CN112535800B - 长效制剂注射器的增强型探针 - Google Patents

长效制剂注射器的增强型探针 Download PDF

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CN112535800B
CN112535800B CN202011023613.9A CN202011023613A CN112535800B CN 112535800 B CN112535800 B CN 112535800B CN 202011023613 A CN202011023613 A CN 202011023613A CN 112535800 B CN112535800 B CN 112535800B
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B·D·科克
L·M·斯尼德
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Abstract

提供了一种药丸输送系统，其包括具有限定通路的内表面的针、更具体的是长效制剂注射器的增强型探针。针具有沿着纵向轴线延伸的第一部分和包括与通路连通的开口的弯曲的第二部分。第二部分横向于纵向轴线延伸。药丸定位在通路中。柱塞可滑动地定位在通路中。柱塞包括具有圆形尖端的轴，所述轴被构造成将药丸推过第一和第二部分并且推出开口而药丸不会卡在通路或开口内。公开了植入物、系统、构造、器械和方法。

Description

长效制剂注射器的增强型探针
本发明专利申请是国际申请号为PCT/US2016/061589，国际申请日为2016年11月11日，进入中国国家阶段的申请号为201680067200.6，名称为“长效制剂注射器的增强型探针”的发明专利申请的分案申请。
技术领域
本发明总体上涉及用于输送长效制剂的医疗装置，并且更具体地涉及一种用于药丸注射器的增强型探针。
背景技术
药物可以通过各种方法输送给患者，包括口服、静脉注射、肌肉注射、吸入、局部或皮下输送。药物可以直接或局部输送到治疗部位(例如，鞘内、脊柱内、关节内等)。选择的输送方法尤其取决于待治疗的病症，以及患者体内需要达到的药物治疗浓度以及必须维持的药物浓度持续时间等。
已经开发了药物药丸，诸如例如长效制剂，其允许将药物引入或施用到患者皮肤下的部位。长效制剂在一段时间内释放药物。长效制剂允许药物在数周、数月甚至数年内以相对均匀的剂量从制剂中释放。使用长效制剂管理药物在治疗包括类风湿性关节炎、骨关节炎、坐骨神经痛、腕管综合征、腰背痛、下肢疼痛、上肢疼痛、癌症、组织疼痛以及与颈椎、胸椎和/或腰椎或椎间盘、肩袖、关节、TMJ、肌腱、韧带、肌肉等的损伤或修复相关的疼痛等慢性病症中调整免疫、炎症和/或疼痛反应时变得尤其重要且普遍。
长效制剂通常通过使用包括套管或针以及将长效制剂推过套管或针的探针或柱塞的两件式装置插入患者皮肤下方的治疗部位。该装置需要使用单独的器械(例如，解剖刀)通过皮肤形成切口。套管或针可以通过切口插入。长效制剂通过套管或针插入，并且使用探针或柱塞将植入物推到套管或针的末端。然后套管或针和探针或柱塞被完全取出，将长效制剂留在植入部位。
套管或针通常是具有弯曲尖端的硬膜外Tuohy针，并且使用包括扁平尖端的探针或柱塞将长效制剂推过套管或针。然而，探针或柱塞的扁平尖端限制了尖端可以进入Tuohy针的弯曲尖端的量，从而防止探针或柱塞到达Tuohy针的弯曲端处的开口。这可能会导致一个或多个长效制剂卡在Tuohy针的弯曲端，因为探针或柱塞无法将长效制剂一直推过Tuohy针。本发明描述了对这些现有技术的改进。
发明内容
在一个实施例中，提供了一种长效制剂输送系统。输送系统包括具有限定通路的内表面的针。针包括沿着纵向轴线延伸的第一部分和包括与通路连通的开口的弯曲的第二部分。第二部分横向于纵向轴线延伸。长效制剂可以是定位在通路中的药丸。柱塞可滑动地定位在通路中。柱塞包括具有圆形尖端的轴，该轴被构造成将长效制剂推过第一和第二部分并且推出开口而长效制剂不会卡在通路或开口内。在一些实施例中，公开了系统、植入物、构造、器械和方法。
