridians.

The functional indications are as follows: killing parasites, removing food retention, promoting qi circulation, inducing diuresis, and preventing malaria; can be used for treating taeniasis, ascariasis, fasciolopsiasis, abdominal pain due to parasitic infestation, dysentery, tenesmus, edema, tinea pedis, and malaria.

Cinnamon:

alias: cinnamomum cassia, and Cinnamomum cassia.

Nature and taste: pungent and sweet in flavor and strongly hot in nature.

Meridian tropism: it enters kidney, spleen, heart and liver meridians.

The functional indications are as follows: has the effects of tonifying fire, supporting yang, guiding fire to the origin, dispelling cold, relieving pain, and warming and dredging channels and collaterals; can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, floating of deficient yang, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.

Clove:

alias: flos Caryophylli, and flos Caryophylli.

Nature and taste: pungent flavor and warm nature.

Meridian tropism: it enters spleen, stomach, lung and kidney meridians.

The functional indications are as follows: has the effects of warming the middle-jiao, lowering the adverse flow of qi, promoting qi circulation, relieving pain, removing dirt, killing parasite, invigorating kidney, and tonifying yang; can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency.

Licorice root:

alias: radix Glycyrrhizae Praeparata, herba Trifolii Praefolii, herba Claoxyli, and herba Lycopodii Serrati

Nature and taste: sweet in flavor and neutral in nature.

Meridian tropism: it enters heart, lung, spleen and stomach meridians.

The functional indications are as follows: invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the above medicines; can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Astragalus root:

nature and taste: warm in nature and sweet in taste.

The functional indications are as follows: tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, and promote granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, prolapse of nasal mucosa and nasal mucosa, chronic nephritis, albuminuria, diabetes, and unhealed wound.

White atractylodes rhizome:

alias: floating thistle, Yuzhu, Dong Bai Zhu, Thunberg, Yang Fu, Wu Zhu, shan thi, Po Qu and shan Ji.

Nature and taste: bitter and sweet in taste and warm in nature.

Meridian tropism: it enters spleen and stomach meridians.

The functional indications are as follows: invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion; tu Bai Zhu strengthens spleen, harmonizes stomach and prevents abortion. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and threatened abortion.

Scutellaria baicalensis:

alias: herba Camelliae Japonicae and radix Scutellariae tea.

Nature and taste: bitter taste and cold nature.

Meridian tropism: it enters lung, gallbladder, spleen, large intestine and small intestine meridians.

The functional indications are as follows: clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage; can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Dandelion:

alias: HUALANG, herba Taraxaci, and herba Taraxaci.

Nature and taste: bitter, sweet and cold.

Meridian tropism: it enters liver and stomach meridians.

The functional indications are as follows: clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, inducing diuresis, and treating stranguria; furuncle, swelling and toxicity, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, stranguria with astringency and pain due to heat.

Radix isatidis:

alias: indigo root, radix Clerodenri Cyrtophylli.

Nature and taste: bitter and cold.

Meridian tropism: heart, stomach, liver, gallbladder channels.

The functional indications are as follows: clearing away heat and toxic materials, cooling blood, relieving sore throat, resisting virus and bacteria; it can be used for treating diseases due to toxic heat, such as influenza, upper respiratory infection, epidemic encephalitis, parotitis, acute enteritis, hepatitis, bacillary dysentery, and epidemic heat toxin.

Agrimony:

alias: wolf tooth, agrimony root tooth.

Nature and taste: cool in nature and bitter in taste.

Meridian tropism: the large intestine channel.

The functional indications are as follows: expelling parasites, removing toxicity and relieving swelling; it is the essential herb for treating tapeworm disease, trichomonas vaginalis, schistosome, cysticercus, ascaris, sore, ulcer, mange, furuncle and dysentery.

Detailed Description

In order that those skilled in the art can better understand the present invention, the following embodiments are provided to further illustrate the present invention.

A traditional Chinese medicine biological feed additive formula for treating toxoplasma gondii in animal bodies comprises the following raw materials in parts by weight: 8-12 parts of torreya grandis seeds, 7-12 parts of agrimony buds, 10-15 parts of raw areca nuts, 2-6 parts of scutellaria baicalensis, 6-10 parts of cinnamon, 3-6 parts of clove and 3-6 parts of liquorice.

Firstly, clinical verification data:

1. 1000 cases in this group, of which: 300 cases of pigs, 100 cases of cattle, 300 cases of sheep and 300 cases of poultry.

2. The purpose of the test is as follows:

2.1 the Chinese medicinal biological feed additive has the effects of inhibiting and killing toxoplasma gondii in blood cells of animals.

2.2 animals were fed a standard amount of the pharmaceutical feed additive daily and observed for disease and epidemic control without any antibiotic injection and feeding.

