CN111419925A - Traditional Chinese medicine external preparation for rapidly improving sexual function and preparation method thereof - Google Patents

Traditional Chinese medicine external preparation for rapidly improving sexual function and preparation method thereof Download PDF

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Publication number
CN111419925A
CN111419925A CN202010469224.2A CN202010469224A CN111419925A CN 111419925 A CN111419925 A CN 111419925A CN 202010469224 A CN202010469224 A CN 202010469224A CN 111419925 A CN111419925 A CN 111419925A
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parts
water
chinese
external preparation
ginseng
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陈京
孟付周
陈欣
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Zhongke Hualu Agricultural Development Co ltd
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Zhongke Hualu Agricultural Development Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/746Morinda
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention relates to the technical field of health-care food, in particular to a traditional Chinese medicine external preparation for rapidly improving sexual function and a preparation method thereof. On the one hand, the traditional Chinese medicine external preparation for rapidly improving the sexual function is provided, and comprises the following components in parts by weight: herba Cynomorii, herba Epimedii, radix Flemingiae Philippinensis, cornu Cervi Pantotrichum, flos Caryophylli, fructus Cnidii, herba asari, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae Indicae, Galla chinensis, Cordyceps, and water; it has quick effect; on the other hand, the preparation method of the traditional Chinese medicine external preparation for rapidly improving the sexual function comprises the following steps: pretreating raw materials; extracting medicinal components; mixing the preparations to obtain a Chinese medicinal external preparation; can effectively extract the nutrient substances in each component.

Description

Traditional Chinese medicine external preparation for rapidly improving sexual function and preparation method thereof
Technical Field
The invention relates to the technical field of health-care food, in particular to a traditional Chinese medicine external preparation for rapidly improving sexual function and a preparation method thereof.
Background
With the acceleration of modern life rhythm, the long-term irregular life with excessive fatigue and over-pressure can easily cause the human body dysfunction, which is manifested by the symptoms of kidney-yang deficiency, essence and blood deficiency, soreness and pain of waist and knees, cold limbs, tiredness and hypodynamia, impotence and premature ejaculation, early graying of hair and beard and the like; in order to build up the body and tonify the kidney and strengthen yang, people select some kidney-tonifying and yang-strengthening medicines or health care products to take.
However, most of the oral health care products have slow effect, can not improve the sexual function of the male quickly, and can cause certain irreversible damage to human bodies.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine external preparation for rapidly improving sexual function, and the external preparation has quick response.
The invention also aims to provide a preparation method of the traditional Chinese medicine external preparation for rapidly improving sexual function, which can effectively extract nutrient substances in each component.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
In a first aspect, a traditional Chinese medicine external preparation for rapidly improving sexual function is provided, which comprises the following components in parts by weight: 8-20 parts of cynomorium songaricum, 8-16 parts of epimedium, 4-15 parts of beautiful millettia root, 15-40 parts of pilose antler, 10-20 parts of clove, 6-15 parts of common cnidium fruit, 5-15 parts of manchurian wildginger, 4-15 parts of morinda officinalis, 5-10 parts of ginseng, 7-20 parts of Chinese angelica, 6-10 parts of flower of sweet night, 5-12 parts of Chinese gall, 10-20 parts of cordyceps sinensis and 15-30 parts of water.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 8-17 parts of cynomorium songaricum, 8-12 parts of epimedium herb, 4-10 parts of bovine datura, 15-28 parts of pilose antler, 10-15 parts of clove, 6-11 parts of common cnidium fruit, 5-10 parts of manchurian wildginger, 4-10 parts of morinda officinalis, 5-8 parts of ginseng, 7-14 parts of Chinese angelica, 6-8 parts of flower of Lantern night, 5-8 parts of Chinese gall, 10-15 parts of cordyceps sinensis and 15-23 parts of water.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 17-20 parts of cynomorium songaricum, 12-16 parts of epimedium, 10-15 parts of beautiful millettia root, 28-40 parts of pilose antler, 15-20 parts of clove, 11-15 parts of common cnidium fruit, 10-15 parts of manchurian wildginger, 10-15 parts of morinda officinalis, 8-10 parts of ginseng, 14-20 parts of Chinese angelica, 8-10 parts of flower of sweet night, 8-12 parts of Chinese gall, 15-20 parts of cordyceps sinensis and 23-30 parts of water.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 17 parts of cynomorium songaricum, 12 parts of epimedium herb, 10 parts of beautiful millettia root, 28 parts of pilose antler, 15 parts of clove, 11 parts of common cnidium fruit, 10 parts of manchurian wildginger, 10 parts of medicinal indianmulberry root, 8 parts of ginseng, 14 parts of Chinese angelica, 8 parts of sweet night flower, 8 parts of Chinese gall, 15 parts of cordyceps sinensis and 23 parts of water.
