CN112604027A - Nutrient solution for comprehensively solving facial collapse - Google Patents

Nutrient solution for comprehensively solving facial collapse Download PDF

Info

Publication number
CN112604027A
CN112604027A CN202011531351.7A CN202011531351A CN112604027A CN 112604027 A CN112604027 A CN 112604027A CN 202011531351 A CN202011531351 A CN 202011531351A CN 112604027 A CN112604027 A CN 112604027A
Authority
CN
China
Prior art keywords
parts
nutrient solution
chinese medicine
traditional chinese
medicine extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011531351.7A
Other languages
Chinese (zh)
Inventor
王秀萍
陈怡如
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Jinsha Technology Co Ltd
Original Assignee
Beijing Jinsha Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Jinsha Technology Co Ltd filed Critical Beijing Jinsha Technology Co Ltd
Priority to CN202011531351.7A priority Critical patent/CN112604027A/en
Publication of CN112604027A publication Critical patent/CN112604027A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3637Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23Carbohydrates
    • A61L2300/232Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/34Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a nutrient solution for comprehensively solving facial collapse, which comprises the following raw materials in parts by weight: 12-18 parts of collagen, 3-8 parts of hyaluronic acid, 3-8 parts of oligopeptide, 1.6-2.4 parts of traditional Chinese medicine extract and 20-30 parts of normal saline; the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 8-12 parts of pseudo-ginseng and 8-12 parts of ganoderma sinensis. The invention has the beneficial effects that: the nutrient solution for comprehensively solving the facial collapse can ensure that the face is full, clear in lines and young, and the defects of fat particles and fat hyperplasia can be reduced; the nutrient solution solves the problem that non-absorbable injection has potential safety hazard, does not generate phenomena of allergy, rejection and the like, has natural effect and lasting effect, and has no risk and no wound in the using process and short recovery period because the nutrient solution adopts an injection mode.

