CN112839940A - 胺基脲敏感性胺氧化酶抑制剂制备及其应用 - Google Patents

胺基脲敏感性胺氧化酶抑制剂制备及其应用 Download PDF

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CN112839940A
CN112839940A CN201980062160.XA CN201980062160A CN112839940A CN 112839940 A CN112839940 A CN 112839940A CN 201980062160 A CN201980062160 A CN 201980062160A CN 112839940 A CN112839940 A CN 112839940A
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CN112839940B (zh
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刘胜洋
邓建稳
冯志勇
江磊
乔智
尚珂
谢小平
徐雪丽
徐圆
赵海霞
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Shanghai Ennovabio Pharmaceuticals Co Ltd
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Abstract

提供了一种胺基脲敏感性胺氧化酶抑制剂制备及其应用。具体地，公开了一种式I所示的化合物或其立体异构体或外消旋体或其药学上可接受的盐。还公开了上述化合物可抑制胺基脲敏感性胺氧化酶。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201980062160.XA 2018-09-25 2019-09-25 氨基脲敏感性胺氧化酶抑制剂制备及其应用 Active CN112839940B (zh)

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CN201811119234.2A CN110938059A (zh) 2018-09-25 2018-09-25 胺基脲敏感性胺氧化酶抑制剂制备及其应用
CN2018111192342 2018-09-25
PCT/CN2019/107972 WO2020063696A1 (zh) 2018-09-25 2019-09-25 胺基脲敏感性胺氧化酶抑制剂制备及其应用

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KR20190110740A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20190110736A (ko) 2018-03-21 2019-10-01 주식회사유한양행 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
TWI835945B (zh) * 2018-12-14 2024-03-21 南韓商柳韓洋行股份有限公司 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物
TW202039486A (zh) * 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
IL296816A (en) * 2020-03-25 2022-11-01 Terns Inc Treatment of respiratory disorders
CN116615416A (zh) 2020-08-25 2023-08-18 伊莱利利公司 Ssao抑制剂的多晶型物
CN114621190B (zh) * 2020-12-14 2023-12-05 上海拓界生物医药科技有限公司 一种烯丙基胺类衍生物及其用途
CN114621189B (zh) * 2020-12-14 2024-01-02 上海拓界生物医药科技有限公司 一种内酰胺类衍生物及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018028517A1 (en) * 2016-08-12 2018-02-15 Eli Lilly And Company Amino pyrimidine ssao inhibitors
WO2018151985A1 (en) * 2017-02-14 2018-08-23 Eli Lilly And Company Amino pyrimidine compounds useful as ssao inhibitors
WO2018196677A1 (zh) * 2017-04-28 2018-11-01 四川科伦博泰生物医药股份有限公司 氟代烯丙胺衍生物及其用途
WO2018233633A1 (zh) * 2017-06-20 2018-12-27 南京明德新药研发股份有限公司 Ssao 抑制剂
CN109251166A (zh) * 2017-07-13 2019-01-22 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2222160B1 (en) * 2007-11-21 2015-03-18 Pharmaxis Ltd. Haloallylamine inhibitors of ssao/vap-1 and uses therefor
PL2844637T3 (pl) * 2012-05-02 2018-09-28 Boehringer Ingelheim International Gmbh Podstawione 3-haloalliloaminowe inhibitory ssao i ich zastosowania
CN109810041B (zh) * 2017-11-21 2023-08-15 药捷安康(南京)科技股份有限公司 卤代烯丙基胺类ssao/vap-1抑制剂及其应用
CN113226296A (zh) * 2018-10-24 2021-08-06 梅塔科林公司 Ssao抑制剂及其用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018028517A1 (en) * 2016-08-12 2018-02-15 Eli Lilly And Company Amino pyrimidine ssao inhibitors
WO2018151985A1 (en) * 2017-02-14 2018-08-23 Eli Lilly And Company Amino pyrimidine compounds useful as ssao inhibitors
WO2018196677A1 (zh) * 2017-04-28 2018-11-01 四川科伦博泰生物医药股份有限公司 氟代烯丙胺衍生物及其用途
WO2018233633A1 (zh) * 2017-06-20 2018-12-27 南京明德新药研发股份有限公司 Ssao 抑制剂
CN109251166A (zh) * 2017-07-13 2019-01-22 广东东阳光药业有限公司 抑制ssao/vap-1的胺类化合物及其在医药上的应用

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