CN112566942A - 用于制造抗体-药物缀合物的有效方法 - Google Patents

用于制造抗体-药物缀合物的有效方法 Download PDF

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CN112566942A
CN112566942A CN201980049551.8A CN201980049551A CN112566942A CN 112566942 A CN112566942 A CN 112566942A CN 201980049551 A CN201980049551 A CN 201980049551A CN 112566942 A CN112566942 A CN 112566942A
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antibody
production method
amino acid
buffer solution
acid sequence
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CN201980049551.8A
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山口达也
樱谷宪司
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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  • Chemical Kinetics & Catalysis (AREA)
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  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980049551.8A 2018-07-25 2019-07-24 用于制造抗体-药物缀合物的有效方法 Pending CN112566942A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-139633 2018-07-25
JP2018139633 2018-07-25
PCT/JP2019/028949 WO2020022363A1 (ja) 2018-07-25 2019-07-24 抗体－薬物コンジュゲートの効果的な製造方法

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CN112566942A true CN112566942A (zh) 2021-03-26

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US (1) US20210283269A1 (https=)
EP (1) EP3828206A4 (https=)
JP (2) JPWO2020022363A1 (https=)
KR (1) KR20210038904A (https=)
CN (1) CN112566942A (https=)
AU (1) AU2019311557A1 (https=)
BR (1) BR112021001194A2 (https=)
CA (1) CA3107417C (https=)
IL (1) IL280295B2 (https=)
SG (1) SG11202100653YA (https=)
TW (2) TWI847992B (https=)
WO (1) WO2020022363A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116135232A (zh) * 2021-11-17 2023-05-19 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途
WO2024041587A1 (zh) * 2022-08-25 2024-02-29 启德医药科技（苏州）有限公司 抗体偶联药物的药物组合物
WO2024109840A1 (zh) * 2022-11-22 2024-05-30 康诺亚生物医药科技（成都）有限公司 稠环类化合物及其偶联物和用途
WO2024222662A1 (zh) * 2023-04-23 2024-10-31 石药集团巨石生物制药有限公司 一种抗体偶联药物的用途
WO2024235274A1 (zh) * 2023-05-16 2024-11-21 石药集团巨石生物制药有限公司 一种抗体药物偶联物的药物组合物
TWI862982B (zh) * 2021-09-15 2024-11-21 日商第一三共股份有限公司 抗體–藥物結合物之用途
WO2025021118A1 (zh) * 2023-07-25 2025-01-30 海南先声再明医药股份有限公司 配体-药物偶联物及其偶联连接子
WO2025067306A1 (zh) * 2023-09-26 2025-04-03 信达生物制药(苏州)有限公司 靶向her3的抗体-药物偶联物

