KR20210038904A - 항체-약물 콘쥬게이트의 효과적인 제조 방법 - Google Patents

항체-약물 콘쥬게이트의 효과적인 제조 방법 Download PDF

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KR20210038904A
KR20210038904A KR1020217005281A KR20217005281A KR20210038904A KR 20210038904 A KR20210038904 A KR 20210038904A KR 1020217005281 A KR1020217005281 A KR 1020217005281A KR 20217005281 A KR20217005281 A KR 20217005281A KR 20210038904 A KR20210038904 A KR 20210038904A
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antibody
drug conjugate
producing
amino acid
buffer solution
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Korean (ko)
Inventor
다츠야 야마구치
겐지 사쿠라타니
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다이이찌 산쿄 가부시키가이샤
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217005281A 2018-07-25 2019-07-24 항체-약물 콘쥬게이트의 효과적인 제조 방법 Ceased KR20210038904A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2018-139633 2018-07-25
JP2018139633 2018-07-25
PCT/JP2019/028949 WO2020022363A1 (ja) 2018-07-25 2019-07-24 抗体－薬物コンジュゲートの効果的な製造方法

Publications (1)

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KR20210038904A true KR20210038904A (ko) 2021-04-08

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KR1020217005281A Ceased KR20210038904A (ko) 2018-07-25 2019-07-24 항체-약물 콘쥬게이트의 효과적인 제조 방법

Country Status (12)

Country Link
US (1) US20210283269A1 (https=)
EP (1) EP3828206A4 (https=)
JP (2) JPWO2020022363A1 (https=)
KR (1) KR20210038904A (https=)
CN (1) CN112566942A (https=)
AU (1) AU2019311557A1 (https=)
BR (1) BR112021001194A2 (https=)
CA (1) CA3107417C (https=)
IL (1) IL280295B2 (https=)
SG (1) SG11202100653YA (https=)
TW (2) TWI847992B (https=)
WO (1) WO2020022363A1 (https=)

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AU2018320470B2 (en) * 2017-08-23 2025-04-24 Daiichi Sankyo Company, Limited Antibody-drug conjugate preparation and lyophilization for same
CN115103858B (zh) * 2020-03-25 2025-07-15 江苏恒瑞医药股份有限公司 一种抗体药物偶联物的制备方法
IL299803A (en) * 2020-07-17 2023-03-01 Daiichi Sankyo Co Ltd Production method for antibody-drug conjugate
JP7848119B2 (ja) * 2020-07-20 2026-04-20 第一三共株式会社 抗ｈｅｒ２抗体－薬物コンジュゲートとｈｅｒ二量体化阻害剤の組み合わせ
JP2023545096A (ja) * 2020-10-09 2023-10-26 アストラゼネカ ユーケー リミテッド 抗体－薬物コンジュゲート及びｐａｒｐ１選択的阻害薬の組み合わせ
AU2021378152A1 (en) * 2020-11-11 2023-06-22 Daiichi Sankyo Company, Limited COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY
CN116583526B (zh) * 2020-12-11 2025-09-26 微境生物医药科技(上海)有限公司 新型喜树碱衍生物、含其的组合物和其用途
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods
TW202320858A (zh) 2021-07-19 2023-06-01 美商薩諾管理公司 免疫接合物及方法
MX2024003277A (es) * 2021-09-15 2024-04-04 Daiichi Sankyo Co Ltd Conjugado de anticuerpo-farmaco para usarse en metodos de tratamiento del cancer resistente a la quimioterapia.
KR20240099178A9 (ko) 2021-10-18 2025-12-10 다이이찌 산쿄 가부시키가이샤 항 cd37 항체-약물 콘주게이트
AU2022389555A1 (en) * 2021-11-17 2024-07-04 CSPC Megalith Biopharmaceutical Co., Ltd. Antibody-drug conjugate and use thereof
EP4514391A1 (en) * 2022-04-27 2025-03-05 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor
CN119255825A (zh) * 2022-05-24 2025-01-03 第一三共株式会社 抗-cdh6抗体-药物缀合物的剂量方案
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