在一个实施例中，提供了一种输送长效制剂的方法。该方法包括形成切口并且通过切口插入长效制剂输送系统的针以形成通向目标部位的路径。针包括限定通路的内表面，沿着纵向轴线延伸的第一部分和包括与通路连通的开口的弯曲的第二部分。第二部分横向于纵向轴线延伸。该方法还包括将长效制剂放置在通路中并且在通路中移动输送系统的柱塞，使得柱塞的圆形尖端将长效制剂推过第一和第二部分，推出开口并邻近于目标部位进入患者体内。柱塞的圆形尖端还用于在输送第一长效制剂之后将长效制剂推出开口，而随后的长效制剂不会卡住。
附图说明
从附有以下附图的具体描述中，本发明将变得更加显而易见，其中：
图1是根据本发明的原理的长效制剂输送系统的横截面图；以及
图2是现有技术系统的横截面图。
具体实施方式
根据用于将长效制剂诸如例如药丸输送到患者解剖结构内的目标部位的医疗装置来讨论所公开的长效制剂输送系统和相关使用方法的示例性实施例。在一些实施例中，药丸输送系统包括用于储存药丸的注射器组件。在一些实施例中，长效制剂输送系统包括硬膜外Tuohy针以创建通向硬膜外腔的路径。在另一个实施例中，长效制剂输送系统包括输送柱塞以将长效制剂诸如药丸输送通过系统。在一些实施例中，药丸长度为4mm并且直径为0.75mm，并且需要坚固的输送柱塞探针以将它们推过注射器组件。在一些实施例中，硬膜外Tuohy针具有弯曲的尖端，其将不允许探针尖端到达Tuohy套管的开口。这可能会导致长效制剂保留在套管内而不是输送给患者，特别是当输送多于一个长效制剂时。为了确保从输送柱塞完全展开，探针具有增强型“弹头”特征。该特征通过在尖端的边缘安装倒角或半径并延伸弯曲部阻碍探针沿着轴进一步向下的点来延长探针插入深度。也就是说，探针尖端处的细长倒角或半径形成弹状形状，以允许探针沿着硬膜外Tuohy针套管的弯曲尖端进一步向下行进，从而降低长效制剂诸如药丸在展开期间保留在套管内的风险。
在一些实施例中，本发明可用于治疗脊柱疾病，诸如例如退行性椎间盘疾病、椎间盘突出、骨质疏松症、脊椎滑脱症、椎管狭窄、脊柱侧凸和其它弯曲畸形、脊柱后凸、肿瘤和骨折。在一些实施例中，本发明可以与其它与骨骼和骨相关的应用一起使用，包括与诊断和治疗相关的应用。在一些实施例中，所公开的脊柱植入物系统可以替代地用于患者处于俯卧或仰卧位置的外科手术治疗中，和/或采用各种外科手术入路进入脊柱，包括前、后、后中线、外侧、后外侧和/或前外侧入路，以及其它身体区域。本发明还可以替代地与用于治疗脊柱的腰部、颈部、胸部、骶骨和骨盆区域的手术一起使用。本发明的药丸输送系统还可以用于动物、骨骼模型和其它非生物基质，诸如例如在训练、测试和示范中。
通过结合附图参考形成本发明的一部分的实施例的以下详细描述，可以更容易地理解本发明。应当理解的是，本申请不限于本文描述和/或示出的具体装置、方法、条件或参数，并且本文所使用的术语仅用于举例描述特定实施例的目的，而并不旨在限制。在一些实施例中，如在说明书并包括所附权利要求书中所使用的，单数形式“一”、“一个”和“该”包括复数，并且对特定数值的引用包括至少该特定值，除非上下文另外清楚地指出。例如，对“长效制剂”的引用是指一个或多个长效制剂。范围在本文中可以表示为从“约”或“近似”一个特定值和/或到“约”或“近似”另一个特定值。当表示这样的范围时，另一实施例包括从一个特定值和/或到另一个特定值。类似地，当数值被表示为近似值时，通过使用先行词“约”，将理解的是，该特定值形成另一实施例。还应理解的是，诸如例如水平、垂直、顶部、上部、下部、底部、左和右之类的所有空间引用仅用于说明的目的，并且可以在本发明的范围内变化。例如，引用“上部”和“下部”是相对的，并且仅在上下文中相对于另一个使用，而不一定是“上”和“下”。