Description

Nutrient solution for comprehensively solving facial collapse
Technical Field
The invention belongs to the technical field of medical cosmetology, and particularly relates to a nutrient solution for comprehensively solving facial collapse.
Background
The skin is a protective barrier of the human body, so that the human body is not damaged by external natural factors and environmental pollution, excessive water can be prevented from being lost from the body, when the skin is subjected to external stimulation or physical damage, the barrier is damaged, physical and chemical indexes of the skin are abnormal, such as dryness, dermatitis, skin darkness, color spots, abnormal keratinization and aging of cutin and the like, when the damage is further aggravated, the skin can generate inflammatory factors and a large number of free radicals, finally scars can be generated, the skin is sunken, and the attractiveness is influenced.
The hyaluronic acid filling agent is injected and filled on the face of a beauty-seeking person to improve the defect of facial depression, and is a very common non-operative medical beauty technique at present. However, the existing operation methods are insufficient in supplementary capacity, have large side effects, and consider less overall facial coordination and later-stage nursing of beauty requesters, so that the requirements of the beauty requesters cannot be met.
Disclosure of Invention
The invention aims to provide a nutrient solution for comprehensively solving the facial collapse.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a nutrient solution for comprehensively solving face collapse, which comprises the following raw materials in parts by weight: 12-18 parts of collagen, 3-8 parts of hyaluronic acid, 3-8 parts of oligopeptide, 1.6-2.4 parts of traditional Chinese medicine extract and 20-30 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 8-12 parts of pseudo-ginseng and 8-12 parts of ganoderma sinensis.
The nutrient solution for comprehensively solving the face collapse comprises the following raw materials in parts by weight as a preferred embodiment: 14-16 parts of collagen, 4-6 parts of hyaluronic acid, 4-6 parts of oligopeptide, 1.9-2.1 parts of traditional Chinese medicine extract and 22-28 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 9-11 parts of pseudo-ginseng and 9-11 parts of ganoderma sinensis.
The nutrient solution for comprehensively solving the face collapse comprises the following raw materials in parts by weight as a preferred embodiment: 15 parts of collagen, 5 parts of hyaluronic acid, 5 parts of oligopeptide, 2 parts of traditional Chinese medicine extract and 25 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 parts of pseudo-ginseng and 10 parts of ganoderma sinensis.
Collagen is a biological macromolecule, the main component of the connective tissue of animals, and is also the functional protein with the largest content and the widest distribution in mammals, accounting for 25% -30% of the total protein amount, and the collagen provides a stable and favorable support framework in the skin, thereby being capable of maintaining the plumpness and luster of the skin. Collagen is supported in the skin like a bracket and a spring, and once the spring is broken, the dermal tissue is collapsed, and wrinkles appear; skin can be flaccid and drooped; after the skin produces oil, the enlarged pores can not be retracted and restored due to the reduction of elasticity, and the pores become large, so that the effect of the collagen on the human body is different and small; the injected collagen can smooth the young lines, repair wrinkles, supplement the collagen, directly permeate into the dermis of the skin, reform the fibrous tissue mechanism of the skin, promote the metabolism of cells, delay the aging of the cells, stretch the fine wrinkles and recover the tightness and elasticity of the skin.
Hyaluronic acid generally refers to hyaluronic acid, is an acidic mucopolysaccharide, is a material which can be absorbed by a human body, has good effects of moisturizing skin, maintaining beauty, keeping young and the like, has the effects of removing wrinkles, enlarging lips and filling faces, can be quickly fused with hyaluronic acid of the hyaluronic acid after being injected into the human body through a pinhole, and is safe to use.