In a second aspect, the present application provides a method for preparing a topical Chinese medicinal preparation for rapidly improving sexual function, including the following steps: pretreatment of raw materials: carrying out ultrasonic cleaning on cynomorium songaricum, beautiful millettia root, pilose antler, medicinal indianmulberry root, ginseng, Chinese angelica, sweet pinkish flower, Chinese gall and Chinese caterpillar fungus by adopting an ultrasonic cleaning machine, drying the cleaned cynomorium songaricum, beautiful millettia root, pilose antler, medicinal indianmulberry root, ginseng, Chinese angelica, sweet pinkish flower, Chinese gall and Chinese caterpillar fungus by adopting an oven, slicing for later use, soaking and cleaning epimedium herb, clove, common cnidium fruit and manchurian wildginger by adopting distilled water, and drying the cleaned epimedium herb, clove, common cnidium fruit and manchurian wildginger by adopting an oven; extracting medicinal components: respectively carrying out water extraction and alcohol extraction on each pretreated component, then combining the water extract and the alcohol extract, and then carrying out concentration, alcohol precipitation and filtration to obtain concentrated liquid medicine of each component; mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 8-20 parts of cynomorium songaricum, 8-16 parts of epimedium herb, 4-15 parts of beautiful millettia root, 15-40 parts of pilose antler, 10-20 parts of clove, 6-15 parts of common cnidium fruit, 5-15 parts of manchurian wildginger, 4-15 parts of morinda officinalis, 5-10 parts of ginseng, 7-20 parts of Chinese angelica, 6-10 parts of flower of sweet night, 5-12 parts of Chinese gall and 10-20 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 15-30 parts of water to 30-60 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding the concentrated mixed liquid medicine into the water, and then continuously heating at constant temperature for 40-80min to obtain the traditional Chinese medicine external preparation.
Further, in some embodiments of the present invention, in the raw material pretreatment process, cynomorium songaricum, beautiful millettia root, pilose antler, morinda root, ginseng, angelica, sweet night flower, gallnut and cordyceps sinensis are cleaned by an ultrasonic cleaning machine for 8-20 min.
Further, in some embodiments of the present invention, during the pretreatment of the raw materials, the epimedium herb, the clove, the common cnidium fruit and the manchurian wildginger are soaked in distilled water for 8-20 min.
Further, in some embodiments of the present invention, the baking temperature of the oven is 38-50 ℃ during the raw material pretreatment.
Further, in some embodiments of the present invention, the water extraction process of the above-mentioned medicinal ingredients is: decocting the above materials with 20-40 times of water for 60-100min, and filtering to obtain water extractive filtrate and residue.
Further, in some embodiments of the present invention, the alcohol extraction process of the above medicinal ingredients is: soaking the water extraction residue of each component in ethanol for 30-60min, and filtering to obtain ethanol extraction filtrate and ethanol extraction residue.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
With respect to the first aspect:
And (3) locking the positive: has effects in invigorating kidney, replenishing vital essence, and moistening dryness, and can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, constipation due to intestinal dryness, paralysis, and sexual hypofunction.
Herba epimedii: pungent and sweet in flavor and warm in nature, and enter liver and kidney meridians; is an essential medicine for nourishing the gate of life, benefiting vital essence and energy, strengthening bones and muscles, tonifying kidney and strengthening yang, is clinically used for treating male impotence, spermatorrhea, premature ejaculation, urinary incontinence, female infertility and other symptoms, can excite sexual function, and has the effect of promoting semen secretion for animals.
Beautiful millettia root: sweet and neutral in flavor, entering lung and kidney meridians; has effects of tonifying deficiency, moistening lung, strengthening tendons, and activating collaterals, and can be used for treating lumbar muscle strain, rheumarthritis, lung heat, cough due to lung deficiency, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, spermatorrhea, and leucorrhea.
Pilose antler: it can be used for treating kidney deficiency, dizziness, deafness, dim eyesight, sexual impotence, spermatorrhea, infertility due to cold womb, marasmus, listlessness, aversion to cold, cold pain of lumbar and spinal cord, tendons and bones flaccidity, metrorrhagia, leukorrhagia, dorsal furuncle, and asthenia due to chronic diseases.
Clove: pungent taste and warm nature; spleen, stomach, lung and kidney meridians; has effects in warming middle-jiao, lowering adverse qi, invigorating kidney, and tonifying yang; can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency.
Fructus cnidii: warm in nature and bitter in taste; mainly used for eliminating dampness, dispelling pathogenic wind, killing parasite, warming kidney and tonifying yang; can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; it can be used for treating vulval eczema, pudendal pruritus, and trichomonal vaginitis.
Asarum: warm in nature and pungent in flavor; entering heart, lung and kidney meridians; has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifice, warming lung, and eliminating phlegm; can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, and cough due to lung cold.
Morinda officinalis: can be used for treating sexual impotence, spermatorrhea, infertility due to cold womb, menoxenia, psychroalgia of lower abdomen, rheumatalgia, and flaccidity of tendons and bones.
Ginseng: sweet, slightly bitter, warm and mild in nature; spleen, lung and heart meridians entered; has the effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing; the main treatment is as follows: asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, asthenia, palpitation, insomnia, sexual impotence, and cold womb; heart failure, cardiogenic shock; can be used for treating short breath, dyspnea, palpitation, amnesia, thirst, hyperhidrosis, anorexia, asthenia, acute and chronic diseases, and shock and collapse caused by blood loss.
Chinese angelica: sweet taste and warm nature; has effects in tonifying blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness, and smoothing intestine; it can be used for treating blood deficiency syndrome, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, metrorrhagia, asthenia cold, abdominal pain, flaccidity arthralgia, numbness of skin, intestinal dryness, constipation, dysentery, carbuncle, skin ulcer, traumatic injury.
The purple sweet rice glue ball is used for flower: sweet taste and warm nature; has effects in invigorating kidney, replenishing vital essence, and tonifying yang; can be used for treating sexual impotence, spermatorrhea, urinary incontinence, and leucorrhea.
Gallnut: sour, astringent and cold in nature; entering lung, large intestine and kidney meridians; has effects in astringing lung, purging pathogenic fire, relieving diarrhea with astringents, arresting sweating, stopping bleeding, eliminating dampness, and healing sore; it can be used for treating chronic cough due to lung deficiency, chronic diarrhea, spontaneous perspiration, night sweat, diabetes, hemafecia, hemorrhoidal bleeding, traumatic hemorrhage, carbuncle, sore, and skin ulcer.