如在说明书并包括所附权利要求中所使用的，疾病或病症的“治疗”或“治疗法”是指执行以下过程，其可包括将一种或多种药物施用于患者(人、正常或相反或其它哺乳动物)，使用可植入装置，和/或使用治疗疾病的仪器，诸如例如用于除去椎间盘膨出部分或椎间盘突出和/或骨刺的微型椎间盘切除仪器，以努力缓解疾病或病症的征兆或体征。可以在出现疾病或病症的征兆或体征之前以及出现之后进行缓解。因此，治疗或治疗法包括预防或防止疾病或不良病症(例如，预防可能易患疾病但尚未诊断出患有疾病的患者发生疾病)。另外，治疗或治疗法不需要完全缓解征兆或体征，不需要治愈，并且具体包括对患者仅有边缘效应的手术。治疗可包括抑制疾病，例如阻止其发展，或缓解疾病，例如使疾病消退。例如，治疗可以包括减轻急性或慢性炎症；缓解疼痛并缓解和催生新韧带、骨和其它组织的再生长；作为手术的辅助手段；和/或任何修复手术。而且，如在说明书中并包括所附权利要求中所使用，术语“组织”包括软组织、韧带、肌腱、软骨和/或骨，除非另外特别指出。
以下讨论包括根据本发明的原理的长效制剂输送系统、相关部件以及使用输送系统的方法的描述。还公开了替代实施例。详细参考在附图中示出的本发明的示例性实施例。转到图1，示出了长效制剂输送系统10的部件。
长效制剂输送系统10的部件可以由适用于医疗应用的生物可接受的材料制成，所述材料包括金属、合成聚合物、陶瓷和骨材料和/或它们的复合物。例如，长效制剂输送系统10的部件可单独地或共同地由以下材料制成，诸如不锈钢合金、商业纯钛、钛合金、5级钛、超弹性钛合金、钴铬合金、不锈钢合金、超弹性金属合金(例如镍钛诺、超弹塑性金属，诸如GUM )，陶瓷及其复合物，诸如磷酸钙(例如，SKELITETM)，热塑性材料，诸如聚芳基醚酮(PAEK)，包括聚醚醚酮(PEEK)、聚醚醚酮(PEKK)和聚醚酮(PEK)、碳-PEEK复合物、PEEK-BaSO4聚合物橡胶、聚对苯二甲酸乙二醇酯(PET)，织物、硅酮、聚氨酯、硅酮-聚氨酯共聚物、聚合物橡胶、聚烯烃橡胶、水凝胶、半刚性和刚性材料、弹性体、橡胶、热塑性弹性体、热固性弹性体、弹性体复合物、刚性聚合物，包括聚苯撑、聚酰胺、聚酰亚胺、聚醚酰亚胺、聚乙烯、环氧树脂，骨材料，包括自体移植物、同种异体移植物、异种移植物或转基因皮层和/或皮质骨，以及组织生长或分化因子，部分可吸收的材料，诸如例如金属和钙基陶瓷的复合物、PEEK和钙基陶瓷的复合物、PEEK和可再吸收聚合物的复合物，完全可再吸收的材料，诸如例如钙基陶瓷，诸如磷酸钙、三钙磷酸盐(TCP)、羟基磷灰石(HA)-TCP、硫酸钙，或其它可再吸收的聚合物，诸如polyaetide、聚乙醇酸交酯、聚酪氨酸碳酸盐、聚乙酸内酯及其组合。
长效制剂输送系统10的各种部件可以具有包括上述材料的材料复合物以实现各种期望的特性，诸如强度、刚性、弹性、顺应性、生物力学性能、耐久性和射线可透性或成像偏好。长效制剂输送系统10的部件还可以单独地或共同地由非均质材料制成，诸如两种或更多种上述材料的组合。如本文所述，长效制剂输送系统10的部件可以单片式形成，整体连接或包括紧固元件和/或器械。
在一些实施例中，长效制剂输送系统10包括套管或针，诸如例如硬膜外Tuohy针12。针12被构造成在患者体内形成通向患者解剖结构内的目标区域的通路，诸如例如，患者的硬膜外腔。针12包括限定通路16的内表面。针12包括平行于纵向轴线L延伸的第一部分12A和包括与通路16连通的开口18的弯曲的第二部分12B。第二部分12B横向于纵向轴线L。
在一些实施例中，第二部分12B连续弯曲。在一些实施例中，通路16沿其整个长度具有均匀的直径。在一些实施例中，通路16可具有各种横截面构型，诸如例如椭圆形、长方形、三角形、矩形、正方形、多边形、不规则的、均匀的、不均匀的、可变的、管状的和/或锥形。在一些实施例中，第一部分12A和/或第二部分12B可以相对于纵向轴线L以交替取向布置，诸如例如横向、垂直和/或其它角度取向，诸如例如锐角或钝角，同轴和/或可以偏移或交错。在一些实施例中，针10包括刚性材料，使得针10不会弯曲而不会断裂。在一些实施例中，针10包括柔性材料，使得针10可以弯曲而不会断裂。