Oligopeptides are a class of polypeptides, generally having a molecular weight range of less than 1000 daltons, which are directly absorbed in the human body. Is the only cosmetic component which can obtain the Nobel prize definitely, and is praised as 'beauty factor' by the beauty profession! The infant skin care liquid is widely stored in human bodies or other animals, is small in amount, can smooth pores, stimulate skin activity, accelerate healing of damaged cells and remove acne marks, is rich in oligopeptide-1 in the skin of infants, gradually attenuates the content of the oligopeptide-1 in the skin along with the gradual increase of the skin, and accordingly, the skin is aged, and the youth degree of the skin is determined by the content of the oligopeptide-1. It can promote the synthesis of collagen and collagenase, secrete collagen substances, hyaluronic acid and glycoprotein, moisten skin, enhance skin elasticity, reduce skin wrinkles and prevent skin aging; can repair damaged cells, relieve damage of direct ultraviolet rays to skin, reduce growth of black spots on the skin after sunburn, eliminate gene mutation factors of the damaged cells, and prevent photoaging.
Notoginseng radix is sweet in flavor and warm in nature, and has effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain. The pseudo-ginseng also has the effect of beautifying, the pseudo-ginseng can promote the metabolism of the skin, provide sufficient nutrition for the skin and clear sediments in blood, and flavonoid compounds contained in the pseudo-ginseng have the characteristics of clearing free radicals and inhibiting lipid peroxidation, namely the pseudo-ginseng has a good effect of delaying senility.
The ganoderma sinensis has a long history as a medicine, has sweet smell and warm nature, and the ganoderma sinensis polysaccharide is one of the most important physiological active substances in the ganoderma sinensis extract, can improve the immunity of an organism, improve the oxygen resistance of the organism, eliminate free radicals and play a role in protecting cells and delaying cell aging. The ganoderma sinensis contains rich polypeptide factors, the polypeptide factors can promote skin regeneration, and nutrient components directly reach the bottom of the skin, so that the skin can enjoy the perfect effects of supplementing moisture and lifting and compacting, cell growth can be accelerated, the damaged stratum corneum can be reconstructed, energy can be given to the bottom of the skin, oxygen content is increased, and the skin can be repaired from inside to outside.
In a second aspect of the present application, there is provided a method for preparing a nutritional liquid for comprehensively solving facial collapse, comprising the steps of:
(1) preparing a traditional Chinese medicine extract;
(2) sterilizing the traditional Chinese medicine extract, and uniformly mixing the sterilized traditional Chinese medicine extract with the rest raw materials in the nutrient solution to obtain the nutrient solution for comprehensively solving the facial collapse.
As a preferred embodiment, the preparation method of the nutrient solution for comprehensively solving the facial collapse comprises the following steps: respectively freeze-drying Notoginseng radix and Ganoderma, respectively pulverizing into powder after drying to obtain Notoginseng radix lyophilized powder and Ganoderma lyophilized powder; mixing Notoginseng radix lyophilized powder and Ganoderma sinensis lyophilized powder uniformly to obtain mixed lyophilized powder, adding water into the mixed lyophilized powder, mixing and stirring uniformly, standing, filtering, and collecting filtrate to obtain lyophilized powder extract; performing ion exchange chromatography on the lyophilized powder extract, and collecting the effluent to obtain the Chinese medicinal extract.
The preparation method of the nutrient solution for comprehensively solving the facial collapse is a preferred embodiment, the freeze-drying temperature is-10 ℃ to 0 ℃, and the freeze-drying time at the temperature is 18-28 h.
The preparation method of the nutrient solution for comprehensively solving the face collapse is a preferred embodiment, water is added into the mixed freeze-dried powder to be mixed and stirred uniformly, standing is carried out, and ultrafiltration treatment is carried out
As a preferred embodiment, the weight ratio of the mixed freeze-dried powder to water is 1: 6-8.
In the above method for preparing a nutrient solution for comprehensively solving the facial collapse, as a preferred embodiment, in the step (2), the sterilization is ultrasonic sterilization.
As a preferable embodiment, the ultrasonic frequency of the ultrasonic sterilization is 15-30KHz, and the ultrasonic sterilization time is 10-50 min.
Compared with the prior art, the invention has the beneficial effects that:
the nutrient solution for comprehensively solving the facial collapse can ensure that the face is full, clear in lines and young, and the defects of fat particles and fat hyperplasia can be reduced; the nutrient solution solves the problem that non-absorbable injection has potential safety hazard, does not generate phenomena of allergy, rejection and the like, has natural effect and lasting effect, and has no risk and no wound in the using process and short recovery period because the nutrient solution adopts an injection mode.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
In the examples of the present invention, 1 part by weight represents 1 g.
Example 1
A nutrient solution for comprehensively solving face collapse comprises the following raw materials in parts by weight: 12 parts of collagen, 3 parts of hyaluronic acid, 3 parts of oligopeptide, 1.6 parts of traditional Chinese medicine extract and 20 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 8 parts of pseudo-ginseng and 8 parts of ganoderma sinensis.
The preparation method of the nutrient solution for comprehensively solving the facial collapse comprises the following steps:
(1) preparing a traditional Chinese medicine extract:
respectively freeze-drying Notoginseng radix and Ganoderma at 0 deg.C for 28 hr, and respectively pulverizing into powder to obtain Notoginseng radix lyophilized powder and Ganoderma sinensis lyophilized powder; uniformly mixing the pseudo-ginseng freeze-dried powder and the ganoderma sinensis freeze-dried powder to prepare mixed freeze-dried powder, adding water into the mixed freeze-dried powder, and uniformly mixing and stirring, wherein the weight ratio of the mixed freeze-dried powder to the water is 1: standing, performing ultrafiltration treatment, and collecting filtrate to obtain lyophilized powder extract; performing ion exchange chromatography on the lyophilized powder extract, and collecting eluate to obtain Chinese medicinal extract;
(2) and (3) carrying out ultrasonic sterilization on the traditional Chinese medicine extract, wherein the ultrasonic frequency of the ultrasonic sterilization is 15KHz, the ultrasonic sterilization time is 50min, and uniformly mixing the sterilized traditional Chinese medicine extract with the rest raw materials in the nutrient solution to obtain the nutrient solution for comprehensively solving the facial collapse.
Example 2
A nutrient solution for comprehensively solving face collapse comprises the following raw materials in parts by weight: 14 parts of collagen, 4 parts of hyaluronic acid, 4 parts of oligopeptide, 1.9 parts of traditional Chinese medicine extract and 22 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 9 parts of pseudo-ginseng and 9 parts of ganoderma sinensis.
The preparation method of the nutrient solution for comprehensively solving the facial collapse comprises the following steps:
(1) preparing a traditional Chinese medicine extract:
respectively freeze-drying Notoginseng radix and Ganoderma at-2 deg.C for 25 hr, and respectively pulverizing into powder to obtain Notoginseng radix lyophilized powder and Ganoderma lyophilized powder; uniformly mixing the pseudo-ginseng freeze-dried powder and the ganoderma sinensis freeze-dried powder to prepare mixed freeze-dried powder, adding water into the mixed freeze-dried powder, and uniformly mixing and stirring, wherein the weight ratio of the mixed freeze-dried powder to the water is 1: standing, performing ultrafiltration treatment, and collecting filtrate to obtain lyophilized powder extract; performing ion exchange chromatography on the lyophilized powder extract, and collecting eluate to obtain Chinese medicinal extract;
(2) and (3) carrying out ultrasonic sterilization on the traditional Chinese medicine extract, wherein the ultrasonic frequency of the ultrasonic sterilization is 18KHz, the ultrasonic sterilization time is 40min, and uniformly mixing the sterilized traditional Chinese medicine extract with the rest raw materials in the nutrient solution to obtain the nutrient solution for comprehensively solving the facial collapse.
Example 3
A nutrient solution for comprehensively solving face collapse comprises the following raw materials in parts by weight: 15 parts of collagen, 5 parts of hyaluronic acid, 5 parts of oligopeptide, 2 parts of traditional Chinese medicine extract and 25 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 parts of pseudo-ginseng and 10 parts of ganoderma sinensis.
The preparation method of the nutrient solution for comprehensively solving the facial collapse comprises the following steps:
(1) preparing a traditional Chinese medicine extract:
