CN112107605A

CN112107605A - Cynomorium songaricum extract and preparation process thereof

Info

Publication number: CN112107605A
Application number: CN202011125177.6A
Authority: CN
Inventors: 邓勇
Original assignee: Jiangxi Wulinxiang Biotechnology Co ltd
Current assignee: Jiangxi Wulinxiang Biotechnology Co ltd
Priority date: 2020-10-20
Filing date: 2020-10-20
Publication date: 2020-12-22

Abstract

The invention relates to the technical field of extracts, and discloses a cynomorium songaricum extract and a preparation process thereof, wherein various kidney-tonifying and yang-tonifying medicines are full of meshes in the current market, but no set of overall effective preparation method is provided, so that the extraction of high-effective medicinal components is reduced, and aiming at the defects of the conventional cynomorium songaricum extract and the preparation process thereof, the cynomorium songaricum extract and the preparation process solve the problem of precipitation generation in the extract by using methods of ethanol extraction and ethanol elution, obtain stable extracting solution, refine and purify the extract by using small-pore adsorption resin, reduce the impurity content of the extract, and provide a good foundation for the pharmacy of the extract. The method of ethanol extraction and ethanol elution has the advantages of simple process, less impurities, strong operability, good stability of the obtained extract, low risk of allergy, low toxicity to human body, and effects of nourishing yin, tonifying yang, improving immunity, and preventing impotence and premature ejaculation.

Description

Cynomorium songaricum extract and preparation process thereof

Technical Field

The invention relates to the technical field of extracts, in particular to a cynomorium songaricum extract and a preparation process thereof.

Background

The extract is generally divided into three types of plant extract, animal extract and traditional Chinese medicine extract from the medical point of view, wherein the traditional Chinese medicine extract is a novel traditional Chinese medicine product fused with the modern pharmaceutical technology, is still a traditional Chinese medicine essentially, and can also be used for other purposes such as cosmetics, health-care food and the like.

In recent years, with the acceleration of social life rhythm, people have more and more pressure, which easily causes consumptive disease injury and insufficiency of essence and blood, thereby causing aching pain in waist and lower extremities, body weakness, low immunity, premature senility and the like, even for adult men, the aching pain in waist and lower extremities can also cause diseases such as impotence, premature ejaculation and the like, and more seriously, the male infertility and sterility are caused. Various kidney-tonifying and yang-strengthening medicines are full of medicines in the market at present, but because an overall effective preparation method is not provided, the extraction of high-effective medicinal components is reduced, the preparation process of the cynomorium songaricum extract is improved, the production cost is reduced, and the increase of the effective components of the cynomorium songaricum medicine becomes an important problem, so that the cynomorium songaricum extract and the preparation process are provided.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the cynomorium songaricum extract and the preparation process thereof, which have the advantages of improving the preparation process of the cynomorium songaricum extract, reducing the production cost and increasing the effective components of the cynomorium songaricum medicament, and solve the problems that no set of overall effective preparation method is available and the extraction of high-effective medicinal components is reduced.

(II) technical scheme

In order to improve the preparation process of the cynomorium songaricum extract, reduce the production cost and increase the effective components of the cynomorium songaricum medicament, the invention provides the following technical scheme:

a cynomorium songaricum extract is prepared from the following raw materials in parts by mass: 0.8-1.2 parts of wild ginseng, 0.6-1.3 parts of cordyceps sinensis, 1-2 parts of radix bupleuri, 10-13 parts of medlar, 13-16 parts of radix astragali, 10-15 parts of earthworm, 10-13 parts of honeycomb, 10-18 parts of cistanche, 12-17 parts of semen cuscutae, 2-7 parts of herba epimedii, 8-12 parts of pilose antler, 9-13 parts of cinnamon, 5-9 parts of saffron crocus, 3-8 parts of lucid ganoderma and 4-9 parts of penis cervi.

The traditional Chinese medicine is prepared from the following raw materials in parts by weight:

the raw materials are as follows: 1 part of wild ginseng, 0.8 part of cordyceps sinensis, 1.5 parts of radix bupleuri, 11 parts of medlar, 15 parts of astragalus membranaceus, 12 parts of lumbricus, 11 parts of honeycomb, 15 parts of cistanche, 16 parts of semen cuscutae, 5 parts of herba epimedii, 10 parts of cornu cervi pantotrichum, 12 parts of cinnamon, 7 parts of saffron, 6 parts of lucid ganoderma, 5 parts of penis cervi, honey, a proper amount of red dates and gastrodia elata.

