CN112617206A - Composite probiotics for reducing inflammatory cytokines and regulating immune function and application thereof - Google Patents
Composite probiotics for reducing inflammatory cytokines and regulating immune function and application thereof Download PDFInfo
- Publication number
- CN112617206A CN112617206A CN202011502396.1A CN202011502396A CN112617206A CN 112617206 A CN112617206 A CN 112617206A CN 202011502396 A CN202011502396 A CN 202011502396A CN 112617206 A CN112617206 A CN 112617206A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- inflammatory cytokines
- immune function
- omega
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006041 probiotic Substances 0.000 title claims abstract description 54
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 54
- 230000002757 inflammatory effect Effects 0.000 title claims abstract description 34
- 108090000695 Cytokines Proteins 0.000 title claims abstract description 33
- 102000004127 Cytokines Human genes 0.000 title claims abstract description 33
- 230000036737 immune function Effects 0.000 title claims abstract description 31
- 239000002131 composite material Substances 0.000 title claims abstract description 18
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 10
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims abstract description 27
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims abstract description 27
- 229940012843 omega-3 fatty acid Drugs 0.000 claims abstract description 27
- 230000000529 probiotic effect Effects 0.000 claims abstract description 27
- 241000121220 Tricholoma matsutake Species 0.000 claims abstract description 26
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims abstract description 25
- 229960002181 saccharomyces boulardii Drugs 0.000 claims abstract description 25
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims abstract description 24
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims abstract description 24
- 229940009289 bifidobacterium lactis Drugs 0.000 claims abstract description 24
- 241001076416 Dendrobium tosaense Species 0.000 claims abstract description 23
- 235000011034 Rubus glaucus Nutrition 0.000 claims abstract description 23
- 235000009122 Rubus idaeus Nutrition 0.000 claims abstract description 23
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 22
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 22
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 22
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 22
- 240000007651 Rubus glaucus Species 0.000 claims abstract description 22
- 240000000950 Hippophae rhamnoides Species 0.000 claims abstract 4
- 230000000694 effects Effects 0.000 abstract description 19
- 241000282414 Homo sapiens Species 0.000 abstract description 16
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 241000229143 Hippophae Species 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 14
- 239000003814 drug Substances 0.000 description 12
- 229940126680 traditional chinese medicines Drugs 0.000 description 8
- 230000001976 improved effect Effects 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 5
- 239000003053 toxin Substances 0.000 description 5
- 231100000765 toxin Toxicity 0.000 description 5
- 108700012359 toxins Proteins 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 241001523681 Dendrobium Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102100037850 Interferon gamma Human genes 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 229940088592 immunologic factor Drugs 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- VSMOENVRRABVKN-UHFFFAOYSA-N oct-1-en-3-ol Chemical compound CCCCCC(O)C=C VSMOENVRRABVKN-UHFFFAOYSA-N 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 241000193163 Clostridioides difficile Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 235000003935 Hippophae Nutrition 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 244000235659 Rubus idaeus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 231100000409 cytocidal Toxicity 0.000 description 1
- 230000000445 cytocidal effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 235000004879 dioscorea Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- -1 etc. Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 229940068140 lactobacillus bifidus Drugs 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000001055 magnesium Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/10—Products from fruits or vegetables; Preparation or treatment thereof of tuberous or like starch containing root crops
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
- A23L31/10—Yeasts or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a composite probiotic for reducing inflammatory cytokines and regulating immune function and application thereof, wherein the composite probiotic comprises the following components: 10-15 parts of saccharomyces boulardii, 5-10 parts of bifidobacterium lactis, 1-5 parts of lactobacillus rhamnosus, 10-20 parts of sea buckthorn, 1-5 parts of raspberry, 5-10 parts of dendrobium officinale, 10-20 parts of Chinese yam, 5-10 parts of tricholoma matsutake and 20-30 parts of omega-3 fatty acid. The invention also provides application of the composite probiotics in the aspects of reducing inflammatory cytokines and regulating immune functions. The composite probiotics provided by the invention can obviously reduce the generation of inflammatory cytokines and obviously improve the immune function of human bodies, is safe, has no toxic or side effect, and is suitable for wide application.