respectively freeze-drying Notoginseng radix and Ganoderma at-5 deg.C for 22 hr, and respectively pulverizing into powder to obtain Notoginseng radix lyophilized powder and Ganoderma lyophilized powder; uniformly mixing the pseudo-ginseng freeze-dried powder and the ganoderma sinensis freeze-dried powder to prepare mixed freeze-dried powder, adding water into the mixed freeze-dried powder, and uniformly mixing and stirring, wherein the weight ratio of the mixed freeze-dried powder to the water is 1: 7, standing, performing ultrafiltration treatment, and collecting filtrate to obtain a freeze-dried powder extracting solution; performing ion exchange chromatography on the lyophilized powder extract, and collecting eluate to obtain Chinese medicinal extract;
(2) and (3) carrying out ultrasonic sterilization on the traditional Chinese medicine extract, wherein the ultrasonic frequency of the ultrasonic sterilization is 22KHz, the ultrasonic sterilization time is 30min, and uniformly mixing the sterilized traditional Chinese medicine extract with the rest raw materials in the nutrient solution to obtain the nutrient solution for comprehensively solving the facial collapse.
Example 4
A nutrient solution for comprehensively solving face collapse comprises the following raw materials in parts by weight: 16 parts of collagen, 6 parts of hyaluronic acid, 6 parts of oligopeptide, 2.1 parts of traditional Chinese medicine extract and 28 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 11 parts of pseudo-ginseng and 11 parts of ganoderma sinensis.
The preparation method of the nutrient solution for comprehensively solving the facial collapse comprises the following steps:
(1) preparing a traditional Chinese medicine extract:
respectively freeze-drying Notoginseng radix and Ganoderma at-8 deg.C for 20 hr, and respectively pulverizing into powder to obtain Notoginseng radix lyophilized powder and Ganoderma lyophilized powder; uniformly mixing the pseudo-ginseng freeze-dried powder and the ganoderma sinensis freeze-dried powder to prepare mixed freeze-dried powder, adding water into the mixed freeze-dried powder, and uniformly mixing and stirring, wherein the weight ratio of the mixed freeze-dried powder to the water is 1: 7, standing, performing ultrafiltration treatment, and collecting filtrate to obtain a freeze-dried powder extracting solution; performing ion exchange chromatography on the lyophilized powder extract, and collecting eluate to obtain Chinese medicinal extract;
(2) and (3) carrying out ultrasonic sterilization on the traditional Chinese medicine extract, wherein the ultrasonic frequency of the ultrasonic sterilization is 28KHz, the ultrasonic sterilization time is 15min, and uniformly mixing the sterilized traditional Chinese medicine extract with the rest raw materials in the nutrient solution to obtain the nutrient solution for comprehensively solving the facial collapse.
Example 5
A nutrient solution for comprehensively solving face collapse comprises the following raw materials in parts by weight: 18 parts of collagen, 8 parts of hyaluronic acid, 8 parts of oligopeptide, 2.4 parts of traditional Chinese medicine extract and 30 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 12 parts of pseudo-ginseng and 12 parts of ganoderma sinensis.
The preparation method of the nutrient solution for comprehensively solving the facial collapse comprises the following steps:
(1) preparing a traditional Chinese medicine extract:
respectively freeze-drying Notoginseng radix and Ganoderma at-10 deg.C for 18 hr, and respectively pulverizing into powder to obtain Notoginseng radix lyophilized powder and Ganoderma lyophilized powder; uniformly mixing the pseudo-ginseng freeze-dried powder and the ganoderma sinensis freeze-dried powder to prepare mixed freeze-dried powder, adding water into the mixed freeze-dried powder, and uniformly mixing and stirring, wherein the weight ratio of the mixed freeze-dried powder to the water is 1: standing, performing ultrafiltration treatment, and collecting filtrate to obtain lyophilized powder extract; performing ion exchange chromatography on the lyophilized powder extract, and collecting eluate to obtain Chinese medicinal extract;
(2) and (3) carrying out ultrasonic sterilization on the traditional Chinese medicine extract, wherein the ultrasonic frequency of the ultrasonic sterilization is 30KHz, the ultrasonic sterilization time is 10min, and uniformly mixing the sterilized traditional Chinese medicine extract with the rest raw materials in the nutrient solution to obtain the nutrient solution for comprehensively solving the facial collapse.
The invention relates to the research on the efficacy of the nutrient solution for comprehensively solving the facial collapse
1. Experimental methods
30 women (age 25-45 years, mean age 35.67) were selected, and injection site: 10 cases of frontotemporal part, 6 cases of middle face, 5 cases of orbital area, 3 cases of cheek part and 6 cases of whole face;