According to the cynomorium songaricum extract, the preparation process of the cynomorium songaricum extract is provided, and comprises the following steps:

(1) firstly, weighing the raw materials in parts by weight respectively;

(2) drying wild ginseng, cordyceps sinensis and radix bupleuri respectively, removing impurities, and crushing into coarse powder for later use;

(3) soaking cornu Cervi Pantotrichum, penis et testis Cervi, nidus Vespae, Cistanchis herba, and semen Cuscutae in Chinese liquor for 3-5 days, heating the supernatant, and adding water to concentrate into fluid extract;

(4) heating and refluxing radix astragali, Lumbricus and cortex Cinnamomi with ethanol, mixing, recovering ethanol, concentrating to obtain soft extract, dissolving the concentrated solution in water, eluting with ethanol using microporous adsorbent resin, recovering ethanol from the eluate, concentrating, and filtering;

(5) mixing herba Epimedii with high concentration Chinese liquor, and steaming;

(6) steaming stigma croci Sativi and Ganoderma, parching, and sun drying to obtain coarse powder.

(7) Removing impurities from other raw materials, cleaning, air drying, pulverizing into coarse powder, extracting with water under reflux for 3 times (each time is not less than 2 hr), mixing all filtrates, filtering, and concentrating the filtrate into fluid extract.

(8) Making the coarse powder into 200-400 mesh fine powder, adding preparation forming adjuvants, dissolving in water, extracting with water under reflux for 3 times (each time is not less than 2 hr), mixing all filtrates, filtering, and concentrating the filtrate into fluid extract.

(9) Soaking the above fluid extract mixture in 10-15 times of water for 4-5 hr, filtering to obtain initial mixed solution, adding 7-12% Borneolum Syntheticum, and bottling after dissolving Borneolum Syntheticum.

Wherein the other raw materials in the step (7) are as follows: 1 part of wild ginseng, 0.8 part of cordyceps sinensis, 1.5 parts of radix bupleuri, 11 parts of medlar, 15 parts of radix astragali, 12 parts of earthworm, 7 parts of saffron crocus, 6 parts of lucid ganoderma, 5 parts of penis cervi, a proper amount of honey, a proper amount of red date and a proper amount of rhizoma gastrodiae.

The medicine properties of the medicines in the invention are as follows:

1. wild ginseng: is dried root of Panax ginseng C.A.Meyer belonging to family Araliaceae. Nature and taste: sweet, slightly bitter and warm. It enters spleen and lung meridians. The method is characterized in that: it is slightly warm and not warm, slightly bitter and not dry. Has the functions of invigorating qi and strengthening the efficacy of the medicine.

2. And (3) cordyceps sinensis: has effects in invigorating kidney and lung, relieving cough, invigorating yang, and treating sexual impotence, premature ejaculation, and neurasthenia.

3. Bupleurum root: has the effects of dispelling pathogenic heat, relieving stagnation, invigorating yang, and lifting sinking.

4. Medlar: has the effects of nourishing liver and kidney, and improving eyesight.

5. Astragalus root: has effects in invigorating qi, strengthening middle warmer, arresting sweating, promoting granulation, inducing diuresis, and relieving swelling.

6. Earthworm: has effects in clearing away heat, arresting convulsion, expelling collateral obstruction, relieving asthma, and promoting urination.

7. Honeycomb: has effects in expelling pathogenic wind, removing toxic materials, killing parasite, and relieving pain.

8. Cistanche deserticola: has effects in invigorating kidney, supporting yang, replenishing essence, nourishing marrow, nourishing blood, moistening dryness, and prolonging life.

9. Dodder seed: has effects in supporting yang, regulating endocrine, and resisting aging.

10. Herba epimedii: has the functions of invigorating kidney, strengthening Yang, strengthening physique, etc.

11. Pilose antler: has effects in warming yang, invigorating qi and blood, and strengthening tendons and bones.

12. Cinnamon: has the functions of benefiting yang, eliminating yin, nourishing spleen and stomach, dispelling cold evil, etc.

13. Saffron: has the functions of promoting blood circulation to disperse blood clots, dispersing depressed vital energy, etc.

14. Ganoderma lucidum: has effects in protecting liver, enhancing immunity, and inhibiting bacteria.

15. Deer penis: nourishing yin and tonifying yang, it is indicated for seminal emission due to kidney deficiency, impotence and premature ejaculation.