And (3) cordyceps sinensis: sweet in taste and neutral in nature; entering lung and kidney meridians; has the effects of tonifying kidney, benefiting lung, stopping bleeding and reducing phlegm; can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, impotence, and soreness of waist and knees due to kidney yang deficiency and essence and blood deficiency.
The cynomorium songaricum, the epimedium herb, the beautiful millettia root and the pilose antler in the components are compatible, so that the effects of nourishing kidney yang and increasing male erection strength can be achieved, and the sexual capacity of the male can be rapidly improved; the clove, the common cnidium fruit, the asarum and the morinda officinalis in the components are compatible, so that the effects of reducing sensitivity and exciting nerves can be achieved, and the male erection time can be prolonged; the ginseng, the angelica, the flower of lily of the purple sweet, the gallnut and the cordyceps sinensis in the components are compatible, so that the effects of strengthening body resistance, cultivating vigor and astringing can be achieved; the nutritional ingredients in the components of the Chinese medicinal external preparation can regulate human pituitary gland and promote secretion of sex hormone to reach normal level, thereby improving sexual dysfunction and sexual function and pleasant sensation; the alkaloid component contained in the traditional Chinese medicine external preparation can act on the human pituitary gland to play a role in resisting fatigue, and the amino acid mineral trace elements contained in the traditional Chinese medicine external preparation can improve the functions of the gonad and each organ of the human body, can comprehensively condition the body and mind and can powerfully improve the sexual function; the components are compatible, the obtained traditional Chinese medicine external preparation is smeared on male sexual organs and mainly acts on the coronary sulcus of penis to play a role of local mucosa, the sensitivity of external genitalia can be reduced, the stimulation intensity for stimulating ejaculation is improved, and the sexual intercourse time is prolonged.
With respect to the second aspect:
The traditional Chinese medicine external preparation prepared by the method in the embodiment is firstly cleaned to remove impurities in each medicine component, so that the purity of the prepared traditional Chinese medicine external preparation is higher, materials in cynomorium songaricum, beautiful millettia root, pilose antler, morinda officinalis, ginseng, Chinese angelica, purple sweet night flower, Chinese gall and cordyceps sinensis can be more thoroughly removed by ultrasonic cleaning, and impurities in medicinal materials can be more effectively removed by soaking epimedium herb, clove, common cnidium fruit and manchurian wildginger in distilled water; the pretreated components are respectively subjected to water extraction and alcohol extraction, so that the nutrient substances in the medicinal materials can be more fully and effectively extracted; then 15-30 parts by weight of water is heated to 30-60 ℃ and added with the concentrated mixed liquid medicine, so that the water has a certain temperature, the components can be better fused with each other, and the using drug effect is better.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
On the one hand, the traditional Chinese medicine external preparation for rapidly improving the sexual function is provided, and comprises the following components in parts by weight: 8-20 parts of cynomorium songaricum, 8-16 parts of epimedium, 4-15 parts of beautiful millettia root, 15-40 parts of pilose antler, 10-20 parts of clove, 6-15 parts of common cnidium fruit, 5-15 parts of manchurian wildginger, 4-15 parts of morinda officinalis, 5-10 parts of ginseng, 7-20 parts of Chinese angelica, 6-10 parts of flower of sweet night, 5-12 parts of Chinese gall, 10-20 parts of cordyceps sinensis and 15-30 parts of water.
And (3) locking the positive: has effects in invigorating kidney, replenishing vital essence, and moistening dryness, and can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, constipation due to intestinal dryness, paralysis, and sexual hypofunction.
Herba epimedii: pungent and sweet in flavor and warm in nature, and enter liver and kidney meridians; is an essential medicine for nourishing the gate of life, benefiting vital essence and energy, strengthening bones and muscles, tonifying kidney and strengthening yang, is clinically used for treating male impotence, spermatorrhea, premature ejaculation, urinary incontinence, female infertility and other symptoms, can excite sexual function, and has the effect of promoting semen secretion for animals.
Beautiful millettia root: sweet and neutral in flavor, entering lung and kidney meridians; has effects of tonifying deficiency, moistening lung, strengthening tendons, and activating collaterals, and can be used for treating lumbar muscle strain, rheumarthritis, lung heat, cough due to lung deficiency, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, spermatorrhea, and leucorrhea.
Pilose antler: it can be used for treating kidney deficiency, dizziness, deafness, dim eyesight, sexual impotence, spermatorrhea, infertility due to cold womb, marasmus, listlessness, aversion to cold, cold pain of lumbar and spinal cord, tendons and bones flaccidity, metrorrhagia, leukorrhagia, dorsal furuncle, and asthenia due to chronic diseases.
Clove: pungent taste and warm nature; spleen, stomach, lung and kidney meridians; has effects in warming middle-jiao, lowering adverse qi, invigorating kidney, and tonifying yang; can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency.
Fructus cnidii: warm in nature and bitter in taste; mainly used for eliminating dampness, dispelling pathogenic wind, killing parasite, warming kidney and tonifying yang; can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; it can be used for treating vulval eczema, pudendal pruritus, and trichomonal vaginitis.
Asarum: warm in nature and pungent in flavor; entering heart, lung and kidney meridians; has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifice, warming lung, and eliminating phlegm; can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, and cough due to lung cold.
Morinda officinalis: can be used for treating sexual impotence, spermatorrhea, infertility due to cold womb, menoxenia, psychroalgia of lower abdomen, rheumatalgia, and flaccidity of tendons and bones.