Description
Technical Field
The invention relates to the technical field of food processing, in particular to a composite probiotic for reducing inflammatory cytokines and regulating immune function and application thereof.
Background
With the continuous research of human beings on microbial flora, it is now well recognized that there is an inseparable internal relationship between human intestinal flora and human health. Specifically, the intestinal flora is vital to the health of human body, can regulate the normal flora of the gastrointestinal tract of the body, keep the balance of micro-ecological environment, improve the digestibility and the biological value of food, reduce serum cholesterol, control endotoxin, inhibit the growth and the reproduction of putrefaction products in the intestinal tract, produce nutrient substances and stimulate the development of tissues, thereby having positive effects on the nutritional state, the physiological function, the cell infection, the drug reaction, the toxin reaction, the immune reaction, the tumorigenesis, the aging process, the emergency reaction and the like of the body.
Based on this, people pay more attention to the research and development of probiotics at present, various complex probiotics are continuously proposed, and people hope to improve the immunity of people through continuous research, development and optimization of probiotics, so that the ability of resisting various viruses of people is continuously improved. It goes without saying that this is particularly of practical significance at the present time.
However, the practical situation fully shows that, for the complex probiotics, how to reasonably cooperate the probiotics with each other to fully exert the ideal cooperativity is a very challenging and significant task to effectively improve the dietotherapy effect in the practical application.
Aiming at the aim of effectively reducing inflammatory cytokines and regulating immune function, the inventor finds that the generation of inflammatory cytokines of a human body can be effectively reduced and the immune function of the human body can be effectively improved by reasonably matching probiotics and traditional Chinese medicines, namely selecting specific probiotics of a proper type and the traditional Chinese medicines and matching the probiotics and the traditional Chinese medicines with reasonable components.
Disclosure of Invention
The invention aims to provide a composite probiotic for reducing inflammatory cytokines and regulating immune function and application thereof, wherein the composite probiotic is prepared by selecting specific probiotics, specific traditional Chinese medicines and omega-3 fatty acid and using the probiotics in a reasonable component compatibility manner, so that the generation of inflammatory cytokines can be obviously reduced, the immune function of a human body can be obviously improved, and the composite probiotic is safe, has no toxic or side effect, and is suitable for being widely used by various crowds.
In order to accomplish the above objects, according to one aspect of the present invention, there is provided a complex probiotic bacteria for reducing inflammatory cytokines and regulating immune function, comprising: 10-15 parts of saccharomyces boulardii, 5-10 parts of bifidobacterium lactis, 1-5 parts of lactobacillus rhamnosus, 10-20 parts of sea buckthorn, 1-5 parts of raspberry, 5-10 parts of dendrobium officinale, 10-20 parts of Chinese yam, 5-10 parts of tricholoma matsutake and 20-30 parts of omega-3 fatty acid.
The invention adopts the combination of the saccharomyces boulardii, the bifidobacterium lactis and the lactobacillus rhamnosus, and the research firstly finds that the saccharomyces boulardii has ideal effects of resisting bacteria, toxins, barriers, immunoregulation and the like, inactivates clostridium difficile toxins A & B, cholera toxins, escherichia coli toxins and the like by releasing specific proteins, can protect intestinal health multiply, can participate in metabolism, improve the absorption of nutrition and glucose, increase the level of short-chain fatty acid, recover the normal fermentation and absorption activities of the intestinal tract, reduce the expression of inflammatory genes, play an anti-inflammatory role, stimulate the secretion of immune factors such as IgA and the activity of immune cells; secondly, experimental research finds that the saccharomyces boulardii is used as probiotics of yeast sources and is combined with the lactobacillus bifidus and the lactobacillus rhamnosus, so that the lactobacillus and the bifidobacterium can be obviously promoted to effectively proliferate, the growth of harmful bacteria is further inhibited, the healthy microbial flora of a human body is helped to recover, and the mucus layer and the mucosa of a host are further protected.
On the basis, the inventor further researches and discovers that the effects of reducing inflammatory cytokines and remarkably improving the immunologic function of a human body can be further obviously improved by adding proper traditional Chinese medicines for reasonable compatibility and adding a proper amount of omega-3 fatty acid on the basis of the probiotics.
Through a large amount of research, the inventor finally selects the following traditional Chinese medicines for the purpose of the invention.
