JP7884818B2 - 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー - Google Patents

神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

Info

Publication number
JP7884818B2
JP7884818B2 JP2020571842A JP2020571842A JP7884818B2 JP 7884818 B2 JP7884818 B2 JP 7884818B2 JP 2020571842 A JP2020571842 A JP 2020571842A JP 2020571842 A JP2020571842 A JP 2020571842A JP 7884818 B2 JP7884818 B2 JP 7884818B2
Authority
JP
Japan
Prior art keywords
phenyl
group
carboxamide
piperidine
cppc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020571842A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021533087A (ja
JP2021533087A5 (enExample
Inventor
ジー ホルティ アンドリュー
ナイク ラヴィ
エフ ダンナルズ ロバート
ジー ポンパー マーティン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of JP2021533087A publication Critical patent/JP2021533087A/ja
Publication of JP2021533087A5 publication Critical patent/JP2021533087A5/ja
Priority to JP2024096077A priority Critical patent/JP2024133496A/ja
Application granted granted Critical
Publication of JP7884818B2 publication Critical patent/JP7884818B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
JP2020571842A 2018-06-26 2019-06-26 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー Active JP7884818B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024096077A JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862689958P 2018-06-26 2018-06-26
US62/689,958 2018-06-26
PCT/US2019/039234 WO2020006075A1 (en) 2018-06-26 2019-06-26 Positron emission tomography (pet) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (csf1r) in neuroinflammation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024096077A Division JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

Publications (3)

Publication Number Publication Date
JP2021533087A JP2021533087A (ja) 2021-12-02
JP2021533087A5 JP2021533087A5 (enExample) 2022-07-25
JP7884818B2 true JP7884818B2 (ja) 2026-07-06

Family

ID=68985080

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020571842A Active JP7884818B2 (ja) 2018-06-26 2019-06-26 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー
JP2024096077A Pending JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024096077A Pending JP2024133496A (ja) 2018-06-26 2024-06-13 神経炎症におけるマクロファージコロニー刺激因子１受容体（ｃｓｆ１ｒ）をイメージングするための陽電子放射断層撮影（ｐｅｔ）放射性トレーサー

Country Status (12)

Country Link
US (1) US20210290784A1 (enExample)
EP (1) EP3813890A4 (enExample)
JP (2) JP7884818B2 (enExample)
KR (1) KR20210013769A (enExample)
CN (2) CN112638431A (enExample)
AU (1) AU2019294699B2 (enExample)
BR (1) BR112020026602A2 (enExample)
CA (1) CA3104520A1 (enExample)
EA (1) EA202092843A1 (enExample)
IL (1) IL279768B2 (enExample)
MX (1) MX2021000141A (enExample)
WO (1) WO2020006075A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA54550A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
AU2019401495B2 (en) * 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2019404576B2 (en) 2018-12-20 2025-07-17 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2020325115B2 (en) 2019-08-02 2026-03-12 Amgen Inc. Pyridine derivatives as KIF18A inhibitors
JP7699100B2 (ja) 2019-08-02 2025-06-26 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
EP4269404A4 (en) * 2020-12-25 2024-12-04 Xizang Haisco Pharmaceutical Co., Ltd. KETOHEXOKINASE INHIBITORS AND USE THEREOF
US20240237960A1 (en) * 2021-06-11 2024-07-18 Jubilant Draximage Inc. Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease
US20250275730A1 (en) * 2022-04-06 2025-09-04 University Of Virginia Patent Foundation Automation of the blood input function computation pipeline for dynamic fdg pet for human brain using machine learning
AU2024214768A1 (en) * 2023-01-30 2025-08-07 The Johns Hopkins University 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor
CN118021811A (zh) * 2023-12-28 2024-05-14 复旦大学附属华山医院 一种靶向于csf1r激酶的6-氟吡啶甲酰苯胺类抑制剂、药物组合物及其核素成像试剂
CN118027009B (zh) * 2024-04-15 2024-07-12 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用
CN119498255B (zh) * 2024-10-24 2025-11-25 香港理工大学深圳研究院 一种抑郁症小鼠模型及其构建方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008517945A (ja) 2004-10-22 2008-05-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ−ｆｍｓキナーゼのインヒビターとしての芳香族アミド

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017258415B2 (en) * 2016-04-29 2023-03-30 Cornell University Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008517945A (ja) 2004-10-22 2008-05-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃ−ｆｍｓキナーゼのインヒビターとしての芳香族アミド

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BAUER F. et al., Bioorganic & Medicinal Chemistry, 2010, 18, pp.5489-5497
ILLIG C. R. et al., Bioorganic & Medicinal Chemistry Letters, 2008, 18, pp.1642-1648
NAIK R. et al., PET tracer for imaging the macrophage cology stimulating factor receptor (CSF1R) in rodent brain, Journal of Nuclear Medicine, 2018, 59(supplement 1), 547

Also Published As

Publication number Publication date
BR112020026602A2 (pt) 2021-03-23
KR20210013769A (ko) 2021-02-05
JP2024133496A (ja) 2024-10-02
US20210290784A1 (en) 2021-09-23
JP2021533087A (ja) 2021-12-02
IL279768A (en) 2021-03-01
EP3813890A1 (en) 2021-05-05
CN112638431A (zh) 2021-04-09
MX2021000141A (es) 2021-03-25
EA202092843A1 (ru) 2021-04-19
AU2019294699A1 (en) 2021-01-21
AU2019294699B2 (en) 2025-05-01
EP3813890A4 (en) 2022-03-23
CN118743770A (zh) 2024-10-08
IL279768B1 (en) 2024-12-01
IL279768B2 (en) 2025-04-01
CA3104520A1 (en) 2020-01-02
WO2020006075A1 (en) 2020-01-02

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20210712

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211011

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220623

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220713

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230428

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230509

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230720

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231109

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240213

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240613

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20240619

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20240906

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20260617

R150 Certificate of patent or registration of utility model

Ref document number: 7884818

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150