VISIA skin tests skin spots, pores, wrinkles and texture characteristics before and 3 months after injection and was scored comprehensively for criteria: including mandibular border, nasolabial sulcus, frontal striation, fishtail striation, glabellar striation, adopt 0-3 to represent nothing, slight, obvious, serious 4 grades separately, every grade adds up and is the final score, total score 0-15, the score is higher to indicate the aging degree is more serious, the result is shown in table 1:
remarking:
form scoring criteria for nasolabial folds:
0 minute: when smiling, only slight nasolabial fold is seen;
1 minute: in static state, no obvious nasolabial fold and nasolabial ridge are seen, and in smile, obvious fold is seen;
and 2, dividing: in a static state, obvious nasolabial fold lines and nasolabial ridges can be seen, but the nasolabial ridges do not exceed the nasolabial ridges;
and 3, dividing: in static state, a deeper nasolabial fold is visible, extending anteriorly beyond the nasolabial fold.
Morphological scoring criteria of mandibular border:
0 is divided into: when sitting at the head and the lower head, the lower jaw edge has no wrinkles;
1 is divided into: when sitting up and looking flat, the lower jaw edge is clear, the skin has no wrinkles, and when the head is lowered, fine and shallow wrinkles appear;
2, dividing into: when sitting up and looking flat, the lower jaw edge is not obvious, the skin has fine and shallow wrinkles, and when the head is raised, the wrinkles disappear;
3, dividing into: when sitting flat, the lower jaw has obvious proud flesh, the skin wrinkles are thick and deep, and the wrinkles do not disappear when looking up.
Morphology scoring criteria for crow's feet:
0 is divided into: in smile, the skin is only raised at the outer canthus of the eye, and no obvious fishtail line is formed;
1 is divided into: in static state, no obvious eye wrinkles are seen, and in smile, fishtail lines are formed;
2, dividing into: when the skin is static, obvious fishtail lines can be seen, but no obvious wrinkles are formed, and the wrinkles can disappear by pulling the skin on two sides of the wrinkles;
3, dividing into: in static state, deeper fishtail lines can be seen, wrinkles are formed, and wrinkles on both sides of the pulled wrinkles cannot disappear.
Morphology scoring criteria for frontal lines:
0 is divided into: no forehead lines are seen in a static state, and only slight skin lines are deepened when the eyebrows are lifted;
1 is divided into: slight forehead wrinkles can be seen in a static state, and the eyebrows can be deepened when lifted, so that clear wrinkles can be formed;
2, dividing into: obvious frontal wrinkles can be seen in a static state, the eyebrow lifting becomes deeper, and the number of the wrinkles is more than that in the static state;
3, dividing into: deeper frontal wrinkles were visible in the static state, and after leveling with the hand, obvious depression marks were still visible.
Morphology scoring criteria for eyebrow striae:
0 is divided into: no eyebrow lines are seen in a static state, and only skin bulges appear when eyebrows are wrinkled;
1 is divided into: slight lines between eyebrows can be seen in a static state, and the lines between eyebrows are deepened when eyebrows are wrinkled, so that clear wrinkles are formed;
2, dividing into: the eyebrow lines are visible in a static state, eyebrow wrinkles become deeper, and eyebrow wrinkles extend to the periphery along the original eyebrows;
and 3, the deep glabellar lines can be seen in a static state, and obvious depression traces can still be seen after the glabellar lines are smoothed by hands.
TABLE 1 VISIA score before and after the nutrient solution of the present invention was injected
Speckle Pores of skin Wrinkle (wrinkle) Texture
Before injection 14.62±2.11 13.89±2.56 14.78±1.89 13.56±2.07
After injection 8.39±1.98 8.13±2.01 8.56±1.59 8.89±2.01
As can be seen from table 1: the nutrient solution for comprehensively solving the facial collapse can play a good filling effect by being injected.
The nutrient solution for comprehensively solving the facial collapse is safe to use, and has the advantages that all the patients with the injection follow-up visit lasts for 3-15 months, no obvious visual swelling is generated 10 days after the injection, the postoperative effect is obvious, the two sides are symmetrical, and none of the patients has complications such as hematoma, skin necrosis, infection, facial nerve injury, skin pigmentation or depigmentation.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims (10)