Sea-buckthorn: it is nutritious, contains active substances such as multiple vitamins, fatty acids, microelements, linoleic acid, fructus Hippophae flavone, superoxide, etc., and various amino acids required by human body, wherein the vitamin C content is very high, and the vitamin has the name of vitamin C king. The sea buckthorn health-care product selects sea buckthorn, aims to fully utilize special pharmacological properties of fatigue resistance, organism vitality enhancement, cancer resistance and the like, protects and accelerates the repair of gastric mucosa, increases the drug property of bifidobacterium lactis, reduces plasma cholesterol and the content of cholesterol in blood vessel walls, can prevent and treat hyperlipidemia and atherosclerosis, and has the effect of promoting wound healing.
Raspberry: the fruit contains rich nutrient elements such as vitamin A, vitamin C, calcium, potassium, magnesium and the like and a large amount of fibers, is sour, sweet and delicious, has the reputation of 'golden fruit', and can effectively relieve cardiovascular diseases such as angina pectoris and the like. However, it should be emphasized that raspberry sometimes causes mild diarrhea, and therefore, the dosage should be especially careful so as not to cause adverse reactions.
Dendrobium officinale: the dendrobium polysaccharide and other active ingredients contained in the dendrobium polysaccharide can increase the activity of T cells and B cells in vivo, so that the body immunity is improved, and meanwhile, the dendrobium officinale has good effects of stabilizing blood sugar, reducing blood fat, relieving insomnia, promoting gastrointestinal health, relieving constipation and improving eyesight.
Chinese yam: is rich in polysaccharide, and has effects in stimulating or regulating immune system, promoting phagocytosis of reticuloendothelial system, enhancing cytocidal power, activating phagocyte, inducing expression of immune factor, and enhancing functions of immune system such as macrophage and lymphocyte.
Matsutake mushroom: contains 18 amino acids, 14 trace elements essential to human body, 49 active nutrients, 5 unsaturated fatty acids, 8 vitamins, 2 glycoproteins, rich dietary fibers and multiple active enzymes, and also contains 3 precious active substances, namely double-chain tricholoma matsutake polysaccharides, tricholoma matsutake polypeptides and a unique anti-cancer substance in the world, namely tricholoma matsutake alcohol, which is the most precious natural medicinal fungus in the world. The tricholoma matsutake is balanced and sufficient in nutrition, and also has various effects of improving immunity, resisting cancer and tumors, treating diabetes and cardiovascular diseases, promoting intestines and stomach, protecting liver and the like.
In addition, the invention also purposefully selects and adds omega-3 fatty acid. The reason for this is that omega-3 fatty acid, as a substance that effectively relieves and inhibits the occurrence of inflammation, can effectively play a role in reducing inflammatory cytokines and pathological platelet aggregation, and the like, and can also enhance the functions of the liver and pancreas, which is beneficial for the rapid recovery of patients after surgery. However, it should be noted that, since the omega-3 fatty acid may have a certain fishy smell, the addition thereof may affect the taste of the final product to a certain extent, and thus the sea buckthorn, the raspberry and the yam are used in combination, which is helpful to improve the taste to a certain extent.
As a preferred aspect, the present invention provides a complex probiotic, comprising: 12-13 parts of saccharomyces boulardii, 5-8 parts of bifidobacterium lactis, 1-3 parts of lactobacillus rhamnosus, 12-15 parts of sea buckthorn, 1-3 parts of raspberry, 6-8 parts of dendrobium officinale, 15-20 parts of Chinese yam, 8-10 parts of tricholoma matsutake and 22-25 parts of omega-3 fatty acid.
As a more preferred aspect, the present invention provides a complex probiotic, comprising: 12 parts by weight of saccharomyces boulardii, 8 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 12 parts by weight of sea buckthorn, 2 parts by weight of raspberry, 6 parts by weight of dendrobium officinale, 15 parts by weight of Chinese yam, 8 parts by weight of tricholoma matsutake and 22 parts by weight of omega-3 fatty acid.