针12被构造成用于将长效制剂诸如例如药丸20设置在通路60中，使得药丸20可被推过通路16并且推出开口18以输送到患者解剖结构内的目标部位。也就是说，药丸20被构造成可移动地设置在通路60中。在一些实施例中，长效制剂可包括一个或多个药丸20。药丸20可以固体药物形式存在。当使用一个或多个药丸时，药丸可以包括多于一种的药物。药丸20包括至少一种药物。在一个实施例中，药丸20包括有效治疗量的可乐定和生物可降解聚合物。然而，可以设想的是，所使用的长效制剂可以包括任何药物或药物组合以及任何聚合物或聚合物组合，诸如例如至少一种生物可降解和/或生物可吸收聚合物。在一些实施例中，长效制剂可以是不同形状的，诸如例如圆柱形、椭圆形、长方形、三角形、正方形、多边形、不规则的、均匀的、不均匀的、偏移的、交错的、波浪形、弓形、可变的和/或锥形。在一些实施例中，药丸20的长度约为4mm并且直径约为0.75mm。在一些实施例中，药丸20具有仅略小于通路16的最大直径的最大直径(例如，比通路16的最大直径小约0.01”到约0.1”)，使得当药丸20移动穿过通路16时，药丸20的外表面接触内表面14。在一些实施例中，药丸20具有小于通路16的最大直径的最大直径，比通路16的最大直径小约0.2”到约0.5”，使得当药丸20移动穿过通路16时，药丸20的外表面与内表面14间隔开。
诸如例如柱塞22的探针可滑动地定位在通路16中并且包括轴24，该轴在轴24的远端具有尖端26。在一些实施例中，柱塞22可从通路16移除。尖端26被构造成将长效制剂20推过第一和第二部分12A、12B并且推出开口18，而长效制剂20不会卡在通路16或开口18内。在一些实施例中，尖端26是圆形的。尖端26包括限定尖端26的弹头特征的细长倒角或半径。在一些实施例中，尖端26是半球形的并且没有任何平坦表面。如图1中所示，倒角相对于纵向轴线L以角度α延伸。在一些实施例中，角度α在约10°与约45°之间以及其中的所有组合和子组合。在一些实施例中，角度α约为35°。
尖端26相对于轴24固定，使得尖端26不能相对于轴24移动。在一些实施例中，尖端26与轴24单片地和/或一体地形成。在一些实施例中，柱塞22包括刚性材料，使得柱塞22无法弯曲而不会断裂。在一些实施例中，尖端26包括与轴24相同的材料。在一些实施例中，尖端26具有小于轴24的最大直径的最大直径。在一些实施例中，通路16具有大于轴24的外径的内径，使得轴24的外表面可滑动地接合内表面14。在一些实施例中，轴24具有仅略小于通路16的最大直径的最大直径(例如，比通路16的最大直径小约0.01”到约0.1”)，使得当轴24移动穿过通路16时，轴24的外表面接触内表面14。在一些实施例中，轴24具有小于通路16的最大直径的最大直径，比通路16的最大直径小约0.2”到约0.5”，使得当轴24移动穿过通路16时，轴24的外表面与内表面14间隔开。
与包括平坦端表面的现有技术尖端相比，尖端26的弹头特征允许尖端26移动到通路16的第二部分12B中达更大的距离。例如，如图1中所示，尖端26的弹头特征允许尖端26移动到通路16的第二部分12B中达距离d1，其允许尖端26移动到通路16的第二部分12B中足够远以将药丸20推出开口18而药丸20不会堵塞在通路16内。如图2中所示，现有技术柱塞具有尖端，该尖端包括平坦端表面，该平坦端表面仅允许尖端移动到通路16的第二部分12B中达距离d2，该距离小于距离d1，并且不允许尖端26移动到通路16的第二部分12B中足够远以将药丸20推出开口18而药丸20和随后的药丸不会堵塞在通路16内。也就是说，与尖端26相比，当使用现有技术的尖端时，增加了药丸20和随后的药丸堵塞在通道16内的可能性。
在操作和使用中，针12被用于在患者解剖结构内的目标区域中创建路径，诸如例如，患者的硬膜外腔。将针12推进穿过该路径，直到开口18定位在目标区域中或邻近于目标区域。一个或多个长效制剂诸如例如药丸20被装载到通路16中。轴24可滑动地定位在通路16内，使得尖端26接触药丸20中的一个。轴24在由图1中的箭头A所示的方向上推进穿过通路16，使得至少一个药丸20通过开口18离开通路16以将至少一个药丸20输送到目标部位而不堵塞在通路16内。在一些实施例中，多于一个药丸20将一个接一个地处于通路16内并且轴24将被推进，使得第二药丸20将离开通路20而不会卡在通路内或在第一药丸20后面，第一药丸20已被成功地排出。轴24可以从通路16中抽出。然后针12可以从路径中抽出。