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018320470B2 (en) * 2017-08-23 2025-04-24 Daiichi Sankyo Company, Limited Antibody-drug conjugate preparation and lyophilization for same
CN115103858B (zh) * 2020-03-25 2025-07-15 江苏恒瑞医药股份有限公司 一种抗体药物偶联物的制备方法
IL299803A (en) * 2020-07-17 2023-03-01 Daiichi Sankyo Co Ltd Production method for antibody-drug conjugate
JP7848119B2 (ja) * 2020-07-20 2026-04-20 第一三共株式会社 抗ｈｅｒ２抗体－薬物コンジュゲートとｈｅｒ二量体化阻害剤の組み合わせ
JP2023545096A (ja) * 2020-10-09 2023-10-26 アストラゼネカ ユーケー リミテッド 抗体－薬物コンジュゲート及びｐａｒｐ１選択的阻害薬の組み合わせ
AU2021378152A1 (en) * 2020-11-11 2023-06-22 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY
CN116583526B (zh) * 2020-12-11 2025-09-26 微境生物医药科技(上海)有限公司 新型喜树碱衍生物、含其的组合物和其用途
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
TW202320858A (zh) 2021-07-19 2023-06-01 美商薩諾管理公司 免疫接合物及方法
KR20240099178A9 (ko) 2021-10-18 2025-12-10 다이이찌 산쿄 가부시키가이샤 항 cd37 항체-약물 콘주게이트
EP4514391A1 (en) * 2022-04-27 2025-03-05 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor
CN119255825A (zh) * 2022-05-24 2025-01-03 第一三共株式会社 抗-cdh6抗体-药物缀合物的剂量方案
EP4737483A1 (en) 2023-06-30 2026-05-06 Daiichi Sankyo Company, Limited Antibody-drug conjugate production method including purification step using activated carbon material
WO2025054996A1 (en) * 2023-09-15 2025-03-20 Duality Biologics (Suzhou) Co., Ltd. Antibody-drug conjugate
WO2025260285A1 (en) * 2024-06-19 2025-12-26 Duality Biologics (Suzhou) Co., Ltd. Antibody drug conjugate
WO2025262130A1 (en) * 2024-06-19 2025-12-26 BioNTech SE Antibody drug conjugate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104744560A (zh) * 2009-10-20 2015-07-01 Abbvie公司 使用蛋白a亲和色谱法分离和纯化抗-il-13抗体
CN105829346A (zh) * 2014-01-31 2016-08-03 第三共株式会社 抗her2抗体－药物偶联物
WO2018066626A1 (ja) * 2016-10-07 2018-04-12 第一三共株式会社 抗ｈｅｒ２抗体－薬物コンジュゲート投与による耐性癌の治療
CN107922477A (zh) * 2015-06-29 2018-04-17 第三共株式会社 用于选择性制造抗体‑药物缀合物的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
CN100340575C (zh) 1999-06-25 2007-10-03 杰南技术公司 人源化抗ErbB2抗体及其在制备药物中的应用
CA2953239A1 (en) 2000-10-06 2002-04-18 Kyowa Hakko Kirin Co., Ltd. Antibody composition-producing cell
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
JP4942643B2 (ja) 2004-03-02 2012-05-30 シアトル ジェネティックス， インコーポレイテッド 部分的に付加された抗体およびそれらの結合体化方法
ES2503719T3 (es) 2005-02-11 2014-10-07 Immunogen, Inc. Procedimiento para preparar conjugados de anticuerpos y de maitansinoides
CA3000520C (en) 2005-08-24 2023-04-04 Immunogen, Inc. Process for preparing antibody maytansinoid conjugates
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
JP4861019B2 (ja) * 2006-01-31 2012-01-25 独立行政法人科学技術振興機構 ヒトＴＮＦ−αに対する抗体酵素およびその利用
KR101598229B1 (ko) 2007-02-16 2016-02-26 메리맥 파마슈티컬즈, 인크. Ｅｒｂｂ3에 대한 항체 및 이의 용도
SG10201810743WA (en) 2009-06-03 2018-12-28 Immunogen Inc Conjugation methods
UY32914A (es) 2009-10-02 2011-04-29 Sanofi Aventis Anticuerpos que se usan específicamente al receptor epha2
MY171008A (en) 2011-03-29 2019-09-23 Immunogen Inc Preparation of maytansinoid antibody conjugates by a one-step process
ES2773710T3 (es) 2012-10-11 2020-07-14 Daiichi Sankyo Co Ltd Enlazadores para conjugados de anticuerpo - fármaco
DK2934582T3 (da) * 2012-12-21 2020-02-24 Ichnos Sciences SA Anti-her2-antistofformulering
AU2014371934B2 (en) 2013-12-25 2020-01-23 Daiichi Sankyo Company, Limited Anti-TROP2 antibody-drug conjugate
RU2680404C2 (ru) 2014-01-10 2019-02-21 Синтон Байофармасьютикалс Б. В. Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
KR102445502B1 (ko) 2014-04-10 2022-09-21 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
CN106999606B (zh) * 2015-02-17 2020-06-19 上海美雅珂生物技术有限责任公司 抗体药物偶联物
JP6679762B2 (ja) 2017-01-17 2020-04-15 第一三共株式会社 抗ｇｐｒ２０抗体及び抗ｇｐｒ２０抗体−薬物コンジュゲート
TW202532104A (zh) 2017-05-15 2025-08-16 日商第一三共股份有限公司 抗體－藥物結合物及其用途
IL324591A (en) 2017-08-31 2026-01-01 Daiichi Sankyo Co Ltd Improved antibody-drug conjugate production methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104744560A (zh) * 2009-10-20 2015-07-01 Abbvie公司 使用蛋白a亲和色谱法分离和纯化抗-il-13抗体
CN105829346A (zh) * 2014-01-31 2016-08-03 第三共株式会社 抗her2抗体－药物偶联物
CN107922477A (zh) * 2015-06-29 2018-04-17 第三共株式会社 用于选择性制造抗体‑药物缀合物的方法
WO2018066626A1 (ja) * 2016-10-07 2018-04-12 第一三共株式会社 抗ｈｅｒ２抗体－薬物コンジュゲート投与による耐性癌の治療

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALEX XENOPOULOSA等: "Selectivity improvements in highly charged UF membranes", DESALINATION, vol. 199, pages 2 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI862982B (zh) * 2021-09-15 2024-11-21 日商第一三共股份有限公司 抗體–藥物結合物之用途
CN116135232A (zh) * 2021-11-17 2023-05-19 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途
WO2023088382A1 (zh) * 2021-11-17 2023-05-25 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途
CN116135232B (zh) * 2021-11-17 2024-06-11 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途
WO2024041587A1 (zh) * 2022-08-25 2024-02-29 启德医药科技（苏州）有限公司 抗体偶联药物的药物组合物
WO2024109840A1 (zh) * 2022-11-22 2024-05-30 康诺亚生物医药科技（成都）有限公司 稠环类化合物及其偶联物和用途
WO2024222662A1 (zh) * 2023-04-23 2024-10-31 石药集团巨石生物制药有限公司 一种抗体偶联药物的用途
WO2024235274A1 (zh) * 2023-05-16 2024-11-21 石药集团巨石生物制药有限公司 一种抗体药物偶联物的药物组合物
WO2025021118A1 (zh) * 2023-07-25 2025-01-30 海南先声再明医药股份有限公司 配体-药物偶联物及其偶联连接子
WO2025067306A1 (zh) * 2023-09-26 2025-04-03 信达生物制药(苏州)有限公司 靶向her3的抗体-药物偶联物

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