Compared with the prior art, the invention can produce the following beneficial technical effects: through the combination of modern biotechnology and traditional Chinese medicine, specific probiotics and traditional Chinese medicine are selected and are compatible with reasonable components, the scientific combination of the probiotics and the traditional Chinese medicine is realized, so that the synergistic effect of the probiotics and the traditional Chinese medicine is fully exerted, the comprehensive effects of absorption, treatment and conditioning are effectively improved, omega-3 fatty acid is added in a targeted manner, the probiotics and the traditional Chinese medicine are reasonably combined, the effects of relieving and inhibiting inflammation are fully exerted, and the effect of reducing inflammatory cytokines is further enhanced. Experiments show that the composite probiotics provided by the invention have satisfactory effects on the aspects of the improvement of IgA content of a human body, the reduction of IFN-gamma content, onset time and the like, so that the generation of inflammatory cytokines can be reliably and effectively reduced, and the immune function of the human body is obviously improved.
Detailed Description
In order that the invention may be more clearly understood, reference will now be made in detail to the following examples.
Example 1
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 10 parts by weight of saccharomyces boulardii, 5 parts by weight of bifidobacterium lactis, 1 part by weight of lactobacillus rhamnosus, 10 parts by weight of sea buckthorn, 1 part by weight of raspberry, 5 parts by weight of dendrobium officinale, 10 parts by weight of Chinese yam, 5 parts by weight of tricholoma matsutake and 20 parts by weight of omega-3 fatty acid.
Example 2
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 15 parts by weight of saccharomyces boulardii, 10 parts by weight of bifidobacterium lactis, 5 parts by weight of lactobacillus rhamnosus, 20 parts by weight of sea buckthorn, 5 parts by weight of raspberry, 10 parts by weight of dendrobium officinale, 20 parts by weight of Chinese yam, 10 parts by weight of tricholoma matsutake and 30 parts by weight of omega-3 fatty acid.
Example 3
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 13 parts by weight of saccharomyces boulardii, 8 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 15 parts by weight of sea buckthorn, 3 parts by weight of raspberry, 8 parts by weight of dendrobium officinale, 15 parts by weight of Chinese yam, 8 parts by weight of tricholoma matsutake and 25 parts by weight of omega-3 fatty acid.
Example 4
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 10 parts by weight of saccharomyces boulardii, 5 parts by weight of bifidobacterium lactis, 1 part by weight of lactobacillus rhamnosus, 20 parts by weight of sea buckthorn, 5 parts by weight of raspberry, 10 parts by weight of dendrobium officinale, 20 parts by weight of Chinese yam, 10 parts by weight of tricholoma matsutake and 20 parts by weight of omega-3 fatty acid.
Example 5
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 10 parts by weight of saccharomyces boulardii, 5 parts by weight of bifidobacterium lactis, 1 part by weight of lactobacillus rhamnosus, 20 parts by weight of sea buckthorn, 5 parts by weight of raspberry, 10 parts by weight of dendrobium officinale, 20 parts by weight of Chinese yam, 10 parts by weight of tricholoma matsutake and 30 parts by weight of omega-3 fatty acid.
Example 6
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 15 parts by weight of saccharomyces boulardii, 10 parts by weight of bifidobacterium lactis, 5 parts by weight of lactobacillus rhamnosus, 10 parts by weight of sea buckthorn, 1 part by weight of raspberry, 5 parts by weight of dendrobium officinale, 10 parts by weight of Chinese yam, 5 parts by weight of tricholoma matsutake and 20 parts by weight of omega-3 fatty acid.
Example 7
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 10 parts by weight of saccharomyces boulardii, 5 parts by weight of bifidobacterium lactis, 1 part by weight of lactobacillus rhamnosus, 20 parts by weight of sea buckthorn, 5 parts by weight of raspberry, 10 parts by weight of dendrobium officinale, 20 parts by weight of Chinese yam, 10 parts by weight of tricholoma matsutake and 25 parts by weight of omega-3 fatty acid.
Example 8
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 12 parts by weight of saccharomyces boulardii, 8 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 12 parts by weight of sea buckthorn, 2 parts by weight of raspberry, 6 parts by weight of dendrobium officinale, 15 parts by weight of Chinese yam, 8 parts by weight of tricholoma matsutake and 22 parts by weight of omega-3 fatty acid.