将理解的是，可以对本文公开的实施例进行各种修改和/或组合。因此，以上描述不应该被解释为限制，而仅仅是作为各种实施例的示例。本领域技术人员将设想处于所附权利要求的范围和精神内的其它修改。

Claims (38)

1.一种长效制剂递送系统，所述长效制剂递送系统包括：
硬膜外针，所述针构造成生成通往硬膜外空间的路径，所述针包括限定出通路的内表面，所述针还包括沿着纵向轴线延伸的平直的第一部分和弯曲的第二部分，所述第二部分包括与所述通路连通的开口，所述第二部分横向于所述纵向轴线延伸；
长效制剂，所述长效制剂位于所述通路中；以及
刚性柱塞，所述柱塞可滑动地定位在所述通路中，并包括具有圆形尖端的轴，所述轴被构造成将所述长效制剂推过所述第一部分和所述第二部分并推出所述开口而所述长效制剂不会卡在所述通路或所述开口中，其中所述尖端具有细长倒角或弯曲半径，所述细长倒角或弯曲半径形成弹头形状的所述尖端；
其中，所述尖端具有弹头特征部，所述弹头特征部允许所述尖端运动到所述通路的所述第二部分中与标准平头探针的尖端相比更远的距离。
2.根据权利要求1所述的长效制剂递送系统，其中所述通路所具有的内径大于所述轴的外径，从而所述轴的外表面可滑动地配合于所述针的所述内表面。
3.根据权利要求1所述的长效制剂递送系统，其中所述尖端的相对于所述针的所述纵向轴线的倒角角度为10°到45°。
4.根据权利要求3所述的长效制剂递送系统，其中所述尖端的相对于所述针的所述纵向轴线的倒角角度为35°。
5.根据权利要求1所述的长效制剂递送系统，其中所述长效制剂是药丸。
6.根据权利要求5所述的长效制剂递送系统，其中所述药丸长度为约4mm且直径为约0.75mm。
7.根据权利要求1所述的长效制剂递送系统，其中所述长效制剂包括多于一个的药丸。
8.根据权利要求1-7中任意一项所述的长效制剂递送系统，其中所述长效制剂包括药物和生物可降解和/或生物可吸收聚合物的组合。
9.根据权利要求1-7中任意一项所述的长效制剂递送系统，其中所述长效制剂包括有效治疗量的可乐定和生物可降解聚合物。
10.根据权利要求1-7中任意一项所述的长效制剂递送系统，其中所述长效制剂包括多于一种的药物。
11.根据权利要求1-7中任意一项所述的长效制剂递送系统，其中所述尖端所具有的最大直径小于所述轴的直径。
12.根据权利要求1-7中任意一项所述的长效制剂递送系统，其中所述针是硬膜外Tuohy针。
13.根据权利要求1-7中任意一项所述的长效制剂递送系统，其中所述长效制剂所具有的最大直径比所述通路的最大直径小0.2英寸(约5mm)和0.5英寸(约13mm)之间。
14.根据权利要求1-7中任意一项所述的长效制剂递送系统，其中所述长效制剂所具有的最大直径比所述通路的最大直径小0.01英寸(约0.25mm)和0.1英寸(约2.5mm)之间。
15.一种长效制剂递送系统，所述系统包括：
柱塞，所述柱塞能够可滑动地位于由硬膜外Tuohy针的内表面所限定的通路中，所述针构造成生成通往硬膜外空间的路径，所述针包括沿着纵向轴线延伸的平直的第一部分和弯曲的第二部分，所述第二部分包括与所述通路连通的开口；
所述柱塞包括具有圆形尖端的轴，所述轴被构造成将所述长效制剂推过所述通路的所述第一部分和所述第二部分并推出所述开口而所述长效制剂不会卡在所述通路或所述开口中，其中所述尖端具有细长倒角或弯曲半径，所述细长倒角或弯曲半径形成弹头形状的所述尖端；
其中，所述尖端具有弹头特征部，所述弹头特征部允许所述尖端运动到所述通路的所述第二部分中与标准平头探针的尖端相比更远的距离。
16.根据权利要求15所述的长效制剂递送系统，其中所述尖端的相对于所述针的所述纵向轴线的倒角角度为10°到45°。
