CN112823165B - 新型l-色氨酸输出蛋白变体及使用其生产l-色氨酸的方法 - Google Patents

新型l-色氨酸输出蛋白变体及使用其生产l-色氨酸的方法 Download PDF

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CN112823165B
CN112823165B CN202080004146.7A CN202080004146A CN112823165B CN 112823165 B CN112823165 B CN 112823165B CN 202080004146 A CN202080004146 A CN 202080004146A CN 112823165 B CN112823165 B CN 112823165B
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leu
ala
gly
amino acid
val
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CN112823165A (zh
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郑武泳
金贤雅
徐昌一
李任相
金智元
金泰延
孙晟光
丁起龙
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CJ CheilJedang Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN202080004146.7A 2019-04-05 2020-03-20 新型l-色氨酸输出蛋白变体及使用其生产l-色氨酸的方法 Active CN112823165B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2019-0040397 2019-04-05
KR1020190040397A KR102205717B1 (ko) 2019-04-05 2019-04-05 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
PCT/KR2020/003855 WO2020204427A1 (ko) 2019-04-05 2020-03-20 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법

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CN112823165A CN112823165A (zh) 2021-05-18
CN112823165B true CN112823165B (zh) 2024-03-26

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US (1) US11524981B2 (enExample)
EP (1) EP3789398A4 (enExample)
JP (2) JP7539871B2 (enExample)
KR (1) KR102205717B1 (enExample)
CN (1) CN112823165B (enExample)
BR (1) BR112021000765B1 (enExample)
CA (1) CA3105666C (enExample)
MX (1) MX2021000685A (enExample)
RU (1) RU2763603C1 (enExample)
WO (1) WO2020204427A1 (enExample)

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KR102647745B1 (ko) * 2020-05-27 2024-03-14 씨제이제일제당 주식회사 신규 l-타이로신 배출 단백질 변이체 및 이를 이용한 l-타이로신을 생산하는 방법
KR102617168B1 (ko) * 2020-12-09 2023-12-21 씨제이제일제당 (주) 쉬와넬라 오네이덴시스 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
KR102284727B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 단백질 HtrL 변이체 및 이를 이용한 L-트립토판 생산 방법
KR102284728B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 H(+)/Cl(-) 익스체인지 트랜스포터 변이체 및 이를 이용한 L-트립토판 생산 방법
KR102284726B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 타우토머레이즈 pptA 변이체 및 이를 이용한 L-트립토판 생산 방법
KR102284725B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 페로체라테이즈 변이체 및 이를 이용한 l-트립토판 생산 방법
KR102284729B1 (ko) * 2021-01-29 2021-08-02 씨제이제일제당 주식회사 신규한 시아네이트 트랜스포터 패밀리 단백질변이체 및 이를 이용한 l-트립토판 생산 방법
KR102688095B1 (ko) * 2021-04-28 2024-07-24 씨제이제일제당 주식회사 변이형 SpoT 단백질 및 이를 이용한 L-아미노산을 생산하는 방법
WO2024090884A1 (ko) * 2022-10-24 2024-05-02 대상 주식회사 페닐알라닌:h+ 동시수송체 phep 신규 변이체 및 이를 이용한 l-방향족 아미노산의 생산 방법
KR102771798B1 (ko) * 2022-10-24 2025-02-25 대상 주식회사 Qin 프로파지; 단백질 YnfQ 신규 변이체 및 이를 이용한 L-방향족 아미노산의 생산 방법
EP4610272A1 (en) * 2022-10-24 2025-09-03 Daesang Corporation Novel variant of dna-binding transcriptional regulator malt and method for producing l-aromatic amino acid using same
KR102877975B1 (ko) * 2022-12-28 2025-10-31 씨제이제일제당 주식회사 외래 글루타민 신테타제가 도입된 미생물 및 이를 이용한 l-트립토판의 생산 방법

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KR20180089329A (ko) * 2018-02-23 2018-08-08 씨제이제일제당 (주) L-트립토판을 생산하는 재조합 코리네형 미생물 및 이를 이용한 l-트립토판을 생산하는 방법

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BR112021000765A2 (pt) 2021-04-13
RU2763603C1 (ru) 2021-12-30
JP7539871B2 (ja) 2024-08-26
KR102205717B1 (ko) 2021-01-22
CA3105666A1 (en) 2020-10-08
EP3789398A1 (en) 2021-03-10
WO2020204427A1 (ko) 2020-10-08
JP2021525108A (ja) 2021-09-24
EP3789398A4 (en) 2021-08-25
CA3105666C (en) 2023-06-27
BR112021000765B1 (pt) 2022-05-10
KR20200118334A (ko) 2020-10-15
US11524981B2 (en) 2022-12-13
CN112823165A (zh) 2021-05-18
US20220009973A1 (en) 2022-01-13
MX2021000685A (es) 2021-03-25
JP2022185040A (ja) 2022-12-13

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