Comparative example 1
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 8 parts by weight of saccharomyces boulardii, 3 parts by weight of bifidobacterium lactis, 1 part by weight of lactobacillus rhamnosus, 8 parts by weight of sea buckthorn, 1 part by weight of raspberry, 3 parts by weight of dendrobium officinale, 8 parts by weight of Chinese yam, 3 parts by weight of tricholoma matsutake and 15 parts by weight of omega-3 fatty acid.
Comparative example 2
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 13 parts by weight of saccharomyces boulardii, 8 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 5 parts by weight of sea buckthorn, 3 parts by weight of dendrobium officinale, 5 parts by weight of Chinese yam, 3 parts by weight of tricholoma matsutake and 25 parts by weight of omega-3 fatty acid.
Comparative example 3
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 13 parts by weight of saccharomyces boulardii, 8 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 25 parts by weight of sea buckthorn, 7 parts by weight of raspberry, 15 parts by weight of dendrobium officinale, 25 parts by weight of Chinese yam, 15 parts by weight of tricholoma matsutake and 25 parts by weight of omega-3 fatty acid.
Comparative example 4
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 13 parts by weight of saccharomyces boulardii, 8 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 25 parts by weight of sea buckthorn, 8 parts by weight of raspberry, 15 parts by weight of dendrobium officinale, 25 parts by weight of Chinese yam, 15 parts by weight of tricholoma matsutake and 18 parts by weight of omega-3 fatty acid.
Comparative example 5
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 13 parts by weight of saccharomyces boulardii, 13 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 25 parts by weight of sea buckthorn, 8 parts by weight of raspberry, 15 parts by weight of dendrobium officinale, 25 parts by weight of Chinese yam, 13 parts by weight of tricholoma matsutake and 32 parts by weight of omega-3 fatty acid.
Comparative example 6
A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 18 parts by weight of saccharomyces boulardii, 12 parts by weight of bifidobacterium lactis, 6 parts by weight of lactobacillus rhamnosus, 22 parts by weight of sea buckthorn, 6 parts by weight of raspberry, 12 parts by weight of dendrobium officinale, 25 parts by weight of Chinese yam, 13 parts by weight of tricholoma matsutake and 32 parts by weight of omega-3 fatty acid.
Clinical trial of efficacy
1. Sample preparation: weighing the raw materials according to the examples and the formula of the proportion to prepare the composite probiotics serving as the test sample.
2. Testing the population: 300 volunteers, aged 25-50 years, who had not taken the drugs related to the tested functions for a short period of time and had no allergy to the product used in the test were selected and randomly divided into 15 groups of 20 subjects.
3. The preparation method of the above test sample is as follows:
step 1: weighing saccharomyces boulardii, bifidobacterium lactis and lactobacillus rhamnosus according to the requirements of the dosage of the components, uniformly mixing, and packaging to obtain a bacterial powder bag;
step 2, weighing the traditional Chinese medicines according to the requirements of the component dosage, drying and dehydrating the traditional Chinese medicines to 5-10% by microwave, then carrying out superfine grinding to 300-400 meshes, and packaging the powder to be used as a traditional Chinese medicine bag;
and 3, putting the bacteria powder bag and the traditional Chinese medicine bag into the same package to form the composite probiotic test sample.
4. The eating method comprises the following steps:
the tested dose of the test medicines of 15 groups of subjects is the same, the fungus powder bag and the traditional Chinese medicine bag are mixed and directly taken orally or taken with warm water, 2 times a day are divided into morning and evening, 15 g is taken each time, and the administration is carried out continuously for 30 days. The results of the clinical trials are shown in the following table.
