CN112618690A - Injection for raising livestock at low temperature and refreshing and preparation method thereof - Google Patents
Injection for raising livestock at low temperature and refreshing and preparation method thereof Download PDFInfo
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- CN112618690A CN112618690A CN202110012353.3A CN202110012353A CN112618690A CN 112618690 A CN112618690 A CN 112618690A CN 202110012353 A CN202110012353 A CN 202110012353A CN 112618690 A CN112618690 A CN 112618690A
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- monkshood
- oxide
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- 238000002347 injection Methods 0.000 title claims abstract description 65
- 239000007924 injection Substances 0.000 title claims abstract description 65
- 244000144972 livestock Species 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000000284 extract Substances 0.000 claims abstract description 76
- KCQPRNAHCFGERG-UHFFFAOYSA-N C12(C(=[O+][O-])CC(CC1)C2(C)C)C Chemical compound C12(C(=[O+][O-])CC(CC1)C2(C)C)C KCQPRNAHCFGERG-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940002508 ginger extract Drugs 0.000 claims abstract description 17
- 235000020708 ginger extract Nutrition 0.000 claims abstract description 17
- 229940069445 licorice extract Drugs 0.000 claims abstract description 15
- 241001465754 Metazoa Species 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims description 51
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- 239000000706 filtrate Substances 0.000 claims description 31
- 238000001914 filtration Methods 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000008395 clarifying agent Substances 0.000 claims description 22
- 239000006228 supernatant Substances 0.000 claims description 22
- 239000008215 water for injection Substances 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 12
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 11
- 239000003963 antioxidant agent Substances 0.000 claims description 11
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- 239000003708 ampul Substances 0.000 claims description 9
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- 238000007789 sealing Methods 0.000 claims description 9
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- 230000001502 supplementing effect Effects 0.000 claims description 9
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
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- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 6
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- 208000031975 Yang Deficiency Diseases 0.000 description 3
- 235000006886 Zingiber officinale Nutrition 0.000 description 3
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
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- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 206010003549 asthenia Diseases 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
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- 206010061428 decreased appetite Diseases 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 208000003532 hypothyroidism Diseases 0.000 description 2
- 230000002989 hypothyroidism Effects 0.000 description 2
- 235000011477 liquorice Nutrition 0.000 description 2
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- 230000028327 secretion Effects 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- DSSYKIVIOFKYAU-XVKPBYJWSA-N (1s,4r)-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical compound C1C[C@@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-XVKPBYJWSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- UCTWMZQNUQWSLP-UHFFFAOYSA-N Adrenaline Natural products CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 1
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- 241000283690 Bos taurus Species 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
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- 206010024642 Listless Diseases 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
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- 206010047700 Vomiting Diseases 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
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- 229960000846 camphor Drugs 0.000 description 1
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- 229940074393 chlorogenic acid Drugs 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
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- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
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- 235000019156 vitamin B Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses an injection for raising livestock at low temperature and refreshing and a preparation method thereof, belonging to the field of biological medicine. Comprises 20-60 parts of camphor oxide, 1-20 parts of monkshood extract, 5-30 parts of dried ginger extract and 5-30 parts of honey-fried licorice extract. The injection can stimulate animal nerves and adrenocortical hormone, so that the nerve activity of animals in a low-temperature state is enhanced, the activity of body cells is mobilized, digestion and eating are promoted, the state of animal dyspnea or mental failure at a low temperature is improved, the immunity is enhanced, intestines and stomach can be adjusted, the appetite is improved, the absorption of feed is promoted, the weight is enhanced, and the survival rate is improved.
Description
Technical Field
The invention relates to the field of biomedicine, and particularly relates to an injection for raising livestock at low temperature and refreshing and a preparation method thereof.
Background
China encourages the development of agricultural science and technology, and the investment in cultivation is increased. The added value of livestock such as pig, cattle, sheep, horse and the like in the breeding industry is high, so that the breeding scale is gradually increased at present. In a low-temperature environment, animals have low activity of various skills of bodies, poor body resistance and immunity, poor spirit, dyspepsia and inappetence, are easy to die and are unfavorable for weight increase. And has negative effects on meat quality, milk quality and fur, and greatly reduces the utilization rate of the feed. The existing improved medicines are mainly energy activating and digestion assisting medicines, such as vitamin B1 injection, mainly contain vitamin B1, B2, nicotinamide, B5, B6 polyoligosaccharide, fructus forsythiae, chlorogenic acid, taurine, vitamin B complex, snake gall and the like, and mainly strengthen heart, relieve spasm, protect liver, invigorate stomach, improve anorexia syndrome and the like. However, other functions of the body are not activated, and the appetite is mainly improved in a low-temperature environment, so that the spirit and the function of the livestock are slightly stimulated and improved.