17.根据权利要求16所述的长效制剂递送系统，其中所述尖端的相对于所述针的所述纵向轴线的倒角角度为35°。
18.根据权利要求15所述的长效制剂递送系统，其中所述尖端所具有的最大直径小于所述轴的直径。
19.根据权利要求15所述的长效制剂递送系统，其中所述长效制剂是药丸。
20.根据权利要求19所述的长效制剂递送系统，其中所述药丸长度为约4mm且直径为约0.75mm。
21.根据权利要求15-20中任意一项所述的长效制剂递送系统，其中所述长效制剂包括药物和生物可降解和/或生物可吸收聚合物。
22.根据权利要求15-20中任意一项所述的长效制剂递送系统，其中所述长效制剂包括有效治疗量的可乐定和生物可降解聚合物。
23.根据权利要求15-20中任意一项所述的长效制剂递送系统，其中所述长效制剂包括多于一种的药物。
24.根据权利要求15-20中任意一项所述的长效制剂递送系统，其中所述长效制剂所具有的最大直径比所述通路的最大直径小0.2英寸(约5mm)和0.5英寸(约13mm)之间。
25.根据权利要求15-20中任意一项所述的长效制剂递送系统，其中所述长效制剂所具有的最大直径比所述通路的最大直径小0.01英寸(约0.25mm)和0.1英寸(约2.5mm)之间。
26.一种长效制剂递送系统，所述系统包括：
硬膜外Tuohy针，所述针构造成生成通往硬膜外空间的路径，所述针包括：
平直的近侧部分，
包括弯曲的尖端的远端，所述尖端包括开口，和
与所述开口连通的通路；以及
刚性的探针，所述探针可滑动地在所述通路中，且构造成将长效制剂推过所述通路并推出所述开口，而所述长效制剂不会卡在所述通路或所述开口中，所述探针包括：
第一端，
第二端，
轴部分，所述轴部分从所述第一端延伸到邻近所述第二端的位置处，和
尖端部分，所述尖端部分从邻近所述第二端的所述位置延伸到所述第二端，所述尖端部分具有弹头形状，其中所述尖端部分的所述弹头形状允许所述尖端部分运动到所述通路中与如果所述尖端部分包括平坦的端部表面相比更远的距离。
27.根据权利要求26所述的长效制剂递送系统，其中所述弹头形状包括从所述轴部分处或邻近所述轴部分处的最大直径到所述第二端处的最小直径的逐渐减小的直径。
28.根据权利要求26所述的长效制剂递送系统，其中所述尖端部分的倒角角度为10°到45°。
29.根据权利要求28所述的长效制剂递送系统，其中所述尖端部分的倒角角度为35°。
30.根据权利要求26-29中任意一项所述的长效制剂递送系统，还包括位于所述通路中的长效制剂。
31.根据权利要求30所述的长效制剂递送系统，其中所述长效制剂包括药丸。
32.根据权利要求31所述的长效制剂递送系统，其中所述药丸具有约4mm的长度和约0.75mm的直径。
33.根据权利要求30所述的长效制剂递送系统，其中所述长效制剂包括药物和至少一种生物可降解和/或生物可吸收聚合物。
34.根据权利要求30所述的长效制剂递送系统，其中所述长效制剂包括有效治疗量的可乐定和生物可降解聚合物。
35.根据权利要求30所述的长效制剂递送系统，其中所述长效制剂包括多个药丸。
36.根据权利要求30所述的长效制剂递送系统，其中所述长效制剂所具有的最大直径比所述通路的最大直径小0.2英寸(约5mm)和0.5英寸(约13mm)之间。
37.根据权利要求30所述的长效制剂递送系统，其中所述长效制剂所具有的最大直径比所述通路的最大直径小0.2英寸(约0.25mm)和0.5英寸(约2.5mm)之间。
38.根据权利要求32所述的长效制剂递送系统，其中所述尖端部分的倒角角度相对于所述探针的纵向轴线为10°到45°。
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US20210236787A1 (en) 2021-08-05
US20170143950A1 (en) 2017-05-25
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