IgA(g/L) | IFN-γ(ng/mL) | Onset time (Tian) | Rate of improvement | |
Example 1 | 3.92±0.96 | 9.02±3.16 | 5-7 | 77% |
Example 2 | 4.56±0.90 | 8.61±3.01 | 3-5 | 82% |
Example 3 | 4.69±0.86 | 8.66±3.10 | 3-5 | 85% |
Example 4 | 4.60±0.69 | 8.76±2.96 | 4-6 | 80% |
Example 5 | 4.56±0.80 | 8.59±3.15 | 3-6 | 83% |
Example 6 | 4.76±0.79 | 8.60±3.06 | 3-5 | 86% |
Example 7 | 4.65±0.73 | 8.86±2.69 | 4-6 | 85% |
Example 8 | 4.98±0.62 | 8.20±2.86 | 2-3 | 90% |
Comparative example 1 | 1.92±0.77 | 19.02±3.06 | 11-15 | 40% |
Comparative example 2 | 2.56±0.95 | 20.80±3.08 | 10-13 | 46% |
Comparative example 3 | 2.36±0.80 | 20.26±2.99 | 11-13 | 50% |
Comparative example 4 | 2.69±0.65 | 20.56±2.96 | 12-14 | 45% |
Comparative example 5 | 2.87±0.65 | 19.86±2.86 | 10-13 | 49% |
Comparative example 6 | 2.90±0.65 | 19.36±2.55 | 11-13 | 51% |
Blank control group | 1.06±1.25 | 23.86±6.26 | Is free of | Is free of |
It is clear from the above table that the administration of the complex probiotics prepared according to the above examples and comparative examples has effects on the reduction of inflammatory cytokines and the improvement of immune function, compared to the blank group. Furthermore, by comparing the examples of the present invention with the comparative examples, it is further apparent that the intake of the complex probiotics prepared according to the examples of the present invention can significantly increase the IgA content in human body and at the same time can significantly reduce the IFN- γ content. In comparison, the effect of example 8 is the best, so it can be seen that the composite probiotics provided by the invention can obviously and effectively reduce the production of inflammatory cytokines and obviously improve the immune function of human body.
The foregoing is provided merely for the purpose of illustrating embodiments of the present invention and it is emphasized that variations and modifications of the present invention may be made by those skilled in the art without departing from the inventive concept thereof.
Claims (4)
1. A complex probiotic for reducing inflammatory cytokines and modulating immune function, comprising: 10-15 parts of saccharomyces boulardii, 5-10 parts of bifidobacterium lactis, 1-5 parts of lactobacillus rhamnosus, 10-20 parts of sea buckthorn, 1-5 parts of raspberry, 5-10 parts of dendrobium officinale, 10-20 parts of Chinese yam, 5-10 parts of tricholoma matsutake and 20-30 parts of omega-3 fatty acid.
2. The composite probiotic of claim 1, comprising: 12-13 parts of saccharomyces boulardii, 5-8 parts of bifidobacterium lactis, 1-3 parts of lactobacillus rhamnosus, 12-15 parts of sea buckthorn, 1-3 parts of raspberry, 6-8 parts of dendrobium officinale, 15-20 parts of Chinese yam, 8-10 parts of tricholoma matsutake and 22-25 parts of omega-3 fatty acid.
3. The composite probiotic of claim 2, comprising: 12 parts by weight of saccharomyces boulardii, 8 parts by weight of bifidobacterium lactis, 3 parts by weight of lactobacillus rhamnosus, 12 parts by weight of sea buckthorn, 2 parts by weight of raspberry, 6 parts by weight of dendrobium officinale, 15 parts by weight of Chinese yam, 8 parts by weight of tricholoma matsutake and 22 parts by weight of omega-3 fatty acid.