Disclosure of Invention
In order to solve the problems, the invention provides an injection for raising the cold spirit of livestock, which can mainly stimulate the activity of organisms at low temperature, improve the mental state of livestock and increase the appetite.
In order to achieve the purpose, the invention is realized by the following technical scheme:
an injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 20-60 parts of camphor oxide, 1-20 parts of monkshood extract, 5-30 parts of dried ginger extract and 5-30 parts of honey-fried licorice extract.
Further, the injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 30-50 parts of camphor oxide, 5-10 parts of monkshood extract, 15-25 parts of dried ginger extract and 10-20 parts of honey-fried licorice extract.
Further, the injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 45-50 parts of camphor oxide, 8-10 parts of monkshood extract, 20-25 parts of dried ginger extract and 15-18 parts of honey-fried licorice extract.
Further, the injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 48 parts of camphor oxide, 10 parts of monkshood extract, 24 parts of dried ginger extract and 18 parts of honey-fried licorice root extract.
Further, the preparation method of the monkshood extract comprises the following steps:
(1) decocting radix Aconiti lateralis in water for 2-3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 1.5-2h, then adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4-6h, and taking supernatant; filtering the supernatant to obtain a clear liquid;
(3) filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
Further, the preparation method of the dried ginger extract comprises the following steps:
(1) decocting Zingiberis rhizoma in water for 2-3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 1.5-2h, then adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4-6h, and taking supernatant; filtering the supernatant to obtain a clear liquid;
(3) filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating the filtrate, and drying to obtain powdered Zingiberis rhizoma extract.
Further, the preparation method of the honey-fried licorice root extract comprises the following steps:
(1) decocting radix Glycyrrhizae Preparata in water for 2-3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 1.5-2h, then adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4-6h, and taking supernatant; filtering the supernatant to obtain a clear liquid;
(3) filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain the powdery honey-fried licorice extract.
Further, in the step (2), the component B is added into the mixture by 2 to 4 percent of the liquid amount; the component A is added in an amount of 1-2% by weight.
The invention also provides a preparation method of the injection for raising livestock at low temperature and refreshing, which comprises the following steps:
(a) taking 50-90% of water for injection, adding an antioxidant, and adjusting the pH value to 4.5-5.5; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting pH value to 4.5-5.5; obtaining the injection
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Further, the antioxidant in the step (a) is any one or more of sodium sulfonate, sodium bisulfite and thiourea.
The pharmacology and the effect of each medicinal material in the invention are as follows:
and (3) oxidizing camphor: oxycocamphor is a white crystalline powder, slightly soluble in water, and easily soluble in ethanol or chloroform. The taste is initially pungent and slightly bitter, and then the tea has cool and paralytic feelings, and is easily oxidized and deteriorated in air or light. It is mainly used for treating central dyspnea and circulatory failure, and can also be used for treating heart failure and dyspnea due to various diseases. Can be used as animal stimulant.
Monkshood: pungent and sweet in flavor and strong in heat; it enters heart, kidney and spleen meridians. Has the effects of reviving yang, rescuing from collapse, tonifying fire, supporting yang, dispelling cold and relieving pain. Can be used for treating yang exhaustion, collapse, cold limbs, slight pulse, deficiency of heart-yang, thoracic obstruction, cardialgia, vomiting and diarrhea due to deficiency cold, abdominal psychroalgia, kidney yang deficiency, sexual impotence, cold womb, yin cold edema, yang deficiency, exogenous pathogenic factor, and arthralgia due to cold-dampness. The invention has the main effects of regulating arrhythmia, heart failure, hypothyroidism, neurasthenia and adrenocortical hypofunction.
Dried ginger: pungent taste and warm nature; it enters lung, spleen and stomach meridians, has strong potency, and is good at warming middle energizer to dispel cold, restoring yang to activate collaterals, warming lung to resolve fluid retention, and treating yang deficiency and middle cold.