Ginseng: sweet, slightly bitter, warm and mild in nature; spleen, lung and heart meridians entered; has the effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing; the main treatment is as follows: asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, asthenia, palpitation, insomnia, sexual impotence, and cold womb; heart failure, cardiogenic shock; can be used for treating short breath, dyspnea, palpitation, amnesia, thirst, hyperhidrosis, anorexia, asthenia, acute and chronic diseases, and shock and collapse caused by blood loss.
Chinese angelica: sweet taste and warm nature; has effects in tonifying blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness, and smoothing intestine; it can be used for treating blood deficiency syndrome, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, metrorrhagia, asthenia cold, abdominal pain, flaccidity arthralgia, numbness of skin, intestinal dryness, constipation, dysentery, carbuncle, skin ulcer, traumatic injury.
The purple sweet rice glue ball is used for flower: sweet taste and warm nature; has effects in invigorating kidney, replenishing vital essence, and tonifying yang; can be used for treating sexual impotence, spermatorrhea, urinary incontinence, and leucorrhea.
Gallnut: sour, astringent and cold in nature; entering lung, large intestine and kidney meridians; has effects in astringing lung, purging pathogenic fire, relieving diarrhea with astringents, arresting sweating, stopping bleeding, eliminating dampness, and healing sore; it can be used for treating chronic cough due to lung deficiency, chronic diarrhea, spontaneous perspiration, night sweat, diabetes, hemafecia, hemorrhoidal bleeding, traumatic hemorrhage, carbuncle, sore, and skin ulcer.
And (3) cordyceps sinensis: sweet in taste and neutral in nature; entering lung and kidney meridians; has the effects of tonifying kidney, benefiting lung, stopping bleeding and reducing phlegm; can be used for treating sexual impotence, spermatorrhea, soreness of waist and knees, impotence, and soreness of waist and knees due to kidney yang deficiency and essence and blood deficiency.
The cynomorium songaricum, the epimedium herb, the beautiful millettia root and the pilose antler in the components are compatible, so that the effects of nourishing kidney yang and increasing male erection strength can be achieved, and the sexual capacity of the male can be rapidly improved; the clove, the common cnidium fruit, the asarum and the morinda officinalis in the components are compatible, so that the effects of reducing sensitivity and exciting nerves can be achieved, and the male erection time can be prolonged; the ginseng, the angelica, the flower of lily of the purple sweet, the gallnut and the cordyceps sinensis in the components are compatible, so that the effects of strengthening body resistance, cultivating vigor and astringing can be achieved; the nutritional ingredients in the components of the Chinese medicinal external preparation can regulate human pituitary gland and promote secretion of sex hormone to reach normal level, thereby improving sexual dysfunction and sexual function and pleasant sensation; the alkaloid component contained in the traditional Chinese medicine external preparation can act on the human pituitary gland to play a role in resisting fatigue, and the amino acid mineral trace elements contained in the traditional Chinese medicine external preparation can improve the functions of the gonad and each organ of the human body, can comprehensively condition the body and mind and can powerfully improve the sexual function; the components are compatible, the obtained traditional Chinese medicine external preparation is smeared on male sexual organs and mainly acts on the coronary sulcus of penis to play a role of local mucosa, the sensitivity of external genitalia can be reduced, the stimulation intensity for stimulating ejaculation is improved, and the sexual intercourse time is prolonged.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 8-17 parts of cynomorium songaricum, 8-12 parts of epimedium herb, 4-10 parts of bovine datura, 15-28 parts of pilose antler, 10-15 parts of clove, 6-11 parts of common cnidium fruit, 5-10 parts of manchurian wildginger, 4-10 parts of morinda officinalis, 5-8 parts of ginseng, 7-14 parts of Chinese angelica, 6-8 parts of flower of Lantern night, 5-8 parts of Chinese gall, 10-15 parts of cordyceps sinensis and 15-23 parts of water. The traditional Chinese medicine external preparation prepared by adopting the proportion has the synergistic interaction effect among the components, and can bring the medicinal value of each component into play to the best.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 17-20 parts of cynomorium songaricum, 12-16 parts of epimedium, 10-15 parts of beautiful millettia root, 28-40 parts of pilose antler, 15-20 parts of clove, 11-15 parts of common cnidium fruit, 10-15 parts of manchurian wildginger, 10-15 parts of morinda officinalis, 8-10 parts of ginseng, 14-20 parts of Chinese angelica, 8-10 parts of flower of sweet night, 8-12 parts of Chinese gall, 15-20 parts of cordyceps sinensis and 23-30 parts of water. The traditional Chinese medicine external preparation prepared by adopting the proportion has the synergistic interaction effect among the components, and can bring the medicinal value of each component into play to the best.
Further, in some embodiments of the present invention, the composition comprises the following components in parts by weight: 17 parts of cynomorium songaricum, 12 parts of epimedium herb, 10 parts of beautiful millettia root, 28 parts of pilose antler, 15 parts of clove, 11 parts of common cnidium fruit, 10 parts of manchurian wildginger, 10 parts of medicinal indianmulberry root, 8 parts of ginseng, 14 parts of Chinese angelica, 8 parts of sweet night flower, 8 parts of Chinese gall, 15 parts of cordyceps sinensis and 23 parts of water. The traditional Chinese medicine external preparation prepared by adopting the proportion has the synergistic interaction effect among the components, and can bring the medicinal value of each component into play to the best.
