IL279768B2 - Positron Emission Tomography (PET) Radiolabels for Imaging Macrophage Colony Inducing Factor 1 Receptor in Neuronal Inflammation - Google Patents

Positron Emission Tomography (PET) Radiolabels for Imaging Macrophage Colony Inducing Factor 1 Receptor in Neuronal Inflammation

Info

Publication number
IL279768B2
IL279768B2 IL279768A IL27976820A IL279768B2 IL 279768 B2 IL279768 B2 IL 279768B2 IL 279768 A IL279768 A IL 279768A IL 27976820 A IL27976820 A IL 27976820A IL 279768 B2 IL279768 B2 IL 279768B2
Authority
IL
Israel
Prior art keywords
substituted
group
alkyl
unsubstituted
phenyl
Prior art date
Application number
IL279768A
Other languages
English (en)
Hebrew (he)
Other versions
IL279768A (en
IL279768B1 (en
Inventor
Martin G Pomper
Andrew G Horti
Ravi Naik
Robert F Dannals
Original Assignee
Univ Johns Hopkins
Martin G Pomper
Andrew G Horti
Ravi Naik
Robert F Dannals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Martin G Pomper, Andrew G Horti, Ravi Naik, Robert F Dannals filed Critical Univ Johns Hopkins
Publication of IL279768A publication Critical patent/IL279768A/en
Publication of IL279768B1 publication Critical patent/IL279768B1/en
Publication of IL279768B2 publication Critical patent/IL279768B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
IL279768A 2018-06-26 2019-06-26 Positron Emission Tomography (PET) Radiolabels for Imaging Macrophage Colony Inducing Factor 1 Receptor in Neuronal Inflammation IL279768B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862689958P 2018-06-26 2018-06-26
PCT/US2019/039234 WO2020006075A1 (en) 2018-06-26 2019-06-26 Positron emission tomography (pet) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (csf1r) in neuroinflammation

Publications (3)

Publication Number Publication Date
IL279768A IL279768A (en) 2021-03-01
IL279768B1 IL279768B1 (en) 2024-12-01
IL279768B2 true IL279768B2 (en) 2025-04-01

Family

ID=68985080

Family Applications (1)

Application Number Title Priority Date Filing Date
IL279768A IL279768B2 (en) 2018-06-26 2019-06-26 Positron Emission Tomography (PET) Radiolabels for Imaging Macrophage Colony Inducing Factor 1 Receptor in Neuronal Inflammation

Country Status (12)

Country Link
US (1) US20210290784A1 (enExample)
EP (1) EP3813890A4 (enExample)
JP (2) JP7884818B2 (enExample)
KR (1) KR20210013769A (enExample)
CN (2) CN112638431A (enExample)
AU (1) AU2019294699B2 (enExample)
BR (1) BR112020026602A2 (enExample)
CA (1) CA3104520A1 (enExample)
EA (1) EA202092843A1 (enExample)
IL (1) IL279768B2 (enExample)
MX (1) MX2021000141A (enExample)
WO (1) WO2020006075A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA54550A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
AU2019401495B2 (en) * 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2019404576B2 (en) 2018-12-20 2025-07-17 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2020325115B2 (en) 2019-08-02 2026-03-12 Amgen Inc. Pyridine derivatives as KIF18A inhibitors
JP7699100B2 (ja) 2019-08-02 2025-06-26 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
EP4269404A4 (en) * 2020-12-25 2024-12-04 Xizang Haisco Pharmaceutical Co., Ltd. KETOHEXOKINASE INHIBITORS AND USE THEREOF
US20240237960A1 (en) * 2021-06-11 2024-07-18 Jubilant Draximage Inc. Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease
US20250275730A1 (en) * 2022-04-06 2025-09-04 University Of Virginia Patent Foundation Automation of the blood input function computation pipeline for dynamic fdg pet for human brain using machine learning
AU2024214768A1 (en) * 2023-01-30 2025-08-07 The Johns Hopkins University 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor
CN118021811A (zh) * 2023-12-28 2024-05-14 复旦大学附属华山医院 一种靶向于csf1r激酶的6-氟吡啶甲酰苯胺类抑制剂、药物组合物及其核素成像试剂
CN118027009B (zh) * 2024-04-15 2024-07-12 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用
CN119498255B (zh) * 2024-10-24 2025-11-25 香港理工大学深圳研究院 一种抑郁症小鼠模型及其构建方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047504A1 (en) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Aromatic amides as inhibitors of c-fms kinase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017258415B2 (en) * 2016-04-29 2023-03-30 Cornell University Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047504A1 (en) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Aromatic amides as inhibitors of c-fms kinase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAUER F ET AL,, SYNTHESIS AND IN VIVO EVALUATION OF [^1^1C]TARIQUIDAR, A POSITRON EMISSION TOMOGRAPHY RADIOTRACER BASED ON A THIRD-GENERATION P-GLYCOPROTEIN INHIBITOR, 1 August 2010 (2010-08-01) *
BERNARD-GAUTHIER VADIM; SCHIRRMACHER RALF,, 5-(4-((4-[18F]FLUOROBENZYL)OXY) -3-METHOXYBENZYL) PYRIMIDINE-2, 4-DIAMINE: A SELECTIVE DUAL INHIBITOR FOR POTENTIAL PET IMAGING OF TRK/CSF-1R, 15 October 2014 (2014-10-15) *
ILLIG C R; CHEN J; WALL M J; WILSON K J; BALLENTINE S K; RUDOLPH M J; DESJARLAIS R L; CHEN Y; SCHUBERT C; PETROUNIA I; CRYSLER C S, DISCOVERY OF NOVEL FMS KINASE INHIBITORS AS ANTI-INFLAMMATORY AGENTS, 1 March 2008 (2008-03-01) *
RAVI NAIK , VARVARA MISHENEVA , IL MINN , TATIANA MELNIKOVA , WILLIAM MATHEWS , ROBERT DANNALS , MARTIN POMPER , ALENA SAVONEKO , , PET TRACER FOR IMAGING THE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR (CSF1R) IN RODENT BRAIN, 1 May 2018 (2018-05-01) *

Also Published As

Publication number Publication date
JP7884818B2 (ja) 2026-07-06
BR112020026602A2 (pt) 2021-03-23
KR20210013769A (ko) 2021-02-05
JP2024133496A (ja) 2024-10-02
US20210290784A1 (en) 2021-09-23
JP2021533087A (ja) 2021-12-02
IL279768A (en) 2021-03-01
EP3813890A1 (en) 2021-05-05
CN112638431A (zh) 2021-04-09
MX2021000141A (es) 2021-03-25
EA202092843A1 (ru) 2021-04-19
AU2019294699A1 (en) 2021-01-21
AU2019294699B2 (en) 2025-05-01
EP3813890A4 (en) 2022-03-23
CN118743770A (zh) 2024-10-08
IL279768B1 (en) 2024-12-01
CA3104520A1 (en) 2020-01-02
WO2020006075A1 (en) 2020-01-02

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