Honey-fried licorice root: has effects in invigorating qi, strengthening middle warmer, moistening lung, relieving cough, clearing away heat and toxic materials, relieving spasm and pain, and regulating drug properties, and can be used for treating spleen deficiency, listlessness, heart deficiency, palpitation, cough, and asthma. Can stimulate adrenal cortical hormone, increase blood pressure of livestock, resist palpitation and ventricular fibrillation at low temperature, improve auditory function, promote pancreatic secretion, and enhance immunity.
The injection for raising livestock at low temperature and refreshing and the preparation method thereof have the beneficial effects that:
(1) the camphor powder mainly contains the camphor oxide, and can stimulate animal nerves, so that the nerve activity of animals in a low-temperature state is enhanced, the activity of body cells is mobilized, digestion and eating are promoted, and the state of dyspnea or mental failure of animals at a low temperature is improved.
(2) The monkshood is added, and can improve symptoms of hypothyroidism and neurasthenia, promote secretion of adrenalin and improve activity of animals. Can be mixed with Camphora oxide for improving sluggish state of animals in low temperature environment, and refreshing.
(3) The monkshood and the ginger are mixed for use, and the mixture of the monkshood and the ginger has the effects of warming and invigorating spleen and kidney, supporting yang and dispelling cold, is more favorable for recovering animals in a low-temperature environment, can regulate intestines and stomach, improve appetite, promote absorption of feed, enhance weight and improve survival rate.
(4) The liquorice is added, and the liquorice can stimulate adrenocortical hormone and revivify. It also has effects in regulating intestine and stomach, stimulating appetite, and promoting feed absorption. It also can suppress toxicity of radix Aconiti lateralis, and enhance immunity.
Detailed Description
The present invention will be described in further detail with reference to the following examples.
Example 1
An injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 60 parts of camphor oxide, 20 parts of monkshood extract, 5 parts of dried ginger extract and 30 parts of honey-fried licorice root extract.
In this embodiment, the preparation method of the monkshood extract includes the following steps:
(1) decocting radix Aconiti lateralis in water for 3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 2 hours, adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4h, and taking supernatant; filtering the supernatant to obtain a clear liquid; wherein the component B is added by 2 percent of liquid; the component A is added in an amount of 1 percent by weight.
(3) Filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
In this example, the preparation method of the zingiber extract and the honey-fried licorice extract is the same as the preparation method of the aconite extract.
An injection for raising livestock for low-temperature refreshing comprises the following steps:
(a) taking 90% of water for injection, adding antioxidant sodium sulfonate, and adjusting the pH value to 4.5; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting the pH value to 4.5; obtaining the injection.
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Example 2
An injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 20 parts of camphor oxide, 1 part of monkshood extract, 5 parts of dried ginger extract and 5 parts of honey-fried licorice root extract.
In this embodiment, the preparation method of the monkshood extract includes the following steps:
(1) decocting radix Aconiti lateralis in water for 3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 2 hours, adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4h, and taking supernatant; filtering the supernatant to obtain a clear liquid; wherein, the component B is added into the mixture by 4 percent of liquid; the component A is added in an amount of 2% by weight.
(3) Filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
In this example, the preparation method of the zingiber extract and the honey-fried licorice extract is the same as the preparation method of the aconite extract.
An injection for raising livestock for low-temperature refreshing comprises the following steps:
(a) taking 90% of water for injection, adding antioxidant sodium bisulfite, and adjusting the pH value to 4.5; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting the pH value to 5.5; obtaining the injection.
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Example 3
An injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 50 parts of camphor oxide, 5 parts of monkshood extract, 15 parts of dried ginger extract and 10 parts of honey-fried licorice root extract.
In this embodiment, the preparation method of the monkshood extract includes the following steps:
(1) decocting radix Aconiti lateralis in water for 2 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 2 hours, adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4h, and taking supernatant; filtering the supernatant to obtain a clear liquid; wherein, the component B is added by 3 percent of liquid; the component A is added in an amount of 1.5% by weight.
(3) Filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
In this example, the preparation method of the zingiber extract and the honey-fried licorice extract is the same as the preparation method of the aconite extract.
An injection for raising livestock for low-temperature refreshing comprises the following steps:
(a) taking 90% of water for injection, adding antioxidant sodium bisulfite, and adjusting the pH value to 5.5; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting the pH value to 4.5; obtaining the injection.
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Example 4
An injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 30 parts of camphor oxide, 10 parts of monkshood extract, 25 parts of dried ginger extract and 20 parts of honey-fried licorice root extract.