On the other hand, the embodiment of the present application provides a method for preparing the external traditional Chinese medicine preparation for rapidly improving sexual function, which comprises the following steps: pretreatment of raw materials: carrying out ultrasonic cleaning on cynomorium songaricum, beautiful millettia root, pilose antler, medicinal indianmulberry root, ginseng, Chinese angelica, sweet pinkish flower, Chinese gall and Chinese caterpillar fungus by adopting an ultrasonic cleaning machine, drying the cleaned cynomorium songaricum, beautiful millettia root, pilose antler, medicinal indianmulberry root, ginseng, Chinese angelica, sweet pinkish flower, Chinese gall and Chinese caterpillar fungus by adopting an oven, slicing for later use, soaking and cleaning epimedium herb, clove, common cnidium fruit and manchurian wildginger by adopting distilled water, and drying the cleaned epimedium herb, clove, common cnidium fruit and manchurian wildginger by adopting an oven; extracting medicinal components: respectively carrying out water extraction and alcohol extraction on each pretreated component, then combining the water extract and the alcohol extract, and then carrying out concentration, alcohol precipitation and filtration to obtain concentrated liquid medicine of each component; mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 8-20 parts of cynomorium songaricum, 8-16 parts of epimedium herb, 4-15 parts of beautiful millettia root, 15-40 parts of pilose antler, 10-20 parts of clove, 6-15 parts of common cnidium fruit, 5-15 parts of manchurian wildginger, 4-15 parts of morinda officinalis, 5-10 parts of ginseng, 7-20 parts of Chinese angelica, 6-10 parts of flower of sweet night, 5-12 parts of Chinese gall and 10-20 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 15-30 parts of water to 30-60 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding the concentrated mixed liquid medicine into the water, and then continuously heating at constant temperature for 40-80min to obtain the traditional Chinese medicine external preparation.
The traditional Chinese medicine external preparation prepared by the method in the embodiment is firstly cleaned to remove impurities in each medicine component, so that the purity of the prepared traditional Chinese medicine external preparation is higher, materials in cynomorium songaricum, beautiful millettia root, pilose antler, morinda officinalis, ginseng, Chinese angelica, purple sweet night flower, Chinese gall and cordyceps sinensis can be more thoroughly removed by ultrasonic cleaning, and impurities in medicinal materials can be more effectively removed by soaking epimedium herb, clove, common cnidium fruit and manchurian wildginger in distilled water; the pretreated components are respectively subjected to water extraction and alcohol extraction, so that the nutrient substances in the medicinal materials can be more fully and effectively extracted; then 15-30 parts by weight of water is heated to 30-60 ℃ and added with the concentrated mixed liquid medicine, so that the water has a certain temperature, the components can be better fused with each other, and the using drug effect is better.
Further, in some embodiments of the present invention, in the raw material pretreatment process, cynomorium songaricum, beautiful millettia root, pilose antler, morinda root, ginseng, angelica, sweet night flower, gallnut and cordyceps sinensis are cleaned by an ultrasonic cleaning machine for 8-20 min.
By adopting the above embodiment, the cleaning is carried out for 8-20min, so that impurities in the medicinal materials can be effectively removed, and simultaneously, the nutritional ingredients in the medicinal materials are not damaged.
Further, in some embodiments of the present invention, during the pretreatment of the raw materials, the epimedium herb, the clove, the common cnidium fruit and the manchurian wildginger are soaked in distilled water for 8-20 min.
By adopting the embodiment, the medicinal materials can be effectively removed by soaking in distilled water for 8-20min, and simultaneously, the nutrient components in the medicinal materials are not damaged.
Further, in some embodiments of the present invention, the baking temperature of the oven is 38-50 ℃ during the raw material pretreatment.
By adopting the embodiment, the baking temperature is 38-50 ℃, so that the nutrient components in the medicinal materials are not damaged while the medicinal materials are dried.
Further, in some embodiments of the present invention, the water extraction process of the above-mentioned medicinal ingredients is: decocting the above materials with 20-40 times of water for 60-100min, and filtering to obtain water extractive filtrate and residue.
By adopting the implementation mode, the nutrient substances in the medicinal materials of all components can be effectively extracted, and the full utilization of the nutrient substances of the medicinal materials is ensured.
Further, in some embodiments of the present invention, the alcohol extraction process of the above medicinal ingredients is: soaking the water extraction residue of each component in ethanol for 30-60min, and filtering to obtain ethanol extraction filtrate and ethanol extraction residue.
By adopting the implementation mode, the nutrient substances in the medicinal materials of all the components can be further effectively extracted, and the full utilization of the nutrient substances of the medicinal materials is ensured.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
Pretreatment of raw materials: ultrasonically cleaning herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps for 8min by using an ultrasonic cleaning machine, oven drying the cleaned herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps, and slicing at 38 deg.C; soaking herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari in distilled water for 8min, cleaning, and oven drying the cleaned herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari at 38 deg.C;
Extracting medicinal components: carrying out water extraction and alcohol extraction on the pretreated components respectively, wherein the water extraction comprises the following steps: decocting the components with 20 times of water for 60min, and filtering to obtain water extraction filtrate and water extraction filter residue of the components, wherein the alcohol extraction is as follows: soaking the water extraction residue of each component in ethanol for 30min, filtering to obtain ethanol extraction filtrate and ethanol extraction residue, mixing the water extraction solution and ethanol extraction solution, concentrating, precipitating with ethanol, and filtering to obtain concentrated medicinal liquid of each component;
Mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 8 parts of cynomorium songaricum, 8 parts of epimedium herb, 4 parts of beautiful millettia root, 15 parts of pilose antler, 10 parts of clove, 6 parts of common cnidium fruit, 5 parts of manchurian wildginger, 4 parts of morinda officinalis, 5 parts of ginseng, 7 parts of Chinese angelica, 6 parts of sweet night flower, 5 parts of Chinese gall and 10 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 15 parts by weight of water to 30 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding all the concentrated mixed liquid medicine into the water, and continuously heating at constant temperature for 40min to obtain the traditional Chinese medicine external preparation.
