RU2763603C1 - Новый вариант белка-экспортера l-триптофана и способ получения l-триптофана с его применением - Google Patents

Новый вариант белка-экспортера l-триптофана и способ получения l-триптофана с его применением Download PDF

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RU2763603C1
RU2763603C1 RU2020139396A RU2020139396A RU2763603C1 RU 2763603 C1 RU2763603 C1 RU 2763603C1 RU 2020139396 A RU2020139396 A RU 2020139396A RU 2020139396 A RU2020139396 A RU 2020139396A RU 2763603 C1 RU2763603 C1 RU 2763603C1
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leu
ala
gly
val
amino acid
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RU2020139396A
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Russian (ru)
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Му Ён ЧОН
Хён А КИМ
Чан Иль СО
Имсан ЛИ
Чжи-вон КИМ
Тэ Ён КИМ
Сун Кван СОН
Ки Ён ЧОН
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СиДжей ЧеилДжеданг Корпорейшн
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
RU2020139396A 2019-04-05 2020-03-20 Новый вариант белка-экспортера l-триптофана и способ получения l-триптофана с его применением RU2763603C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020190040397A KR102205717B1 (ko) 2019-04-05 2019-04-05 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법
KR10-2019-0040397 2019-04-05
PCT/KR2020/003855 WO2020204427A1 (ko) 2019-04-05 2020-03-20 신규 l-트립토판 배출 단백질 변이체 및 이를 이용한 l-트립토판을 생산하는 방법

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RU2763603C1 true RU2763603C1 (ru) 2021-12-30

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RU2020139396A RU2763603C1 (ru) 2019-04-05 2020-03-20 Новый вариант белка-экспортера l-триптофана и способ получения l-триптофана с его применением

Country Status (10)

Country Link
US (1) US11524981B2 (enExample)
EP (1) EP3789398A4 (enExample)
JP (2) JP7539871B2 (enExample)
KR (1) KR102205717B1 (enExample)
CN (1) CN112823165B (enExample)
BR (1) BR112021000765B1 (enExample)
CA (1) CA3105666C (enExample)
MX (1) MX2021000685A (enExample)
RU (1) RU2763603C1 (enExample)
WO (1) WO2020204427A1 (enExample)

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KR102647745B1 (ko) * 2020-05-27 2024-03-14 씨제이제일제당 주식회사 신규 l-타이로신 배출 단백질 변이체 및 이를 이용한 l-타이로신을 생산하는 방법
KR102617168B1 (ko) * 2020-12-09 2023-12-21 씨제이제일제당 (주) 쉬와넬라 오네이덴시스 유래 단백질을 발현하는 미생물, 및 이를 이용한 l-아미노산 생산 방법
KR102284727B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 단백질 HtrL 변이체 및 이를 이용한 L-트립토판 생산 방법
KR102284725B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 페로체라테이즈 변이체 및 이를 이용한 l-트립토판 생산 방법
KR102284726B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 타우토머레이즈 pptA 변이체 및 이를 이용한 L-트립토판 생산 방법
KR102284728B1 (ko) * 2021-01-25 2021-08-02 씨제이제일제당 주식회사 신규한 H(+)/Cl(-) 익스체인지 트랜스포터 변이체 및 이를 이용한 L-트립토판 생산 방법
KR102284729B1 (ko) * 2021-01-29 2021-08-02 씨제이제일제당 주식회사 신규한 시아네이트 트랜스포터 패밀리 단백질변이체 및 이를 이용한 l-트립토판 생산 방법
KR102688095B1 (ko) * 2021-04-28 2024-07-24 씨제이제일제당 주식회사 변이형 SpoT 단백질 및 이를 이용한 L-아미노산을 생산하는 방법
KR102771797B1 (ko) * 2022-10-24 2025-02-25 대상 주식회사 GlpM 패밀리 단백질 신규 변이체 및 이를 이용한 L-방향족 아미노산의 생산 방법
US20260152769A1 (en) * 2022-10-24 2026-06-04 Daesang Corporation Novel variant of dna-binding transcriptional regulator malt and method for producing l-aromatic amino acid using same
WO2024090884A1 (ko) * 2022-10-24 2024-05-02 대상 주식회사 페닐알라닌:h+ 동시수송체 phep 신규 변이체 및 이를 이용한 l-방향족 아미노산의 생산 방법
KR102877975B1 (ko) * 2022-12-28 2025-10-31 씨제이제일제당 주식회사 외래 글루타민 신테타제가 도입된 미생물 및 이를 이용한 l-트립토판의 생산 방법
WO2026099434A2 (en) 2024-11-08 2026-05-15 Cysbio Aps Eama transporter mutants and uses thereof

Citations (2)

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EP1013765A1 (en) * 1998-12-23 2000-06-28 Ajinomoto Co., Ltd. Gene and method for producing L-amino acids
RU2593957C2 (ru) * 2012-01-10 2016-08-10 СиДжей ЧЕИЛДЗЕДАНГ КОРПОРЕЙШН МИКРООРГАНИЗМ ИЗ РОДА Escherichia, ОБЛАДАЮЩИЙ УСИЛЕННОЙ СПОСОБНОСТЬЮ К ПРОДУКЦИИ L-ТРИПТОФАНА, И СПОСОБ ПОЛУЧЕНИЯ L-ТРИПТОФАНА С ЕГО ИСПОЛЬЗОВАНИЕМ

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RU2175351C2 (ru) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
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WO2020204427A1 (ko) 2020-10-08
US11524981B2 (en) 2022-12-13
EP3789398A1 (en) 2021-03-10
KR102205717B1 (ko) 2021-01-22
BR112021000765B1 (pt) 2022-05-10
US20220009973A1 (en) 2022-01-13
CN112823165A (zh) 2021-05-18
CN112823165B (zh) 2024-03-26
CA3105666C (en) 2023-06-27
BR112021000765A2 (pt) 2021-04-13
JP2021525108A (ja) 2021-09-24
JP7539871B2 (ja) 2024-08-26
JP2022185040A (ja) 2022-12-13
MX2021000685A (es) 2021-03-25
KR20200118334A (ko) 2020-10-15
CA3105666A1 (en) 2020-10-08
EP3789398A4 (en) 2021-08-25

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