In this embodiment, the preparation method of the monkshood extract includes the following steps:
(1) decocting radix Aconiti lateralis in water for 2 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 2 hours, adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4h, and taking supernatant; filtering the supernatant to obtain a clear liquid; wherein, the component B is added by 3 percent of liquid; the component A is added in an amount of 2% by weight.
(3) Filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
In this example, the preparation method of the zingiber extract and the honey-fried licorice extract is the same as the preparation method of the aconite extract.
An injection for raising livestock for low-temperature refreshing comprises the following steps:
(a) taking 90% of water for injection, adding thiourea serving as an antioxidant, and adjusting the pH value to 5.5; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting the pH value to 4.5; obtaining the injection.
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Example 5
An injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 50 parts of camphor oxide, 8 parts of monkshood extract, 20 parts of dried ginger extract and 18 parts of honey-fried licorice root extract.
In this embodiment, the preparation method of the monkshood extract includes the following steps:
(1) decocting radix Aconiti lateralis in water for 2 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 2 hours, adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4h, and taking supernatant; filtering the supernatant to obtain a clear liquid; wherein, the component B is added by 3 percent of liquid; the component A is added in an amount of 2% by weight.
(3) Filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
In this example, the preparation method of the zingiber extract and the honey-fried licorice extract is the same as the preparation method of the aconite extract.
An injection for raising livestock for low-temperature refreshing comprises the following steps:
(a) mixing 90% of water for injection, adding sodium sulfonate antioxidant and thiourea according to the ratio of 2:1, and adjusting the pH value to 5.0; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting the pH value to 4.5; obtaining the injection.
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Example 6
An injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 45 parts of camphor oxide, 10 parts of monkshood extract, 25 parts of dried ginger extract and 15 parts of honey-fried licorice root extract.
In this embodiment, the preparation method of the monkshood extract includes the following steps:
(1) decocting radix Aconiti lateralis in water for 3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 2 hours, adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4h, and taking supernatant; filtering the supernatant to obtain a clear liquid; wherein, the component B is added into the mixture by 4 percent of liquid; the component A is added in an amount of 1 percent by weight.
(3) Filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
In this example, the preparation method of the zingiber extract and the honey-fried licorice extract is the same as the preparation method of the aconite extract.
An injection for raising livestock for low-temperature refreshing comprises the following steps:
(a) mixing 90% of water for injection, adding sodium sulfonate serving as an antioxidant and sodium bisulfite, and adjusting the pH value to 4.5, wherein the sodium sulfonate and the sodium bisulfite are mixed according to the ratio of 1: 1; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting the pH value to 4.5; obtaining the injection.
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Example 7
An injection for raising livestock at low temperature and refreshing comprises the following components in parts by weight: 48 parts of camphor oxide, 10 parts of monkshood extract, 24 parts of dried ginger extract and 18 parts of honey-fried licorice root extract.
In this embodiment, the preparation method of the monkshood extract includes the following steps:
(1) decocting radix Aconiti lateralis in water for 3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 2 hours, adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4h, and taking supernatant; filtering the supernatant to obtain a clear liquid; wherein, the component B is added into the mixture by 4 percent of liquid; the component A is added in an amount of 2% by weight.
(3) Filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
In this example, the preparation method of the zingiber extract and the honey-fried licorice extract is the same as the preparation method of the aconite extract.
An injection for raising livestock for low-temperature refreshing comprises the following steps:
(a) taking 90% of water for injection, adding antioxidant sodium sulfonate, and adjusting the pH value to 4.5; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting the pH value to 4.5; obtaining the injection.
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
Test results
20 adult pigs are divided into four groups, namely 1 group, 2 groups, 3 groups and 4 groups, and the four adult pigs are respectively placed at-5 ℃ to 5 ℃. The group 1 is blank without medicine, the group 2 is injected with camphor sulfonate, the group 3 is injected with vitamin B1 injection, and the group 4 is injected with the injection of the invention in the embodiment 7. The results obtained are shown in the following table:
as can be seen from the above table, the present invention is improved at low temperature compared to the conventional common stimulant camphorsulfonate and vitamin B1 injection, but vitamin B1 can stimulate appetite and treat cold and diarrhea, and the camphorsulfonate is only used as stimulant. The embodiment of the invention can not only improve the clearness but also increase the appetite, has good mental status, but also has excitement, which shows that the invention has mild lifting effect and also has the functions of dispelling cold and improving intestines and stomach.