Example 2
Pretreatment of raw materials: ultrasonically cleaning herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps for 20min by using an ultrasonic cleaning machine, oven drying the cleaned herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps, and slicing at 50 deg.C; soaking herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari in distilled water for 20min, washing, oven drying the washed herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari at 50 deg.C;
Extracting medicinal components: carrying out water extraction and alcohol extraction on the pretreated components respectively, wherein the water extraction comprises the following steps: decocting the components with 40 times of water for 100min, and filtering to obtain water extraction filtrate and water extraction filter residue of the components, wherein the alcohol extraction is as follows: soaking the water extraction residue of each component in ethanol for 60min, filtering to obtain ethanol extraction filtrate and ethanol extraction residue, mixing the water extraction solution and ethanol extraction solution, concentrating, precipitating with ethanol, and filtering to obtain concentrated medicinal liquid of each component;
Mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 20 parts of cynomorium songaricum, 16 parts of epimedium herb, 15 parts of beautiful millettia root, 40 parts of pilose antler, 20 parts of clove, 15 parts of common cnidium fruit, 15 parts of manchurian wildginger, 15 parts of morinda officinalis, 10 parts of ginseng, 20 parts of Chinese angelica, 10 parts of sweet night flower, 12 parts of Chinese gall and 20 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 30 parts by weight of water to 60 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding all the concentrated mixed liquid medicine into the water, and continuously heating at constant temperature for 80min to obtain the traditional Chinese medicine external preparation.
Example 3
Pretreatment of raw materials: ultrasonically cleaning herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps for 16min by using an ultrasonic cleaning machine, oven drying the cleaned herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps, and slicing for use, wherein the oven baking temperature is 44 deg.C; soaking herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari in distilled water for 16min, cleaning, and oven drying the cleaned herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari at 44 deg.C;
Extracting medicinal components: carrying out water extraction and alcohol extraction on the pretreated components respectively, wherein the water extraction comprises the following steps: decocting the components with 30 times of water for 80min, and filtering to obtain water extraction filtrate and water extraction filter residue of the components, wherein the alcohol extraction is as follows: soaking the water extraction residue of each component in ethanol for 45min, filtering to obtain ethanol extraction filtrate and ethanol extraction residue, mixing the water extraction solution and ethanol extraction solution, concentrating, precipitating with ethanol, and filtering to obtain concentrated medicinal liquid of each component;
Mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 17 parts of cynomorium songaricum, 12 parts of epimedium herb, 10 parts of beautiful millettia root, 28 parts of pilose antler, 15 parts of clove, 11 parts of common cnidium fruit, 10 parts of manchurian wildginger, 10 parts of morinda officinalis, 8 parts of ginseng, 14 parts of Chinese angelica, 8 parts of flower of dark night, 8 parts of Chinese gall and 15 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 18 parts by weight of water to 45 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding all the concentrated mixed liquid medicine into the water, and continuously heating at constant temperature for 60min to obtain the traditional Chinese medicine external preparation.
Example 4
Pretreatment of raw materials: ultrasonically cleaning herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps for 14min by using an ultrasonic cleaning machine, oven drying the cleaned herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps, and slicing at 42 deg.C; soaking herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari in distilled water for 14min, cleaning, and oven drying the cleaned herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari at 40 deg.C;
Extracting medicinal components: carrying out water extraction and alcohol extraction on the pretreated components respectively, wherein the water extraction comprises the following steps: decocting the components with 25 times of water for 70min, and filtering to obtain water extraction filtrate and water extraction filter residue of the components, wherein the ethanol extraction is as follows: soaking the water extraction residue of each component in ethanol for 40min, filtering to obtain ethanol extraction filtrate and ethanol extraction residue, mixing the water extraction solution and ethanol extraction solution, concentrating, precipitating with ethanol, and filtering to obtain concentrated medicinal liquid of each component;
Mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 12 parts of cynomorium songaricum, 10 parts of epimedium herb, 8 parts of beautiful millettia root, 22 parts of pilose antler, 12 parts of clove, 8 parts of common cnidium fruit, 7 parts of manchurian wildginger, 7 parts of morinda officinalis, 7 parts of ginseng, 11 parts of Chinese angelica, 7 parts of sweet night flower, 7 parts of Chinese gall and 13 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 20 parts by weight of water to 40 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding all the concentrated mixed liquid medicine into the water, and continuously heating at constant temperature for 50min to obtain the traditional Chinese medicine external preparation.