The cynomorium songaricum medicament of the invention has the following application and dosage: spraying within 15-20 minutes before each room, 4-6 times for each time, and the product can be used together with lubricant.

The cynomorium songaricum medicine prepared by the method has good effects of strengthening physique and enhancing sexual function, is particularly suitable for patients with kidney deficiency, impotence, premature ejaculation, low back pain, hypodynamia, premature senility and the like in different degrees, and is particularly suitable for busy and fast-paced people.

(III) advantageous effects

Compared with the prior art, the invention provides the cynomorium songaricum extract and the preparation process thereof, and the cynomorium songaricum extract has the following beneficial effects:

1. the cynomorium songaricum extract and the preparation process solve the problem of precipitate generation in the extract by the methods of ethanol extraction and ethanol elution, obtain stable extract, and refine and purify the extract by adopting the small-pore adsorption resin, so that the impurity content of the extract is reduced, and a good basis is provided for the pharmacy of the extract.

2. The cynomorium songaricum extract and the preparation process thereof have the advantages of simple process, less impurities, stronger operability, good stability of the obtained extract, low allergy risk and lower toxicity to human bodies by using the methods of ethanol extraction and ethanol elution, and have the effects of nourishing yin, tonifying yang, improving immunity and preventing impotence and premature ejaculation.

Drawings

FIG. 1 is a schematic diagram of the penis erection latent period of different mass parts of the extract of the present invention;

FIG. 2 is a graph showing the comparative penile erection stiffness values of the second extract of the present invention;

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example one

the raw materials are as follows: 0.8 part of wild ginseng, 0.6 part of cordyceps sinensis, 1 part of radix bupleuri, 10 parts of medlar, 13 parts of astragalus membranaceus, 10 parts of lumbricus, 10 parts of honeycomb, 10 parts of cistanche, 12 parts of semen cuscutae, 2 parts of herba epimedii, 8 parts of cornu cervi pantotrichum, 9 parts of cinnamon, 5 parts of saffron, 3 parts of lucid ganoderma, 4 parts of penis cervi, honey, a proper amount of red dates and gastrodia elata.

(1) firstly, weighing the raw materials in parts by weight respectively;

(5) mixing herba Epimedii with high concentration Chinese liquor, and steaming;

The cynomorium songaricum medicament of the invention has the following application and dosage: spraying within 15-20 minutes before each room, 4-6 times for each time, and the product can be used together with lubricant. Example two

A cynomorium songaricum extract is prepared from the following raw materials in parts by mass: 1g of wild ginseng, 0.8g of cordyceps sinensis, 1.5g of radix bupleuri, 11g of medlar, 15g of astragalus membranaceus, 12g of lumbricus, 11g of honeycomb, 15g of cistanche, 16g of semen cuscutae, 5g of herba epimedii, 10g of cornu cervi pantotrichum, 12g of cinnamon, 7g of saffron, 6g of lucid ganoderma, 5g of penis cervi, honey, a proper amount of red dates and gastrodia elata.

the raw materials are as follows: 1 part of wild ginseng, 0.95 part of cordyceps sinensis, 1.5 parts of radix bupleuri, 11.5 parts of medlar, 14.5 parts of astragalus membranaceus, 12.5 parts of lumbricus, 11.5 parts of honeycomb, 14 parts of cistanche, 14.5 parts of semen cuscutae, 4.5 parts of epimedium, 10 parts of cornu cervi pantotrichum, 11 parts of cinnamon, 7 parts of saffron crocus, 5.5 parts of lucid ganoderma, 6.5 parts of penis cervi, and a proper amount of honey, red dates and gastrodia elata.

(1) firstly, weighing the raw materials in parts by weight respectively;

(5) mixing herba Epimedii with high concentration Chinese liquor, and steaming;

EXAMPLE III

A cynomorium songaricum extract is prepared from the following raw materials in parts by mass: 0.5g of wild ginseng, 0.4g of cordyceps sinensis, 0.75g of radix bupleuri, 6.5g of medlar, 7.5g of astragalus membranaceus, 6g of lumbricus, 5.5g of honeycomb, 7.5g of cistanche, 8g of semen cuscutae, 2.5g of epimedium, 5g of cornu cervi pantotrichum, 6g of cinnamon, 3.5g of saffron crocus, 3g of lucid ganoderma, 2.5g of penis cervi, and proper amount of honey, red dates and gastrodia elata.

the raw materials are as follows: 1.2 parts of wild ginseng, 1.3 parts of cordyceps sinensis, 2 parts of radix bupleuri, 13 parts of medlar, 16 parts of astragalus membranaceus, 15 parts of lumbricus, 13 parts of honeycomb, 18 parts of cistanche, 17 parts of semen cuscutae, 7 parts of herba epimedii, 12 parts of cornu cervi pantotrichum, 13 parts of cinnamon, 9 parts of saffron, 8 parts of lucid ganoderma, 9 parts of penis cervi, honey, a proper amount of red dates and gastrodia elata.