2.3 after the animals eat a certain amount of the medicinal feed additive according to the standard every day, the growth condition (growth cycle) of the animals is observed under the condition that the animals do not take any growth-promoting hormone.

2.4 observing the quality change of meat quality of various animals (whether the meat quality reaches high quality) after the animals expel toxoplasma gondii

3. Diagnostic criteria:

3.1 GB/T30224-2013 national standard of the people's republic of China, "Toxoplasma gondii test clinical application just di".

3.2 WS/T486-2015 sanitary industry Standard toxoplasmosis of the people's republic of China.

3.3 the diagnosis of the disease names all accord with the international health organization disease diagnosis standard (including clinical symptoms, physical signs and laboratory examination indexes).

II, dialectical treatment:

30 days is a course of treatment, and according to the activity and clinical symptoms of pathogenic Toxoplasma gondii in blood checked by laboratories, treatment schemes are made according to animal species, such as:

1. pork pigs; a Chinese medicinal biological feed additive (commercial feed containing 5-10% of Chinese medicinal biological feed additive) for resisting animal toxoplasma is administered at a dose of 1-3kg for 2 times per day.

2. Beef cattle: a Chinese medicinal biological feed additive (commercial feed containing 5-10% of Chinese medicinal biological feed additive) for resisting animal toxoplasma is administered once a day 2 times (5-10 kg each time).

3. Mutton sheep: a Chinese medicinal biological feed additive (commercial feed containing 5-10% of Chinese medicinal biological feed additive) for resisting animal toxoplasma is administered at a dose of 1-2kg each time 2 times per day.

4. Poultry: the Chinese medicinal biological feed additive (commercial feed containing 5-10% Chinese medicinal biological feed additive) for resisting animal toxoplasma is administered 2 times per day, 0.01-0.02kg per time.

Thirdly, observation of curative effect

1. Standard of care

1.1 cure: the humoral immune response time is less than 5 minutes, the cellular immunity is strong, the morbidity of a disease source body is less than that of a parasitism body, a toxoplasma body and a swallow-shaped body are absent, and the clinical symptoms basically disappear;

1.2 effective: the humoral immune response time is less than 5 minutes, the cellular immunity is strong, the morbidity of a disease source body is less than that of a host, a small amount of swallow-shaped bodies exist, and the clinical symptoms are relieved;

1.3 invalid: laboratory examination results and clinical symptoms were not significantly improved.

2. Treatment outcome statistics were as follows:

disorders of the disease	Number of	Cure of disease	Show effect	Invalidation	Effective rate (%)
						Pork pig	200	150	40	10	95
Beef cattle	100	70	25	5	95
						Mutton sheep	200	170	20	10	95
Poultry raising	500	400	70	30	94
						Total up to	1000	810	145	55	95.5

3. And (3) analyzing the curative effect:

the treatment time was 4 months minimum and 12 months maximum in 1000 animals. The traditional Chinese medicine composition is prepared from 810 cured cases, 145 effective cases and 55 ineffective cases, the effective rate of treatment is 95.5 percent on average, and 55 ineffective cases comprise 30 poultry cases, 10 pork pigs, 10 mutton sheep and 5 beef cattle. Statistics show that the treatment result is related to the dietary structure of animals, the time for taking additives, the living space environment and the like.

The 4 animals are all common animals, no diseases occur in the feeding period, the growth vigor is good, the weight of some animals is even more than that of the animals fed with somatotrophic hormones, and the meat quality is excellent and completely meets the national standard. Greatly reduces the breeding risk of the breeding industry, improves the enthusiasm of farmers, and completely conforms to the six strategies and principles of the animal husbandry development of the national agricultural and rural departments in research projects.

The Chinese medicinal biological feed additive for treating toxoplasma in animals provided by the invention is described in detail above. The description of the specific embodiments is only intended to facilitate an understanding of the method of the invention and its core ideas. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.

Claims

1. A traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animal bodies is characterized in that: the medicine comprises the following raw materials in parts by weight: 8-12 parts of torreya seeds, 7-12 parts of agrimony and 10-15 parts of raw areca nuts.

2. The traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animals according to claim 1, which is characterized in that: the medicine also comprises the following medicine raw materials in parts by weight: 2-6 parts of scutellaria baicalensis, 12-15 parts of dandelion and 8-15 parts of isatis root.

3. The traditional Chinese medicine biological feed additive for treating toxoplasma gondii in animals according to claim 2, which is characterized in that: the medicine also comprises the following medicine raw materials in parts by weight: 15-20 parts of astragalus membranaceus, 5-9 parts of bighead atractylodes rhizome, 6-10 parts of cinnamon, 3-6 parts of clove and 3-6 parts of liquorice.