AU2019294699B2 - Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (CSF1R) in neuroinflammation - Google Patents

Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (CSF1R) in neuroinflammation Download PDF

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AU2019294699B2
AU2019294699B2 AU2019294699A AU2019294699A AU2019294699B2 AU 2019294699 B2 AU2019294699 B2 AU 2019294699B2 AU 2019294699 A AU2019294699 A AU 2019294699A AU 2019294699 A AU2019294699 A AU 2019294699A AU 2019294699 B2 AU2019294699 B2 AU 2019294699B2
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AU2019294699A1 (en
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Robert F. Dannals
Andrew G. HORTI
Ravi NAIK
Martin G. Pomper
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Johns Hopkins University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
AU2019294699A 2018-06-26 2019-06-26 Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (CSF1R) in neuroinflammation Active AU2019294699B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862689958P 2018-06-26 2018-06-26
US62/689,958 2018-06-26
PCT/US2019/039234 WO2020006075A1 (en) 2018-06-26 2019-06-26 Positron emission tomography (pet) radiotracers for imaging macrophage colony-stimulating factor 1 receptor (csf1r) in neuroinflammation

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AU2019294699A1 AU2019294699A1 (en) 2021-01-21
AU2019294699B2 true AU2019294699B2 (en) 2025-05-01

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US (1) US20210290784A1 (enExample)
EP (1) EP3813890A4 (enExample)
JP (2) JP7884818B2 (enExample)
KR (1) KR20210013769A (enExample)
CN (2) CN112638431A (enExample)
AU (1) AU2019294699B2 (enExample)
BR (1) BR112020026602A2 (enExample)
CA (1) CA3104520A1 (enExample)
EA (1) EA202092843A1 (enExample)
IL (1) IL279768B2 (enExample)
MX (1) MX2021000141A (enExample)
WO (1) WO2020006075A1 (enExample)

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MA54550A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
AU2019401495B2 (en) * 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2019404576B2 (en) 2018-12-20 2025-07-17 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2020325115B2 (en) 2019-08-02 2026-03-12 Amgen Inc. Pyridine derivatives as KIF18A inhibitors
JP7699100B2 (ja) 2019-08-02 2025-06-26 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
EP4269404A4 (en) * 2020-12-25 2024-12-04 Xizang Haisco Pharmaceutical Co., Ltd. KETOHEXOKINASE INHIBITORS AND USE THEREOF
US20240237960A1 (en) * 2021-06-11 2024-07-18 Jubilant Draximage Inc. Expert scoring system for measurement of severity, treatment response and prognosis of peripheral arterial disease
US20250275730A1 (en) * 2022-04-06 2025-09-04 University Of Virginia Patent Foundation Automation of the blood input function computation pipeline for dynamic fdg pet for human brain using machine learning
AU2024214768A1 (en) * 2023-01-30 2025-08-07 The Johns Hopkins University 18 f-labeled pet radiotracers for imaging macrophage colony stimulating factor 1 receptor
CN118021811A (zh) * 2023-12-28 2024-05-14 复旦大学附属华山医院 一种靶向于csf1r激酶的6-氟吡啶甲酰苯胺类抑制剂、药物组合物及其核素成像试剂
CN118027009B (zh) * 2024-04-15 2024-07-12 北京师范大学 一类靶向于csf1r激酶的苯基酰胺类化合物及其应用
CN119498255B (zh) * 2024-10-24 2025-11-25 香港理工大学深圳研究院 一种抑郁症小鼠模型及其构建方法与应用

Citations (1)

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WO2006047504A1 (en) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Aromatic amides as inhibitors of c-fms kinase

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AU2017258415B2 (en) * 2016-04-29 2023-03-30 Cornell University Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047504A1 (en) * 2004-10-22 2006-05-04 Janssen Pharmaceutica, N.V. Aromatic amides as inhibitors of c-fms kinase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAUER F ET AL: "Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor", Bioorganic Medicinal Chemistry, 2010, vol. 18, no. 15, pages 5489 - 5497. *
CARL R. ILLIG ET AL: "Discovery of novel FMS kinase inhibitors as anti-inflammatory agents", Bioorganic & Medicinal Chemistry Letters, 2008, vol. 18, pages 1642-1648 *
CARL R. ILLIG ET AL: "Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate (JNJ-28312141)", 《J. MED. CHEM.》, vol. 54 *
NAIK RAVI ET AL: "PET tracer for imaging the macrophage colony stimulating factor receptor", Journal of Nuclear Medicine, 2018, vol. 59 (supplement 1), page 547 *

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JP7884818B2 (ja) 2026-07-06
BR112020026602A2 (pt) 2021-03-23
KR20210013769A (ko) 2021-02-05
JP2024133496A (ja) 2024-10-02
US20210290784A1 (en) 2021-09-23
JP2021533087A (ja) 2021-12-02
IL279768A (en) 2021-03-01
EP3813890A1 (en) 2021-05-05
CN112638431A (zh) 2021-04-09
MX2021000141A (es) 2021-03-25
EA202092843A1 (ru) 2021-04-19
AU2019294699A1 (en) 2021-01-21
EP3813890A4 (en) 2022-03-23
CN118743770A (zh) 2024-10-08
IL279768B1 (en) 2024-12-01
IL279768B2 (en) 2025-04-01
CA3104520A1 (en) 2020-01-02
WO2020006075A1 (en) 2020-01-02

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