(1) firstly, weighing the raw materials in parts by weight respectively;

(5) mixing herba Epimedii with high concentration Chinese liquor, and steaming;

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A cynomorium songaricum extract is characterized in that: the feed is prepared from the following raw materials in parts by weight: 0.8-1.2 parts of wild ginseng, 0.6-1.3 parts of cordyceps sinensis, 1-2 parts of radix bupleuri, 10-13 parts of medlar, 13-16 parts of radix astragali, 10-15 parts of earthworm, 10-13 parts of honeycomb, 10-18 parts of cistanche, 12-17 parts of semen cuscutae, 2-7 parts of herba epimedii, 8-12 parts of pilose antler, 9-13 parts of cinnamon, 5-9 parts of saffron crocus, 3-8 parts of lucid ganoderma and 4-9 parts of penis cervi.

2. The cynomorium songaricum extract as claimed in claim 1, wherein: the raw materials also comprise a proper amount of honey, red dates and gastrodia elata.

3. The cynomorium songaricum extract as claimed in claim 1, wherein: the raw materials are as follows: 1 part of wild ginseng, 0.8 part of cordyceps sinensis, 1.5 parts of radix bupleuri, 11 parts of medlar, 15 parts of astragalus membranaceus, 12 parts of lumbricus, 11 parts of honeycomb, 15 parts of cistanche, 16 parts of semen cuscutae, 5 parts of herba epimedii, 10 parts of cornu cervi pantotrichum, 12 parts of cinnamon, 7 parts of saffron, 6 parts of lucid ganoderma, 5 parts of penis cervi, honey, a proper amount of red dates and gastrodia elata.

4. The cynomorium songaricum extract according to claim 1, the preparation process of the cynomorium songaricum extract is provided, and is characterized in that: the preparation process comprises the following steps:

(1) firstly, weighing the raw materials in parts by weight respectively;

(5) mixing herba Epimedii with high concentration Chinese liquor, and steaming;

5. The preparation process of the cynomorium songaricum extract according to claim 4, which is characterized in that: wherein the other raw materials in the step (7) are as follows: 1 part of wild ginseng, 0.8 part of cordyceps sinensis, 1.5 parts of radix bupleuri, 11 parts of medlar, 15 parts of radix astragali, 12 parts of earthworm, 7 parts of saffron crocus, 6 parts of lucid ganoderma, 5 parts of penis cervi, a proper amount of honey, a proper amount of red date and a proper amount of rhizoma gastrodiae.

6. The preparation process of the cynomorium songaricum extract according to claim 4, which is characterized in that: the preparation process comprises the following steps:

drying the mountain ginseng, the cordyceps sinensis and the radix bupleuri at 40-70 ℃ for 5-7 hours respectively, crushing into coarse powder, and sieving with a 30-50-mesh sieve for later use;

step (3) mixing coarse powder of pilose antler, deer penis, honeycomb, desertliving cistanche and dodder, adding 5-10 times of white spirit for soaking for 3-5 days, and finally adding water and concentrating into clear paste for later use;

heating and refluxing the astragalus, the earthworm and the cinnamon by using 70% ethanol, mixing, recovering ethanol, concentrating into thick paste, adding water to dissolve the concentrated solution, then using microporous adsorption resin, eluting by using ethanol, finally recovering the ethanol from the eluent, concentrating the density of the filtrate to 1.2-1.5, and then filtering for later use;

step (5), mixing and steaming the epimedium herb by using high-concentration white spirit;

step (6), steaming, frying and drying the saffron and the lucid ganoderma to obtain coarse powder for later use

And (7) removing impurities from other raw materials, cleaning, airing, crushing into coarse powder, performing reflux extraction for 3 times by water, wherein the time of each time is not less than 2 hours, combining all filtrates, filtering, and concentrating the filtrate into clear paste.