The technical solutions provided by the embodiments of the present invention are described in detail above, and the principles and embodiments of the present invention are explained herein by using specific examples, and the descriptions of the embodiments are only used to help understanding the principles of the embodiments of the present invention; meanwhile, for a person skilled in the art, according to the embodiments of the present invention, there may be variations in the specific implementation manners and application ranges, and in summary, the content of the present description should not be construed as a limitation to the present invention.
Claims (8)
1. An injection for raising livestock at low temperature and refreshing, which is characterized in that: the paint comprises the following components in parts by weight: 20-60 parts of camphor oxide, 1-20 parts of monkshood extract, 5-30 parts of dried ginger extract and 5-30 parts of honey-fried licorice extract.
2. The injection for cold refreshment in livestock according to claim 1, characterized in that: the paint comprises the following components in parts by weight: 30-50 parts of camphor oxide, 5-10 parts of monkshood extract, 15-25 parts of dried ginger extract and 10-20 parts of honey-fried licorice extract.
3. The injection for cold refreshment in livestock according to claim 1, characterized in that: the paint comprises the following components in parts by weight: 45-50 parts of camphor oxide, 8-10 parts of monkshood extract, 20-25 parts of dried ginger extract and 15-18 parts of honey-fried licorice extract.
4. The injection for cold refreshment in livestock according to claim 1, characterized in that: the paint comprises the following components in parts by weight: 48 parts of camphor oxide, 10 parts of monkshood extract, 24 parts of dried ginger extract and 18 parts of honey-fried licorice root extract.
5. The injection for cold refreshment in livestock according to claim 1, characterized in that: the preparation method of the monkshood extract comprises the following steps:
(1) decocting radix Aconiti lateralis in water for 2-3 times to obtain decoction;
(2) adding a ZTC1+1 II clarifying agent into the boiled liquid, adding the component B into the ZTC1+1 II clarifying agent for clarifying for 1.5-2h, then adding the component A, and stirring until the clear liquid is transparent; standing in a clarifying tank for 4-6h, and taking supernatant; filtering the supernatant to obtain a clear liquid;
(3) filtering the clear solution through 1.2 μm micropores to obtain filtrate; concentrating and drying the filtrate to obtain powdered monkshood extract.
6. The injection for cold refreshment in livestock according to claim 1, characterized in that: in the step (2), the component B is added into the mixture according to the liquid amount by 2 to 4 percent; the component A is added in an amount of 1-2% by weight.
7. A method for preparing the injection for animal cold refreshment according to any one of claims 1-6, wherein: the method comprises the following steps:
(a) taking 50-90% of water for injection, adding an antioxidant, and adjusting the pH value to 4.5-5.5; adding Camphora oxide, radix Aconiti lateralis Preparata extract, Zingiberis rhizoma extract and radix Glycyrrhizae Preparata extract, mixing and dissolving; adjusting pH value to 4.5-5.5; obtaining the injection
(b) Supplementing the injection liquid in the step (a) with water for injection to 100 percent; filtering the injection with 0.20 μm filter membrane, filling the obtained filtrate into ampoule bottle, sealing, and sterilizing.
8. The preparation method of the injection for livestock low temperature refreshing according to claim 7, is characterized in that: the antioxidant in the step (a) is any one or more of sodium sulfonate, sodium bisulfite and thiourea.
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Citations (3)
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| CN101238851A (en) * | 2008-01-28 | 2008-08-13 | 吴忠尚 | Chinese medicinal composition for promoting growing and fattening of meat chicken and preparation thereof |
| CN103430903A (en) * | 2013-09-11 | 2013-12-11 | 桂林医学院 | Method for preparing non-human animal model with opportunistic infections and chronic wasting diseases and medicament screened by using same |
| CN104208615A (en) * | 2014-08-16 | 2014-12-17 | 严中明 | Pig fattening composition |
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2021
- 2021-01-06 CN CN202110012353.3A patent/CN112618690A/en active Pending
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| CN101238851A (en) * | 2008-01-28 | 2008-08-13 | 吴忠尚 | Chinese medicinal composition for promoting growing and fattening of meat chicken and preparation thereof |
| CN103430903A (en) * | 2013-09-11 | 2013-12-11 | 桂林医学院 | Method for preparing non-human animal model with opportunistic infections and chronic wasting diseases and medicament screened by using same |
| CN104208615A (en) * | 2014-08-16 | 2014-12-17 | 严中明 | Pig fattening composition |
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Application publication date: 20210409 |