4. Use of composite probiotics according to any one of claims 1 to 3, characterized in that: the composite probiotics are used for reducing inflammatory cytokines and regulating immune functions.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011502396.1A CN112617206A (en) | 2020-12-18 | 2020-12-18 | Composite probiotics for reducing inflammatory cytokines and regulating immune function and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011502396.1A CN112617206A (en) | 2020-12-18 | 2020-12-18 | Composite probiotics for reducing inflammatory cytokines and regulating immune function and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112617206A true CN112617206A (en) | 2021-04-09 |
Family
ID=75317037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011502396.1A Pending CN112617206A (en) | 2020-12-18 | 2020-12-18 | Composite probiotics for reducing inflammatory cytokines and regulating immune function and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112617206A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2532062A1 (en) * | 2005-01-14 | 2006-07-14 | Nutrinor Cooperative Agro-Alimentaire Du Saguenay Lac St-Jean | Food composition for maintaining and restoring digestive functions |
CN108685006A (en) * | 2018-05-31 | 2018-10-23 | 杭州天龙健康产品有限公司 | A kind of 3 solid beverage of omega |
CN110604781A (en) * | 2019-09-23 | 2019-12-24 | 石家庄君乐宝乳业有限公司 | Lactobacillus paracasei N1115-containing bacterial powder capable of preventing and relieving diabetes, and preparation method and application thereof |
CN112056399A (en) * | 2020-06-28 | 2020-12-11 | 武汉康复得生物科技股份有限公司 | Probiotic composition for enhancing immunity and application thereof |
-
2020
- 2020-12-18 CN CN202011502396.1A patent/CN112617206A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2532062A1 (en) * | 2005-01-14 | 2006-07-14 | Nutrinor Cooperative Agro-Alimentaire Du Saguenay Lac St-Jean | Food composition for maintaining and restoring digestive functions |
CN108685006A (en) * | 2018-05-31 | 2018-10-23 | 杭州天龙健康产品有限公司 | A kind of 3 solid beverage of omega |
CN110604781A (en) * | 2019-09-23 | 2019-12-24 | 石家庄君乐宝乳业有限公司 | Lactobacillus paracasei N1115-containing bacterial powder capable of preventing and relieving diabetes, and preparation method and application thereof |
CN112056399A (en) * | 2020-06-28 | 2020-12-11 | 武汉康复得生物科技股份有限公司 | Probiotic composition for enhancing immunity and application thereof |
Non-Patent Citations (1)
Title |
---|
郑金辉: "《肿瘤免疫学研究进展》", vol. 1, 28 February 2018, pages: 280 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN110338402A (en) | A kind of compound probiotic powder and preparation method thereof | |
CN108991500A (en) | A kind of tumour patient full nutrition formula food | |
CN105029407A (en) | Medical formula food for inflammatory bowel disease | |
CN108968037A (en) | Senile dementia full nutrition formula food | |
CN109757733A (en) | A kind of oral polypeptide powder and its preparation method and application | |
KR20010072587A (en) | Dietary supplement derived from fermented milks for the prevention of osteoporosis | |
CN107373672A (en) | A kind of irregular menstruation women tailored version clinical nutrition formula and preparation method thereof | |
CN108936628A (en) | A kind of specific full nutritional formulas and preparation method thereof that patients with cerebral apoplexy is edible | |
CN106993788A (en) | All Pure Nature royal jelly lozenge and preparation method thereof | |
CN104839695A (en) | Inflammatory bowel disease non-total nutrient formula food | |
CN111543605A (en) | Comprehensive nutrition powder for people with hypertension, hyperlipidemia and obesity | |
CN110692884A (en) | Probiotic health-care beverage assisting in reducing hypertension, hyperglycemia and hyperlipidemia | |
CN107319550A (en) | Brain trauma full nutrition formula food | |
CN112385843A (en) | Balanced nutrition powder containing composite prebiotics and preparation method thereof | |
CN110326776A (en) | A kind of integration of drinking and medicinal herbs compound formulation of the raising immunity of suitable spacefarer | |
CN115777931A (en) | Dietary supplement for coordinating intestines and stomach and preparation method and application thereof | |
CN112617206A (en) | Composite probiotics for reducing inflammatory cytokines and regulating immune function and application thereof | |
CN109043554A (en) | A kind of Special food of high dietary-fiber and preparation method thereof | |
CN113812637A (en) | Nutritional supplement before and after operation and application | |
CN107712875A (en) | Black quinoa weight losing meal-replacing | |
CN109805235B (en) | Wheat-flavor composite polypeptide solid beverage for assisting in reducing hypertension, hyperglycemia and hyperlipidemia, and preparation method and application thereof | |
CN110050972B (en) | Aloe and hawthorn ball and preparation method thereof | |
Ayyadurai et al. | Beneficial role of fermented rice in healthy lifestyle | |
CN109043525A (en) | The specific full nutritional formulas and preparation method thereof that paralytic eats | |
CN109043521A (en) | The edible specific full nutritional formulas and preparation method thereof of inpatient with haematological diseases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Bai Li Inventor after: Bai Chunmei Inventor after: Wu Zhiyong Inventor after: Zhang Wendong Inventor after: Wei Dong Inventor before: Jiao Shunchang Inventor before: Zhang Wendong Inventor before: Wu Zhiyong Inventor before: Wei Dong |
|
CB03 | Change of inventor or designer information |