Example 5
Pretreatment of raw materials: ultrasonically cleaning herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps for 18min by using an ultrasonic cleaning machine, oven drying the cleaned herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps, and slicing for use, wherein the oven baking temperature is 48 deg.C; soaking herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari in distilled water for 19min, washing, oven drying the washed herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari at 45 deg.C;
Extracting medicinal components: carrying out water extraction and alcohol extraction on the pretreated components respectively, wherein the water extraction comprises the following steps: decocting the components respectively by using 38 times of water for 90min, and filtering to obtain water extraction filtrate and water extraction filter residue of the components, wherein the alcohol extraction is as follows: soaking the water extraction residue of each component in ethanol for 55min, filtering to obtain ethanol extraction filtrate and ethanol extraction residue, mixing the water extraction solution and ethanol extraction solution, concentrating, precipitating with ethanol, and filtering to obtain concentrated medicinal liquid of each component;
Mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 19 parts of cynomorium songaricum, 14 parts of epimedium herb, 12 parts of beautiful millettia root, 35 parts of pilose antler, 17 parts of clove, 13 parts of common cnidium fruit, 12 parts of manchurian wildginger, 12 parts of morinda officinalis, 9 parts of ginseng, 18 parts of Chinese angelica, 9 parts of flower of dark night, 10 parts of Chinese gall and 19 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 28 parts by weight of water to 55 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding all the concentrated mixed liquid medicine into the water, and continuously heating at constant temperature for 75min to obtain the traditional Chinese medicine external preparation.
Example of clinical test
The inventor collects 100 male volunteers from 6 months to 3 months in 2020 in 2019, the male volunteers are 22-45 years old, and all the volunteers have symptoms of insufficiency of kidney-yang, deficiency of essence and blood, impotence, premature ejaculation and the like; 100 volunteers were randomly divided into a treatment group and a control group, wherein 50 volunteers in the experimental group and 50 volunteers in the control group were administered with the external preparation of Chinese medicinal materials prepared in examples 1-5, and common oral health-care drugs for enhancing sexual function on the market.
After 40 consecutive days, the conditions of the volunteers of the experimental group and the control group are shown in Table 1:
TABLE 1
Figure BDA0002513726180000181
From the results of table 1, it can be seen that: the traditional Chinese medicine external preparation provided by the invention is quick in effect and does not need to be used for a long time.
In summary, the embodiments of the present invention have at least the following advantages or beneficial effects:
On one hand:
The cynomorium songaricum, the epimedium herb, the beautiful millettia root and the pilose antler are compatible, so that the effects of nourishing kidney yang and increasing male erection strength can be achieved, and the sexual capacity of the male can be rapidly improved; the clove, the common cnidium fruit, the asarum and the morinda officinalis are combined to play a role in reducing sensitivity and exciting nerves and prolong male erection time; the compatibility of ginseng, angelica, sweet night flower, gallnut and cordyceps sinensis can play the roles of strengthening the body resistance, cultivating vigor and astringing; the nutritional ingredients in the components of the Chinese medicinal external preparation can regulate human pituitary gland and promote secretion of sex hormone to reach normal level, thereby improving sexual dysfunction and sexual function and pleasant sensation; the alkaloid component contained in the traditional Chinese medicine external preparation can act on the human pituitary gland to play a role in resisting fatigue, and the amino acid mineral trace elements contained in the traditional Chinese medicine external preparation can improve the functions of the gonad and each organ of the human body, can comprehensively condition the body and mind and can powerfully improve the sexual function; the components are compatible, the obtained traditional Chinese medicine external preparation is smeared on male sexual organs and mainly acts on the coronary sulcus of penis to play a role of local mucosa, the sensitivity of external genitalia can be reduced, the stimulation intensity for stimulating ejaculation is improved, and the sexual intercourse time is prolonged.
On the other hand:
The traditional Chinese medicine external preparation prepared by the method in the embodiment is firstly cleaned to remove impurities in each medicine component, so that the purity of the prepared traditional Chinese medicine external preparation is higher, materials in cynomorium songaricum, beautiful millettia root, pilose antler, morinda officinalis, ginseng, Chinese angelica, purple sweet night flower, Chinese gall and cordyceps sinensis can be more thoroughly removed by ultrasonic cleaning, and impurities in medicinal materials can be more effectively removed by soaking epimedium herb, clove, common cnidium fruit and manchurian wildginger in distilled water; the pretreated components are respectively subjected to water extraction and alcohol extraction, so that the nutrient substances in the medicinal materials can be more fully and effectively extracted; then 15-30 parts by weight of water is heated to 30-60 ℃ and added with the concentrated mixed liquid medicine, so that the water has a certain temperature, the components can be better fused with each other, and the using drug effect is better.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. A traditional Chinese medicine external preparation for rapidly improving sexual function is characterized in that: the paint comprises the following components in parts by weight:
8-20 parts of cynomorium songaricum, 8-16 parts of epimedium, 4-15 parts of beautiful millettia root, 15-40 parts of pilose antler, 10-20 parts of clove, 6-15 parts of common cnidium fruit, 5-15 parts of manchurian wildginger, 4-15 parts of morinda officinalis, 5-10 parts of ginseng, 7-20 parts of Chinese angelica, 6-10 parts of flower of sweet night, 5-12 parts of Chinese gall, 10-20 parts of cordyceps sinensis and 15-30 parts of water.
2. The external traditional Chinese medicine preparation for rapidly improving sexual function according to claim 1, which is characterized in that: the paint comprises the following components in parts by weight: 8-17 parts of cynomorium songaricum, 8-12 parts of epimedium herb, 4-10 parts of bovine datura, 15-28 parts of pilose antler, 10-15 parts of clove, 6-11 parts of common cnidium fruit, 5-10 parts of manchurian wildginger, 4-10 parts of morinda officinalis, 5-8 parts of ginseng, 7-14 parts of Chinese angelica, 6-8 parts of flower of Lantern night, 5-8 parts of Chinese gall, 10-15 parts of cordyceps sinensis and 15-23 parts of water.