1. The nutrient solution for comprehensively solving the face collapse is characterized by comprising the following raw materials in parts by weight: 12-18 parts of collagen, 3-8 parts of hyaluronic acid, 3-8 parts of oligopeptide, 1.6-2.4 parts of traditional Chinese medicine extract and 20-30 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 8-12 parts of pseudo-ginseng and 8-12 parts of ganoderma sinensis.
2. The nutrient solution for comprehensively solving the face collapse according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 14-16 parts of collagen, 4-6 parts of hyaluronic acid, 4-6 parts of oligopeptide, 1.9-2.1 parts of traditional Chinese medicine extract and 22-28 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 9-11 parts of pseudo-ginseng and 9-11 parts of ganoderma sinensis.
3. The nutrient solution for comprehensively solving the face collapse according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15 parts of collagen, 5 parts of hyaluronic acid, 5 parts of oligopeptide, 2 parts of traditional Chinese medicine extract and 25 parts of normal saline;
the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 parts of pseudo-ginseng and 10 parts of ganoderma sinensis.
4. A method for preparing a nutritional liquid for comprehensively solving facial collapse as claimed in any one of claims 1 to 3, comprising the steps of:
(1) preparing a traditional Chinese medicine extract;
(2) sterilizing the traditional Chinese medicine extract, and uniformly mixing the sterilized traditional Chinese medicine extract with the rest raw materials in the nutrient solution to obtain the nutrient solution for comprehensively solving the facial collapse.
5. The preparation method of the nutrient solution for comprehensively solving the facial collapse as claimed in claim 4, wherein the preparation method of the traditional Chinese medicine extract comprises the following steps: respectively freeze-drying Notoginseng radix and Ganoderma, respectively pulverizing into powder after drying to obtain Notoginseng radix lyophilized powder and Ganoderma lyophilized powder; mixing Notoginseng radix lyophilized powder and Ganoderma sinensis lyophilized powder uniformly to obtain mixed lyophilized powder, adding water into the mixed lyophilized powder, mixing and stirring uniformly, standing, filtering, and collecting filtrate to obtain lyophilized powder extract; performing ion exchange chromatography on the lyophilized powder extract, and collecting the effluent to obtain the Chinese medicinal extract.
6. The method for preparing the nutrient solution for comprehensively solving the facial collapse as claimed in claim 5, wherein the temperature of freeze-drying is from-10 ℃ to 0 ℃, and the time of freeze-drying at the temperature is from 18 to 28 hours.
7. The method for preparing the nutrient solution for comprehensively solving the facial collapse as claimed in claim 5, wherein water is added into the mixed freeze-dried powder, the mixture is uniformly mixed and stirred, and the mixture is kept stand and subjected to ultrafiltration treatment.
8. The preparation method of the nutrient solution for comprehensively solving the facial collapse as claimed in claim 5, wherein the weight ratio of the mixed freeze-dried powder to water is 1: 6-8.
9. The method for preparing the nutrient solution for comprehensively solving the facial collapse as claimed in claim 4, wherein in the step (2), the sterilization is ultrasonic sterilization.
10. The method for preparing the nutrient solution for comprehensively solving the facial collapse as claimed in claim 9, wherein the ultrasonic frequency of the ultrasonic sterilization is 15-30KHz, and the ultrasonic sterilization time is 10-50 min.
CN202011531351.7A 2020-12-22 2020-12-22 Nutrient solution for comprehensively solving facial collapse Pending CN112604027A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011531351.7A CN112604027A (en) 2020-12-22 2020-12-22 Nutrient solution for comprehensively solving facial collapse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011531351.7A CN112604027A (en) 2020-12-22 2020-12-22 Nutrient solution for comprehensively solving facial collapse

