CN112638431A - 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 - Google Patents

用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 Download PDF

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CN112638431A
CN112638431A CN201980056945.6A CN201980056945A CN112638431A CN 112638431 A CN112638431 A CN 112638431A CN 201980056945 A CN201980056945 A CN 201980056945A CN 112638431 A CN112638431 A CN 112638431A
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cyano
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安德鲁·G·霍尔蒂
拉维·奈克
罗伯特·F·达纳尔斯
M·G·庞珀
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Johns Hopkins University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Life Sciences & Earth Sciences (AREA)
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  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
CN201980056945.6A 2018-06-26 2019-06-26 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂 Pending CN112638431A (zh)

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CN202410732670.6A CN118743770A (zh) 2018-06-26 2019-06-26 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂

Applications Claiming Priority (3)

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US201862689958P 2018-06-26 2018-06-26
US62/689,958 2018-06-26
PCT/US2019/039234 WO2020006075A1 (en) 2018-06-26 2019-06-26 Positron emission tomography (pet) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (csf1r) in neuroinflammation

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CN202410732670.6A Division CN118743770A (zh) 2018-06-26 2019-06-26 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂

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CN202410732670.6A Pending CN118743770A (zh) 2018-06-26 2019-06-26 用于对神经炎症中的巨噬细胞集落刺激因子1受体(csf1r)进行成像的正电子发射断层成像术(pet)放射性示踪剂

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US (1) US20210290784A1 (enExample)
EP (1) EP3813890A4 (enExample)
JP (2) JP7884818B2 (enExample)
KR (1) KR20210013769A (enExample)
CN (2) CN112638431A (enExample)
AU (1) AU2019294699B2 (enExample)
BR (1) BR112020026602A2 (enExample)
CA (1) CA3104520A1 (enExample)
EA (1) EA202092843A1 (enExample)
IL (1) IL279768B2 (enExample)
MX (1) MX2021000141A (enExample)
WO (1) WO2020006075A1 (enExample)

Cited By (2)

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CN118021811A (zh) * 2023-12-28 2024-05-14 复旦大学附属华山医院 一种靶向于csf1r激酶的6-氟吡啶甲酰苯胺类抑制剂、药物组合物及其核素成像试剂
CN118027009A (zh) * 2024-04-15 2024-05-14 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用

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MA54550A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
AU2019401495B2 (en) * 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2019404576B2 (en) 2018-12-20 2025-07-17 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2020325115B2 (en) 2019-08-02 2026-03-12 Amgen Inc. Pyridine derivatives as KIF18A inhibitors
JP7699100B2 (ja) 2019-08-02 2025-06-26 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
EP4269404A4 (en) * 2020-12-25 2024-12-04 Xizang Haisco Pharmaceutical Co., Ltd. KETOHEXOKINASE INHIBITORS AND USE THEREOF
US20240237960A1 (en) * 2021-06-11 2024-07-18 Jubilant Draximage Inc. Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease
US20250275730A1 (en) * 2022-04-06 2025-09-04 University Of Virginia Patent Foundation Automation of the blood input function computation pipeline for dynamic fdg pet for human brain using machine learning
AU2024214768A1 (en) * 2023-01-30 2025-08-07 The Johns Hopkins University 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor
CN119498255B (zh) * 2024-10-24 2025-11-25 香港理工大学深圳研究院 一种抑郁症小鼠模型及其构建方法与应用

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AU2017258415B2 (en) * 2016-04-29 2023-03-30 Cornell University Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors

Patent Citations (1)

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CN101084208A (zh) * 2004-10-22 2007-12-05 詹森药业有限公司 作为c－fms激酶抑制剂的芳族酰胺

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CARL R. ILLIG ET AL: "Discovery of novel FMS kinase inhibitors as anti-inflammatory agents", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》, vol. 18, pages 1642 *
CARL R. ILLIG ET AL: "Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide(JNJ-28312141)", 《J. MED. CHEM.》, vol. 54 *
FLORIAN BAUER ET AL: "Synthesis and in vivo evaluation of [11C] tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
FLORIAN BAUER ET AL: "Synthesis and in vivo evaluation of [11C] tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor", 《BIOORGANIC & MEDICINAL CHEMISTRY》, 22 June 2010 (2010-06-22), pages 1 *
NAIK RAVI ET AL: "PET tracer for imaging the macrophage colony stimulating factor receptor", 《JOURNAL OF NUCLEAR MEDICINE》, vol. 59, 1 May 2018 (2018-05-01), pages 1, XP009524792 *
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118021811A (zh) * 2023-12-28 2024-05-14 复旦大学附属华山医院 一种靶向于csf1r激酶的6-氟吡啶甲酰苯胺类抑制剂、药物组合物及其核素成像试剂
CN118027009A (zh) * 2024-04-15 2024-05-14 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用
CN118027009B (zh) * 2024-04-15 2024-07-12 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用

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JP7884818B2 (ja) 2026-07-06
BR112020026602A2 (pt) 2021-03-23
KR20210013769A (ko) 2021-02-05
JP2024133496A (ja) 2024-10-02
US20210290784A1 (en) 2021-09-23
JP2021533087A (ja) 2021-12-02
IL279768A (en) 2021-03-01
EP3813890A1 (en) 2021-05-05
MX2021000141A (es) 2021-03-25
EA202092843A1 (ru) 2021-04-19
AU2019294699A1 (en) 2021-01-21
AU2019294699B2 (en) 2025-05-01
EP3813890A4 (en) 2022-03-23
CN118743770A (zh) 2024-10-08
IL279768B1 (en) 2024-12-01
IL279768B2 (en) 2025-04-01
CA3104520A1 (en) 2020-01-02
WO2020006075A1 (en) 2020-01-02

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