3. The external traditional Chinese medicine preparation for rapidly improving sexual function according to claim 1, which is characterized in that: the paint comprises the following components in parts by weight: 17-20 parts of cynomorium songaricum, 12-16 parts of epimedium, 10-15 parts of beautiful millettia root, 28-40 parts of pilose antler, 15-20 parts of clove, 11-15 parts of common cnidium fruit, 10-15 parts of manchurian wildginger, 10-15 parts of morinda officinalis, 8-10 parts of ginseng, 14-20 parts of Chinese angelica, 8-10 parts of flower of sweet night, 8-12 parts of Chinese gall, 15-20 parts of cordyceps sinensis and 23-30 parts of water.
4. The external traditional Chinese medicine preparation for rapidly improving sexual function according to claim 1, which is characterized in that: the paint comprises the following components in parts by weight: 17 parts of cynomorium songaricum, 12 parts of epimedium herb, 10 parts of beautiful millettia root, 28 parts of pilose antler, 15 parts of clove, 11 parts of common cnidium fruit, 10 parts of manchurian wildginger, 10 parts of medicinal indianmulberry root, 8 parts of ginseng, 14 parts of Chinese angelica, 8 parts of sweet night flower, 8 parts of Chinese gall, 15 parts of cordyceps sinensis and 23 parts of water.
5. A method for preparing the external traditional Chinese medicine preparation for rapidly improving sexual function according to any one of claims 1 to 4, which is characterized in that: the method comprises the following steps:
Pretreatment of raw materials: carrying out ultrasonic cleaning on cynomorium songaricum, beautiful millettia root, pilose antler, medicinal indianmulberry root, ginseng, Chinese angelica, sweet pinkish flower, Chinese gall and Chinese caterpillar fungus by adopting an ultrasonic cleaning machine, drying the cleaned cynomorium songaricum, beautiful millettia root, pilose antler, medicinal indianmulberry root, ginseng, Chinese angelica, sweet pinkish flower, Chinese gall and Chinese caterpillar fungus by adopting an oven, slicing for later use, soaking and cleaning epimedium herb, clove, common cnidium fruit and manchurian wildginger by adopting distilled water, and drying the cleaned epimedium herb, clove, common cnidium fruit and manchurian wildginger by adopting an oven;
Extracting medicinal components: respectively carrying out water extraction and alcohol extraction on each pretreated component, then combining the water extract and the alcohol extract, and then carrying out concentration, alcohol precipitation and filtration to obtain concentrated liquid medicine of each component;
Mixing the preparation: mixing the concentrated liquid medicine of each component according to the following parts by weight: 8-20 parts of cynomorium songaricum, 8-16 parts of epimedium herb, 4-15 parts of beautiful millettia root, 15-40 parts of pilose antler, 10-20 parts of clove, 6-15 parts of common cnidium fruit, 5-15 parts of manchurian wildginger, 4-15 parts of morinda officinalis, 5-10 parts of ginseng, 7-20 parts of Chinese angelica, 6-10 parts of flower of sweet night, 5-12 parts of Chinese gall and 10-20 parts of Chinese caterpillar fungus to obtain mixed concentrated liquid medicine, heating 15-30 parts of water to 30-60 ℃, adding the concentrated mixed liquid medicine into the water at constant temperature, continuously stirring, adding the concentrated mixed liquid medicine into the water, and then continuously heating at constant temperature for 40-80min to obtain the traditional Chinese medicine external preparation.
6. The method for preparing a Chinese medicinal external preparation according to claim 5, which is characterized in that: in the raw material pretreatment process, herba Cynomorii, radix Millettiae Speciosae, cornu Cervi Pantotrichum, radix Morindae officinalis, Ginseng radix, radix Angelicae sinensis, flos Lawsoniae, Galla chinensis and Cordyceps are cleaned with ultrasonic cleaner for 8-20 min.
7. The method for preparing a Chinese medicinal external preparation according to claim 5, which is characterized in that: in the raw material pretreatment process, herba Epimedii, flos Caryophylli, fructus Cnidii and herba asari are soaked in distilled water for 8-20 min.
8. The method for preparing a Chinese medicinal external preparation according to claim 5, which is characterized in that: in the raw material pretreatment process, the baking temperature of the oven is 38-50 ℃.
9. The method for preparing a Chinese medicinal external preparation according to claim 5, which is characterized in that: the water extraction in the extraction process of the medicinal components is as follows: decocting the above materials with 20-40 times of water for 60-100min, and filtering to obtain water extractive filtrate and residue.
10. The method for preparing a traditional Chinese medicine external preparation according to claim 9, which is characterized in that: the medicinal components are extracted by alcohol in the extraction process: soaking the water extraction residue of each component in ethanol for 30-60min, and filtering to obtain ethanol extraction filtrate and ethanol extraction residue.
CN202010469224.2A 2020-05-28 2020-05-28 Traditional Chinese medicine external preparation for rapidly improving sexual function and preparation method thereof Pending CN111419925A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN112107605A (en) * 2020-10-20 2020-12-22 江西五麟祥生物科技有限公司 Cynomorium songaricum extract and preparation process thereof

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Publication number Priority date Publication date Assignee Title
CN104666513A (en) * 2015-02-13 2015-06-03 烟台华威药业有限公司 Externally-applied traditional Chinese medicine for treating prospermia and enhancing erection and preparation method of externally-applied traditional Chinese medicine

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Publication number Priority date Publication date Assignee Title
CN104666513A (en) * 2015-02-13 2015-06-03 烟台华威药业有限公司 Externally-applied traditional Chinese medicine for treating prospermia and enhancing erection and preparation method of externally-applied traditional Chinese medicine

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112107605A (en) * 2020-10-20 2020-12-22 江西五麟祥生物科技有限公司 Cynomorium songaricum extract and preparation process thereof

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