Publications (1)

Publication Number Publication Date
CN112604027A true CN112604027A (en) 2021-04-06

Family

ID=75244123

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011531351.7A Pending CN112604027A (en) 2020-12-22 2020-12-22 Nutrient solution for comprehensively solving facial collapse

Country Status (1)

Country Link
CN (1) CN112604027A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114146219A (en) * 2021-12-29 2022-03-08 上海璞聚生物科技有限公司 Soft tissue filler and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140301958A1 (en) * 2011-04-21 2014-10-09 Krzysztof Bojanowski Transoral methods and compositions for wrinkle reduction and cosmetic lip and facial augmentation
CN108096145A (en) * 2018-01-09 2018-06-01 广州环亚化妆品科技有限公司 A kind of delay aging drug composition and its preparation method and application
CN109528642A (en) * 2018-12-27 2019-03-29 上海欧邦医疗管理有限公司 A kind of autogenous repairing nutrient injection and its application method
CN109528612A (en) * 2019-01-18 2019-03-29 广州市普高管理咨询有限公司 Crease-resistant tightening cosmetic composition, lotion and its preparation method and application
CN110279593A (en) * 2019-05-31 2019-09-27 上海欧邦医疗管理有限公司 A kind of compounding nutrient solution for comprehensive solution eye circumference aging
CN110801516A (en) * 2019-10-30 2020-02-18 通化力神保健品有限公司 Eye nutrient spray liquid and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140301958A1 (en) * 2011-04-21 2014-10-09 Krzysztof Bojanowski Transoral methods and compositions for wrinkle reduction and cosmetic lip and facial augmentation
CN108096145A (en) * 2018-01-09 2018-06-01 广州环亚化妆品科技有限公司 A kind of delay aging drug composition and its preparation method and application
CN109528642A (en) * 2018-12-27 2019-03-29 上海欧邦医疗管理有限公司 A kind of autogenous repairing nutrient injection and its application method
CN109528612A (en) * 2019-01-18 2019-03-29 广州市普高管理咨询有限公司 Crease-resistant tightening cosmetic composition, lotion and its preparation method and application
CN110279593A (en) * 2019-05-31 2019-09-27 上海欧邦医疗管理有限公司 A kind of compounding nutrient solution for comprehensive solution eye circumference aging
CN110801516A (en) * 2019-10-30 2020-02-18 通化力神保健品有限公司 Eye nutrient spray liquid and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
谢秀琼: "《现代中药制剂新技术》", 30 June 2004, 化学工业出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114146219A (en) * 2021-12-29 2022-03-08 上海璞聚生物科技有限公司 Soft tissue filler and preparation method thereof

Similar Documents

Publication Publication Date Title
CN107496309A (en) Antiallergic Face-protecting mask
CN109512691A (en) A kind of indigo plant copper peptide freeze-dried powder preparation and preparation method thereof
CN113786376B (en) Eye cream composition with eye pattern removing effect and preparation method thereof
CN110664650A (en) Multi-effect skin care composition and essence and preparation method thereof
CN109771348B (en) Whitening, moisturizing and wrinkle-removing face cream rich in natural product extract components and preparation method thereof
CN109044941B (en) Skin firming, nourishing and moisturizing composition and preparation method and application thereof
CN109431854A (en) A kind of bFGF acne hole maintenance freeze-dried powder preparation and preparation method thereof
CN106333880B (en) toner based on thin emulsion and preparation method thereof
CN106309260B (en) A kind of Radix Notoginseng is preserved youthful looks facial mask
CN106333909B (en) A kind of desalination red blood trace on face repairs the lotion and preparation method thereof of skin
CN105267123A (en) Whitening and hydrating toner and method for manufacturing same
CN113384482B (en) Moisturizing and skin-tendering essence and preparation method thereof
CN112891292B (en) A moisturizing facial cleanser containing natural plant effective components for removing speckle, caring skin, and nourishing skin, and its preparation method
KR102014979B1 (en) Mask pack with improved elasticity manufactured by using biodegradable polymer and loess, and the method for manufacturing the mask pack
CN112604027A (en) Nutrient solution for comprehensively solving facial collapse
CN110559226A (en) Whitening lotion and preparation method thereof
CN108653060A (en) One kind is dispelled pregnant line face cream
CN110859758A (en) Whitening anti-aging repair type medical cold compress patch and preparation method thereof
CN111759762A (en) Black eye removing composition, essence and preparation method thereof
CN110613643A (en) Repair wrinkle-removing cream and preparation method thereof
CN107441340B (en) Hand and foot chap cream for relieving swelling, pain and itching and nourishing skin and preparation method thereof
CN109157485A (en) A kind of santal white tea essence cream and preparation method thereof
CN114159341A (en) Freeze-dried eye patch and preparation method thereof
CN109646359B (en) Rose-agaric mud membrane paste with effects of cleaning, purifying, maintaining beauty and keeping young and preparation method thereof
CN112402319A (en) Nutrient solution for improving skin quality and preparation and use methods thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20210406

RJ01 Rejection of invention patent application after publication